{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:00:44Z","timestamp":1648674044606},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s00108-012-3215-2","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T08:18:59Z","timestamp":1368433139000},"page":"709-714","source":"Crossref","is-referenced-by-count":0,"title":["Monoklonale Gammopathie unklarer Signifikanz und monoklonale B-Lymphozytose"],"prefix":"10.1007","volume":"54","author":[{"given":"K.","family":"H\u00fcbel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hallek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"3215_CR1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1146\/annurev-pathol-011110-130249","volume":"6","author":"Anderson","year":"2011","unstructured":"Anderson KC, Carrasco RD (2011) Pathogenesis of myeloma. Annu Rev Pathol 6:249\u2013274","journal-title":"Annu Rev Pathol"},{"key":"3215_CR2","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1182\/blood-2008-06-164228","volume":"112","author":"Barlogie","year":"2008","unstructured":"Barlogie B, Rhee F van, Shaughnessy\u00a0JD\u00a0Jr et\u00a0al (2008) Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease. Blood 112:3122\u20133125","journal-title":"Blood"},{"key":"3215_CR3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","volume":"106","author":"Bergsagel","year":"2005","unstructured":"Bergsagel PL, Kuehl WM, Zhan F et\u00a0al (2005) Cyclin\u00a0D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 106:296\u2013303","journal-title":"Blood"},{"key":"3215_CR4","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1182\/blood-2010-04-277566","volume":"116","author":"Bianchi","year":"2010","unstructured":"Bianchi G, Kyle RA, Colby CL et\u00a0al (2010) Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications. Blood 116:2019\u20132025","journal-title":"Blood"},{"key":"3215_CR5","doi-asserted-by":"crossref","first-page":"6618","DOI":"10.1182\/blood-2011-05-357251","volume":"118","author":"Fazi","year":"2011","unstructured":"Fazi C, Scarfo L, Pecciarini L et\u00a0al (2011) General population low-count CLL-like MBL persists over time without clinical progression, through carrying the same cytogenetic abnormalities of CLL. Blood 118:6618\u20136625","journal-title":"Blood"},{"key":"3215_CR6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2141.2010.08339.x","volume":"151","author":"Goldin","year":"2010","unstructured":"Goldin LR, Lanasa MC, Slager SL et\u00a0al (2010) Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol 151:152\u2013158","journal-title":"Br J Haematol"},{"key":"3215_CR7","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","volume":"111","author":"Hallek","year":"2008","unstructured":"Hallek M, Cheson BD, Catovsky D et\u00a0al (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111:5446\u20135456","journal-title":"Blood"},{"key":"3215_CR8","doi-asserted-by":"crossref","first-page":"5573","DOI":"10.1182\/blood-2011-01-270140","volume":"117","author":"Korde","year":"2011","unstructured":"Korde N, Kristinsson SY, Landgren O (2011) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM): novel biological insights and development of early treatment strategies. Blood 117:5573\u20135581","journal-title":"Blood"},{"key":"3215_CR9","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/leu.2010.60","volume":"24","author":"Kyle","year":"2010","unstructured":"Kyle RA, Durie BG, Rajkumar SV et\u00a0al (2010) Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 24:1121\u20131127","journal-title":"Leukemia"},{"key":"3215_CR10","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood-2010-01-262394","volume":"116","author":"Landgren","year":"2010","unstructured":"Landgren O, Rajkumar SV, Pfeiffer RM et\u00a0al (2010) Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance among black and white women. Blood 116:1056\u20131059","journal-title":"Blood"},{"key":"3215_CR11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1182\/blood.V114.22.614.614","volume":"114","author":"Mateos","year":"2009","unstructured":"Mateos MV, Lopez-Corral L, Hernandez MT et\u00a0al (2009) Multicenter, randomized, open-label, phase\u00a0III trial of lenalidomid-dexamethasone (Len\/dex) vs therapeutic abstention in smoldering multiple myeloma at high risk of progression to symptomatic MM: results of the first interim analysis. Blood 114:614","journal-title":"Blood"},{"key":"3215_CR12","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood-2006-03-001164","volume":"108","author":"Merlini","year":"2006","unstructured":"Merlini G, Stone M (2006) Dangerous small B-cell clones. Blood 108:2520\u20132530","journal-title":"Blood"},{"key":"3215_CR13","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1182\/blood-2010-10-300970","volume":"117","author":"Munshi","year":"2011","unstructured":"Munshi NC, Anderson KC, Bergsagel PL et\u00a0al (2011) Concensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel\u00a02. Blood 117:4696\u20134700","journal-title":"Blood"},{"key":"3215_CR14","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/cncr.23783","volume":"113","author":"Musto","year":"2008","unstructured":"Musto P, Petrucci MT, Bringhen S et\u00a0al (2008) A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 113:1588\u20131595","journal-title":"Cancer"},{"key":"3215_CR15","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1182\/blood-2007-05-088443","volume":"110","author":"Perez-Persona","year":"2007","unstructured":"Perez-Persona E, Vidriales MB, Mateo G et\u00a0al (2007) New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. Blood 110:2586\u20132592","journal-title":"Blood"},{"key":"3215_CR16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4065\/mcp.2010.0520","volume":"85","author":"Rajkumar","year":"2010","unstructured":"Rajkumar SV, Kyle RA, Buadi FK (2010) Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence. Mayo Clin Proc 85:945\u2013948","journal-title":"Mayo Clin Proc"},{"key":"3215_CR17","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2005-03-1038","volume":"106","author":"Rajkumar","year":"2005","unstructured":"Rajkumar SV, Kyle RA, Therneau TM et\u00a0al (2005) Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 106:812\u2013817","journal-title":"Blood"},{"key":"3215_CR18","doi-asserted-by":"crossref","unstructured":"Rawstron AC, Bennett FL, O\u2019Connor SJ et\u00a0al (2008) Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N\u00a0Engl J Med 359:575\u2013583","DOI":"10.1056\/NEJMoa075290"},{"key":"3215_CR19","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/leu.2009.287","volume":"24","author":"Shanafeld","year":"2010","unstructured":"Shanafeld TD, Ghia P, Lanasa MC et\u00a0al (2010) Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 24:512\u2013520","journal-title":"Leukemia"},{"key":"3215_CR20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1182\/blood-2008-12-192575","volume":"114","author":"Vachon","year":"2009","unstructured":"Vachon CM, Kyle RA, Therneau TM et\u00a0al (2009) Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance. Blood 114:785\u2013790","journal-title":"Blood"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-012-3215-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-012-3215-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-012-3215-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T17:22:47Z","timestamp":1595784167000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-012-3215-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["3215"],"URL":"https:\/\/doi.org\/10.1007\/s00108-012-3215-2","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"value":"0020-9554","type":"print"},{"value":"1432-1289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}