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In der Otorhinolaryngologie kommt die Methode v.\u202fa. bei Plattenepithelkarzinomen (\u201esquamous cell carcinoma\u201c, SCC) der Mundh\u00f6hle, des Pharynx und des Larynx zum Einsatz. Die diagnostische Pr\u00e4zision ist f\u00fcr SCC insgesamt hoch, variiert jedoch je nach Lokalisation und wird insbesondere durch Vorbehandlungen wie Radiotherapie oder neoadjuvante Chemotherapie eingeschr\u00e4nkt. F\u00fcr Nicht-SCC-Entit\u00e4ten, z.\u202fB. Speicheldr\u00fcsentumoren oder Lymphome, ist die Aussagekraft intraoperativer Diagnostik deutlich begrenzter. Neue Technologien wie stimulierte Raman-Histologie und schnelle Immunohistochemie k\u00f6nnten zuk\u00fcnftig die intraoperative Diagnostik im Kopf-Hals-Bereich beschleunigen und weiter pr\u00e4zisieren.<\/jats:p>","DOI":"10.1007\/s00106-025-01715-z","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:18:31Z","timestamp":1768990711000},"page":"647-652","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Pathologie bei Kopf-Hals-Tumoren","Intraoperative pathology in head and neck tumors"],"prefix":"10.1007","volume":"74","author":[{"given":"Alexander","family":"Quaas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ir","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"1715_CR1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1186\/s12885-020-07644-0","volume":"20","author":"HH Algadi","year":"2020","unstructured":"Algadi\u00a0HH, Abou-Bakr\u00a0AA, Jamali\u00a0OM et\u00a0al (2020) Toluidine blue versus frozen section for assessment of mucosal tumor margins in oral squamous cell carcinoma. 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