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Hinsichtlich einer zus\u00e4tzlichen Strahlentherapie gibt es in Bezug auf den Zeitpunkt und die Art der Therapie unterschiedliche Ans\u00e4tze. In dieser Studie werden das Gesamt\u00fcberleben und das rezidivfreie \u00dcberleben zweier am Universit\u00e4tsklinikum Essen behandelter Patienten mit ACC der Speicheldr\u00fcsen verglichen, die (A)\u00a0entweder unmittelbar nach operativer Therapie oder (B)\u00a0erst bei Auftreten eines Lokalrezidivs eine Strahlentherapie mit schnellen Neutronen und Photonen (Mixed-beam-Technik) erhielten. Gruppe\u00a0A (<jats:italic>n<\/jats:italic>\u202f=\u200928, Erstdiagnose [ED]: 09\/1991\u201309\/2009) erhielt unmittelbar postoperativ eine adjuvante Strahlentherapie, Gruppe\u00a0B (<jats:italic>n<\/jats:italic>\u202f=\u200924, ED: 06\/1979\u201311\/2001) erhielt dem damaligen Therapieregime entsprechend prim\u00e4r ausschlie\u00dflich eine Tumorresektion und wurde erst bei Auftreten eines Lokalrezidivs bestrahlt. Gruppe\u00a0A wies im Vergleich zu Gruppe\u00a0B eine geringere Rezidivrate und ein signifikant l\u00e4ngeres lokal rezidivfreies \u00dcberleben auf, Gruppe\u00a0B dagegen ein signifikant h\u00f6heres Gesamt\u00fcberleben. Eine Fernmetastasierung trat in beiden Gruppen gleich h\u00e4ufig auf, der Zeitpunkt des Auftretens war in Gruppe\u00a0A jedoch signifikant fr\u00fcher. Fernmetastasierung hatte generell einen relevant negativen Einfluss auf das Gesamt\u00fcberleben. Nach alleinig operativer Prim\u00e4rtherapie ist die lokale Rezidivrate sehr hoch, die unmittelbare adjuvante High-LET(linearer Energietransfer)-Radiatio senkt die lokale Rezidivrate. Eine Bestrahlung nach Eintreten eines Rezidivs beeinflusste das Gesamt\u00fcberleben positiv. Insgesamt erm\u00f6glicht die definitive High-LET-Bestrahlung in Mixed-beam-Technik sowohl prim\u00e4r postoperativ als auch bei lokoregion\u00e4ren Rezidiven hohe Kontrollraten.<\/jats:p>","DOI":"10.1007\/s00106-020-00913-1","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T10:38:11Z","timestamp":1598006291000},"page":"678-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resultate der operativen und strahlentherapeutischen Behandlung von adenoidzystischen Karzinomen der Speicheldr\u00fcsen","Results of surgical and radiotherapeutic treatment of adenoid cystic carcinoma of the salivary glands"],"prefix":"10.1007","volume":"68","author":[{"given":"T.","family":"Bastian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"D\u2019Heygere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Deu\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wittig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Sauerwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Arweiler-Harbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"issue":"10","key":"913_CR1","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1002\/lary.26565","volume":"127","author":"S Ali","year":"2017","unstructured":"Ali\u00a0S, Palmer\u00a0FL, Katabi\u00a0N, Lee\u00a0N, Shah\u00a0JP, Patel\u00a0SG, Ganly\u00a0I (2017) Long term control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and post-operative radiation. 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