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Radiochemotherapie ist mit einer schlechten Prognose verbunden. Die Salvage-Operation stellt in diesen F\u00e4llen die wichtigste therapeutische Option dar.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Erfasst wurden die Rate an Rezidiv- und Residualtumoren sowie die \u00dcberlebensraten und die Komplikationsrate nach Salvage-Chirurgie des Kehlkopfs an dem akademischen Tumorzentrum der Autor(inn)en.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Retrospektiv wurden alle Patienten untersucht, bei denen zwischen 2001 und 2019 eine Salvage-Operation aufgrund eines Tumorresiduums oder Rezidivs nach prim\u00e4rer nichtchirurgischer Therapie erfolgt war.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Es wurden 33\u00a0Salvage-Operationen durchgef\u00fchrt. Die Defektrekonstruktion erfolgte in 30,3\u202f% der F\u00e4lle (<jats:italic>n<\/jats:italic>\u202f=\u200910) mittels freier und in 15,2\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u20095) mittels regionaler Lappenplastik. Ein Patient hat sowohl eine freie als auch gleichzeitig eine gestielte Lappenplastik erhalten. Das Gesamt\u00fcberleben nach einem, 2\u00a0und 5\u00a0Jahren betrug 68,7\u202f%; 47,9\u202f% bzw. 24,2\u202f%, das krankheitsfreie \u00dcberleben 81,6\u202f%; 47,8\u202f% bzw. 24,2\u202f% bei insgesamt 48,5\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200916) postoperativen Tumorrezidiven. Das krankheitsfreie \u00dcberleben war signifikant k\u00fcrzer bei Tumorausdehnung im bzw. auf den Hypopharynx (<jats:italic>p<\/jats:italic>\u202f=\u20090,041). Postoperativ entwickelten 72,7\u202f% der Patienten eine pharyngokutane Fistel unabh\u00e4ngig von einer simultanen Defektrekonstruktion. Nur 24\u202f% der der aufgetretenen Fisteln mussten operativ therapiert werden. Der Krankenhausaufenthalt betrug 28,0\u202f\u00b1\u200916,1 Tage.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die Salvage-Laryngektomie ist mit vielen, aber beherrschbaren Komplikationen und einer hohen Morbidit\u00e4t verbunden. In Anbetracht der behandelten fortgeschrittenen Tumorkategorien und der Gesamtsituation des Patienten sind respektable onkologische Ergebnisse zu erreichen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-021-01029-w","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T18:03:14Z","timestamp":1617991394000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvage-Laryngektomie nach prim\u00e4rer Radio- und Radiochemotherapie","Salvage laryngectomy after primary radio- and radiochemotherapy"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-4049","authenticated-orcid":false,"given":"Matti","family":"Sievert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedicta","family":"Binder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarina K.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"D\u00fcrr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Traxdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Iro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoniu-Oreste","family":"Gostian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"1029_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005537-200003001-00001","volume":"110","author":"WJ Goodwin Jr.","year":"2000","unstructured":"Goodwin\u00a0WJ Jr. (2000) Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? 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