{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:25:53Z","timestamp":1776749153766,"version":"3.51.2"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["HNO"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00106-015-0005-x","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T17:50:56Z","timestamp":1430416256000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lokale allergische Rhinitis auf Alternaria alternata","Local allergic rhinitis to Alternaria alternata"],"prefix":"10.1007","volume":"63","author":[{"given":"L.","family":"Klimek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bardenhewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Spielhaupter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Harai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pfaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"issue":"3","key":"5_CR1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00106-012-2584-0","volume":"61","author":"L Klimek","year":"2013","unstructured":"Klimek L, Von Bernus L, Pfaar O (2013) Local (exclusive) IgE production in the nasal mucosa. Evidence for local allergic rhinitis. HNO 61(3):217\u2013223","journal-title":"HNO"},{"issue":"35","key":"5_CR2","first-page":"4061","volume":"164","author":"AR Linneberg","year":"2002","unstructured":"Linneberg AR, Nielsen NH, Madsen FF, Frolund L, Dirksen A, Jorgensen T (2002) Increasing prevalence of specific IgE against aeroallergens in an adult Danish population \u2013 two cross-sectional studies in 1990 and 1998. Ugeskr Laeger 164(35):4061\u20134065","journal-title":"Ugeskr Laeger"},{"issue":"3","key":"5_CR3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11882-002-0020-3","volume":"2","author":"WJ Fokkens","year":"2002","unstructured":"Fokkens WJ (2002) Thoughts on the pathophysiology of nonallergic rhinitis. Curr Allergy Asthma Rep 2(3):203\u2013209","journal-title":"Curr Allergy Asthma Rep"},{"issue":"9","key":"5_CR4","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1398-9995.2007.01355.x","volume":"62","author":"E Molgaard","year":"2007","unstructured":"Molgaard E, Thomsen SF, Lund T, Pedersen L, Nolte H, Backer V (2007) Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy 62(9):1033\u20131037","journal-title":"Allergy"},{"issue":"Suppl 86","key":"5_CR5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","volume":"63","author":"J Bousquet","year":"2008","unstructured":"Bousquet J, Khaltaev N, Cruz AA et al (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63(Suppl 86):8\u2013160","journal-title":"Allergy"},{"issue":"10","key":"5_CR6","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1046\/j.1365-2222.2000.00913.x","volume":"30","author":"ML Ng","year":"2000","unstructured":"Ng ML, Warlow RS, Chrishanthan N, Ellis C, Walls RS (2000) Preliminary criteria for the definition of allergic rhinitis: a systematic evaluation of clinical parameters in a disease cohort (II). Clin Exp Allergy 30(10):1417\u20131422","journal-title":"Clin Exp Allergy"},{"issue":"12","key":"5_CR7","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1398-9995.2005.00975.x","volume":"60","author":"JB Rijswijk Van","year":"2005","unstructured":"Van Rijswijk JB, Blom HM, Fokkens WJ (2005) Idiopathic rhinitis, the ongoing quest. Allergy 60(12):1471\u20131481","journal-title":"Allergy"},{"issue":"10","key":"5_CR8","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1046\/j.1365-2222.2003.01737.x","volume":"33","author":"DG Powe","year":"2003","unstructured":"Powe DG, Jagger C, Kleinjan A, Carney AS, Jenkins D, Jones NS (2003) \u201aEntopy\u2018: localized mucosal allergic disease in the absence of systemic responses for atopy. Clin Exp Allergy 33(10):1374\u20131379","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"5_CR9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.jaci.2007.01.006","volume":"119","author":"C Rondon","year":"2007","unstructured":"Rondon C, Romero JJ, Lopez S et al (2007) Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol 119(4):899\u2013905","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"5_CR10","first-page":"25","volume":"41","author":"JB Rijswijk Van","year":"2003","unstructured":"Van Rijswijk JB, Blom HM, Kleinjan A, Mulder PG, Rijntjes E, Fokkens WJ (2003) Inflammatory cells seem not to be involved in idiopathic rhinitis. Rhinology 41(1):25\u201330","journal-title":"Rhinology"},{"issue":"6","key":"5_CR11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1365-2222.2001.01106.x","volume":"31","author":"DG Powe","year":"2001","unstructured":"Powe DG, Huskisson RS, Carney AS, Jenkins D, Jones NS (2001) Evidence for an inflammatory pathophysiology in idiopathic rhinitis. Clin Exp Allergy 31(6):864\u2013872","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"5_CR12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1081-1206(10)62369-1","volume":"88","author":"DR Webb","year":"2002","unstructured":"Webb DR, Meltzer EO, Finn AF Jr et al (2002) Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann Allergy Asthma Immunol 88(4):385\u2013390","journal-title":"Ann Allergy Asthma Immunol"},{"key":"5_CR13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5414\/ALP34307","volume":"34","author":"L Klimek","year":"2011","unstructured":"Klimek L, Schendzielorz P, H\u00f6gger P (2011) Nasale Glukokortikosteroid-Therapie: Ein Update. Allergologie 34:307","journal-title":"Allergologie"},{"issue":"11","key":"5_CR14","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1046\/j.1365-2222.1998.00421.x","volume":"28","author":"HM Blom","year":"1998","unstructured":"Blom HM, Severijnen LA, Van Rijswijk JB, Mulder PG, Van Wijk RG, Fokkens WJ (1998) The long-term effects of capsaicin aqueous spray on the nasal mucosa. Clin Exp Allergy 28(11):1351\u20131358","journal-title":"Clin Exp Allergy"},{"issue":"7","key":"5_CR15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1046\/j.1365-2222.1997.670842.x","volume":"27","author":"HM Blom","year":"1997","unstructured":"Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T, Gerth Van Wijk R (1997) Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. Clin Exp Allergy 27(7):796\u2013801","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"5_CR16","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.jaci.2009.02.018","volume":"123","author":"C Rondon","year":"2009","unstructured":"Rondon C, Dona I, Torres MJ, Campo P, Blanca M (2009) Evolution of patients with nonallergic rhinitis supports conversion to allergic rhinitis. J Allergy Clin Immunol 123(5):1098\u20131102","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"5_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ACI.0b013e328334f5fb","volume":"10","author":"C Rondon","year":"2010","unstructured":"Rondon C, Canto G, Blanca M (2010) Local allergic rhinitis: a new entity, characterization and further studies. Curr Opin Allergy Clin Immunol 10(1):1\u20137","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"5","key":"5_CR18","first-page":"364","volume":"20","author":"C Rondon","year":"2010","unstructured":"Rondon C, Fernandez J, Canto G, Blanca M (2010) Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach. J Investig Allergol Clin Immunol 20(5):364\u2013371 (quiz 362 p following 371)","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"6","key":"5_CR19","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.jaci.2012.02.032","volume":"129","author":"C Rondon","year":"2012","unstructured":"Rondon C, Campo P, Togias A et al (2012) Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol 129(6):1460\u20131467","journal-title":"J Allergy Clin Immunol"},{"key":"5_CR20","volume-title":"Allergologie-Handbuch: Grundlagen und klinische Praxis.","author":"L Klimek","year":"2011","unstructured":"Klimek L, Buhl R, Knop J (2011) Allergologie-Handbuch: Grundlagen und klinische Praxis. Schattauer Verlag, Stuttgart"},{"issue":"7361","key":"5_CR21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/bmj.325.7361.411","volume":"325","author":"M Zureik","year":"2002","unstructured":"Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J, Neukirch F (2002) cross sectional study from European Community respiratory health survey. BMJ 325(7361):411\u2013414","journal-title":"BMJ"},{"issue":"9","key":"5_CR22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/oem.2004.018291","volume":"62","author":"M Simoni","year":"2005","unstructured":"Simoni M, Lombardi E, Berti G et al (2005) Mould\/dampness exposure at home is associated with respiratory disorders in Italian children and adolescents: the SIDRIA-2 Study. Occup Environ Med 62(9):616\u2013622","journal-title":"Occup Environ Med"},{"key":"5_CR23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-0348-7491-5_27","volume":"51","author":"G Schultze-Werninghaus","year":"1987","unstructured":"Schultze-Werninghaus G, Levy J, Bergmann EM, Kappos AD, Meier-Sydow J (1987) Clinical significance of airborne Alternaria tenuis-spores: seasonal symptoms, positive skin and bronchial challenge tests with Alternaria in subjects with asthma and rhinitis. Experientia Suppl 51:153\u2013156","journal-title":"Experientia Suppl"},{"issue":"4","key":"5_CR24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0091-6749(99)70247-2","volume":"103","author":"C Neukirch","year":"1999","unstructured":"Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F (1999) Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol 103(4):709\u2013711","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"5_CR25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaci.2007.04.045","volume":"120","author":"TB Pulimood","year":"2007","unstructured":"Pulimood TB, Corden JM, Bryden C, Sharples L, Nasser SM (2007) Epidemic asthma and the role of the fungal mold Alternaria alternata. J Allergy Clin Immunol 120(3):610\u2013617","journal-title":"J Allergy Clin Immunol"},{"key":"5_CR26","volume-title":"Exogen-allergische Alveolitis","author":"J Sennekamp","year":"1998","unstructured":"Sennekamp J (1998) Exogen-allergische Alveolitis. Dustri, M\u00fcnchen-Deisenhofen"},{"key":"5_CR27","first-page":"525","volume":"9","author":"G Schultze-Werninghaus","year":"1986","unstructured":"Schultze-Werninghaus G, Levy J, Bergmann EM, Kappos AD, Meier-Sydow J (1986) Klinische Bedeutung von Sensibilisierungen gegen Alternaria tenuis bei Asthma bronchiale: Vergleich von Anamnese, Haut- und Provokationsproben mit Sporenh\u00e4ufigkeit im Aeroplankton \u2013 eine retrospektive Analyse. Allergologie 9:525\u2013531","journal-title":"Allergologie"},{"key":"5_CR28","first-page":"29","volume":"11","author":"H Riechelmann","year":"2002","unstructured":"Riechelmann H, Bachert C, Goldschmidt O et al (2002) Durchf\u00fchrung des nasalen Provokationstests bei Erkrankungen der oberen Atemwege. Allergo J 11:29\u201336","journal-title":"Allergo J"},{"key":"5_CR29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2500\/105065896782159738","volume":"10","author":"L Klimek","year":"1996","unstructured":"Klimek L, Riechelmann H, Amedee R (1996) Eosinophil Cationic Protein in nasal secretions and blood serum in grass-pollen allergic rhinitis. Am J Rhinol 10:319\u2013323","journal-title":"Am J Rhinol"},{"key":"5_CR30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1055\/s-2007-997654","volume":"75","author":"L Klimek","year":"1996","unstructured":"Klimek L, Rasp G (1996) Zellaktivierungsmarker bei Rhinitis und Rhinosinusitis: Eosinophiles Kationisches Protein (ECP. Laryngo-Rhino-Otol 75:665\u2013670","journal-title":"Laryngo-Rhino-Otol"},{"issue":"8","key":"5_CR31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","volume":"12","author":"S Romagnani","year":"1991","unstructured":"Romagnani S (1991) Human TH1 and TH2 subsets: doubt no more. Immunol Today 12(8):256\u2013257","journal-title":"Immunol Today"},{"key":"5_CR32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00106-011-2294-z","volume":"59","author":"L Klimek","year":"2011","unstructured":"Klimek L, Pfaar O (2011) Allergische Rhinitis Immunologische und neurogene Mechanismen. Hno 59:1191\u20131197","journal-title":"HNO"},{"issue":"1","key":"5_CR33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00130832-200402000-00009","volume":"4","author":"PG Holt","year":"2004","unstructured":"Holt PG, Upham JW (2004) The role of dendritic cells in asthma. Curr Opin Allergy Clin Immunol 4(1):39\u201344","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"2","key":"5_CR34","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1398-9995.2003.00315.x","volume":"59","author":"DG Powe","year":"2004","unstructured":"Powe DG, Huskisson RS, Carney AS et al (2004) Mucosal T-cell phenotypes in persistent atopic and nonatopic rhinitis show an association with mast cells. Allergy 59(2):204\u2013212","journal-title":"Allergy"},{"issue":"6","key":"5_CR35","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0021-8707(70)90086-9","volume":"46","author":"KS Tse","year":"1970","unstructured":"Tse KS, Wicher K, Arbesman CE (1970) IgE antibodies in nasal secretions of ragweed-allergic subjects. J Allergy 46(6):352\u2013357","journal-title":"J Allergy"},{"issue":"4","key":"5_CR36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0021-8707(70)90023-7","volume":"46","author":"K Ishizaka","year":"1970","unstructured":"Ishizaka K, Newcomb RW (1970) Presence of gammaE in nasal washings and sputum from asthmatic patients. J Allergy 46(4):197\u2013204","journal-title":"J Allergy"},{"issue":"6","key":"5_CR37","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.4049\/jimmunol.122.6.2218","volume":"122","author":"TA Platts-Mills","year":"1979","unstructured":"Platts-Mills TA (1979) Local production of IgG, IgA and IgE antibodies in grass pollen hay fever. J Immunol 122(6):2218\u20132225","journal-title":"J Immunol"},{"issue":"2","key":"5_CR38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1084\/jem.172.2.463","volume":"172","author":"JF Gauchat","year":"1990","unstructured":"Gauchat JF, Lebman DA, Coffman RL, Gascan H, De Vries JE (1990) Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 172(2):463\u2013473","journal-title":"J Exp Med"},{"issue":"5","key":"5_CR39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2500\/105065800781329582","volume":"14","author":"R Pawankar","year":"2000","unstructured":"Pawankar R, Yamagishi S, Yagi T (2000) Revisiting the roles of mast cells in allergic rhinitis and its relation to local IgE synthesis. Am J Rhinol 14(5):309\u2013317","journal-title":"Am J Rhinol"},{"issue":"12","key":"5_CR40","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1002\/1521-4141(200112)31:12<3422::AID-IMMU3422>3.0.CO;2-T","volume":"31","author":"L Smurthwaite","year":"2001","unstructured":"Smurthwaite L, Walker SN, Wilson DR et al (2001) Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol 31(12):3422\u20133431","journal-title":"Eur J Immunol"},{"issue":"4","key":"5_CR41","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1067\/mai.2001.114339","volume":"107","author":"S Ying","year":"2001","unstructured":"Ying S, Humbert M, Meng Q et al (2001) Local expression of epsilon germline gene transcripts and RNA for the epsilon heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma. J Allergy Clin Immunol 107(4):686\u2013692","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"5_CR42","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.4049\/jimmunol.171.7.3816","volume":"171","author":"L Cameron","year":"2003","unstructured":"Cameron L, Gounni AS, Frenkiel S, Lavigne F, Vercelli D, Hamid Q (2003) evidence for direct as well as sequential class switch recombination. J Immunol 171(7):3816\u20133822","journal-title":"J Immunol"},{"issue":"10","key":"5_CR43","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.4049\/jimmunol.171.10.5602","volume":"171","author":"HA Coker","year":"2003","unstructured":"Coker HA, Durham SR, Gould HJ (2003) Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients. J Immunol 171(10):5602\u20135610","journal-title":"J Immunol"},{"issue":"11","key":"5_CR44","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1002\/eji.1830271123","volume":"27","author":"SR Durham","year":"1997","unstructured":"Durham SR, Gould HJ, Thienes CP et al (1997) Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol 27(11):2899\u20132906","journal-title":"Eur J Immunol"},{"issue":"10","key":"5_CR45","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1398-9995.2008.01695.x","volume":"63","author":"C Rondon","year":"2008","unstructured":"Rondon C, Dona I, Lopez S et al (2008) Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response. Allergy 63(10):1352\u20131358","journal-title":"Allergy"},{"issue":"4","key":"5_CR46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0091-6749(97)70079-4","volume":"99","author":"A Kleinjan","year":"1997","unstructured":"Kleinjan A, Godthelp T, Van Toornenenbergen AW, Fokkens WJ (1997) Allergen binding to specific IgE in the nasal mucosa of allergic patients. J Allergy Clin Immunol 99(4):515\u2013521","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"5_CR47","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI119311","volume":"99","author":"R Pawankar","year":"1997","unstructured":"Pawankar R, Okuda M, Yssel H, Okumura K, Ra C (1997) Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40\u202fL, IL-4, and IL-13, and can induce IgE synthesis in B cells. J Clin Invest 99(7):1492\u20131499","journal-title":"J Clin Invest"},{"issue":"1","key":"5_CR48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000237349","volume":"111","author":"AW Zurcher","year":"1996","unstructured":"Zurcher AW, Derer T, Lang AB, Stadler BM (1996) Culture and IgE synthesis of nasal B cells. Int Arch Allergy Immunol 111(1):77\u201382","journal-title":"Int Arch Allergy Immunol"},{"issue":"7926","key":"5_CR49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(75)90056-2","volume":"2","author":"KG Huggins","year":"1975","unstructured":"Huggins KG, Brostoff J (1975) Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests. Lancet 2(7926):148\u2013150","journal-title":"Lancet"},{"issue":"1","key":"5_CR50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4049\/jimmunol.97.1.75","volume":"97","author":"K Ishizaka","year":"1966","unstructured":"Ishizaka K, Ishizaka T, Hornbrook MM (1966) Physico-chemical properties of human reaginic antibody. IV. Presence of a unique immunoglobulin as a carrier of reaginic activity. J Immunol 97(1):75\u201385","journal-title":"J Immunol"},{"issue":"8","key":"5_CR51","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.148.8.2390","volume":"148","author":"SR Durham","year":"1992","unstructured":"Durham SR, Ying S, Varney VA et al (1992) Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte\/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol 148(8):2390\u20132394","journal-title":"J Immunol"},{"issue":"1","key":"5_CR52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2500\/105065897781446775","volume":"11","author":"G Berger","year":"1997","unstructured":"Berger G, Goldberg A, Ophir D (1997) The inferior turbinate mast cell population of patients with perennial allergic and nonallergic rhinitis. Am J Rhinol 11(1):63\u201366","journal-title":"Am J Rhinol"},{"issue":"4","key":"5_CR53","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0091-6749(92)90444-7","volume":"89","author":"AM Bentley","year":"1992","unstructured":"Bentley AM, Jacobson MR, Cumberworth V et al (1992) increases in activated eosinophils and epithelial mast cells. J Allergy Clin Immunol 89(4):877\u2013883","journal-title":"J Allergy Clin Immunol"},{"issue":"3 Suppl 1","key":"5_CR54","doi-asserted-by":"crossref","first-page":"S414","DOI":"10.1016\/j.jaci.2004.12.1134","volume":"115","author":"PH Howarth","year":"2005","unstructured":"Howarth PH, Persson CG, Meltzer EO, Jacobson MR, Durham SR, Silkoff PE (2005) Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol 115(3 Suppl 1):S414\u2013441","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"5_CR55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000235281","volume":"93","author":"WJ Fokkens","year":"1990","unstructured":"Fokkens WJ, Holm AF, Rijntjes E, Mulder PG, Vroom TM (1990) Characterization and quantification of cellular infiltrates in nasal mucosa of patients with grass pollen allergy, non-allergic patients with nasal polyps and controls. Int Arch Allergy Appl Immunol 93(1):66\u201372","journal-title":"Int Arch Allergy Appl Immunol"},{"issue":"2","key":"5_CR56","first-page":"86","volume":"43","author":"A Wedback","year":"2005","unstructured":"Wedback A, Enbom H, Eriksson NE, Moverare R, Malcus I (2005) Seasonal non-allergic rhinitis (SNAR) \u2013 a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. Rhinology 43(2):86\u201392","journal-title":"Rhinology"},{"issue":"10","key":"5_CR57","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1046\/j.1365-2745.2002.01465.x","volume":"32","author":"AS Carney","year":"2002","unstructured":"Carney AS, Powe DG, Huskisson RS, Jones NS (2002) Atypical nasal challenges in patients with idiopathic rhinitis: more evidence for the existence of allergy in the absence of atopy? Clin Exp Allergy 32(10):1436\u20131440","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"5_CR58","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jaci.2010.12.013","volume":"127","author":"C Rondon","year":"2011","unstructured":"Rondon C, Blanca-Lopez N, Aranda A et al (2011) Local allergic rhinitis: allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen. J Allergy Clin Immunol 127(4):1069\u20131071","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"5_CR59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM198507113130201","volume":"313","author":"RM Naclerio","year":"1985","unstructured":"Naclerio RM, Proud D, Togias AG et al (1985) Inflammatory mediators in late antigen-induced rhinitis. N Engl J Med 313(2):65\u201370","journal-title":"N Engl J Med"},{"issue":"3 Pt 1","key":"5_CR60","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0091-6749(88)90005-X","volume":"82","author":"M Castells","year":"1988","unstructured":"Castells M, Schwartz LB (1988) Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response. J Allergy Clin Immunol 82(3 Pt 1):348\u2013355","journal-title":"J Allergy Clin Immunol"},{"issue":"5 Pt 1","key":"5_CR61","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0091-6749(88)90092-9","volume":"82","author":"B Lebel","year":"1988","unstructured":"Lebel B, Bousquet J, Morel A, Chanal I, Godard P, Michel FB (1988) Correlation between symptoms and the threshold for release of mediators in nasal secretions during nasal challenge with grass-pollen grains. J Allergy Clin Immunol 82(5 Pt 1):869\u2013877","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"5_CR62","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1398-9995.2005.00867.x","volume":"60","author":"M Wagenmann","year":"2005","unstructured":"Wagenmann M, Schumacher L, Bachert C (2005) The time course of the bilateral release of cytokines and mediators after unilateral nasal allergen challenge. Allergy 60(9):1132\u20131138","journal-title":"Allergy"},{"issue":"5","key":"5_CR63","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jaci.2009.07.018","volume":"124","author":"C Rondon","year":"2009","unstructured":"Rondon C, Fernandez J, Lopez S et al (2009) Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol 124(5):1005\u20131011 (e1001)","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"5_CR64","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1398-9995.2006.01140.x","volume":"61","author":"U Bodtger","year":"2006","unstructured":"Bodtger U, Poulsen LK, Linneberg A (2006) Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults. Allergy 61(6):712\u2013716","journal-title":"Allergy"},{"issue":"4","key":"5_CR65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2222.2007.02675.x","volume":"37","author":"GK Scadding","year":"2007","unstructured":"Scadding GK (2007) Further marches: allergic and non-allergic. Clin Exp Allergy 37(4):485\u2013487","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"5_CR66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.aller.2011.03.010","volume":"40","author":"N Fuiano","year":"2012","unstructured":"Fuiano N, Fusilli S, Incorvaia C (2012) A role for measurement of nasal IgE antibodies in diagnosis of Alternaria-induced rhinitis in children. Allergol Immunopathol (Madr) 40(2):71\u201374","journal-title":"Allergol Immunopathol (Madr)"},{"key":"5_CR67","first-page":"1","volume":"9","author":"L Klimek","year":"2009","unstructured":"Klimek L, Pfaar O, Grevers G (2009) Therapeutische M\u00f6glichkeiten bei allergischer Rhinitis. MMW 9:1\u20134","journal-title":"MMW"},{"issue":"2","key":"5_CR68","first-page":"AB37","volume":"125","author":"C Rondon","year":"2009","unstructured":"Rondon C, Lopez S, Lisbona J, Mel\u00e9ndez L, Torres MJ, Blanca M (2009) Immunotherapy with grass pollen in patients with \u201eLocal Allergic Rhinitis\u201c. J Allergy Clin Immunol 125(2):AB37 (Supp.1)","journal-title":"J Allergy Clin Immunol"}],"container-title":["HNO"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-015-0005-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00106-015-0005-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-015-0005-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T23:37:48Z","timestamp":1691624268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00106-015-0005-x"}},"subtitle":["Nachweis bei Patienten mit persistierender nasaler Symptomatik","Evidence for local IgE production exclusively in the nasal mucosa"],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["5"],"URL":"https:\/\/doi.org\/10.1007\/s00106-015-0005-x","relation":{},"ISSN":["0017-6192","1433-0458"],"issn-type":[{"value":"0017-6192","type":"print"},{"value":"1433-0458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}