{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:13:57Z","timestamp":1763705637229},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Internist"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s00108-019-0637-0","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T13:03:36Z","timestamp":1561554216000},"page":"814-820","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pruritus bei systemischen Erkrankungen"],"prefix":"10.1007","volume":"60","author":[{"given":"A. E.","family":"Kremer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Mettang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"637_CR1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.revmed.2003.12.015","volume":"25","author":"Y Afifi","year":"2004","unstructured":"Afifi\u00a0Y, Aubin\u00a0F, Puzenat\u00a0E et\u00a0al (2004) Pruritus sine materia: a\u00a0prospective study of 95 patients. Rev Med Interne 25:490\u2013493","journal-title":"Rev. Med. Interne"},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1053\/bega.2000.0109","volume":"14","author":"NV Bergasa","year":"2000","unstructured":"Bergasa\u00a0NV, Mehlman\u00a0JK, Jones\u00a0EA (2000) Pruritus and fatigue in primary biliary cirrhosis. Baillieres Best Pract Res Clin Gastroenterol 14:643\u2013655","journal-title":"Baillieres Best Pract Res Clin Gastroenterol"},{"key":"637_CR3","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1001\/jama.2013.282023","volume":"310","author":"TG Berger","year":"2013","unstructured":"Berger\u00a0TG, Shive\u00a0M, Harper\u00a0GM (2013) Pruritus in the older patient: a\u00a0clinical review. JAMA 310:2443\u20132450","journal-title":"JAMA"},{"key":"637_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ncpgasthep0521","volume":"3","author":"U Beuers","year":"2006","unstructured":"Beuers\u00a0U (2006) Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 3:318\u2013328","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"637_CR5","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jhep.2009.09.018","volume":"51","author":"U Beuers","year":"2009","unstructured":"Beuers U, Boberg KM, Chapman RW, Chazouilleres O, Invernizzi P, Jones DE, Lammert F, Pares A, Trauner M (2009) EASL Clinical Practice Guidelines: Management of cholestatic liver diseases. J\u00a0Hepatol 51:237\u2013267","journal-title":"J\u00a0Hepatol"},{"key":"637_CR6","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/hep.26909","volume":"60","author":"U Beuers","year":"2014","unstructured":"Beuers\u00a0U, Kremer\u00a0AE, Bolier\u00a0R et\u00a0al (2014) Pruritus in cholestasis: facts and fiction. Hepatology 60:399\u2013407","journal-title":"Hepatology"},{"key":"637_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1053\/j.ajkd.2006.03.082","volume":"48","author":"YC Chen","year":"2006","unstructured":"Chen\u00a0YC, Chiu\u00a0WT, Wu\u00a0MS (2006) Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. Am J Kidney Dis 48:69\u201376","journal-title":"Am J Kidney Dis"},{"key":"637_CR8","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1056\/NEJMoa1714519","volume":"378","author":"C Corpechot","year":"2018","unstructured":"Corpechot\u00a0C, Chazouilleres\u00a0O, Rousseau\u00a0A et al (2018) A placebo-controlled trial of bezafibrate in primary biliary cholangitis. N\u00a0Engl J Med 378:2171\u20132181","journal-title":"N Engl J Med"},{"key":"637_CR9","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1126\/science.aar5703","volume":"360","author":"J Feng","year":"2018","unstructured":"Feng\u00a0J, Luo\u00a0J, Yang\u00a0P et al (2018) Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch. Science 360:530\u2013533","journal-title":"Science"},{"key":"637_CR10","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.3748\/wjg.15.2049","volume":"15","author":"V Geenes","year":"2009","unstructured":"Geenes\u00a0V, Williamson\u00a0C (2009) Intrahepatic cholestasis of pregnancy. World J Gastroenterol 15:2049\u20132066","journal-title":"World J Gastroenterol"},{"key":"637_CR11","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1002\/1097-0142(19830515)51:10<1934::AID-CNCR2820511030>3.0.CO;2-R","volume":"51","author":"PG Gobbi","year":"1983","unstructured":"Gobbi\u00a0PG, Attardo-Parrinello\u00a0G, Lattanzio\u00a0G et al (1983) Severe pruritus should be a\u00a0B-symptom in Hodgkin\u2019s disease. Cancer 51:1934\u20131936","journal-title":"Cancer"},{"key":"637_CR12","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/bjd.13157","volume":"171","author":"SA Johannesdottir","year":"2014","unstructured":"Johannesdottir\u00a0SA, Farkas\u00a0DK, Vinding\u00a0GR et\u00a0al (2014) Cancer incidence among patients with a\u00a0hospital diagnosis of pruritus: a\u00a0nationwide Danish cohort study. Br J Dermatol 171:839\u2013846","journal-title":"Br J Dermatol"},{"key":"637_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1155\/2000\/747495","volume":"14","author":"EA Jones","year":"2000","unstructured":"Jones\u00a0EA, Bergasa\u00a0NV (2000) Evolving concepts of the pathogenesis and treatment of the pruritus of cholestasis. Can J Gastroenterol 14:33\u201340","journal-title":"Can J Gastroenterol"},{"key":"637_CR14","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/j.1365-4632.2007.03288.x","volume":"46","author":"A Kilic","year":"2007","unstructured":"Kilic\u00a0A, Gul\u00a0U, Soylu\u00a0S (2007) Skin findings in internal malignant diseases. Int J Dermatol 46:1055\u20131060","journal-title":"Int J Dermatol"},{"key":"637_CR15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1093\/ndt\/gfi204","volume":"21","author":"M Kimmel","year":"2006","unstructured":"Kimmel\u00a0M, Alscher\u00a0DM, Dunst\u00a0R et al (2006) The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients. Nephrol Dial Transplant 21:749\u2013755","journal-title":"Nephrol Dial Transplant"},{"key":"637_CR16","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s12185-017-2333-y","volume":"107","author":"K Kirito","year":"2018","unstructured":"Kirito\u00a0K, Suzuki\u00a0K, Miyamura\u00a0K et al (2018) Ruxolitinib is effective and safe in Japanese patients with hydroxyurea-resistant or hydroxyurea-intolerant polycythemia vera with splenomegaly. Int J Hematol 107:173\u2013184","journal-title":"Int J Hematol"},{"key":"637_CR17","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1159\/000360518","volume":"32","author":"AE Kremer","year":"2014","unstructured":"Kremer\u00a0AE, Bolier\u00a0R, van Dijk\u00a0R et\u00a0al (2014) Advances in pathogenesis and management of pruritus in cholestasis. Dig Dis 32:637\u2013645","journal-title":"Dig Dis"},{"key":"637_CR18","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1053\/j.gastro.2010.05.009","volume":"139","author":"AE Kremer","year":"2010","unstructured":"Kremer\u00a0AE, Martens\u00a0JJ, Kulik\u00a0W et\u00a0al (2010) Lysophosphatidic acid is a\u00a0potential mediator of cholestatic pruritus. Gastroenterology 139:1008\u20131018","journal-title":"Gastroenterology"},{"key":"637_CR19","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/ndt\/gfp588","volume":"25","author":"H Kumagai","year":"2010","unstructured":"Kumagai\u00a0H, Ebata\u00a0T, Takamori\u00a0K et al (2010) Effect of a\u00a0novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a\u00a0Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant 25:1251\u20131257","journal-title":"Nephrol Dial Transplant"},{"key":"637_CR20","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1093\/ndt\/gfh202","volume":"19","author":"DR Kuypers","year":"2004","unstructured":"Kuypers\u00a0DR, Claes\u00a0K, Evenepoel\u00a0P et\u00a0al (2004) A prospective proof of concept study of the efficacy of tacrolimus ointment on uraemic pruritus (UP) in patients on chronic dialysis therapy. Nephrol Dial Transplant 19:1895\u20131901","journal-title":"Nephrol Dial Transplant"},{"key":"637_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cncr.22365","volume":"109","author":"RA Mesa","year":"2007","unstructured":"Mesa\u00a0RA, Niblack\u00a0J, Wadleigh\u00a0M et al (2007) The burden of fatigue and quality of life in myeloproliferative disorders (MPDs): an international Internet-based survey of 1179 MPD patients. Cancer 109:68\u201376","journal-title":"Cancer"},{"key":"637_CR22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/ki.2013.454","volume":"87","author":"T Mettang","year":"2015","unstructured":"Mettang\u00a0T, Kremer\u00a0AE (2015) Uremic pruritus. Kidney Int 87:685\u2013691","journal-title":"Kidney Int"},{"key":"637_CR23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1177\/089686080002000641","volume":"20","author":"C Pauli-Magnus","year":"2000","unstructured":"Pauli-Magnus\u00a0C, Klumpp\u00a0S, Alscher\u00a0DM et al (2000) Short-term efficacy of tacrolimus ointment in severe uremic pruritus. Perit Dial Int 20:802\u2013803","journal-title":"Perit Dial Int"},{"key":"637_CR24","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.2215\/CJN.03280317","volume":"12","author":"HC Rayner","year":"2017","unstructured":"Rayner\u00a0HC, Larkina\u00a0M, Wang\u00a0M et\u00a0al (2017) International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis. Clin J Am Soc Nephrol 12:2000\u20132007","journal-title":"Clin J Am Soc Nephrol"},{"key":"637_CR25","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2340\/00015555-0650","volume":"89","author":"A Reich","year":"2009","unstructured":"Reich\u00a0A, Stander\u00a0S, Szepietowski\u00a0JC (2009) Drug-induced pruritus: a\u00a0review. Acta Derm Venereol 89:236\u2013244","journal-title":"Acta Derm Venereol"},{"key":"637_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ajg.2017.287","volume":"113","author":"A Reig","year":"2018","unstructured":"Reig\u00a0A, Sese\u00a0P, Pares\u00a0A (2018) Effects of bezafibrate on outcome and pruritus in primary biliary cholangitis with suboptimal ursodeoxycholic acid response. Am J Gastroenterol 113:49\u201355","journal-title":"Am J Gastroenterol"},{"key":"637_CR27","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000051779","volume":"203","author":"R Strumia","year":"2001","unstructured":"Strumia\u00a0R, Varotti\u00a0E, Manzato\u00a0E et\u00a0al (2001) Skin signs in anorexia nervosa. Dermatology 203:314\u2013317","journal-title":"Dermatology"},{"key":"637_CR28","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2215\/CJN.09600818","volume":"14","author":"N Sukul","year":"2019","unstructured":"Sukul\u00a0N, Speyer\u00a0E, Tu\u00a0C et al (2019) Pruritus and patient reported outcomes in non-dialysis CKD. Clin J Am Soc Nephrol 14:673\u2013681","journal-title":"Clin J Am Soc Nephrol"},{"key":"637_CR29","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1182\/blood-2006-12-064287","volume":"110","author":"AM Vannucchi","year":"2007","unstructured":"Vannucchi\u00a0AM, Antonioli\u00a0E, Guglielmelli\u00a0P et\u00a0al (2007) Clinical profile of homozygous JAK2 617V\u3009F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 110:840\u2013846","journal-title":"Blood"},{"key":"637_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/cncr.28441","volume":"120","author":"S Verstovsek","year":"2014","unstructured":"Verstovsek\u00a0S, Passamonti\u00a0F, Rambaldi\u00a0A et\u00a0al (2014) A phase 2 study of ruxolitinib, an oral JAK1 and JAK2 Inhibitor, in patients with advanced polycythemia vera who are refractory or intolerant to hydroxyurea. Cancer 120:513\u2013520","journal-title":"Cancer"},{"key":"637_CR31","doi-asserted-by":"publisher","first-page":"816","DOI":"10.2340\/00015555-2023","volume":"95","author":"M Weiss","year":"2015","unstructured":"Weiss\u00a0M, Mettang\u00a0T, Tschulena\u00a0U et al (2015) Prevalence of chronic itch and associated factors in haemodialysis patients: a\u00a0representative cross-sectional study. Acta Derm Venereol 95:816\u2013821","journal-title":"Acta Derm Venereol"},{"key":"637_CR32","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2340\/00015555-1959","volume":"95","author":"E Weisshaar","year":"2015","unstructured":"Weisshaar\u00a0E, Weiss\u00a0M, Mettang\u00a0T et\u00a0al (2015) Paraneoplastic itch: an expert position statement from the Special Interest Group (SIG) of the International Forum on the Study of Itch (IFSI). Acta Derm Venereol 95:261\u2013265","journal-title":"Acta Derm Venereol"},{"key":"637_CR33","doi-asserted-by":"publisher","first-page":"e2935","DOI":"10.1097\/MD.0000000000002935","volume":"95","author":"HY Wu","year":"2016","unstructured":"Wu\u00a0HY, Peng\u00a0YS, Chen\u00a0HY et\u00a0al (2016) A comparison of uremic pruritus in patients receiving peritoneal dialysis and hemodialysis. Medicine 95:e2935","journal-title":"Medicine"},{"key":"637_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2337\/dc09-0632","volume":"33","author":"H Yamaoka","year":"2010","unstructured":"Yamaoka\u00a0H, Sasaki\u00a0H, Yamasaki\u00a0H et\u00a0al (2010) Truncal pruritus of unknown origin may be a\u00a0symptom of diabetic polyneuropathy. Diabetes Care 33:150\u2013155","journal-title":"Diabetes Care"},{"key":"637_CR35","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11255-014-0795-x","volume":"47","author":"J Yue","year":"2015","unstructured":"Yue\u00a0J, Jiao\u00a0S, Xiao\u00a0Y et al (2015) Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a\u00a0prospective, randomized, double-blind study. Int Urol Nephrol 47:161\u2013167","journal-title":"Int Urol Nephrol"},{"key":"637_CR36","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1093\/ndt\/gfl461","volume":"21","author":"RL Pisoni","year":"2006","unstructured":"Pisoni\u00a0RL, Wikstrom\u00a0B, Elder\u00a0SJ et\u00a0al (2006) Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 21:3495\u20133505","journal-title":"Nephrol Dial Transplant"}],"container-title":["Der Internist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-019-0637-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00108-019-0637-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-019-0637-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T23:43:23Z","timestamp":1593042203000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00108-019-0637-0"}},"subtitle":["H\u00e4ufiges und Seltenes"],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["637"],"URL":"https:\/\/doi.org\/10.1007\/s00108-019-0637-0","relation":{},"ISSN":["0020-9554","1432-1289"],"issn-type":[{"value":"0020-9554","type":"print"},{"value":"1432-1289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"26 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.E.\u00a0Kremer und T.\u00a0Mettang geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}