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Als paraneoplastisches Syndrom zeigten sich eine Hypernatri\u00e4mie sowie Polyurie infolge eines zentralen Diabetes insipidus (CDI), welcher mittels Desmopressingabe kontrolliert werden konnte. Nach Einleitung einer Induktionstherapie kam es im Verlauf nach Beendigung der Desmopressintherapie noch vor Anstieg des Blastenanteils zu einer erneuten Hypernatri\u00e4mie und Polyurie als Hinweis auf eine prim\u00e4re Refrakt\u00e4rit\u00e4t.<\/jats:p>","DOI":"10.1007\/s00108-022-01381-1","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:04:04Z","timestamp":1657879444000},"page":"1194-1199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypernatri\u00e4mie und Polyurie bei einer Patientin mit Erstdiagnose einer sekund\u00e4ren akuten myeloischen Leuk\u00e4mie","Hypernatremia and polyuria in a female patient with an initial diagnosis of secondary acute myeloid leukemia"],"prefix":"10.1007","volume":"63","author":[{"given":"E.","family":"Aydilek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Xhaxho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Akdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wallbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Br\u00f6kers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"issue":"2","key":"1381_CR1","first-page":"231","volume":"31","author":"M Zuffa","year":"1984","unstructured":"Zuffa\u00a0M, Kubancok\u00a0J, Rusn\u00e1k\u00a0I, Mensatoris\u00a0K, Horv\u00e1th\u00a0A (1984) Early paraneoplastic syndrome in medical oncology: clinicopathological analysis of 1694\u00a0patients treated over 20\u00a0years. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}