{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:31:27Z","timestamp":1717655487092},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum M\u00fcnster"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["HNO"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Aufgrund der unterschiedlichen Karzinogenese, Prognose und klinischen Manifestation werden seit der 8.\u00a0Auflage des TNM-Klassifikationssystems der UICC\/AJCC (UICC\u00a08) humane Papillomavirus (HPV)-assoziierte und HPV-negative oropharyngeale Plattenepithelkarzinome (OSCC) als 2\u00a0Entit\u00e4ten separat klassifiziert.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Insgesamt 524 Patienten mit einem im Zeitraum von 2000\u20132016 in der HNO-Klinik des Universit\u00e4tsklinikums M\u00fcnster behandelten OSCC wurden hinsichtlich des Nachweises von HPV-Typ-16-spezifischer DNA (HPV16-DNA), des Nikotin- und Alkoholkonsums sowie des Therapieeinflusses auf das Gesamt\u00fcberleben (G\u00dc) untersucht.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Ein signifikanter Anstieg der j\u00e4hrlichen Pr\u00e4valenz der HPV16-DNA-positiven OSCC von 40\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200912\/30) im Jahr 2000 auf 46\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u200918\/39) im Jahr 2016 wurde verzeichnet (<jats:italic>p<\/jats:italic>\u202f=\u20090,025, \u03b2\u202f=\u20090,539). 89\u202f% (<jats:italic>n<\/jats:italic>\u202f=\u2009212) der HPV16-DNA-positiven OSCC wurden anhand der UICC\u00a08 gegen\u00fcber der UICC\u00a07 herabgestuft. Im Gesamtkollektiv zeigten der h\u00e4ufige Alkohol- und Nikotinkonsum (\u2265\u202f10\u00a0Packungsjahre) einen statistisch relevanten negativen Einfluss auf das G\u00dc (<jats:italic>p<\/jats:italic>\u202f=\u20090,004 und <jats:italic>p<\/jats:italic>\u202f=\u20090,009). Auch h\u00e4ufiger Alkoholkonsum war in der HPV16-DNA-negativen Gruppe prognoserelevant (<jats:italic>p<\/jats:italic>\u202f=\u20090,049). In der HPV16-DNA-positiven Gruppe zeigte sich bez\u00fcglich des G\u00dc zwischen den UICC-Stadien\u00a0I und\u00a0II (<jats:italic>p<\/jats:italic>\u202f=\u20090,481) sowie zwischen\u00a0III und\u00a0IV (<jats:italic>p<\/jats:italic>\u202f=\u20090,439) gem\u00e4\u00df UICC\u00a08 kein statistischer Unterschied.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Die UICC\u00a08 verbessert zwar die Prognosestratifikation der OSCC durch die Trennung von HPV-positiven und HPV-negativen Tumoren im Vergleich zu UICC\u00a07, die prognostische Aussagekraft der UICC\u00a08 f\u00fcr die HPV-assoziierten OSCC ist jedoch weiterhin unzureichend. Der Noxenkonsum k\u00f6nnte zuk\u00fcnftig Einfluss auf die UICC-Klassifikation nehmen, um die prognostische Aussagekraft weiter zu verbessern.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-021-01076-3","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T13:03:14Z","timestamp":1624626194000},"page":"102-109","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognosefaktoren f\u00fcr das Gesamt\u00fcberleben bei Oropharynxkarzinomen in Abh\u00e4ngigkeit vom HPV-Status"],"prefix":"10.1007","volume":"70","author":[{"given":"A.","family":"Riders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Oberste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Abbaspour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Beule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rudack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"issue":"1","key":"1076_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/hed.24528","volume":"39","author":"P Baumeister","year":"2017","unstructured":"Baumeister\u00a0P, Rauch\u00a0J, Jacobi\u00a0C et\u00a0al (2017) Impact of comorbidity and anemia in patients with oropharyngeal cancer primarily treated with surgery in the human papillomavirus era. Head Neck 39(1):7\u201316","journal-title":"Head Neck"},{"issue":"4","key":"1076_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","volume":"26","author":"AK Chaturvedi","year":"2008","unstructured":"Chaturvedi\u00a0AK, Engels\u00a0EA, Anderson\u00a0WF, Gillison\u00a0ML (2008) Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J\u00a0Clin Oncol 26(4):612\u2013619","journal-title":"J Clin Oncol"},{"issue":"32","key":"1076_CR3","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","volume":"29","author":"AK Chaturvedi","year":"2011","unstructured":"Chaturvedi\u00a0AK, Engels\u00a0EA, Pfeiffer\u00a0RM et\u00a0al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J\u00a0Clin Oncol 29(32):4294\u20134301","journal-title":"J Clin Oncol"},{"issue":"19","key":"1076_CR4","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1056\/NEJMoa065497","volume":"356","author":"G D\u2019Souza","year":"2007","unstructured":"D\u2019Souza\u00a0G, Kreimer\u00a0AR, Viscidi\u00a0R et al (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N\u00a0Engl J Med 356(19):1944\u20131956","journal-title":"N Engl J Med"},{"issue":"9","key":"1076_CR5","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.oraloncology.2015.06.005","volume":"51","author":"KR Dahlstrom","year":"2015","unstructured":"Dahlstrom\u00a0KR, Bell\u00a0D, Hanby\u00a0D et\u00a0al (2015) Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior. Oral Oncol 51(9):832\u2013838","journal-title":"Oral Oncol"},{"key":"1076_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3389\/fonc.2018.00273","volume":"8","author":"S Deschuymer","year":"2018","unstructured":"Deschuymer\u00a0S, Dok\u00a0R, Laenen\u00a0A, Hauben\u00a0E, Nuyts\u00a0S (2018) Patient selection in human papillomavirus related oropharyngeal cancer: the added value of prognostic models in the new TNM 8th edition era. Front Oncol 8:273","journal-title":"Front Oncol"},{"key":"1076_CR7","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3389\/fonc.2020.00398","volume":"10","author":"A Fazel","year":"2020","unstructured":"Fazel\u00a0A, Quabius\u00a0ES, Fabian\u00a0A et al (2020) The influence of smoking and co-morbidity on dose achievement in primary or adjuvant radio(chemo)therapy in head and neck squamous cell carcinoma (HNSCC). Front Oncol 10:398","journal-title":"Front Oncol"},{"issue":"5","key":"1076_CR8","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3892\/mco.2020.2120","volume":"13","author":"A Fazel","year":"2020","unstructured":"Fazel\u00a0A, Quabius\u00a0ES, Gonzales-Donate\u00a0M et al (2020) Alteration of smoking habit at time of first diagnosis influences survival of patients with HNSCC. Mol Clin Oncol 13(5):50","journal-title":"Mol Clin Oncol"},{"issue":"10166","key":"1076_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","volume":"393","author":"ML Gillison","year":"2019","unstructured":"Gillison\u00a0ML, Trotti\u00a0AM, Harris\u00a0J et al (2019) Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a\u00a0randomised, multicentre, non-inferiority trial [published correction appears in Lancet. 2020, 395(10226):784. Lancet 393(10166):40\u201350","journal-title":"Lancet"},{"issue":"45","key":"1076_CR10","doi-asserted-by":"publisher","first-page":"4655","DOI":"10.18632\/oncotarget.27079","volume":"10","author":"C Gr\u00f8nh\u00f8j","year":"2019","unstructured":"Gr\u00f8nh\u00f8j\u00a0C, Jensen\u00a0JS, Wagner\u00a0S et al (2019) Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a\u00a0multicenter retrospective study. Oncotarget 10(45):4655\u20134663","journal-title":"Oncotarget"},{"key":"1076_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.oraloncology.2019.06.035","volume":"96","author":"C Gr\u00f8nh\u00f8j","year":"2019","unstructured":"Gr\u00f8nh\u00f8j\u00a0C, Kronberg Jakobsen\u00a0K, Kj\u00e6r\u00a0E, Friborg\u00a0J, von Buchwald\u00a0C (2019) Comorbidity in HPV+ and HPV-oropharyngeal cancer patients: a population-based, case-control study. Oral Oncol 96:1\u20136","journal-title":"Oral Oncol"},{"issue":"6","key":"1076_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10552-017-0889-8","volume":"28","author":"P Javadi","year":"2017","unstructured":"Javadi\u00a0P, Sharma\u00a0A, Zahnd\u00a0WE, Jenkins\u00a0WD (2017) Evolving disparities in the epidemiology of oral cavity and oropharyngeal cancers. Cancer Causes Control 28(6):635\u2013645","journal-title":"Cancer Causes Control"},{"issue":"15","key":"1076_CR13","doi-asserted-by":"publisher","first-page":"4791","DOI":"10.1158\/0008-5472.CAN-13-0587","volume":"73","author":"RJ Kimple","year":"2013","unstructured":"Kimple\u00a0RJ, Smith\u00a0MA, Blitzer\u00a0GC et al (2013) Enhanced radiation sensitivity in HPV-positive head and neck cancer. Cancer Res 73(15):4791\u20134800","journal-title":"Cancer Res"},{"issue":"10","key":"1076_CR14","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1158\/1055-9965.EPI-19-0038","volume":"28","author":"BA Mahal","year":"2019","unstructured":"Mahal\u00a0BA, Catalano\u00a0PJ, Haddad\u00a0RI et al (2019) Incidence and demographic burden of HPV-associated oropharyngeal head and neck cancers in the United States. Cancer Epidemiol Biomarkers Prev 28(10):1660\u20131667","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"15","key":"1076_CR15","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/j.ejca.2014.07.001","volume":"50","author":"L Masterson","year":"2014","unstructured":"Masterson\u00a0L, Moualed\u00a0D, Liu\u00a0ZW et al (2014) De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a\u00a0systematic review and meta-analysis of current clinical trials. Eur J Cancer 50(15):2636\u20132648","journal-title":"Eur J Cancer"},{"issue":"10166","key":"1076_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(18)32752-1","volume":"393","author":"H Mehanna","year":"2019","unstructured":"Mehanna\u00a0H, Robinson\u00a0M, Hartley\u00a0A et al (2019) Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet 393(10166):51\u201360","journal-title":"Lancet"},{"issue":"6","key":"1076_CR17","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s00066-019-01451-8","volume":"195","author":"A Modesto","year":"2019","unstructured":"Modesto\u00a0A, Galissier\u00a0T, Lusque\u00a0A et al (2019) Definitive Radiochemotherapie oder initiale Operation beim Oropharynxkarzinom: In welchem Umfang kann die p16-Expression im Entscheidungsprozess verwendet werden? Strahlenther Onkol 195(6):496\u2013503","journal-title":"Strahlenther Onkol"},{"issue":"1","key":"1076_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.14639\/0392-100X-1905","volume":"39","author":"P Morbini","year":"2019","unstructured":"Morbini\u00a0P, Alberizzi\u00a0P, Ferrario\u00a0G et al (2019) The evolving landscape of human papillomavirus-related oropharyngeal squamous cell carcinoma at a\u00a0single institution in Northern Italy. Acta Otorhinolaryngol Ital 39(1):9\u201317","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"5","key":"1076_CR19","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1093\/annonc\/mdy060","volume":"29","author":"IH Nauta","year":"2018","unstructured":"Nauta\u00a0IH, Rietbergen\u00a0MM, van Bokhoven\u00a0AAJD et al (2018) Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing. Ann Oncol 29(5):1273\u20131279","journal-title":"Ann Oncol"},{"key":"1076_CR20","doi-asserted-by":"publisher","first-page":"100207","DOI":"10.1016\/j.pvr.2020.100207","volume":"10","author":"ES Quabius","year":"2020","unstructured":"Quabius\u00a0ES, Fazel\u00a0A, Knieling\u00a0C et al (2020) No association between HPV-status in tonsillar tissue and sexual behavior of the patients in a\u00a0northern German population\u2014critical view of the link between HPV natural history and HPV-driven carcinogenesis. Papillomavirus Res 10:100207","journal-title":"Papillomavirus Res"},{"issue":"2","key":"1076_CR21","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.radonc.2013.03.013","volume":"107","author":"T Rieckmann","year":"2013","unstructured":"Rieckmann\u00a0T, Tribius\u00a0S, Grob\u00a0TJ et\u00a0al (2013) HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol 107(2):242\u2013246","journal-title":"Radiother Oncol"},{"issue":"10","key":"1076_CR22","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1002\/lary.26566","volume":"127","author":"MH Stenmark","year":"2017","unstructured":"Stenmark\u00a0MH, Shumway\u00a0D, Guo\u00a0C et\u00a0al (2017) Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States. Laryngoscope 127(10):2270\u20132278","journal-title":"Laryngoscope"},{"issue":"7","key":"1076_CR23","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s41416-020-0964-x","volume":"123","author":"S Wagner","year":"2020","unstructured":"Wagner\u00a0S, Prigge\u00a0ES, Wuerdemann\u00a0N et al (2020) Evaluation of p16INK4a expression as a\u00a0single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation. Br J Cancer 123(7):1114\u20131122","journal-title":"Br J Cancer"},{"issue":"6","key":"1076_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1158\/1940-6207.CAPR-19-0098","volume":"12","author":"C Wittekindt","year":"2019","unstructured":"Wittekindt\u00a0C, Wagner\u00a0S, Bushnak\u00a0A et\u00a0al (2019) Increasing incidence rates of oropharyngeal squamous cell carcinoma in Germany and significance of disease burden attributed to human papillomavirus. Cancer Prev Res 12(6):375\u2013382","journal-title":"Cancer Prev Res"},{"issue":"S 01","key":"1076_CR25","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1055\/s-0043-121596","volume":"97","author":"C Wittekindt","year":"2018","unstructured":"Wittekindt\u00a0C, Wagner\u00a0S, Sharma\u00a0SJ et\u00a0al (2018) HPV\u2014a different view on head and neck cancer. Laryngorhinootologie 97(S 01):S48\u2013S113","journal-title":"Laryngorhinootologie"},{"issue":"6","key":"1076_CR26","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000477097","volume":"40","author":"N Wuerdemann","year":"2017","unstructured":"Wuerdemann\u00a0N, Wittekindt\u00a0C, Sharma\u00a0SJ et al (2017) Risk factors for overall survival outcome in surgically treated human papillomavirus-negative and positive patients with oropharyngeal cancer. Oncol Res Treat 40(6):320\u2013327","journal-title":"Oncol Res Treat"},{"key":"1076_CR27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3389\/fonc.2017.00129","volume":"7","author":"N W\u00fcrdemann","year":"2017","unstructured":"W\u00fcrdemann\u00a0N, Wagner\u00a0S, Sharma\u00a0SJ et\u00a0al (2017) Prognostic impact of AJCC\/UICC 8th edition: new staging rules in oropharyngeal squamous cell carcinoma. Front Oncol 7:129","journal-title":"Front Oncol"}],"container-title":["HNO"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-021-01076-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00106-021-01076-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-021-01076-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T12:04:03Z","timestamp":1643889843000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00106-021-01076-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["1076"],"URL":"https:\/\/doi.org\/10.1007\/s00106-021-01076-3","relation":{},"ISSN":["0017-6192","1433-0458"],"issn-type":[{"value":"0017-6192","type":"print"},{"value":"1433-0458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"assertion":[{"value":"18 May 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.\u00a0Riders, M.\u00a0Oberste, B.\u00a0Abbaspour, A.\u00a0Beule und C.\u00a0Rudack geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am humanen Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethik-Kommission durchgef\u00fchrt.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}