{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:13:37Z","timestamp":1786979617155,"version":"build-2736575974"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>\n                      Tsutsugamushi-Fieber ist eine durch\n                      <jats:italic>Orientia tsutsugamushi<\/jats:italic>\n                      verursachte, in Europa selten diagnostizierte Infektion, die in mehreren L\u00e4ndern Asiens, sowie in Chile endemisch ist. Das klinische Bild ist h\u00e4ufig unspezifisch und reicht von Fieber, Myalgien, Lymphadenopathie und einem makulopapul\u00f6sen Exanthem bis hin zu schweren Verl\u00e4ufen mit Multiorganbeteiligung.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Fallbericht<\/jats:title>\n                    <jats:p>\n                      Ein 34-j\u00e4hriger Mann stellte sich nach R\u00fcckkehr aus Thailand mit Fieber, Myalgien, Lymphadenopathie und einem makulopapul\u00f6sen Exanthem vor. Trotz kalkulierter antiinfektiver Therapie kam es zu einer raschen klinischen Verschlechterung mit respiratorischer Insuffizienz, Vigilanzminderung und Hypotonie. Mit einer PCR aus Vollblut konnte\n                      <jats:italic>Orientia tsutsugamushi<\/jats:italic>\n                      nachgewiesen werden. Unter Doxycyclin sowie Meropenem bei einer nosokomialen Pneumonie besserte sich der Zustand rasch.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerungen<\/jats:title>\n                    <jats:p>Dieser Fall unterstreicht die Bedeutung, bei Reiser\u00fcckkehrer:innen mit Fieber unklarer Genese an Tsutsugamushi-Fieber zu denken. Eine zeitgerechte klinische oder molekulare Diagnostik sowie die rasche Einleitung einer wirksamen Therapie sind entscheidend, um schwere Verl\u00e4ufe mit Multiorganbeteiligung und sekund\u00e4ren Komplikationen zu verhindern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00108-026-02124-2","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:56:52Z","timestamp":1778860612000},"page":"926-929","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Infektion mit Orientia tsustugamushi und nosokomiale Pneumonie","Infection with Orientia tsutsugamushi and hospital-acquired pneumonia"],"prefix":"10.1007","volume":"67","author":[{"given":"Ilka","family":"Grewe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Winzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Steinmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Francke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman Gamal","family":"Abdelrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Hennigs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylyn M.","family":"Addo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ramharter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schmiedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"issue":"9","key":"2124_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005838","volume":"11","author":"A Bonell","year":"2017","unstructured":"Bonell\u00a0A, Lubell\u00a0Y, Newton\u00a0PN, Crump\u00a0JA, Paris\u00a0DH (2017) Estimating the burden of scrub typhus: A systematic review. 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