{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:25:59Z","timestamp":1778538359584,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2010,8,21]],"date-time":"2010-08-21T00:00:00Z","timestamp":1282348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s00108-010-2661-y","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T09:10:05Z","timestamp":1282209005000},"page":"1196-1201","source":"Crossref","is-referenced-by-count":23,"title":["Analgetikaintoleranz","Aspirin-Intolerance-Syndrom"],"prefix":"10.1007","volume":"51","author":[{"given":"C.","family":"Umbreit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Virchow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"H\u00f6rmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Pfaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,21]]},"reference":[{"key":"2661_CR1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1056\/NEJMe020116","volume":"347","author":"Arm","year":"2002","unstructured":"Arm JP, Austen KF (2002) Leukotriene receptors and aspirin sensitivity. N Engl J Med 347:1524\u20131526","journal-title":"N Engl J Med"},{"key":"2661_CR2","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1378\/chest.118.5.1470","volume":"118","author":"Babu","year":"2000","unstructured":"Babu KS, Salvi SS (2000) Aspirin and asthma. Chest 118:1470\u20131476","journal-title":"Chest"},{"key":"2661_CR3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1081-1206(10)62084-4","volume":"89","author":"Berges-Gimeno","year":"2002","unstructured":"Berges-Gimeno MP, Simon RA, Stevenson DD (2002) The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 89:474\u2013478","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2661_CR4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1067\/mai.2003.7","volume":"111","author":"Berges-Gimeno","year":"2003","unstructured":"Berges-Gimeno MP, Simon RA, Stevenson DD (2003) Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 111:180\u2013186","journal-title":"J Allergy Clin Immunol"},{"key":"2661_CR5","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI620","volume":"101","author":"Cowburn","year":"1998","unstructured":"Cowburn AS, Sladek K, Soja J et al (1998) Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 101:834\u2013846","journal-title":"J Clin Invest"},{"key":"2661_CR6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2005.12.070","volume":"533","author":"Dahlen","year":"2006","unstructured":"Dahlen SE (2006) Treatment of asthma with antileukotrienes: first line or last resort therapy? Eur J Pharmacol 533:40\u201356","journal-title":"Eur J Pharmacol"},{"key":"2661_CR7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5414\/ALP30240","volume":"30","author":"Dollner","year":"2007","unstructured":"Dollner R, Klimek L, Pfaar O et al (2007) In-vitro-Testverfahren bei Analgetika-Intoleranz. Allergologie 30:240\u2013248","journal-title":"Allergologie"},{"key":"2661_CR8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/archotol.127.3.316","volume":"127","author":"Gosepath","year":"2001","unstructured":"Gosepath J, Schaefer D, Amedee RG, Mann WJ (2001) Individual monitoring of aspirin desensitization. Arch Otolaryngol Head Neck Surg 127:316\u2013321","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2661_CR9","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.iac.2009.07.008","volume":"29","author":"Klimek","year":"2009","unstructured":"Klimek L, Pfaar O (2009) Aspirin intolerance: does desensitization alter the course of the disease? Immunol Allergy Clin North Am 29:669\u2013675","journal-title":"Immunol Allergy Clin North Am"},{"key":"2661_CR10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaci.2006.09.011","volume":"119","author":"Lee","year":"2007","unstructured":"Lee JY, Simon RA, Stevenson DD (2007) Selection of aspirin dosages for aspirin desensitization treatment in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 119:157\u2013164","journal-title":"J Allergy Clin Immunol"},{"key":"2661_CR11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jaci.2007.09.039","volume":"121","author":"Makowska","year":"2008","unstructured":"Makowska JS, Grzegorczyk J, Bienkiewicz B et al (2008) Systemic responses after bronchial aspirin challenge in sensitive patients with asthma. J Allergy Clin Immunol 121:348\u2013354","journal-title":"J Allergy Clin Immunol"},{"key":"2661_CR12","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1046\/j.1365-2222.1999.00655.x","volume":"29","author":"May","year":"1999","unstructured":"May A, Weber A, Gall H et al (1999) Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. Clin Exp Allergy 29:1402\u20131411","journal-title":"Clin Exp Allergy"},{"key":"2661_CR13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00005537-200003000-00017","volume":"110","author":"Molnar-Gabor","year":"2000","unstructured":"Molnar-Gabor E, Endreffy E, Rozsasi A (2000) HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope 110:422\u2013425","journal-title":"Laryngoscope"},{"key":"2661_CR14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1398-9995.2007.01409.x","volume":"62","author":"Nizankowska-Mogilnicka","year":"2007","unstructured":"Nizankowska-Mogilnicka E, Bochenek G, Mastalerz L et al (2007) EAACI\/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy 62:1111\u20131118","journal-title":"Allergy"},{"key":"2661_CR15","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1097\/01.MLG.0000166702.38850.1B","volume":"115","author":"Parikh","year":"2005","unstructured":"Parikh AA, Scadding GK (2005) Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial. Laryngoscope 115:1385\u20131390","journal-title":"Laryngoscope"},{"key":"2661_CR16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.all.0000225153.45027.6a","volume":"6","author":"Pfaar","year":"2006","unstructured":"Pfaar O, Klimek L (2006) Aspirin desensitization in aspirin intolerance: update on current standards and recent improvements. Curr Opin Allergy Clin Immunol 6:161\u2013166","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2661_CR17","first-page":"5","volume":"57","author":"Pfaar","year":"2006","unstructured":"Pfaar O, Klimek L (2006) Eicosanoids, aspirin-intolerance and the upper airways\u2013current standards and recent improvements of the desensitization therapy. J Physiol Pharmacol 57 (Suppl 12):5\u201313","journal-title":"J Physiol Pharmacol"},{"key":"2661_CR18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s11882-002-0089-8","volume":"2","author":"Picado","year":"2002","unstructured":"Picado C (2002) Aspirin intolerance and nasal polyposis. Curr Allergy Asthma Rep 2:488\u2013493","journal-title":"Curr Allergy Asthma Rep"},{"key":"2661_CR19","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/j.1398-9995.2008.01658.x","volume":"63","author":"Rozsasi","year":"2008","unstructured":"Rozsasi A, Polzehl D, Deutschle T et al (2008) Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily. Allergy 63:1228\u20131234","journal-title":"Allergy"},{"key":"2661_CR20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.7326\/0003-4819-68-5-975","volume":"68","author":"Samter","year":"1968","unstructured":"Samter M, Beers RF Jr (1968) Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Med 68:975\u2013983","journal-title":"Ann Intern Med"},{"key":"2661_CR21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/thx.51.9.919","volume":"51","author":"Schafer","year":"1996","unstructured":"Schafer D, Lindenthal U, Wagner M et al (1996) Effect of prostaglandin E2 on eicosanoid release by human bronchial biopsy specimens from normal and inflamed mucosa. Thorax 51:919\u2013923","journal-title":"Thorax"},{"key":"2661_CR22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11882-009-0023-4","volume":"9","author":"Stevenson","year":"2009","unstructured":"Stevenson DD (2009) Aspirin sensitivity and desensitization for asthma and sinusitis. Curr Allergy Asthma Rep 9:155\u2013163","journal-title":"Curr Allergy Asthma Rep"},{"key":"2661_CR23","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0091-6749(96)70123-9","volume":"98","author":"Stevenson","year":"1996","unstructured":"Stevenson DD, Hankammer MA, Mathison DA et al (1996) Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 98:751\u2013758","journal-title":"J Allergy Clin Immunol"},{"key":"2661_CR24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2222.2001.01075.x","volume":"31","author":"Szczeklik","year":"2001","unstructured":"Szczeklik A, Nizankowska E, Bochenek G et al (2001) Safety of a specific COX-2 inhibitor in aspirin-induced asthma. Clin Exp Allergy 31:219\u2013225","journal-title":"Clin Exp Allergy"},{"key":"2661_CR25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1034\/j.1399-3003.2000.016003432.x","volume":"16","author":"Szczeklik","year":"2000","unstructured":"Szczeklik A, Nizankowska E, Duplaga M (2000) Natural history of aspirin-induced asthma. AIANE Investigators. European network on aspirin-induced asthma. Eur Respir J 16:432\u2013436","journal-title":"Eur Respir J"},{"key":"2661_CR26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00063198-200401000-00009","volume":"10","author":"Szczeklik","year":"2004","unstructured":"Szczeklik A, Sanak M, Nizankowska-Mogilnicka E, Kielbasa B (2004) Aspirin intolerance and the cyclooxygenase-leukotriene pathways. Curr Opin Pulm Med 10:51\u201356","journal-title":"Curr Opin Pulm Med"},{"key":"2661_CR27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0091-6749(99)70106-5","volume":"104","author":"Szczeklik","year":"1999","unstructured":"Szczeklik A, Stevenson DD (1999) Aspirin-induced asthma: advances in pathogenesis and management. J Allergy Clin Immunol 104:5\u201313","journal-title":"J Allergy Clin Immunol"},{"key":"2661_CR28","first-page":"253","volume":"14","author":"Weck","year":"2004","unstructured":"Weck AL de, Sanz ML (2004) Cellular Allergen Stimulation Test (CAST) 2003, a review. J Investig Allergol Clin Immunol 14:253\u2013273","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2661_CR29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/02770908709070955","volume":"24","author":"Widal","year":"1987","unstructured":"Widal F, Abrami P, Lermoyez J (1987) First complete description of the aspirin idiosyncrasy-asthma-nasal polyposis syndrome (plus urticaria) 1922 (with a note on aspirin desensitization). J Asthma 24:297\u2013300","journal-title":"J Asthma"},{"key":"2661_CR30","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0091-6749(76)90059-2","volume":"57","author":"Zeiss","year":"1976","unstructured":"Zeiss C, Lockey RF (1976) Refractory period to aspirin in a patient with aspirin-induced asthma. J Allergy Clin Immunol 57:440\u2013448","journal-title":"J Allergy Clin Immunol"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-010-2661-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-010-2661-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-010-2661-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:12:18Z","timestamp":1558584738000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-010-2661-y"}},"subtitle":["Ein h\u00e4ufiges, interdisziplin\u00e4res Krankheitsbild","A common and interdisciplinary disease"],"short-title":[],"issued":{"date-parts":[[2010,8,21]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["2661"],"URL":"https:\/\/doi.org\/10.1007\/s00108-010-2661-y","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"value":"0020-9554","type":"print"},{"value":"1432-1289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,21]]}}}