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Neben operativen Ma\u00dfnahmen werden topische und systemische Steroide sowie eine adaptive Acetylsalicyls\u00e4ure(ASS)-Desaktivierung bei entsprechenden Indikationskriterien eingesetzt. Seit 2019 erg\u00e4nzen 3\u00a0spezifische Antik\u00f6rper das therapeutische Portfolio.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methoden<\/jats:title>\n                <jats:p>Es erfolgte eine retrospektive Auswertung aller Patienten, die in den Jahren 2007 und 2008 (Kollektiv\u00a0A) sowie 2017 und 2018 (Kollektiv\u00a0B) erstmalig aufgrund einer CRSwNP ambulant vorstellig wurden, bis inklusive Juni 2023.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Der klinische Verlauf von 463 Patienten (Durchschnittsalter: 49,1\u00a0Jahre; Spannbreite: 5\u201382\u00a0Jahre, 65,9\u202f% m\u00e4nnlich) wurde in die Auswertung eingeschlossen. Eine vor Erstvorstellung begonnene konservative Behandlung mit nasalen Kortikosteroiden wurde in Kollektiv\u00a0B h\u00e4ufiger durchgef\u00fchrt (Kollektiv\u00a0A 43,9\u202f% vs. Kollektiv\u00a0B 72,2\u202f%). Bei 278 der 463 Patienten (60\u202f%; A:\u00a062\u202f%, B:\u00a058\u202f%) erfolgte nach Erstvorstellung mindestens eine Nasennebenh\u00f6hlenoperation. Bei 101 Patienten (36,3\u202f%) davon kam es nach einer Operation im weiteren Verlauf im Mittel nach 2,4\u00a0Jahren zu einem behandlungsbed\u00fcrftigen Polyposisrezidiv. Die Indikation zur ASS-Provokation\/-Desaktivierung wurde im Kollektiv\u00a0B seltener gestellt, nicht zuletzt aufgrund der hohen Abbruchrate (mindestens 38\u202f%) der Erhaltungstherapie. Bei 16\u00a0Patienten der Gesamtkohorte (3,5\u202f%, A:\u00a0<jats:italic>n<\/jats:italic>\u202f=\u20098, B:\u00a0<jats:italic>n<\/jats:italic>\u202f=\u20098) war bei Auftreten des Rezidivs inzwischen die Einstellung auf eine Therapie mit einem Antik\u00f6rper erfolgt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Ein stufenweises leitlinienkonformes Vorgehen ist sinnvoll. Der systemische Einsatz von Antik\u00f6rpern bei therapieresistenten CRSwNP-Verl\u00e4ufen stellt eine verh\u00e4ltnism\u00e4\u00dfig neue Behandlungsoption dar, welche die relativ nebenwirkungsreiche und compliancearme ASS-Desaktivierung reduzieren wird.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00106-024-01479-y","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T12:01:55Z","timestamp":1714737715000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronische Rhinosinusitis mit Polyposis nasi","Chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1007","volume":"72","author":[{"given":"J.","family":"Strauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lochbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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