{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:42:58Z","timestamp":1740184978499,"version":"3.37.3"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Die Transthyretin-Amyloidose (ATTR-Amyloidose) f\u00fchrt zur Ablagerung von unl\u00f6slichen Fibrillen im Interstitium der betroffenen Organe. Eine kardiale Beteiligung kann sich durch Dyspnoe, \u00d6deme, Rhythmusst\u00f6rungen bis hin zur manifesten Herzinsuffizienz und Tod \u00e4u\u00dfern.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Fallbericht<\/jats:title>\n                <jats:p>Ein 79-j\u00e4hriger Mann stellte sich mit Dyspnoe sowie Gewichtszunahme vor. In der Echokardiographie Hypertrophie bei restriktiver Kardiomyopathie. In der Knochenszintigraphie Tracer-Mehranreicherung, hochverd\u00e4chtig auf eine ATTR-Amyloidose, welche mittels Biopsie best\u00e4tigt werden konnte.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerungen<\/jats:title>\n                <jats:p>Die Diagnose einer kardialen ATTR-Amyloidose stellt f\u00fcr den Kliniker eine Herausforderung dar und setzt dessen erh\u00f6hte Aufmerksamkeit voraus. Die Diagnosestellung sollte strukturiert erfolgen unter Einbeziehung von Labor, bildgebenden Verfahren sowie Myokardbiopsie.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00108-022-01358-0","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T16:36:27Z","timestamp":1656002187000},"page":"994-999","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dyspnoe und \u00d6deme bei einem 79-j\u00e4hrigen Patienten","Dyspnea and edema in a\u00a079-year old male"],"prefix":"10.1007","volume":"63","author":[{"given":"Frederic","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Greulich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"1358_CR1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.berh.2003.09.001","volume":"17","author":"MD Benson","year":"2003","unstructured":"Benson\u00a0MD (2003) The hereditary amyloidoses. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}