{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:54:15Z","timestamp":1766181255338},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00108-019-0611-x","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T15:32:19Z","timestamp":1557502339000},"page":"555-563","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Kardiales Troponin und mehr beim akuten Koronarsyndrom"],"prefix":"10.1007","volume":"60","author":[{"given":"M.","family":"Vafaie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Stoyanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Giannitsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"611_CR1","first-page":"143","volume":"38","author":"S Agewall","year":"2017","unstructured":"Agewall S, Beltrame JF, Reynolds HR et al (2017) ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart\u00a0J 38:143\u2013153","journal-title":"Eur Heart J"},{"key":"611_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.clinbiochem.2014.08.021","volume":"48","author":"FS Apple","year":"2015","unstructured":"Apple FS, Jaffe AS, Collinson P et\u00a0al (2015) IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays. Clin Biochem 48:201\u2013203","journal-title":"Clin Biochem"},{"key":"611_CR3","doi-asserted-by":"publisher","DOI":"10.1177\/2048872618819421","author":"M Arslan","year":"2019","unstructured":"Arslan M, Dedic A, Boersma E et al (2019) Serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and a\u00a0single high baseline measurement for swift rule-in: A systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care. \n                    https:\/\/doi.org\/10.1177\/2048872618819421","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"611_CR4","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/2048872615610869","volume":"5","author":"M Biener","year":"2016","unstructured":"Biener M, Giannitsis E, Lamerz J et al (2016) Prognostic value of elevated high-sensitivity cardiac troponin T levels in a\u00a0low risk outpatient population with cardiovascular disease. Eur Heart J Acute Cardiovasc Care 5:409\u2013418","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"611_CR5","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1161\/CIRCULATIONAHA.117.031806","volume":"137","author":"AR Chapman","year":"2018","unstructured":"Chapman AR, Shah ASV, Lee KK et al (2018) Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury. Circulation 137:1236\u20131245","journal-title":"Circulation"},{"key":"611_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.clinbiochem.2018.05.004","volume":"56","author":"RH Christenson","year":"2018","unstructured":"Christenson RH, Mullins K, Duh SH (2018) Validation of high-sensitivity performance for a\u00a0United States Food and Drug Administration cleared cardiac troponin I assay. Clin Biochem 56:4\u201310","journal-title":"Clin Biochem"},{"key":"611_CR7","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1056\/NEJMoa011053","volume":"345","author":"JA de Lemos","year":"2001","unstructured":"de Lemos JA, Morrow DA, Bentley JH et al (2001) The prognostic value of B\u2011type natriuretic peptide in patients with acute coronary syndromes. N\u00a0Engl J Med 345:1014\u20131021","journal-title":"N Engl J Med"},{"key":"611_CR8","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1001\/jama.2015.12735","volume":"314","author":"AC Fanaroff","year":"2015","unstructured":"Fanaroff AC, Rymer JA, Goldstein SA et\u00a0al (2015) Does this patient with chest pain have acute coronary syndrome?: the rational clinical examination systematic review. JAMA 314:1955\u20131965","journal-title":"JAMA"},{"key":"611_CR9","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrcardio.2012.142","volume":"9","author":"E Giannitsis","year":"2012","unstructured":"Giannitsis E, Katus HA (2012) Pros and cons of high-sensitivity assays for cardiac troponin. Nat Rev Cardiol 9:616\u2013618","journal-title":"Nat Rev Cardiol"},{"key":"611_CR10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrcardio.2013.129","volume":"10","author":"E Giannitsis","year":"2013","unstructured":"Giannitsis E, Katus HA (2013) Cardiac troponin level elevations not related to acute coronary syndromes. Nat Rev Cardiol 10:623\u2013634","journal-title":"Nat Rev Cardiol"},{"key":"611_CR11","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","volume":"56","author":"E Giannitsis","year":"2010","unstructured":"Giannitsis E, Kurz K, Hallermayer K et al (2010) Analytical validation of a\u00a0high-sensitivity cardiac troponin T assay. Clin Chem 56:254\u2013261","journal-title":"Clin Chem"},{"key":"611_CR12","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1001\/archinte.163.19.2345","volume":"163","author":"CB Granger","year":"2003","unstructured":"Granger CB, Goldberg RJ, Dabbous O et\u00a0al (2003) Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med 163:2345\u20132353","journal-title":"Arch Intern Med"},{"issue":"2","key":"611_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"B Ibanez","year":"2017","unstructured":"Ibanez B, James S, Agewall S et al (2017) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart\u00a0J 39(2):119\u2013177. \n                    https:\/\/doi.org\/10.1093\/eurheartj\/ehx393","journal-title":"Eur Heart\u00a0J"},{"key":"611_CR14","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1161\/CIRCULATIONAHA.106.685503","volume":"115","author":"SQ Khan","year":"2007","unstructured":"Khan SQ, Dhillon OS, O\u2019Brien RJ et al (2007) C\u2011terminal provasopressin (copeptin) as a\u00a0novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation 115:2103\u20132110","journal-title":"Circulation"},{"key":"611_CR15","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.amjcard.2014.01.436","volume":"113","author":"MJ Lipinski","year":"2014","unstructured":"Lipinski MJ, Escarcega RO, D\u2019Ascenzo F et al (2014) A systematic review and collaborative meta-analysis to determine the incremental value of copeptin for rapid rule-out of acute myocardial infarction. Am J Cardiol 113:1581\u20131591","journal-title":"Am J Cardiol"},{"key":"611_CR16","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1161\/CIRCOUTCOMES.114.001384","volume":"8","author":"SA Mahler","year":"2015","unstructured":"Mahler SA, Riley RF, Hiestand BC et\u00a0al (2015) The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes 8:195\u2013203","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"611_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cca.2008.03.022","volume":"393","author":"M Mockel","year":"2008","unstructured":"Mockel M, Danne O, Muller R et\u00a0al (2008) Development of an optimized multimarker strategy for early risk assessment of patients with acute coronary syndromes. Clin Chim Acta 393:103\u2013109","journal-title":"Clin Chim Acta"},{"key":"611_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/eurheartj\/ehu178","volume":"36","author":"M Mockel","year":"2015","unstructured":"Mockel M, Searle J, Hamm C et\u00a0al (2015) Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a\u00a0randomized, controlled clinical process study. Eur Heart\u00a0J 36:369\u2013376","journal-title":"Eur Heart J"},{"key":"611_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1373\/clinchem.2016.258392","volume":"63","author":"M Mueller-Hennessen","year":"2017","unstructured":"Mueller-Hennessen M, Mueller C, Giannitsis E et al (2017) Serial sampling of high-sensitivity cardiac troponin T may not be required for prediction of acute myocardial infarction diagnosis in chest pain patients with highly abnormal concentrations at presentation. Clin Chem 63:542\u2013551","journal-title":"Clin Chem"},{"key":"611_CR20","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.annemergmed.2015.11.013","volume":"68","author":"C Mueller","year":"2016","unstructured":"Mueller C, Giannitsis E, Christ M et al (2016) Multicenter evaluation of a\u00a00-hour\/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T. Ann Emerg Med 68:76\u201387e4","journal-title":"Ann Emerg Med"},{"key":"611_CR21","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1001\/jamacardio.2018.3368","volume":"3","author":"JW Pickering","year":"2018","unstructured":"Pickering JW, Young JM, George PM et al (2018) Validity of a\u00a0novel point-of-care troponin assay for single-test rule-out of acute myocardial infarction. JAMA Cardiol 3:1108\u20131112","journal-title":"JAMA Cardiol"},{"key":"611_CR22","doi-asserted-by":"publisher","first-page":"e0202133","DOI":"10.1371\/journal.pone.0202133","volume":"13","author":"T Reinhold","year":"2018","unstructured":"Reinhold T, Giannitsis E, Mockel M et\u00a0al (2018) Cost analysis of early discharge using combined copeptin\/cardiac troponin testing versus serial cardiac troponin testing in patients with suspected acute coronary syndrome. PLoS ONE 13:e202133","journal-title":"PLoS ONE"},{"key":"611_CR23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"M Roffi","year":"2016","unstructured":"Roffi M, Patrono C, Collet JP et al (2016) 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart\u00a0J 37:267\u2013315","journal-title":"Eur Heart J"},{"key":"611_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1373\/clinchem.2016.255521","volume":"63","author":"Y Sandoval","year":"2017","unstructured":"Sandoval Y, Thygesen K (2017) Myocardial infarction type 2 and myocardial injury. Clin Chem 63:101\u2013107","journal-title":"Clin Chem"},{"key":"611_CR25","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.clinbiochem.2013.04.016","volume":"46","author":"HG Schneider","year":"2013","unstructured":"Schneider HG, Ablitt P, Taylor J (2013) Improved sensitivity of point of care troponin I values using reporting to below the 99 th percentile of normals. Clin Biochem 46:979\u2013982","journal-title":"Clin Biochem"},{"key":"611_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1001\/jamainternmed.2013.11362","volume":"174","author":"M Than","year":"2014","unstructured":"Than M, Aldous S, Lord SJ et al (2014) A 2\u2011hour diagnostic protocol for possible cardiac chest pain in the emergency department: a\u00a0randomized clinical trial. JAMA Intern Med 174:51\u201358","journal-title":"JAMA Intern. Med."},{"key":"611_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","volume":"40","author":"K Thygesen","year":"2019","unstructured":"Thygesen K, Alpert JS, Jaffe AS et\u00a0al (2019) Fourth universal definition of myocardial infarction (2018). Eur Heart\u00a0J 40:237\u2013269","journal-title":"Eur Heart J"},{"key":"611_CR28","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ijcard.2015.06.122","volume":"198","author":"M Vafaie","year":"2015","unstructured":"Vafaie M, Biener M, Mueller M et al (2015) Addition of copeptin improves diagnostic performance of point-of-care testing (POCT) for cardiac troponin T in early rule-out of myocardial infarction\u2014A pilot study. Int J Cardiol 198:26\u201330","journal-title":"Int J Cardiol"},{"key":"611_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00059-018-4717-z","volume":"43","author":"M Vafaie","year":"2018","unstructured":"Vafaie M, Giannitsis E, Katus HA (2018) Essential cardiac biomarkers in the differential diagnosis of acute chest pain : An update. Herz 43:469\u2013482","journal-title":"Herz"},{"key":"611_CR30","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00059-013-3989-6","volume":"38","author":"M Vafaie","year":"2013","unstructured":"Vafaie M, Katus HA (2013) Myokardinfarkt. Herz 38:821\u2013827","journal-title":"Herz"},{"key":"611_CR31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijcard.2011.12.105","volume":"162","author":"S von Haehling","year":"2012","unstructured":"von Haehling S, Papassotiriou J, Morgenthaler NG et\u00a0al (2012) Copeptin as a\u00a0prognostic factor for major adverse cardiovascular events in patients with coronary artery disease. Int J Cardiol 162:27\u201332","journal-title":"Int J Cardiol"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-019-0611-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-019-0611-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-019-0611-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T23:09:52Z","timestamp":1588979392000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-019-0611-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["611"],"URL":"https:\/\/doi.org\/10.1007\/s00108-019-0611-x","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"value":"0020-9554","type":"print"},{"value":"1432-1289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]},"assertion":[{"value":"10 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"Der korrespondierende Autor weist auf folgende Beziehungen hin: M.\u00a0Vafaie hat finanzielle Unterst\u00fctzung f\u00fcr klinische Studien von Bayer Healthcare Germany und Daiichi Sankyo erhalten. Ihm wurden Reisekosten und Teilnahmegeb\u00fchren f\u00fcr Fortbildungsveranstaltungen erstattet von Roche Diagnostics und BRAHMS. K.M.\u00a0Stoyanov gibt an, dass kein Interessenkonflikt besteht. H.A.\u00a0Katus hat den kardialen Troponin-T-Test entwickelt und hielt hierf\u00fcr gemeinsam mit Roche Diagnostics ein Patent bis zu dessen Ablauf. Er hat F\u00f6rderungen von mehreren Firmen erhalten und war als Referent f\u00fcr die Firma Roche Diagnostics t\u00e4tig. E.\u00a0Giannitsis hat finanzielle Unterst\u00fctzung f\u00fcr klinische Studien erhalten von Roche Diagnostics Ltd., Schweiz, Mitsubishi Chemicals, Deutschland, Siemens Healthcare, BRAHMS Biomarkers, Clinical Diagnostics Division, Thermo Fisher Scientific, Deutschland. Er ist Berater von Roche Diagnostics und BRAHMS Biomarkers und hat Vortragshonorare von Roche Diagnostics, Siemens Healthcare, BRAHMS Biomarkers und Mitsubishi Chemicals erhalten.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}