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Die Wasserschluckzeit war als prim\u00e4rer Endpunkt definiert. Der Saxon-Test, die maxillomandibul\u00e4re Distanz, der Mallampati-Score, der Quotient aus K\u00f6rpergr\u00f6\u00dfe zu Gewicht, eine nasale Penetration, das Vorhandensein einer Ern\u00e4hrungssonde\/Tracheostomie sowie 4\u00a0validierte Frageb\u00f6gen (Visuelle Analogskala zur Mundtrockenheit, Sicca\u00a0VAS; MD Anderson Dysphagia Inventory, MDADI; Voice Handicap Index, VHI; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire \u2013 Head and Neck Cancer \u2013 35 Items, QLQ-H&amp;N35) dienten als sonstige Endpunkte zur Beurteilung der Funktion und Lebensqualit\u00e4t.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Die Gesamtkohorte an operierten Patienten zeigte eine erh\u00f6hte Rate an nasaler Penetration (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090,0001), was mit einer verl\u00e4ngerten Wasserschluckzeit verbunden war (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090,05). Durch eine modifizierte Rekonstruktion des Weichgaumens wurde die nasale Penetration in der chirurgisch therapierten Gruppe im Vergleich zur klassischen Rekonstruktion signifikant reduziert (<jats:italic>p<\/jats:italic>\u202f=\u20090,0001). Patienten mit pRCT litten signifikant st\u00e4rker an einer Xerostomie (Saxon-Test) als Patienten nach TMR+Tx und Adjuvanz (<jats:italic>p<\/jats:italic>\u202f=\u20090,001). In den Frageb\u00f6gen zur Funktionalit\u00e4t und Lebensqualit\u00e4t zeigte sich kein Unterschied zwischen den Gruppen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schussfolgerung<\/jats:title>\n                <jats:p>Die TMR+Tx mit modifizierter Rekonstruktion und adjuvante Therapie zeigte gegen\u00fcber der pRCT vergleichbare funktionelle Ergebnisse.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-020-00930-0","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T23:19:48Z","timestamp":1600125588000},"page":"110-121","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Funktionelle Ergebnisse nach transmandibul\u00e4rer Resektion und prim\u00e4rer Radiochemotherapie bei fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen"],"prefix":"10.1007","volume":"69","author":[{"given":"A.","family":"Knopf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hofauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Wakonig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Teutsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"issue":"2","key":"930_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","volume":"55","author":"DM Parkin","year":"2005","unstructured":"Parkin\u00a0DM, Bray\u00a0F, Ferlay\u00a0J, Pisani\u00a0P (2005) Global cancer statistics, 2002. 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Eur Arch Otorhinolaryngol 270(1):305\u2013312","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["HNO"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-020-00930-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00106-020-00930-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-020-00930-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T23:15:46Z","timestamp":1631574946000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00106-020-00930-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["930"],"URL":"https:\/\/doi.org\/10.1007\/s00106-020-00930-0","relation":{},"ISSN":["0017-6192","1433-0458"],"issn-type":[{"value":"0017-6192","type":"print"},{"value":"1433-0458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]},"assertion":[{"value":"14 September 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.\u00a0Knopf, N.\u00a0Mansour, B.\u00a0Hofauer, F.\u00a0Johnson, H.\u00a0Bier, F.\u00a0Wakonig und S.\u00a0Teutsch geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Die Studie wurde von der Ethikkommission gepr\u00fcft und genehmigt (Nr. 389\/16S).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}