{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:05:17Z","timestamp":1773147917258,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00108-018-0408-3","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T07:37:48Z","timestamp":1523345868000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Kachexie und Sarkopenie bei chronischer Herzinsuffizienz","Cachexia and sarcopenia in chronic heart failure"],"prefix":"10.1007","volume":"59","author":[{"given":"N.","family":"Ebner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"von Haehling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"408_CR1","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1007\/s12603-009-0201-z","volume":"13","author":"G Abellan van Kan","year":"2009","unstructured":"Abellan van Kan G (2009) Epidemiology and consequences of sarcopenia. J\u00a0Nutr Health Aging 13:708\u2013712","journal-title":"J Nutr Health Aging"},{"issue":"7","key":"408_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1080\/07853890410017467","volume":"36","author":"S Anker","year":"2004","unstructured":"Anker S, Steinborn W, Strassburg S (2004) Cardiac cachexia. Ann Med 36(7):518\u2013529","journal-title":"Ann Med"},{"issue":"8","key":"408_CR3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/oxfordjournals.aje.a009520","volume":"147","author":"RN Baumgartner","year":"1998","unstructured":"Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, Garry PJ, Lindeman RD (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755\u2013763","journal-title":"Am J Epidemiol"},{"key":"408_CR4","first-page":"776","volume-title":"Ern\u00e4hrungsmedizin","author":"HK Biesalski","year":"2018","unstructured":"Biesalski HK, Bischoff SC, Pirlich M, Weimann A (2018) Kapitel 56: Kardiale und pulmonale Kachexie. In: von Haehling S, Heilmann M (Hrsg) Ern\u00e4hrungsmedizin. Thieme, Stuttgart, S\u00a0776\u2013785"},{"issue":"4","key":"408_CR5","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1093\/ageing\/afq034","volume":"39","author":"AJ Cruz-Jentoft","year":"2010","unstructured":"Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkov\u00e1 E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older People (2010l) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4):412\u2013423","journal-title":"Age Ageing"},{"issue":"3","key":"408_CR6","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jamda.2016.09.006","volume":"18","author":"MR Dos Santos","year":"2017","unstructured":"Dos Santos MR, Saitoh M, Ebner N, Valentova M, Konishi M, Ishida J, Emami A, Springer J, Sandek A, Doehner W, Anker SD, von Haehling S (2017) Sarcopenia and endothelial function in patients with chronic heart failure: results from the studies investigating comorbidities aggravating heart failure (SICA-HF). J\u00a0Am Med Dir Assoc 18(3):240\u2013245","journal-title":"J Am Med Dir Assoc"},{"key":"408_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.exger.2013.01.011","volume":"48","author":"M Drey","year":"2013","unstructured":"Drey M, Grosch C, Neuwirth C, Bauer JM, Sieber CC (2013) The motor unit number index (MUNIX) in sarcopenic patients. Exp Gerontol 48:381\u2013384","journal-title":"Exp Gerontol"},{"issue":"1","key":"408_CR8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/jcsm.12106","volume":"7","author":"N Ebner","year":"2016","unstructured":"Ebner N, von Haehling S (2016) Unlocking the wasting enigma: highlights from the 8th cachexia conference. J\u00a0Cachexia Sarcopenia Muscle 7(1):90\u201394","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"408_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.maturitas.2013.03.014","volume":"75","author":"N Ebner","year":"2013","unstructured":"Ebner N, Springer J, Kalantar-Zadeh K, Lainscak M, Doehner W, Anker SD, von Haehling S (2013) Mechanism and novel therapeutic approaches to wasting in chronic disease. Maturitas 75(3):199\u2013206","journal-title":"Maturitas"},{"issue":"5 Suppl","key":"408_CR10","first-page":"998S","volume":"127","author":"W Evans","year":"1997","unstructured":"Evans W (1997) Functional and metabolic consequences of sarcopenia. J\u00a0Nutr 127(5 Suppl):998S\u20131003S","journal-title":"J Nutr"},{"key":"408_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.clnu.2008.06.013","volume":"27","author":"WJ Evans","year":"2008","unstructured":"Evans WJ, Morley JE, Argiles JM, Bales C, Baracos V, Guttridge D et\u00a0al (2008) Cachexia: a new definition. Clin Nutr 27:793\u2013799","journal-title":"Clin Nutr"},{"issue":"7","key":"408_CR12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/eurheartj\/ehs381","volume":"34","author":"S F\u00fclster","year":"2013","unstructured":"F\u00fclster S, Tacke M, Sandek A, Ebner N, Tsch\u00f6pe C, Doehner W, Anker SD, von Haehling S (2013) Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF). Eur Heart\u00a0J 34(7):512\u2013519","journal-title":"Eur Heart J"},{"key":"408_CR13","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1161\/CIRCULATIONAHA.111.047381","volume":"125","author":"S Gielen","year":"2012","unstructured":"Gielen S, Sandri M, Kozarez I, Kratzsch J, Teupser D, Thiery J, Erbs S, Mangner N, Lenk K, Hambrecht R, Schuler G, Adams V (2012) Exercise training attenuates MuRF-1 expression in the skeletal muscle of patients with chronic heart failure independent of age: the randomized Leipzig Exercise Intervention in Chronic Heart Failure and Aging catabolism study. Circulation 125:2716\u20132727","journal-title":"Circulation"},{"key":"408_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/ncb0203-87","volume":"5","author":"DJ Glass","year":"2003","unstructured":"Glass DJ (2003) Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol 5:87\u201390","journal-title":"Nat Cell Biol"},{"issue":"4","key":"408_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1017\/S0029665115002438","volume":"74","author":"S Haehling von","year":"2015","unstructured":"von Haehling S (2015) The wasting continuum in heart failure: from sarcopenia to cachexia. Proc Nutr Soc 74(4):367\u2013377","journal-title":"Proc Nutr Soc"},{"key":"408_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/978-3-89935-305-1_1","volume-title":"Kachexie bei Tumorerkrankungen","author":"S Haehling von","year":"2017","unstructured":"von Haehling S (2017) Tumorkachexie: Definition, Epidemiologie und Verlauf. In: Kachexie bei Tumorerkrankungen. Springer, Berlin, Heidelberg, S\u00a010\u201319"},{"key":"408_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.pharmthera.2008.09.009","volume":"121","author":"S Haehling von","year":"2009","unstructured":"von Haehling S, Lainscak M, Springer J, Anker SD (2009) Cardiac cachexia: a systematic overview. Pharmacol Ther 121:227\u2013252","journal-title":"Pharmacol Ther"},{"issue":"2","key":"408_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/ajcn\/76.2.473","volume":"76","author":"VA Hughes","year":"2002","unstructured":"Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MA (2002) Longitudinal changes in body composition in older men and women: role of body weight change and physical activity. Am J Clin Nutr 76(2):473\u2013481","journal-title":"Am J Clin Nutr"},{"key":"408_CR19","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1046\/j.1532-5415.2002.50216.x","volume":"50","author":"I Janssen","year":"2002","unstructured":"Janssen I, Heymsfield SB, Ross R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J\u00a0Am Geriatr Soc 50:889\u2013896","journal-title":"J Am Geriatr Soc"},{"key":"408_CR20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/BF02982705","volume":"12","author":"JE Morley","year":"2008","unstructured":"Morley JE (2008) Sarcopenia: diagnosis and treatment. J\u00a0Nutr Health Aging 12:452\u2013456","journal-title":"J Nutr Health Aging"},{"key":"408_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1249\/JES.0000000000000012","volume":"42","author":"FM Purves-Smith","year":"2014","unstructured":"Purves-Smith FM, Sgarioto N, Hepple RT (2014) Fiber typing in aging muscle. Exerc Sport Sci Rev 42:45\u201345","journal-title":"Exerc Sport Sci Rev"},{"issue":"7","key":"408_CR22","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/BF02982704","volume":"12","author":"Y Rolland","year":"2008","unstructured":"Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G, Woo J, Baumgartner R, Pillard F, Boirie Y, Chumlea WM, Vellas B (2008) Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J\u00a0Nutr Health Aging 12(7):433\u2013450","journal-title":"J Nutr Health Aging"},{"key":"408_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/MCO.0b013e328340c2c2","volume":"14","author":"Y Rolland","year":"2011","unstructured":"Rolland Y, Abellan Van Kana G, Gillette-Guyonnet S, Vellas B (2011) Cachexia versus sarcopenia. Curr Opin Clin Nutr Metab Care 14:15\u201321","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"5 Suppl","key":"408_CR24","doi-asserted-by":"publisher","first-page":"990S","DOI":"10.1093\/jn\/127.5.990S","volume":"127","author":"IH Rosenberg","year":"1997","unstructured":"Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J\u00a0Nutr 127(5 Suppl):990S\u2013991S","journal-title":"J Nutr"},{"key":"408_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s13539-010-0008-0","volume":"1","author":"P Rozentryt","year":"2010","unstructured":"Rozentryt P, von Haehling S, Lainscak M, Nowak JU, Kalantar-Zadeh K, Polonski L, Anker SD (2010) The effects of a\u00a0high-caloric protein-rich oral nutritional supplement in patients with chronic heart failure and cachexia on quality of life, body composition, and inflammation markers: a\u00a0randomized, double-blind pilot study. J\u00a0Cachexia Sarcopenia Muscle 1:35\u201342","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"Suppl 7","key":"408_CR26","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00508-016-1112-8","volume":"128","author":"M Saitoh","year":"2016","unstructured":"Saitoh M, dos Santos MR, Ebner N, Emami A, Konishi M, Ishida J, Valentova M, Sandek A, Doehner W, Anker SD, von Haehling S (2016) Nutritional status and its effects on muscle wasting in patients with chronic heart failure: insights from studies investigating co-morbidities aggravating heart failure. Wien Klin Wochenschr 128(Suppl 7):497\u2013504","journal-title":"Wien Klin Wochenschr"},{"key":"408_CR27","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/ncpendmet0247","volume":"2","author":"J Springer","year":"2006","unstructured":"Springer J, von Haehling S, Anker SD (2006) The need for a\u00a0standardized definition for cachexia in chronic illness. Nat Clin Pract Endocrinol Metab 2:416\u2013417","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"4","key":"408_CR28","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1097\/XEB.0000000000000018","volume":"12","author":"S Yu","year":"2014","unstructured":"Yu S, Umapathysivam K, Visvanathan R (2014) Sarcopenia in older people. Int J Evid Based Healthc 12(4):227\u2013243","journal-title":"Int J Evid Based Healthc"},{"key":"408_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/5978523","volume":"2016","author":"SC Yu","year":"2016","unstructured":"Yu SC, Khow KS, Jadczak AD, Visvanathan R (2016) Clinical screening tools for sarcopenia and its management. Curr Gerontol Geriatr Res 2016:1\u201310","journal-title":"Curr Gerontol Geriatr Res"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-018-0408-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-018-0408-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-018-0408-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T20:13:45Z","timestamp":1554840825000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-018-0408-3"}},"subtitle":["Ver\u00e4nderung von Muskelkraft und Muskelaufbau","Change in muscle strength and muscle structure"],"short-title":[],"issued":{"date-parts":[[2018,4,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["408"],"URL":"https:\/\/doi.org\/10.1007\/s00108-018-0408-3","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"value":"0020-9554","type":"print"},{"value":"1432-1289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,10]]},"assertion":[{"value":"10 April 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"N.\u00a0Ebner und S.\u00a0von Haehling geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine von den Autoren durchgef\u00fchrten Studien an Menschen oder Tieren.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}