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Ziel dieser Studie war die Evaluation onkologischer Parameter sowie immunsuppressiver Komorbidit\u00e4ten als potenzielle Risikofaktoren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methoden<\/jats:title>\n                    <jats:p>Insgesamt wurden 137\u00a0Patienten, die zwischen 2007 und 2017 behandelt wurden, in die Studie eingeschlossen (31\u00a0SCC der Ohrmuschel bzw. des Geh\u00f6rgangseingangs mit EAM-Beteiligung, 60\u00a0Ohrmuschel-SCC, 9\u00a0Lippen-SCC und 37\u00a0Nasen-SCC). Onkologische Parameter sowie immunsuppressive Komorbidit\u00e4ten wurden retrospektiv analysiert.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      SCC mit EAM-Beteiligung wiesen im Vergleich zu allen anderen Subgruppen einen h\u00f6heren T\u2011 und N\u2011Status auf. Eine Beteiligung des EAM war mit einem 1,2-fach erh\u00f6hten Risiko f\u00fcr ein Tumorrezidiv assoziiert (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,016), w\u00e4hrend ein erh\u00f6hter T\u2011 bzw. N\u2011Status mit einem 1,8- bzw. 2,5-fach erh\u00f6hten Risiko f\u00fcr einen tumorassoziierten Tod einherging. Nach Adjustierung f\u00fcr den T\u2011 und N\u2011Status war das Gesamt\u00fcberleben von Patienten mit EAM-Beteiligung mit dem der \u00fcbrigen Tumorlokalisationen vergleichbar. Immunsuppressive Komorbidit\u00e4ten wurden bei 25\u202f% der Patienten festgestellt. Am h\u00e4ufigsten lagen Diabetes mellitus, h\u00e4matologische Erkrankungen sowie eine vorausgegangene Herz- oder Nierentransplantation vor. In der Cox-Regressionsanalyse zeigte sich jedoch kein signifikanter Einfluss immunsuppressiver Komorbidit\u00e4ten auf das rezidivfreie oder das Gesamt\u00fcberleben.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Patienten mit kutanem SCC der Ohrmuschel oder des Geh\u00f6rgangseingangs und EAM-Beteiligung wiesen zum Zeitpunkt der Diagnose einen signifikant h\u00f6heren T\u2011 und N\u2011Status auf, was die Notwendigkeit eines aggressiveren therapeutischen Vorgehens einschlie\u00dflich einer adjuvanten Therapie unterstreicht. Nach Adjustierung f\u00fcr den T\u2011 und N\u2011Status deutet das vergleichbare Gesamt\u00fcberleben darauf hin, dass die ung\u00fcnstigere Prognose prim\u00e4r durch das fortgeschrittene Tumorstadium und nicht durch ein eigenst\u00e4ndiges biologisches Verhalten der EAM-Beteiligung bedingt ist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00106-026-01802-9","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:52:10Z","timestamp":1789642330000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vergleich kutaner Platteneptihelkarzinome des Gesichtes und des Ohres mit und ohne Beteiligung des \u00e4u\u00dferen Geh\u00f6rgangs","Comparison of cutaneous squamous cell carcinomas of the face and ear with and without external auditory canal involvement"],"prefix":"10.1007","author":[{"given":"Manuel Christoph","family":"Ketterer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Storck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Knopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"3","key":"1802_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12105-018-0908-4","volume":"12","author":"BM Allanson","year":"2018","unstructured":"Allanson\u00a0BM, Low\u00a0TH, Clark\u00a0JR, Gupta\u00a0R (2018) Squamous Cell Carcinoma of the External Auditory Canal and Temporal Bone: An Update. 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Die Studie wurde durch die Ethikkommission des Klinikums gem\u00e4\u00df der Deklaration von Helsinki (Washington, 2002) genehmigt (Ethikkommission der Technischen Universit\u00e4t M\u00fcnchen, Votum Nr. 104\/18S). Alle Teilnehmer wurden \u00fcber die Einbeziehung in klinische retrospektive Studien informiert. Eine studienspezifische Einwilligung wurde aufgrund des retrospektiven Studiendesigns erlassen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}}]}}