{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:28Z","timestamp":1785772468494,"version":"3.56.0"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das Anti-p200-Pemphigoid ist eine seltene subepidermale bull\u00f6se Autoimmundermatose, die sich klinisch variabel pr\u00e4sentieren und damit andere blasenbildende Dermatosen imitieren kann. Wir berichten \u00fcber einen 65-j\u00e4hrigen Patienten mit ausgepr\u00e4gten palmoplantaren Bullae und Vesikulae sowie Schleimhautbeteiligung, welche in der Zusammenschau an ein Erythema exsudativum multiforme (EEM) erinnerten. Die weiterf\u00fchrende Diagnostik ergab in der direkten Immunfluoreszenz (DIF) lineare IgA-, IgG- und C3-Ablagerungen entlang der dermoepidermalen Junktionszone. Mittels indirekter Immunfluoreszenz (IIF) auf NaCl-separierter humaner Spalthaut (\u201esalt-split skin\u201c) wurden IgA- und IgG-Antik\u00f6rper im Bereich des Blasenbodens nachgewiesen. Im Immunoblot konnten Autoantik\u00f6rper gegen das p200-Antigen sowie Laminin-\u03b24 nachgewiesen werden. Erst dadurch konnte die Diagnose eines IgA-positiven Anti-p200-Pemphigoids gestellt werden, einer sehr seltenen und bislang kaum beschriebenen Variante des Anti-p200-Pemphigoids. Das pr\u00e4sentierte Fallbeispiel unterstreicht somit die Bedeutung des Algorithmus aus Histologie, DIF und IIF zur korrekten Diagnosestellung bei bull\u00f6sen Dermatosen.<\/jats:p>","DOI":"10.1007\/s00105-026-05642-0","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:56:00Z","timestamp":1769000160000},"page":"532-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Erythema exsudativum multiforme imitierendes IgA-positives Anti-p200-Pemphigoid","IgA-positive anti-p200 pemphigoid mimicking erythema multiforme"],"prefix":"10.1007","volume":"77","author":[{"given":"Greta","family":"Ancker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara L.","family":"Blomen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Booken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Siemann-Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"issue":"6","key":"5642_CR1","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/1523-1747.ep12349283","volume":"106","author":"D Zillikens","year":"1996","unstructured":"Zillikens\u00a0D, Kawahara\u00a0Y, Ishiko\u00a0A, Shimizu\u00a0H, Mayer\u00a0J, Rank\u00a0CV et\u00a0al (1996) A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone. J\u00a0Invest Dermatol 106(6):1333\u20131338","journal-title":"J Invest Dermatol"},{"key":"5642_CR2","doi-asserted-by":"crossref","unstructured":"Kasperkiewicz\u00a0M, Pigors\u00a0M, Holtsche\u00a0MM, Goletz\u00a0S, Schmidt\u00a0E (2025) Anti-p200 pemphigoid. Br J Dermatol","DOI":"10.1093\/bjd\/ljaf324"},{"key":"5642_CR3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jdcr.2022.01.011","volume":"21","author":"L S\u00e9m\u00e9ria","year":"2022","unstructured":"S\u00e9m\u00e9ria\u00a0L, Lamiaux\u00a0M, Quinchon\u00a0JF, Modiano\u00a0P (2022) Anti-p200 pemphigoid mimicking erythema multiforme. JAAD Case Rep 21:157\u2013159","journal-title":"JAAD Case Rep"},{"issue":"3","key":"5642_CR4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1346-8138.2009.00793.x","volume":"37","author":"T Dainichi","year":"2010","unstructured":"Dainichi\u00a0T, Koga\u00a0H, Tsuji\u00a0T, Ishii\u00a0N, Ohyama\u00a0B, Ueda\u00a0A et\u00a0al (2010) From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. J\u00a0Dermatol 37(3):231\u2013238","journal-title":"J Dermatol"},{"issue":"4","key":"5642_CR5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jaad.2023.11.014","volume":"90","author":"S Goletz","year":"2024","unstructured":"Goletz\u00a0S, Pigors\u00a0M, Lari\u00a0TR, Hammers\u00a0CM, Wang\u00a0Y, Emtenani\u00a0S et\u00a0al (2024) Laminin \u03b24 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid. J\u00a0Am Acad Dermatol 90(4):790\u2013797","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"5642_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1093\/bjd\/ljae136","volume":"191","author":"S Goletz","year":"2024","unstructured":"Goletz\u00a0S, Probst\u00a0C, Komorowski\u00a0L, Radzimski\u00a0C, Mindorf\u00a0S, Holtsche\u00a0MM et\u00a0al (2024) Sensitive and specific assay for the serological diagnosis of anti-p200 pemphigoid based on the recombinant laminin \u03b24 subunit. Br J Dermatol 191(1):140\u2013141","journal-title":"Br J Dermatol"},{"issue":"9","key":"5642_CR7","first-page":"1038","volume":"21","author":"C Buj\u00e1n-Bonino","year":"2023","unstructured":"Buj\u00e1n-Bonino\u00a0C, Bosch-Amate\u00a0X, Hashimoto\u00a0T, Ishii\u00a0N, Mascar\u00f3\u00a0JM Jr (2023) IgA anti-p200 pemphigoid with areolar tropism. J\u00a0Dtsch Dermatol Ges 21(9):1038\u20131040","journal-title":"J Dtsch Dermatol Ges"}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-026-05642-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-026-05642-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-026-05642-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:06:57Z","timestamp":1785769617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-026-05642-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["5642"],"URL":"https:\/\/doi.org\/10.1007\/s00105-026-05642-0","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"value":"2731-7005","type":"print"},{"value":"2731-7013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"27 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"G.\u00a0Ancker, C.L.\u00a0Blomen, N.\u00a0Booken, U.\u00a0Siemann-Harms und S.W.\u00a0Schneider geben an, dass kein Interessenkonflikt besteht.","order":1,"name":"Ethics","label":"Interessenkonflikt","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}