{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:49:57Z","timestamp":1758980997464,"version":"3.41.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00108-016-0132-9","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T13:12:35Z","timestamp":1473340355000},"page":"1042-1051","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management der rheumatoiden Arthritis","Management of rheumatoid arthritis"],"prefix":"10.1007","volume":"57","author":[{"given":"C.","family":"Fiehn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"132_CR1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO et\u00a0al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"132_CR2","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/annrheumdis-2011-200726","volume":"71","author":"JA Avina-Zubieta","year":"2012","unstructured":"Avina-Zubieta JA, Thomas J, Sadatsafavi M, Lehman AJ, Lacaille D (2012) Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies. Ann Rheum Dis 71:1524\u20131529","journal-title":"Ann Rheum Dis"},{"key":"132_CR3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/acr.22166","volume":"66","author":"A Bili","year":"2014","unstructured":"Bili A, Tang X, Pranesh S, Bozaite R, Morris SJ, Antohe JL et\u00a0al (2014) Tumor necrosis factor alpha inhibitor use and decreased risk for incident coronary events in rheumatoid arthritis. Arthritis Care Res (Hoboken ) 66:355\u2013363","journal-title":"Arthritis Care Res (Hoboken )"},{"issue":"1","key":"132_CR4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.23144","volume":"58","author":"J Braun","year":"2008","unstructured":"Braun J, Kastner P, Flaxenberg P, Wahrisch J, Hanke P, Demary W et al (2008) Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial. Arthritis Rheum 58(1):73\u201381","journal-title":"Arthritis Rheum"},{"key":"132_CR5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/art.30129","volume":"63","author":"DT Felson","year":"2011","unstructured":"Felson DT, Smolen JS, Wells G, Zhang B, van Tuyl LH, Funovits J et\u00a0al (2011) American College of Rheumatology\/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum 63:573\u2013586","journal-title":"Arthritis Rheum"},{"key":"132_CR6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s10067-013-2325-0","volume":"32","author":"C Fiehn","year":"2013","unstructured":"Fiehn C, Belke-Voss E, Krause D, Wassenberg S, Rau R (2013) Improved radiological outcome of rheumatoid arthritis: the importance of early treatment with methotrexate in the era of biological drugs. Clin Rheumatol 32:1735\u20131742","journal-title":"Clin Rheumatol"},{"key":"132_CR7","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/art.39595","volume":"68","author":"JE Gottenberg","year":"2016","unstructured":"Gottenberg JE, Courvoisier DS, Hernandez MV et al (2016) Brief report: association of rheumatoid factor and anti-citrullinated protein antibody positivity with better effectiveness of abatacept: results from the Pan-European registry analysis. Arthritis Rheumatol 68:1346\u20131352","journal-title":"Arthritis Rheumatol"},{"key":"132_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-eular.1277","author":"LR Harrold","year":"2016","unstructured":"Harrold LR, Litman HJ, Connolly SE et al (2016) Impact of anti-cyclic-citrullinated-peptide and rheumatoid factor status on response to abatacept therapy: findings from a US observational cohort. Ann Rheum Dis(Suppl. 123). doi: 10.1136\/annrheumdis-2016-eular.1277","journal-title":"Ann Rheum Dis"},{"key":"132_CR9","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00393-012-1038-0","volume":"71","author":"K Kruger","year":"2012","unstructured":"Kruger K, Wollenhaupt J, Albrecht K, Alten R, Backhaus M, Baerwald C et\u00a0al (2012) German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm. Z\u00a0Rheumatol 71:592\u2013603","journal-title":"Z Rheumatol"},{"key":"132_CR10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00393-014-1534-5","volume":"74","author":"K Kr\u00fcger","year":"2015","unstructured":"Kr\u00fcger K, Edelmann E (2015) Therapieabbau bei stabil eingestellter rheumatoider Arthritis \u2013 Stand des Wissens. Z\u00a0Rheumatol 74:414\u2013420","journal-title":"Z Rheumatol"},{"issue":"2","key":"132_CR11","doi-asserted-by":"crossref","first-page":"e89442","DOI":"10.1371\/journal.pone.0089442","volume":"9","author":"Q Lv","year":"2014","unstructured":"Lv Q, Yin Y, Li X, Shan G, Wu X, Liang D et al (2014) The status of rheumatoid factor and anti-cyclic citrullinated peptide antibody are not associated with the effect of anti-TNFalpha agent treatment in patients with rheumatoid arthritis: a metaanalysis. PLOS ONE 9(2):e89442","journal-title":"PLOS ONE"},{"key":"132_CR12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00296-016-3506-3","volume":"36","author":"E Martin-Mola","year":"2016","unstructured":"Martin-Mola E, Balsa A, Garcia-Vicunja R et al (2016) Anti-citrullinated peptide antibodies and their value for predicting responses to biologic agents: a review. Rheumatol Int 36:1043\u20131063","journal-title":"Rheumatol Int"},{"key":"132_CR13","doi-asserted-by":"publisher","first-page":"h5079","DOI":"10.1136\/bmj.h5079","volume":"351","author":"C Mohan","year":"2015","unstructured":"Mohan C, Assassi S (2015) Biomarkers in rheumatic diseases: how can they facilitate diagnosis and assessment of disease activity? BMJ 351:h5079. doi: 10.1136\/bmj.h5079","journal-title":"BMJ"},{"key":"132_CR14","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1002\/art.34498","volume":"64","author":"LW Moreland","year":"2012","unstructured":"Moreland LW, O\u2019Dell JR, Paulus HE, Curtis JR, Bathon JM, St Clair EW, Bridges SL Jr, Zhang J, McVie T, Howard G, van der Heijde D, Cofield SS, TEAR Investigators (2012) A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum 64:2824\u20132835","journal-title":"Arthritis Rheum"},{"key":"132_CR15","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/annrheumdis-2013-204577","volume":"73","author":"JL Nam","year":"2014","unstructured":"Nam JL, Ramiro S, Gaujoux-Viala C et al (2014) Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis 73:516\u2013528","journal-title":"Ann Rheum Dis"},{"key":"132_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1056\/nejmoa1303006","volume":"369","author":"JR O\u2019Dell","year":"2013","unstructured":"O\u2019Dell JR, Mikuls TR, Taylor TH, Ahluwalia V, Brophy M, Warren SR, Lew RA, Cannella AC, Kunkel G, Phibbs CS, Anis AH, Leatherman S, Keystone E, CSP 551 RACAT Investigators (2013) CSP 551 RACAT Investigators. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med 369:307\u2013318. doi: 10.1056\/nejmoa1303006","journal-title":"N Engl J Med"},{"key":"132_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209201","author":"G Schett","year":"2016","unstructured":"Schett G, Emery P, Tanaka Y et\u00a0al (2016) Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions. Ann Rheum Dis 75. doi: 10.1136\/annrheumdis-2016-209201","journal-title":"Ann Rheum Dis"},{"key":"132_CR18","volume-title":"Interdisziplin\u00e4re Leitlinie \u2013 Management der fr\u00fchen rheumatoiden Arthritis","author":"M Schneider","year":"2011","unstructured":"Schneider M, Lelgemann M, Abholz HH, Blumenroth M, Fl\u00fcgge C, Gerken M et\u00a0al (2011) Interdisziplin\u00e4re Leitlinie \u2013 Management der fr\u00fchen rheumatoiden Arthritis. www.dgrh.de\/leitlinien.html . Zugegriffen: 1.9.2016"},{"issue":"8","key":"132_CR19","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00393-011-0840-4","volume":"70","author":"F Schuch","year":"2011","unstructured":"Schuch F, Kern P, Kreher G, Kr\u00fcger K, Wendler J, Fiehn C (2011) Das Curriculum \u201eRheumatologischeFachassistenzDGRh-BDRh\u201c als Weg der Professionalisierung medizinischer Assistenzberufe \u2013 Konzept und Ergebnisse einer Evaluation. Z\u00a0Rheumatol 70(8):670\u2013677","journal-title":"Z Rheumatol"},{"key":"132_CR20","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","volume":"376","author":"DL Scott","year":"2010","unstructured":"Scott DL, Wolfe F, Huizinga TW (2010) Rheumatoid arthritis. Lancet 376:1094\u20131108","journal-title":"Lancet"},{"key":"132_CR21","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1136\/ard.2009.126532","volume":"69","author":"JS Smolen","year":"2010","unstructured":"Smolen JS, Landewe R, Breedveld FC, Dougados M, Emery P, Gaujoux-Viala C et al (2010) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis 69:964\u2013975","journal-title":"Ann Rheum Dis"},{"key":"132_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid Arthritis. Lancet. doi: 10.1016\/S0140-6736(16)30173-8","journal-title":"Lancet"},{"issue":"1","key":"132_CR23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/annrheumdis-2015-207524","volume":"75","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Breedveld FC, Burmester GR, Bykerk V, Dougados M, Emery P et\u00a0al (2016) Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis 75(1):3\u201315","journal-title":"Ann Rheum Dis"},{"key":"132_CR24","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1136\/ard.2011.151043","volume":"70","author":"A Strangfeld","year":"2011","unstructured":"Strangfeld A, Eveslage M, Schneider M et al (2011) Treatment benefit or survival of the fittest: what drives the time-dependent decrease in serious infection rates under TNF inhibition and what does this imply for the individual patient? Ann Rheum Dis 70:1914\u20131920","journal-title":"Ann Rheum Dis"},{"issue":"Suppl. 2","key":"132_CR25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/annrheumdis-2016-eular.1375","volume":"75","author":"S Tarp","year":"2016","unstructured":"Tarp S, Furst DE, Dessing A et\u00a0al (2016) Defining the optimal biological monotherapy in rheumatoid arthritis: a systematic review and network metaanalysis of randomised trials. Ann Rheum Dis 75(Suppl. 2):423","journal-title":"Ann Rheum Dis"},{"key":"132_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-54676-1_421-1","volume":"05","author":"C Fiehn","year":"2015","unstructured":"Fiehn C (2015) Rheumatoide Arthritis. Springer Ref Inn Med 05:1\u201315. doi: 10.1007\/978-3-642-54676-1_421-1","journal-title":"Springer Ref Inn Med"},{"key":"132_CR27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11812-008-0046-0","volume":"3","author":"G Stummvoll","year":"2008","unstructured":"Stummvoll G, N\u00f6bauer-Huhmann I, Machold K et al (2008) Rheumatoide Arthritis. Wien Klin Wochenschr Educ 3:135","journal-title":"Wien Klin Wochenschr Educ"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-016-0132-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-016-0132-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-016-0132-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:31:53Z","timestamp":1749576713000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-016-0132-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["132"],"URL":"https:\/\/doi.org\/10.1007\/s00108-016-0132-9","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"type":"print","value":"0020-9554"},{"type":"electronic","value":"1432-1289"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}