{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T01:16:13Z","timestamp":1748049373526,"version":"3.37.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Die Infektion mit <jats:italic>Echinococcus multilocularis<\/jats:italic> f\u00fchrt zum Krankheitsbild der alveol\u00e4ren Echinokokkose. Diese ist gekennzeichnet durch Ausbildung von alveol\u00e4ren Lebertumoren, welche im Verlauf meist nekrotisch zerfallen. Es kommt zur Ausbildung von Pseudozysten. Vor allem in fr\u00fchen Stadien wird die kurative Resektion mit anschlie\u00dfender Langzeitbehandlung mit Albendazol empfohlen. Eine nicht seltene Komplikation unter Albendazoltherapie ist die Entwicklung einer Hepatitis. Wir pr\u00e4sentieren den seltenen Fall einer albendazolassoziierten Hepatitis bei nicht operabler <jats:italic>Echinococcus-multilocularis<\/jats:italic>-Infektion mit g\u00fcnstigem Verlauf durch Umstellung der Therapie auf Mebendazol.<\/jats:p>","DOI":"10.1007\/s00108-024-01796-y","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:15:18Z","timestamp":1727183718000},"page":"231-235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatotoxizit\u00e4t durch Albendazol: sichere Alternativen bei Echinokokkosetherapie","Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy"],"prefix":"10.1007","volume":"66","author":[{"given":"Laura","family":"Muana Wilhelm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joschka","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"issue":"1","key":"1796_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","volume":"114","author":"E Brunetti","year":"2010","unstructured":"Brunetti\u00a0E, Kern\u00a0P, Vuitton\u00a0DA (2010) Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. 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UNI-MED, Bremen, S\u00a0832"},{"key":"1796_CR6","doi-asserted-by":"publisher","first-page":"Doc01","DOI":"10.3205\/id000027","volume":"5","author":"B Gr\u00fcner","year":"2017","unstructured":"Gr\u00fcner\u00a0B et\u00a0al (2017) Comprehensive diagnosis and treatment of alveolar echinococcosis: a\u00a0single-center, long-term observational study of 312 patients in Germany. GMS Infect Dis 5:Doc1. https:\/\/doi.org\/10.3205\/id000027","journal-title":"GMS Infect Dis"},{"issue":"4","key":"1796_CR7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.21614\/chirurgia.114.4.524","volume":"114","author":"Y Asenov","year":"2019","unstructured":"Asenov\u00a0Y, Akin\u00a0M, Ibi\u015f\u00a0C, Tekant\u00a0Y, \u00d6zden\u00a0I (2019) Observed or predicted albendazole hetotoxicity as an indication for a\u00a0resection procedure in hepatic hydatid disease\u2014A short series of cases. Chirurgia 114(4):524. https:\/\/doi.org\/10.21614\/chirurgia.114.4.524","journal-title":"Chirurgia"},{"issue":"3","key":"1796_CR8","doi-asserted-by":"publisher","first-page":"301","DOI":"10.4269\/ajtmh.2008.79.301","volume":"79","author":"T Junghanss","year":"2008","unstructured":"Junghanss\u00a0T, da Silva\u00a0AM, Horton\u00a0J, Chiodini\u00a0PL, Brunetti\u00a0E (2008) Clinical management of cystic echinococcosis: state of the art, problems, and perspectives. Am J Trop Med Hyg 79(3):301\u2013311","journal-title":"Am J Trop Med Hyg"},{"key":"1796_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00075-18","author":"H Wen","year":"2019","unstructured":"Wen\u00a0H et\u00a0al (2019) Echinococcosis: Advances in the 21st\u00a0Century. Clin Microbiol Rev. https:\/\/doi.org\/10.1128\/CMR.00075-18","journal-title":"Clin Microbiol Rev"}],"container-title":["Die Innere Medizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-024-01796-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00108-024-01796-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-024-01796-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T10:50:34Z","timestamp":1738752634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00108-024-01796-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1796"],"URL":"https:\/\/doi.org\/10.1007\/s00108-024-01796-y","relation":{},"ISSN":["2731-7080","2731-7099"],"issn-type":[{"type":"print","value":"2731-7080"},{"type":"electronic","value":"2731-7099"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"30 August 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.\u00a0Muana Wilhelm, J.\u00a0Bachmann, M.\u00a0Cornberg, H.\u00a0Wedemeyer und B.\u00a0Heinrich geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}