{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T18:28:42Z","timestamp":1776364122958,"version":"3.51.2"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["HNO"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Das nasale Mikrobiom wird als Synonym f\u00fcr die Summe und die Diversit\u00e4t der Bakterien im Nasenbereich verwendet. W\u00e4hrend das Darmmikrobiom in den letzten Jahren aufgrund von Fortschritten bei den Diagnosetechnologien im Mittelpunkt der Mikrobiomforschung stand, richtet sich die Aufmerksamkeit nun zunehmend auf mikrobielle \u00d6kosysteme in anderen K\u00f6rperregionen einschlie\u00dflich der Atemwege. Prinzipiell entspricht eine vermehrte und stabile Vielfalt (\u03b1-Diversit\u00e4t) einer \u201egesunden\u201c Flora, und <jats:italic>vice versa<\/jats:italic> zeigt sich eine verminderte bakterielle Diversit\u00e4t z.\u202fB. im Krankheitsbild einer chronischen Rhinosinusitis. Ob dies als Ursache f\u00fcr die Entstehung der Krankheit oder als deren Konsequenz zu werten ist, kann anl\u00e4sslich der aktuellen Datenlage noch nicht sicher beantwortet werden. Bedingt durch die geringe mikrobielle Biomasse in der Nase und die daraus resultierenden erschwerten Analysem\u00f6glichkeiten, aber auch aufgrund der uneinheitlichen Probengewinnung und Datenauswertung wegen fehlender Guidelines ist eine Interpretation der aktuellen heterogenen Studienlage erschwert. Dies unterstreicht die Notwendigkeit konsistenter, leitliniengest\u00fcrzter Forschungsprotokolle in diesem neuen Bereich.<\/jats:p>","DOI":"10.1007\/s00106-025-01661-w","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T13:14:46Z","timestamp":1755263686000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Das Mikrobiom bei Erkrankungen der Nase und der Nasennebenh\u00f6hlen","The microbiome in diseases of the nose and paranasal sinuses"],"prefix":"10.1007","volume":"73","author":[{"given":"Tina","family":"Bartosik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"issue":"7402","key":"1661_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","unstructured":"Human Microbiome Project Consortium (2012) Structure, function and diversity of the healthy human microbiome. 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