{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T17:22:05Z","timestamp":1751304125716},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["HNO"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Tinnitus und Schwindel wurden schon auf vielf\u00e4ltige Weise untersucht. Daraus ergaben sich multiple Erkl\u00e4rungsans\u00e4tze aus verschiedenen medizinischen Disziplinen. Auch die Muskulatur des Kiefers und der Halswirbels\u00e4ule wurde diesbez\u00fcglich erforscht. Es zeigten sich deutliche Hinweise daf\u00fcr, dass bei Funktionsst\u00f6rungen dieser Muskulatur Tinnitus ausgel\u00f6st werden kann. Diese Unterart des Tinnitus wird als sog. zervikogener somatosensorischer Tinnitus bezeichnet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Studie<\/jats:title>\n                <jats:p>Das Ziel war die Untersuchung des Effekts der manuellen Therapie auf die von Probanden berichtete, individuell empfundene Beeintr\u00e4chtigung durch zervikogenen somatosensorischen Tinnitus (Tinnitus Handicap Inventory), auf die Schwindelsymptomatik (Dizziness Handicap Inventory) und auf die hypertone zervikokraniale Muskulatur.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methodik<\/jats:title>\n                <jats:p>In einer prospektiven randomisierten Studie wurden 80\u00a0Patient*innen (40\u00a0in der Interventionsgruppe und 40\u00a0in der Kontrollgruppe) \u00e4rztlich untersucht und befragt. Anschlie\u00dfend erhielten sie manuelle Therapie.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Nach manueller Therapie zeigten sich bzgl. des Tinnitus Handicap Inventory, des Dizziness Handicap Inventory und muskul\u00e4rer Hypertonien signifikante Unterschiede zwischen den Gruppen zugunsten der Interventionsgruppe.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Die manuelle Untersuchung und Therapie stellten sich als wirksam heraus. Sie sollte bei ausbleibender HNO-\u00e4rztlicher Organpathologie und Verdacht auf zervikogenen somatosensorischen Tinnitus verst\u00e4rkt zur Anwendung kommen. Die Rolle der einzelnen Muskeln gilt es tiefergehend zu untersuchen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-022-01198-2","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T12:02:48Z","timestamp":1659528168000},"page":"675-684","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pilotstudie: manualmedizinische Methodenevaluation zur Modulierbarkeit des Leitsymptoms Tinnitus"],"prefix":"10.1007","volume":"70","author":[{"given":"A.","family":"Fobbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"B\u00f6kel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lesinski-Schiedat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gutenbrunner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"issue":"4","key":"1198_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1007\/s00106-014-2971-9","volume":"63","author":"E Biesinger","year":"2015","unstructured":"Biesinger\u00a0E, Groth\u00a0A, H\u00f6ing\u00a0R, H\u00f6lzl\u00a0M (2015) Somatosensorischer Tinnitus. HNO 63(4):266\u2013271. https:\/\/doi.org\/10.1007\/s00106-014-2971-9","journal-title":"HNO"},{"key":"1198_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00106-019-0633-7#Sec48","volume":"67","author":"RFF Cima","year":"2019","unstructured":"Cima\u00a0RFF, Mazurek\u00a0B, Haider\u00a0H, Kikidis\u00a0D, Lapira\u00a0A, Nore\u00f1a\u00a0A, Hoare\u00a0DJ (2019) A multidisciplinary European guideline for tinnitus: diagnostics, assessment, and treatment. HNO 67:10\u201342. https:\/\/doi.org\/10.1007\/s00106-019-0633-7#Sec48","journal-title":"HNO"},{"key":"1198_CR3","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"1988","unstructured":"Cohen\u00a0J (1988) Statistical power analysis for the behavioral sciences, 2.\u00a0Aufl. Lawrence Erlbaum, Hilldale","edition":"2"},{"key":"1198_CR4","first-page":"277","volume":"25","author":"KK Hansraj","year":"2014","unstructured":"Hansraj\u00a0KK (2014) Assessment of stresses in the cervical spine caused by posture and position of the head. Surg Technol Int 25:277\u2013279","journal-title":"Surg Technol Int"},{"issue":"5","key":"1198_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00337-015-0029-z","volume":"53","author":"W von Heymann","year":"2015","unstructured":"von Heymann\u00a0W (2015) Kopfschmerz, Schwindel, Tinnitus und Halswirbels\u00e4ule. Man Med 53(5):361\u2013373. https:\/\/doi.org\/10.1007\/s00337-015-0029-z","journal-title":"Man Med"},{"issue":"3","key":"1198_CR6","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00106-018-0479-4","volume":"66","author":"M H\u00f6lzl","year":"2018","unstructured":"H\u00f6lzl\u00a0M, Behrmann\u00a0R, Biesinger\u00a0E, von Heymann\u00a0W, H\u00fclse\u00a0R, Arens\u00a0C (2018) Ausgew\u00e4hlte HNO-Symptome bei funktionellen St\u00f6rungen der oberen Halswirbels\u00e4ule und der Kiefergelenke. HNO 66(3):237\u2013250. https:\/\/doi.org\/10.1007\/s00106-018-0479-4","journal-title":"HNO"},{"issue":"1","key":"1198_CR7","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1055\/s-2006-940218","volume":"34","author":"T Kleinjung","year":"2007","unstructured":"Kleinjung\u00a0T, Fischer\u00a0B, Langguth\u00a0B, Sand\u00a0P, Hajak\u00a0G, Dvorakova\u00a0J, Eichhammer\u00a0P (2007) Validierung einer deutschsprachigen Version des \u201eTinnitus Handicap Inventory\u201d. Psychiat Prax 34(1):140\u2013142. https:\/\/doi.org\/10.1055\/s\u20132006\u2013940218","journal-title":"Psychiat Prax"},{"issue":"3","key":"1198_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/MAO.0b013e3181977e09","volume":"30","author":"A Kurre","year":"2009","unstructured":"Kurre\u00a0A, van Gool\u00a0CJAW, Bastiaenen\u00a0CHG, Gloor-Juzi\u00a0T, Straumann\u00a0D, de Bruin\u00a0ED (2009) Translation, cross-cultural adaptation and reliability of the german version of the dizziness handicap inventory. Otol Neurotol 30(3):359\u2013367. https:\/\/doi.org\/10.1097\/MAO.0b013e3181977e09","journal-title":"Otol Neurotol"},{"issue":"3","key":"1198_CR9","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/pm\/pnz278","volume":"21","author":"P Delgado de la Serna","year":"2020","unstructured":"Delgado de la Serna\u00a0P, Plaza-Manzano\u00a0G, Cleland\u00a0J, Fern\u00e1ndez-de-Las-Pe\u00f1as\u00a0C, Mart\u00edn-Casas\u00a0P, D\u00edaz-Arribas\u00a0MJ (2020) Effects of cervico-mandibular manual therapy in patients with temporomandibular pain disorders and associated somatic tinnitus: a randomized clinical trial. Pain Med 21(3):613\u2013624. https:\/\/doi.org\/10.1093\/pm\/pnz278","journal-title":"Pain Med"},{"issue":"1","key":"1198_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1055\/s-0042-119419","volume":"96","author":"B Mazurek","year":"2017","unstructured":"Mazurek\u00a0B, Szczepek\u00a0AJ, Br\u00fcggemann\u00a0P (2017) Tinnitus \u2013 Klinik und Therapie. Laryngorhinootologie 96(1):47\u201359. https:\/\/doi.org\/10.1055\/s-0042-119419","journal-title":"Laryngorhinootologie"},{"issue":"5","key":"1198_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1365-2273.2001.00490.x","volume":"26","author":"A McCombe","year":"2001","unstructured":"McCombe\u00a0A, Baguley\u00a0D, Coles\u00a0R, McKenna\u00a0L, McKinney\u00a0C, Windle-Taylor\u00a0P (2001) Guidelines for the grading of tinnitus severity: the results of a\u00a0working group commissioned by the British association of otolaryngologists, head and neck surgeons, 1999. Clin Otolaryngol Allied Sci 26(5):388\u2013393. https:\/\/doi.org\/10.1046\/j.1365-2273.2001.00490.x","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"4","key":"1198_CR12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1097\/MAO.0000000000000670","volume":"36","author":"S Michiels","year":"2015","unstructured":"Michiels\u00a0S, De Hertogh\u00a0W, Truijen\u00a0S, Van de Heyning\u00a0P (2015) Cervical spine dysfunctions in patients with chronic subjective tinnitus. Otol Neurotol 36(4):741\u2013745. https:\/\/doi.org\/10.1097\/MAO.0000000000000670","journal-title":"Otol Neurotol"},{"key":"1198_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.math.2016.08.005","volume":"26","author":"S Michiels","year":"2016","unstructured":"Michiels\u00a0S, Van de Heyning\u00a0P, Truijen\u00a0S, Hallemans\u00a0A, De Hertogh\u00a0W (2016) Does multi-modal cervical physical therapy improve tinnitus in patients with cervicogenic somatic tinnitus? Man Ther 26:125\u2013131. https:\/\/doi.org\/10.1016\/j.math.2016.08.005","journal-title":"Man Ther"},{"key":"1198_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3389\/fnins.2016.00545","volume":"10","author":"S Michiels","year":"2016","unstructured":"Michiels\u00a0S, Naessens\u00a0S, Van de Heyning\u00a0P, Braem\u00a0M, Visscher\u00a0CM, Gilles\u00a0A, de Hertogh\u00a0W (2016) The effect of physical therapy treatment in patients with subjective tinnitus: a systematic review. Front Neurosci 10:545. https:\/\/doi.org\/10.3389\/fnins.2016.00545","journal-title":"Front Neurosci"},{"key":"1198_CR15","doi-asserted-by":"publisher","first-page":"233121651879640","DOI":"10.1177\/2331216518796403","volume":"22","author":"S Michiels","year":"2018","unstructured":"Michiels\u00a0S, Ganz Sanchez\u00a0T, Oron\u00a0Y, Gilles\u00a0A, Haider\u00a0HF, Erlandsson\u00a0S, Bechter\u00a0K, Vielsmeier\u00a0V, Biesinger\u00a0E, Nam\u00a0E\u2011C, Oiticica\u00a0J, de Medeiros \u00cdRT, Bezerra Rocha\u00a0C, Langguth\u00a0B, Van de Heyning\u00a0P, De Hertogh\u00a0W, Hall\u00a0DA (2018) Diagnostic criteria for somatosensory tinnitus: a Delphi process and face-to-face meeting to establish consensus. Trends Hear 22:2331216518796403. https:\/\/doi.org\/10.1177\/2331216518796403","journal-title":"Trends Hear"},{"key":"1198_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.math.2016.02.006","volume":"23","author":"RAB Oostendorp","year":"2016","unstructured":"Oostendorp\u00a0RAB, Bakker\u00a0I, Elvers\u00a0H, Mikolajewska\u00a0E, Michiels\u00a0S, De Hertogh\u00a0W, Samwel\u00a0H (2016) Cervicogenic somatosensory tinnitus: an indication for manual therapy plus education? Part 2: a pilot study. Man Ther 23:106\u2013113. https:\/\/doi.org\/10.1016\/j.math.2016.02.006","journal-title":"Man Ther"},{"key":"1198_CR17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.math.2015.11.008","volume":"23","author":"RAB Oostendorp","year":"2016","unstructured":"Oostendorp\u00a0RAB, Bakker\u00a0I, Elvers\u00a0H, Mikolajewska\u00a0E, Michiels\u00a0S, De Hertogh\u00a0W, Samwel\u00a0H (2016) Cervicogenic somatosensory tinnitus: an indication for manual therapy? Part 1: theoretical concept. Man Ther 23:120\u2013123. https:\/\/doi.org\/10.1016\/j.math.2015.11.008","journal-title":"Man Ther"},{"issue":"7","key":"1198_CR18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s00106-002-0750-5","volume":"51","author":"I Peroz","year":"2003","unstructured":"Peroz\u00a0I (2003) Funktionsst\u00f6rungen des Kauorgans bei Tinnituspatienten im Vergleich zu einer Kontrollgruppe. HNO 51(7):544\u2013549. https:\/\/doi.org\/10.1007\/s00106-002-0750-5","journal-title":"HNO"},{"issue":"3","key":"1198_CR19","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1177\/0300060517707673","volume":"45","author":"M Ralli","year":"2017","unstructured":"Ralli\u00a0M, Greco\u00a0A, Turchetta\u00a0R, Altissimi\u00a0G, de Vincentiis\u00a0M, Cianfrone\u00a0G (2017) Somatosensory tinnitus: current evidence and future perspectives. J\u00a0Int Med Res 45(3):933\u2013947. https:\/\/doi.org\/10.1177\/0300060517707673","journal-title":"J Int Med Res"},{"issue":"2","key":"1198_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s00106-005-1349-4","volume":"54","author":"A Reisshauer","year":"2006","unstructured":"Reisshauer\u00a0A, Mathiske-Schmidt\u00a0K, K\u00fcchler\u00a0I, Umland\u00a0G, Klapp\u00a0BF, Mazurek\u00a0B (2006) Funktionsst\u00f6rungen der Halswirbels\u00e4ule bei Tinnitus. HNO 54(2):125\u2013131. https:\/\/doi.org\/10.1007\/s00106-005-1349-4","journal-title":"HNO"},{"issue":"6","key":"1198_CR21","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1590\/S1807-59322011000600028","volume":"66","author":"TG Sanchez","year":"2011","unstructured":"Sanchez\u00a0TG, Rocha\u00a0CB (2011) Diagnosis and management of somatosensory tinnitus: review article. Clinics (Sao Paulo) 66(6):1089\u20131094. https:\/\/doi.org\/10.1590\/S1807-59322011000600028","journal-title":"Clinics (Sao Paulo)"},{"issue":"10","key":"1198_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1055\/s-0041-106137","volume":"13","author":"S Sch\u00e4dler","year":"2015","unstructured":"Sch\u00e4dler\u00a0S, Kurre\u00a0A (2015) Dem Schwindel auf die Schliche kommen\u2014Dizziness Handicap Inventory. physiopraxis 13(10):35\u201337. https:\/\/doi.org\/10.1055\/s-0041-106137","journal-title":"physiopraxis"},{"issue":"8","key":"1198_CR23","first-page":"15","volume":"2020","author":"M Schultes","year":"2020","unstructured":"Schultes\u00a0M, Dubiel\u00a0M, Stark\u00a0H (2020) Tinnitus-Ich h\u00f6re was, was Du nicht h\u00f6rst. Pharmakon 2020(8):15\u201328","journal-title":"Pharmakon"},{"issue":"1","key":"1198_CR24","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1038\/s41598-018-21625-1","volume":"8","author":"D Shahar","year":"2018","unstructured":"Shahar\u00a0D, Sayers\u00a0MGL (2018) Prominent exostosis projecting from the occipital squama more substantial and prevalent in young adult than older age groups. Sci Rep 8(1):3354. https:\/\/doi.org\/10.1038\/s41598-018-21625-1","journal-title":"Sci Rep"},{"key":"1198_CR25","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0079-6123(07)66010-5","volume-title":"Neural mechanisms underlying somatic tinnitus tinnitus: pathophysiology and treatment","author":"S Shore","year":"2007","unstructured":"Shore\u00a0S, Zhou\u00a0J, Koehler\u00a0S (2007) Neural mechanisms underlying somatic tinnitus tinnitus: pathophysiology and treatment Bd. 166. Elsevier, S\u00a0107\u2013548"},{"issue":"3","key":"1198_CR26","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/nrneurol.2016.12","volume":"12","author":"SE Shore","year":"2016","unstructured":"Shore\u00a0SE, Roberts\u00a0LE, Langguth\u00a0B (2016) Maladaptive plasticity in tinnitus-triggers, mechanisms and treatment. Nat Rev Neurol 12(3):150\u2013160. https:\/\/doi.org\/10.1038\/nrneurol.2016.12","journal-title":"Nat Rev Neurol"},{"key":"1198_CR27","volume-title":"Handbuch der Muskel-Triggerpunkte","author":"DG Simons","year":"2001","unstructured":"Simons\u00a0DG, Travell\u00a0JG, Simons\u00a0LS, Cummings\u00a0BD (2001) Handbuch der Muskel-Triggerpunkte. Urban & Fischer, M\u00fcnchen"},{"key":"1198_CR28","doi-asserted-by":"publisher","DOI":"10.30965\/9783846753361","volume-title":"Ohrenrausch und G\u00f6tterstimmen. Eine Kulturgeschichte des Tinnitus","author":"UC Steiner","year":"2012","unstructured":"Steiner\u00a0UC (2012) Ohrenrausch und G\u00f6tterstimmen. Eine Kulturgeschichte des Tinnitus. Fink, Paderborn"},{"issue":"4","key":"1198_CR29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s00337-009-0696-8","volume":"47","author":"W v. Heymann","year":"2009","unstructured":"v. Heymann\u00a0W, K\u00f6neke\u00a0C (2009) Tinnitus bei \u201eHirnstamm-Irritations-Syndrom\u201c. Man Med 47(4):239\u2013246. https:\/\/doi.org\/10.1007\/s00337-009-0696-8","journal-title":"Man Med"},{"issue":"2","key":"1198_CR30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00129492-200403000-00010","volume":"25","author":"SL Whitney","year":"2004","unstructured":"Whitney\u00a0SL, Wrisley\u00a0DM, Brown\u00a0KE, Furman\u00a0JM (2004) Is perception of handicap related to functional performance in persons with vestibular dysfunction? Otol Neurotol 25(2):139\u2013143. https:\/\/doi.org\/10.1097\/00129492-200403000-00010","journal-title":"Otol Neurotol"},{"issue":"5","key":"1198_CR31","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1007\/s00586-011-2096-8","volume":"21","author":"MA Williams","year":"2012","unstructured":"Williams\u00a0MA, Williamson\u00a0E, Gates\u00a0S, Cooke\u00a0MW (2012) Reproducibility of the cervical range of motion (CROM) device for individuals with sub-acute whiplash associated disorders. Eur Spine\u00a0J 21(5):872\u2013878. https:\/\/doi.org\/10.1007\/s00586-011-2096-8","journal-title":"Eur Spine J"},{"issue":"2","key":"1198_CR32","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/0194599811403882","volume":"145","author":"F Zeman","year":"2011","unstructured":"Zeman\u00a0F, Koller\u00a0M, Figueiredo\u00a0R, Aazevedo\u00a0A, Rates\u00a0M, Coelho\u00a0C, Kleinjung\u00a0T, de Ridder\u00a0D, Langguth\u00a0B, Landgrebe\u00a0M (2011) Tinnitus handicap inventory for evaluating treatment effects: which changes are clinically relevant? Otolaryngol Head Neck Surg 145(2):282\u2013287. https:\/\/doi.org\/10.1177\/0194599811403882","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["HNO"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-022-01198-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00106-022-01198-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00106-022-01198-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T13:06:28Z","timestamp":1661432788000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00106-022-01198-2"}},"subtitle":["Eine prospektive randomisierte Studie"],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["1198"],"URL":"https:\/\/doi.org\/10.1007\/s00106-022-01198-2","relation":{},"ISSN":["0017-6192","1433-0458"],"issn-type":[{"value":"0017-6192","type":"print"},{"value":"1433-0458","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"30 June 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.\u00a0Fobbe, A.\u00a0B\u00f6kel, A.\u00a0Lesinski-Schiedat, C.\u00a0Gutenbrunner und C.\u00a0Sturm geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission der MHH, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}