{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T05:39:15Z","timestamp":1695706755063},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s00108-023-01584-0","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:01:36Z","timestamp":1694599296000},"page":"955-960","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behandlung der h\u00e4mophagozytischen Lymphohistiozytose bei Patienten auf der Intensivstation","Treatment of hemophagocytic lymphohistiocytosis in patients in the intensive care unit"],"prefix":"10.1007","volume":"64","author":[{"given":"Dennis A.","family":"Eichenauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"La Ros\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"1584_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05271-w","author":"A Abdelhay","year":"2023","unstructured":"Abdelhay\u00a0A, Mahmoud\u00a0A, Mostafa\u00a0M et al (2023) Delay in treatment of adult hemophagocytic lymphohistiocytosis is associated with worse in-hospital outcomes. Ann Hematol. https:\/\/doi.org\/10.1007\/s00277-023-05271-w","journal-title":"Ann Hematol"},{"key":"1584_CR2","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1136\/ard-2022-223739","volume":"82","author":"F De Benedetti","year":"2023","unstructured":"De Benedetti\u00a0F, Grom\u00a0AA, Brogan\u00a0PA et\u00a0al (2023) Efficacy and safety of emapalumab in macrophage activation syndrome. Ann Rheum Dis 82:857\u2013865. https:\/\/doi.org\/10.1136\/ard-2022-223739","journal-title":"Ann Rheum Dis"},{"key":"1584_CR3","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s00432-020-03139-4","volume":"146","author":"S Birndt","year":"2020","unstructured":"Birndt\u00a0S, Schenk\u00a0T, Heinevetter\u00a0B et\u00a0al (2020) Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a\u00a0nationwide German registry. J\u00a0Cancer Res Clin Oncol 146:1065\u20131077. https:\/\/doi.org\/10.1007\/s00432-020-03139-4","journal-title":"J Cancer Res Clin Oncol"},{"key":"1584_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/bjh.14147","volume":"174","author":"E Brisse","year":"2016","unstructured":"Brisse\u00a0E, Wouters\u00a0CH, Matthys\u00a0P (2016) Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: differences and similarities. Br J Haematol 174:203\u2013217. https:\/\/doi.org\/10.1111\/bjh.14147","journal-title":"Br J Haematol"},{"key":"1584_CR5","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1093\/ajcp\/aqw076","volume":"145","author":"F Debaugnies","year":"2016","unstructured":"Debaugnies\u00a0F, Mahadeb\u00a0B, Ferster\u00a0A et al (2016) Performances of the H\u2011score for diagnosis of hemophagocytic lymphohistiocytosis in adult and pediatric patients. Am J Clin Pathol 145:862\u2013870. https:\/\/doi.org\/10.1093\/ajcp\/aqw076","journal-title":"Am J Clin Pathol"},{"key":"1584_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13613-022-01075-9","volume":"12","author":"T Dupont","year":"2022","unstructured":"Dupont\u00a0T, Darmon\u00a0M, Mariotte\u00a0E et al (2022) Etoposide treatment in secondary hemophagocytic syndrome: impact on healthcare-associated infections and survival. Ann Intensive Care 12:101. https:\/\/doi.org\/10.1186\/s13613-022-01075-9","journal-title":"Ann Intensive Care"},{"key":"1584_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00063-021-00781-9","volume":"116","author":"DA Eichenauer","year":"2021","unstructured":"Eichenauer\u00a0DA, Lachmann\u00a0G, La Ros\u00e9e\u00a0P (2021) Die h\u00e4mophagozytische Lymphohistiozytose bei kritisch kranken Patienten. Med Klin Intensivmed Notfallmed 116:129\u2013134. https:\/\/doi.org\/10.1007\/s00063-021-00781-9","journal-title":"Med Klin Intensivmed Notfallmed"},{"key":"1584_CR8","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1002\/art.38690","volume":"66","author":"L Fardet","year":"2014","unstructured":"Fardet\u00a0L, Galicier\u00a0L, Lambotte\u00a0O et\u00a0al (2014) Development and validation of the HScore, a\u00a0score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol 66:2613\u20132620. https:\/\/doi.org\/10.1002\/art.38690","journal-title":"Arthritis Rheumatol"},{"key":"1584_CR9","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/S0140-6736(06)68232-9","volume":"367","author":"JI Henter","year":"2006","unstructured":"Henter\u00a0JI, Chow\u00a0CB, Leung\u00a0CW, Lau\u00a0YL (2006) Cytotoxic therapy for severe avian influenza A (H5N1) infection. Lancet 367:870\u2013873. https:\/\/doi.org\/10.1016\/S0140-6736(06)68232-9","journal-title":"Lancet"},{"key":"1584_CR10","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/pbc.21039","volume":"48","author":"JI Henter","year":"2007","unstructured":"Henter\u00a0JI, Horne\u00a0A, Arico\u00a0M et al (2007) HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48:124\u2013131. https:\/\/doi.org\/10.1002\/pbc.21039","journal-title":"Pediatr Blood Cancer"},{"key":"1584_CR11","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1007\/s15010-022-01786-y","volume":"50","author":"M-L Hieber","year":"2022","unstructured":"Hieber\u00a0M\u2011L, Sprute\u00a0R, Eichenauer\u00a0DA et al (2022) Hemophagocytic lymphohistiocytosis after SARS-CoV\u20112 vaccination. Infection 50:1399\u20131404. https:\/\/doi.org\/10.1007\/s15010-022-01786-y","journal-title":"Infection"},{"key":"1584_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.03.006","author":"MR Hines","year":"2023","unstructured":"Hines\u00a0MR, Knight\u00a0TE, McNerney\u00a0KO et al (2023) Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome. Transplant Cell Ther. https:\/\/doi.org\/10.1016\/j.jtct.2023.03.006","journal-title":"Transplant Cell Ther"},{"key":"1584_CR13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436","author":"P Horby","year":"2020","unstructured":"Horby\u00a0P, Lim\u00a0WS, Emberson\u00a0JR et al (2020) Dexamethasone in hospitalized patients with Covid-19\u2014preliminary report. N\u00a0Engl J Med. https:\/\/doi.org\/10.1056\/NEJMoa2021436","journal-title":"N Engl J Med"},{"key":"1584_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s13054-020-02941-3","volume":"24","author":"C Knaak","year":"2020","unstructured":"Knaak\u00a0C, Nyvlt\u00a0P, Schuster\u00a0FS et al (2020) Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore. Crit Care 24:244. https:\/\/doi.org\/10.1186\/s13054-020-02941-3","journal-title":"Crit Care"},{"key":"1584_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004581","author":"C Knaak","year":"2020","unstructured":"Knaak\u00a0C, Schuster\u00a0FS, Nyvlt\u00a0P et\u00a0al (2020) Treatment and mortality of hemophagocytic lymphohistiocytosis in adult critically ill patients: a\u00a0systematic review with pooled analysis. Crit Care Med. https:\/\/doi.org\/10.1097\/CCM.0000000000004581","journal-title":"Crit Care Med"},{"key":"1584_CR16","first-page":"330","volume":"10","author":"G Kumar","year":"2020","unstructured":"Kumar\u00a0G, Hererra\u00a0M, Patel\u00a0D et al (2020) Outcomes of adult critically ill patients with hemophagocytic lymphohistiocytosis in united states-analysis from an administrative database from 2007 to 2015. Am J Blood Res 10:330\u2013338","journal-title":"Am J Blood Res"},{"key":"1584_CR17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/bjh.18617","volume":"201","author":"D Kuron","year":"2023","unstructured":"Kuron\u00a0D, Voran\u00a0JC, von Samson-Himmelstjerna\u00a0FA et al (2023) Epidemiology of haemophagocytic lymphohistiocytosis at the population level in Germany. Br J Haematol 201:285\u2013289. https:\/\/doi.org\/10.1111\/bjh.18617","journal-title":"Br J Haematol"},{"key":"1584_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/CCM.0000000000004131","volume":"48","author":"G Lachmann","year":"2020","unstructured":"Lachmann\u00a0G, Knaak\u00a0C, Vorderwulbecke\u00a0G et\u00a0al (2020) Hyperferritinemia in critically ill patients. Crit Care Med 48:459\u2013465. https:\/\/doi.org\/10.1097\/CCM.0000000000004131","journal-title":"Crit Care Med"},{"key":"1584_CR19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/SHK.0000000000001048","volume":"50","author":"G Lachmann","year":"2018","unstructured":"Lachmann\u00a0G, Spies\u00a0C, Schenk\u00a0T et\u00a0al (2018) Hemophagocytic lymphohistiocytosis: potentially underdiagnosed in intensive care units. Shock 50:149\u2013155. https:\/\/doi.org\/10.1097\/SHK.0000000000001048","journal-title":"Shock"},{"key":"1584_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/bjh.13462","volume":"170","author":"K Lehmberg","year":"2015","unstructured":"Lehmberg\u00a0K, Sprekels\u00a0B, Nichols\u00a0KE et al (2015) Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents. Br J Haematol 170:539\u2013549. https:\/\/doi.org\/10.1111\/bjh.13462","journal-title":"Br J Haematol"},{"key":"1584_CR21","doi-asserted-by":"publisher","first-page":"18277","DOI":"10.1038\/s41598-020-75260-w","volume":"10","author":"G Lorenz","year":"2020","unstructured":"Lorenz\u00a0G, Moog\u00a0P, Bachmann\u00a0Q et al (2020) Title: Cytokine release syndrome is not usually caused by secondary hemophagocytic lymphohistiocytosis in a\u00a0cohort of 19 critically ill COVID-19\u00a0patients. Sci Rep 10:18277. https:\/\/doi.org\/10.1038\/s41598-020-75260-w","journal-title":"Sci Rep"},{"key":"1584_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619837139","author":"NK Meena","year":"2019","unstructured":"Meena\u00a0NK, Sinokrot\u00a0O, Duggal\u00a0A et\u00a0al (2019) The performance of diagnostic criteria for hemophagocytic lymphohistiocytosis in critically ill patients. J\u00a0Intensive Care Med. https:\/\/doi.org\/10.1177\/0885066619837139","journal-title":"J Intensive Care Med"},{"key":"1584_CR23","doi-asserted-by":"publisher","first-page":"107606","DOI":"10.1016\/j.intimp.2021.107606","volume":"96","author":"G-Q Meng","year":"2021","unstructured":"Meng\u00a0G\u2011Q, Wang\u00a0J\u2011S, Wang\u00a0Y\u2011N et al (2021) Rituximab-containing immuno-chemotherapy regimens are effective for the elimination of EBV for EBV-HLH with only and mainly B lymphocytes of EBV infection. Int Immunopharmacol 96:107606. https:\/\/doi.org\/10.1016\/j.intimp.2021.107606","journal-title":"Int Immunopharmacol"},{"key":"1584_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000526980","volume":"146","author":"HW Park","year":"2023","unstructured":"Park\u00a0HW, Min\u00a0GJ, Kim\u00a0TY, Cho\u00a0S\u2011G (2023) A case of hemophagocytic lymphohistiocytosis following second dose of COVID-19 vaccination. Acta Haematol 146:65\u201371. https:\/\/doi.org\/10.1159\/000526980","journal-title":"Acta Haematol"},{"key":"1584_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26668","author":"S Priyadarshini","year":"2022","unstructured":"Priyadarshini\u00a0S, Harris\u00a0A, Treisman\u00a0D et al (2022) Hemophagocytic lymphohistiocytosis secondary to \u3008scp\u3009CAR-T\u3008\/scp\u3009 cells: Update from the \u3008scp\u3009FDA\u3008\/scp\u3009 and Vizient databases. Am J Hematol. https:\/\/doi.org\/10.1002\/ajh.26668","journal-title":"Am J Hematol"},{"key":"1584_CR26","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1182\/blood.2018894618","volume":"133","author":"P La Ros\u00e9e","year":"2019","unstructured":"La Ros\u00e9e\u00a0P, Horne\u00a0A, Hines\u00a0M et\u00a0al (2019) Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. Blood 133:2465\u20132477. https:\/\/doi.org\/10.1182\/blood.2018894618","journal-title":"Blood"},{"key":"1584_CR27","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1097\/CCM.0000000000001402","volume":"44","author":"B Shakoory","year":"2016","unstructured":"Shakoory\u00a0B, Carcillo\u00a0JA, Chatham\u00a0WW et al (2016) Interleukin\u20111 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a\u00a0prior phase\u00a0III trial. Crit Care Med 44:275\u2013281. https:\/\/doi.org\/10.1097\/CCM.0000000000001402","journal-title":"Crit Care Med"},{"key":"1584_CR28","doi-asserted-by":"publisher","first-page":"59977","DOI":"10.18632\/oncotarget.19230","volume":"8","author":"H Wang","year":"2017","unstructured":"Wang\u00a0H, Xiong\u00a0L, Tang\u00a0W et al (2017) A systematic review of malignancy-associated hemophagocytic lymphohistiocytosis that needs more attentions. Oncotarget 8:59977\u201359985. https:\/\/doi.org\/10.18632\/oncotarget.19230","journal-title":"Oncotarget"},{"key":"1584_CR29","doi-asserted-by":"publisher","first-page":"e247022","DOI":"10.1136\/bcr-2021-247022","volume":"15","author":"V Wu","year":"2022","unstructured":"Wu\u00a0V, Lopez\u00a0CA, Hines\u00a0AM, Barrientos\u00a0JC (2022) Haemophagocytic lymphohistiocytosis following COVID-19 mRNA vaccination. BMJ Case Rep 15:e247022. https:\/\/doi.org\/10.1136\/bcr-2021-247022","journal-title":"BMJ Case Rep"},{"key":"1584_CR30","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1182\/blood-2022-164496","volume":"140","author":"D Zhou","year":"2022","unstructured":"Zhou\u00a0D, Huang\u00a0X, Li\u00a0X et al (2022) Ruxolitinib combined with dexamethasone in adult patients with newly diagnosed hemophagocytic lymphohistiocytosis: a\u00a0prospective, single-center, single-arm, phase\u00a02 clinical trial. Blood 140:2620\u20132621. https:\/\/doi.org\/10.1182\/blood-2022-164496","journal-title":"Blood"},{"key":"1584_CR31","doi-asserted-by":"publisher","first-page":"167","DOI":"10.2147\/TCRM.S155488","volume":"14","author":"S Zhou","year":"2018","unstructured":"Zhou\u00a0S, Qiao\u00a0J, Bai\u00a0J et al (2018) Biological therapy of traditional therapy-resistant adult-onset still\u2019s disease: an evidence-based review. Ther Clin Risk Manag 14:167\u2013171. https:\/\/doi.org\/10.2147\/TCRM.S155488","journal-title":"Ther Clin Risk Manag"},{"key":"1584_CR32","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1182\/blood.2021012764","volume":"139","author":"A Zoref-Lorenz","year":"2022","unstructured":"Zoref-Lorenz\u00a0A, Murakami\u00a0J, Hofstetter\u00a0L et al (2022) An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis. Blood 139:1098\u20131110. https:\/\/doi.org\/10.1182\/blood.2021012764","journal-title":"Blood"},{"key":"1584_CR33","unstructured":"https:\/\/www.onkopedia.com\/de\/onkopedia\/guidelines\/car-t-zellen-management-von-nebenwirkungen\/@@guideline\/html\/index.html. Zugegriffen: 14.07.2023"}],"container-title":["Die Innere Medizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-023-01584-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00108-023-01584-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-023-01584-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:02:52Z","timestamp":1695632572000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00108-023-01584-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1584"],"URL":"https:\/\/doi.org\/10.1007\/s00108-023-01584-0","relation":{},"ISSN":["2731-7080","2731-7099"],"issn-type":[{"value":"2731-7080","type":"print"},{"value":"2731-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]},"assertion":[{"value":"10 August 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"D.A.\u00a0Eichenauer und P.\u00a0La\u00a0Ros\u00e9e geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}