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Die Nierenbiopsie mit Nachweis einer linearen Immunglobulin-G-Ablagerung entlang der Basalmembran stellt den Goldstandard dar, der von serologischen Analysen begleitet wird. Standardassays zur Anti-GBM-Bestimmung weisen hohe Raten an falsch-negativen Befunden auf. Eine Zunahme der Proteinurie trotz Standardtherapie mit Plasmapherese, Steroid und Cyclophosphamid war das klinische Korrelat des Erkrankungsrezidivs. Rituximab f\u00fchrte zu einer vollst\u00e4ndigen Ausheilung.<\/jats:p>","DOI":"10.1007\/s00108-020-00773-5","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T16:04:06Z","timestamp":1584374646000},"page":"416-423","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Erfolgreiche Rituximabtherapie des Rezidivs einer Glomerulonephritis assoziiert mit\u00a0Antik\u00f6rpern gegen die glomerul\u00e4re Basalmembran","Successful rituximab treatment of recurrent glomerulonephritis associated with antibodies against the glomerular basement membrane"],"prefix":"10.1007","volume":"61","author":[{"given":"D.","family":"Chittka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lennartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Banas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Bergler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"773_CR1","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.2215\/CJN.13591215","volume":"11","author":"M Canney","year":"2016","unstructured":"Canney\u00a0M, O\u2019Hara\u00a0PV, McEvoy\u00a0CM, Medani\u00a0S, Connaughton\u00a0DM, Abdalla\u00a0AA, Doyle\u00a0R, Stack\u00a0AG, O\u2019Seaghdha\u00a0CM, Clarkson\u00a0MR, Griffin\u00a0MD, Holian\u00a0J, Dorman\u00a0AM, Niland\u00a0A, Keogan\u00a0M, Wallace\u00a0EM, Conlon\u00a0NP, Walsh\u00a0C, Kelly\u00a0A, Little\u00a0MA (2016) Spatial and temporal clustering of anti-glomerular basement membrane disease. 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