{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T14:10:14Z","timestamp":1737727814224,"version":"3.33.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00108-024-01827-8","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:55:20Z","timestamp":1736344520000},"page":"31-39","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronisch-entz\u00fcndliche Darmerkrankungen bei Kindern und Jugendlichen","Inflammatory bowel diseases in children and adolescents"],"prefix":"10.1007","volume":"66","author":[{"given":"Tobias","family":"Schwerd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"1827_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1053\/j.gastro.2021.04.063","volume":"161","author":"M Agrawal","year":"2021","unstructured":"Agrawal\u00a0M, Spencer\u00a0EA, Colombel\u00a0J\u2011F, Ungaro\u00a0RC (2021) Approach to the Management of Recently Diagnosed Inflammatory Bowel Disease Patients: A\u00a0User\u2019s Guide for Adult and Pediatric Gastroenterologists. Gastroenterology 161:47\u201365. https:\/\/doi.org\/10.1053\/j.gastro.2021.04.063","journal-title":"Gastroenterology"},{"key":"1827_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae094","author":"O Atia","year":"2024","unstructured":"Atia\u00a0O, Buchuk\u00a0R, Lujan\u00a0R et\u00a0al (2024) Predictors of Complicated Disease Course in Children and Adults With Ulcerative Colitis: A\u00a0Nationwide Study From the epi-IIRN. Inflamm Bowel Dis. https:\/\/doi.org\/10.1093\/ibd\/izae094","journal-title":"Inflamm Bowel Dis"},{"key":"1827_CR3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00439-022-02464-7","volume":"142","author":"A Azabdaftari","year":"2023","unstructured":"Azabdaftari\u00a0A, Jones\u00a0KDJ, Kammermeier\u00a0J, Uhlig\u00a0HH (2023) Monogenic inflammatory bowel disease-genetic variants, functional mechanisms and personalised medicine in clinical practice. Hum Genet 142:599\u2013611. https:\/\/doi.org\/10.1007\/s00439-022-02464-7","journal-title":"Hum Genet"},{"key":"1827_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3238\/arztebl.2015.0121","volume":"112","author":"S Buderus","year":"2015","unstructured":"Buderus\u00a0S, Scholz\u00a0D, Behrens\u00a0R et\u00a0al (2015) Inflammatory bowel disease in pediatric patients: Characteristics of newly diagnosed patients from the CEDATA-GPGE Registry. Dtsch \u00c4rztebl Int 112:121\u2013127. https:\/\/doi.org\/10.3238\/arztebl.2015.0121","journal-title":"Dtsch \u00c4rztebl Int"},{"key":"1827_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/ecco-jcc\/jjac135","volume":"17","author":"NM Croft","year":"2023","unstructured":"Croft\u00a0NM, de Ridder\u00a0L, Griffiths\u00a0AM et\u00a0al (2023) Paediatric Inflammatory Bowel Disease: A\u00a0Multi-Stakeholder Perspective to Improve Development of Drugs for Children and Adolescents. J\u00a0Crohns Colitis 17:249\u2013258. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjac135","journal-title":"J Crohns Colitis"},{"key":"1827_CR6","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1053\/j.gastro.2020.02.023","volume":"158","author":"E Crowley","year":"2020","unstructured":"Crowley\u00a0E, Warner\u00a0N, Pan\u00a0J et\u00a0al (2020) Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a\u00a0Single Center. Gastroenterology 158:2208\u20132220. https:\/\/doi.org\/10.1053\/j.gastro.2020.02.023","journal-title":"Gastroenterology"},{"key":"1827_CR7","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s10578-014-0471-5","volume":"46","author":"G Engelmann","year":"2015","unstructured":"Engelmann\u00a0G, Erhard\u00a0D, Petersen\u00a0M et\u00a0al (2015) Health-related quality of life in adolescents with inflammatory bowel disease depends on disease activity and psychiatric comorbidity. Child Psychiatry Hum Dev 46:300\u2013307. https:\/\/doi.org\/10.1007\/s10578-014-0471-5","journal-title":"Child Psychiatry Hum Dev"},{"key":"1827_CR8","doi-asserted-by":"publisher","first-page":"i14","DOI":"10.1093\/ecco-jcc\/jjad212.0008","volume":"18","author":"L Fachal","year":"2024","unstructured":"Fachal\u00a0L, on behalf of the International IBD Genetics Consortium (2024) OP08 Multi-ancestry genome-wide association study of inflammatory bowel disease identifies 125 novel loci and directly implicates new genes in disease susceptibility. J\u00a0Crohn\u2019s Colitis 18:i14\u2013i15. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjad212.0008","journal-title":"J Crohn\u2019s Colitis"},{"key":"1827_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18264","author":"M Granot","year":"2024","unstructured":"Granot\u00a0M, Kopylov\u00a0U, Loberman-Nachum\u00a0N et\u00a0al (2024) Differences in disease characteristics and treatment exposures between paediatric and adult-onset inflammatory bowel disease using a\u00a0registry-based cohort. Aliment Pharmacol Ther. https:\/\/doi.org\/10.1111\/apt.18264","journal-title":"Aliment Pharmacol Ther"},{"key":"1827_CR10","unstructured":"Hoelz H, Bragagna L, Litwin A et\u00a0al Pediatric IBD Patients Treated With Infliximab and Proactive Drug Monitoring Benefit From Early Concomitant Immunomodulatory Therapy: A\u00a0Retrospective Analysis of a\u00a010-Year Real-Life Cohort."},{"key":"1827_CR11","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00439-023-02521-9","volume":"142","author":"D Jans","year":"2023","unstructured":"Jans\u00a0D, Cleynen\u00a0I (2023) The genetics of non-monogenic IBD. Hum Genet 142:669\u2013682. https:\/\/doi.org\/10.1007\/s00439-023-02521-9","journal-title":"Hum Genet"},{"key":"1827_CR12","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00103-020-03166-z","volume":"63","author":"K Krohn","year":"2020","unstructured":"Krohn\u00a0K, Pfeifer\u00a0M, Manzey\u00a0P, Koletzko\u00a0S (2020) Inflammatory bowel diseases-the biopsychosocial reality in childhood and adolescence. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63:839\u2013845. https:\/\/doi.org\/10.1007\/s00103-020-03166-z","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"1827_CR13","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","volume":"162","author":"ME Kuenzig","year":"2022","unstructured":"Kuenzig\u00a0ME, Fung\u00a0SG, Marderfeld\u00a0L et\u00a0al (2022) Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review. Gastroenterology 162:1147\u20131159.e4. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.282","journal-title":"Gastroenterology"},{"key":"1827_CR14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/ibd.23013","volume":"19","author":"A Levine","year":"2013","unstructured":"Levine\u00a0A, de Bie\u00a0CI, Turner\u00a0D et\u00a0al (2013) Atypical disease phenotypes in pediatric ulcerative colitis: 5\u2011year analyses of the EUROKIDS Registry. Inflamm Bowel Dis 19:370\u2013377. https:\/\/doi.org\/10.1002\/ibd.23013","journal-title":"Inflamm Bowel Dis"},{"key":"1827_CR15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/MPG.0000000000000239","volume":"58","author":"A Levine","year":"2014","unstructured":"Levine\u00a0A, Koletzko\u00a0S, Turner\u00a0D et\u00a0al (2014) ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents. J\u00a0Pediatr Gastroenterol Nutr 58:795\u2013806. https:\/\/doi.org\/10.1097\/MPG.0000000000000239","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1827_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.crohns.2009.07.001","volume":"3","author":"F Prenzel","year":"2009","unstructured":"Prenzel\u00a0F, Uhlig\u00a0HH (2009) Frequency of indeterminate colitis in children and adults with IBD\u2014a\u00a0metaanalysis. J\u00a0Crohns Colitis 3:277\u2013281. https:\/\/doi.org\/10.1016\/j.crohns.2009.07.001","journal-title":"J Crohns Colitis"},{"key":"1827_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1053\/j.gastro.2018.03.069","volume":"155","author":"M Quaranta","year":"2018","unstructured":"Quaranta\u00a0M, Wilson\u00a0R, Gon\u00e7alves\u00a0SE et\u00a0al (2018) Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease. Gastroenterology 155:231\u2013234. https:\/\/doi.org\/10.1053\/j.gastro.2018.03.069","journal-title":"Gastroenterology"},{"key":"1827_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa161","author":"PF van Rheenen","year":"2020","unstructured":"van Rheenen\u00a0PF, Aloi\u00a0M, Assa\u00a0A et\u00a0al (2020) The Medical Management of Paediatric Crohn\u2019s Disease: an ECCO-ESPGHAN Guideline Update. J\u00a0Crohns Colitis. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa161","journal-title":"J Crohns Colitis"},{"key":"1827_CR19","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","volume":"160","author":"D Turner","year":"2021","unstructured":"Turner\u00a0D, Ricciuto\u00a0A, Lewis\u00a0A et\u00a0al (2021) STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD. Gastroenterology 160:1570\u20131583. https:\/\/doi.org\/10.1053\/j.gastro.2020.12.031","journal-title":"Gastroenterology"},{"key":"1827_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/MPG.0000000000002035","volume":"67","author":"D Turner","year":"2018","unstructured":"Turner\u00a0D, Ruemmele\u00a0FM, Orlanski-Meyer\u00a0E et\u00a0al (2018) Management of Paediatric Ulcerative Colitis, Part\u00a01: Ambulatory Care\u2014An Evidence-based Guideline From European Crohn\u2019s and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J\u00a0Pediatr Gastroenterol Nutr 67:257\u2013291. https:\/\/doi.org\/10.1097\/MPG.0000000000002035","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1827_CR21","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1097\/MPG.0000000000003017","volume":"72","author":"HH Uhlig","year":"2021","unstructured":"Uhlig\u00a0HH, Charbit-Henrion\u00a0F, Kotlarz\u00a0D et\u00a0al (2021) Clinical Genomics for the Diagnosis of Monogenic Forms of Inflammatory Bowel Disease: A\u00a0Position Paper From the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J\u00a0Pediatr Gastroenterol Nutr 72:456\u2013473. https:\/\/doi.org\/10.1097\/MPG.0000000000003017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1827_CR22","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1053\/j.gastro.2014.07.023","volume":"147","author":"HH Uhlig","year":"2014","unstructured":"Uhlig\u00a0HH, Schwerd\u00a0T, Koletzko\u00a0S et\u00a0al (2014) The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology 147:990\u20131007.e3. https:\/\/doi.org\/10.1053\/j.gastro.2014.07.023","journal-title":"Gastroenterology"},{"key":"1827_CR23","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/MPG.0000000000002162","volume":"68","author":"R Wittig","year":"2019","unstructured":"Wittig\u00a0R, Albers\u00a0L, Koletzko\u00a0S et\u00a0al (2019) Pediatric Chronic Inflammatory Bowel Disease in a\u00a0German Statutory Health INSURANCE-Incidence Rates From 2009 to 2012. J\u00a0Pediatr Gastroenterol Nutr 68:244\u2013250. https:\/\/doi.org\/10.1097\/MPG.0000000000002162","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"1827_CR24","unstructured":"https:\/\/www.destatis.de"}],"container-title":["Die Innere Medizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-024-01827-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00108-024-01827-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-024-01827-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T13:29:32Z","timestamp":1737725372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00108-024-01827-8"}},"subtitle":["Eine \u00dcbersicht unter besonderer Ber\u00fccksichtigung der genetischen Diagnostik","An overview with particular attention to genetic testing"],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["1827"],"URL":"https:\/\/doi.org\/10.1007\/s00108-024-01827-8","relation":{},"ISSN":["2731-7080","2731-7099"],"issn-type":[{"type":"print","value":"2731-7080"},{"type":"electronic","value":"2731-7099"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"27 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"T.\u00a0Schwerd gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}