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Salvage surgery is the most important therapeutic option in these cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The study assessed rates of recurrence and residual tumor as well as survival and complication rates after salvage laryngectomy at the authors\u2019 academic cancer center.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A\u00a0retrospective examination of all patients receiving laryngectomy between 2001 and 2019 due to tumor residuals or recurrence after primary radio- and radiochemotherapy was conducted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 33\u00a0salvage procedures were performed. Defect reconstruction was performed by free flap surgery in 30.3% (<jats:italic>n<\/jats:italic>\u202f=\u200910) and regional flap surgery in 15.2% (<jats:italic>n<\/jats:italic>\u202f=\u20095) . One patient received regional flap surgery and free flap surgery simultaneously. Overall survival after 1, 2, and 5\u00a0years was 68.7, 47.9, and 24.2%, and disease-free survival was 81.6, 47.8, and 24.2%, respectively, with 48.5% (<jats:italic>n<\/jats:italic>\u202f=\u200916) postoperative tumor recurrences overall. Disease-free survival was significantly shorter for tumor extension into or onto the hypopharynx (<jats:italic>p<\/jats:italic>\u202f=\u20090.041). Postoperatively, 72.7% of patients developed a\u00a0pharyngocutaneous fistula, of which 24.2% required surgical treatment. The hospital stay was 28.0\u202f\u00b1\u200916.1 days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Salvage laryngectomy is associated with a\u00a0high rate of treatable complications and high morbidity. Nevertheless, considering the advanced tumor stages treated, it allows for respectable oncological results.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-021-01030-3","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T13:03:33Z","timestamp":1621602213000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Salvage laryngectomy after primary radio- and radiochemotherapy","Salvage-Laryngektomie nach prim\u00e4rer Radio- und Radiochemotherapie"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-4049","authenticated-orcid":false,"given":"Matti","family":"Sievert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicta","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina K.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Rupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"D\u00fcrr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Traxdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Iro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniu-Oreste","family":"Gostian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"1030_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005537-200003001-00001","volume":"110","author":"WJ Goodwin Jr.","year":"2000","unstructured":"Goodwin\u00a0WJ Jr. (2000) Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive tract: when do the ends justify the means? 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