{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:48:56Z","timestamp":1782737336635,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Innere Medizin"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00108-026-02138-w","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:33:59Z","timestamp":1780414439000},"page":"725-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rheumatoide Arthritis\u00a0\u2013 eine \u201einternistische\u201c Gelenkerkrankung","Rheumatoid arthritis\u2014more than just a joint disease"],"prefix":"10.1007","volume":"67","author":[{"given":"Lien","family":"Meerkatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Wiebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"2138_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/03009742.2024.2312693","volume":"53","author":"J Wang","year":"2024","unstructured":"Wang\u00a0J, Vordenb\u00e4umen\u00a0S, Schneider\u00a0M, Brinks\u00a0R (2024) Population-based epidemiological projections of rheumatoid arthritis in Germany until 2040. Scandinavian Journal of Rheumatology 53:161\u2013172","journal-title":"Scandinavian Journal of Rheumatology"},{"key":"2138_CR2","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo\u00a0A, Bathon\u00a0JM, Emery\u00a0P (2023) Rheumatoid arthritis. Lancet 402:2019\u20132033","journal-title":"Lancet"},{"key":"2138_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","volume":"388","author":"EM Gravallese","year":"2023","unstructured":"Gravallese\u00a0EM, Firestein\u00a0GS (2023) Rheumatoid Arthritis \u2014 Common Origins, Divergent Mechanisms. New England Journal of Medicine 388:529\u2013542","journal-title":"New England Journal of Medicine"},{"key":"2138_CR4","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes\u00a0IB, Schett\u00a0G (2011) The Pathogenesis of Rheumatoid Arthritis. New England Journal of Medicine 365:2205\u20132219","journal-title":"New England Journal of Medicine"},{"key":"2138_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110766","volume":"39","author":"N Meednu","year":"2022","unstructured":"Meednu\u00a0N, Rangel-Moreno\u00a0J, Zhang\u00a0F, Escalera-Rivera\u00a0K, Corsiero\u00a0E, Prediletto\u00a0E et\u00a0al (2022) Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression. Cell Reports 39:110766","journal-title":"Cell Reports"},{"key":"2138_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15293-5","volume":"12","author":"U Hardt","year":"2022","unstructured":"Hardt\u00a0U, Carlberg\u00a0K, Af Klint\u00a0E, Sahlstr\u00f6m\u00a0P, Larsson\u00a0L, Van Vollenhoven\u00a0A et\u00a0al (2022) Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis. Sci Rep 12:11876","journal-title":"Sci Rep"},{"key":"2138_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrrheum.2015.31","volume":"11","author":"F Buttgereit","year":"2015","unstructured":"Buttgereit\u00a0F, Smolen\u00a0JS, Coogan\u00a0AN, Cajochen\u00a0C (2015) Clocking in: chronobiology in rheumatoid arthritis. Nat Rev Rheumatol 11:349\u2013356","journal-title":"Nat Rev Rheumatol"},{"key":"2138_CR8","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","volume":"320","author":"D Aletaha","year":"2018","unstructured":"Aletaha\u00a0D, Smolen\u00a0JS (2018) Diagnosis and Management of Rheumatoid Arthritis: A\u00a0Review. JAMA 320:1360\u20131372","journal-title":"JAMA"},{"key":"2138_CR9","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.1007\/s10067-021-05831-3","volume":"40","author":"S Ebrahimian","year":"2021","unstructured":"Ebrahimian\u00a0S, Salami\u00a0A, Malek Mahdavi\u00a0A, Esalatmanesh\u00a0K, Khabbazi\u00a0A, Hajialilo\u00a0M (2021) Can treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs at the window of opportunity with tight control strategy lead to long-term remission and medications free remission in real-world clinical practice? A cohort study. Clin Rheumatol 40:4485\u20134491","journal-title":"Clin Rheumatol"},{"key":"2138_CR10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1136\/annrheumdis-2012-203130","volume":"73","author":"JaB Nies","year":"2014","unstructured":"Nies\u00a0JaB, Krabben\u00a0A, Schoones\u00a0JW, Huizinga\u00a0TWJ, Kloppenburg\u00a0M, van der Helm-van Mil\u00a0AHM (2014) What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann Rheum Dis 73:861\u2013870","journal-title":"Ann Rheum Dis"},{"key":"2138_CR11","doi-asserted-by":"publisher","first-page":"e743","DOI":"10.1016\/S2665-9913(23)00242-4","volume":"5","author":"S Bugatti","year":"2023","unstructured":"Bugatti\u00a0S, De Stefano\u00a0L, Gandolfo\u00a0S, Ciccia\u00a0F, Montecucco\u00a0C (2023) Autoantibody-negative rheumatoid arthritis: still a challenge for the rheumatologist. Lancet Rheumatol 5:e743\u2013e755","journal-title":"Lancet Rheumatol"},{"key":"2138_CR12","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/art.42860","volume":"76","author":"SR Johnson","year":"2024","unstructured":"Johnson\u00a0SR, Bernstein\u00a0EJ, Bolster\u00a0MB, Chung\u00a0JH, Danoff\u00a0SK, George\u00a0MD et\u00a0al (2024) 2023 American College of Rheumatology (ACR)\/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases. Arthritis & Rheumatology 76:1201\u20131213","journal-title":"Arthritis & Rheumatology"},{"key":"2138_CR13","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha\u00a0D, Neogi\u00a0T, Silman\u00a0AJ, Funovits\u00a0J, Felson\u00a0DT, Bingham\u00a0CO et\u00a0al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"2138_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00185","volume":"5","author":"CK Orr","year":"2018","unstructured":"Orr\u00a0CK, Najm\u00a0A, Young\u00a0F, McGarry\u00a0T, Biniecka\u00a0M, Fearon\u00a0U et\u00a0al (2018) The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis. Front Med (Lausanne) 5:185","journal-title":"Front Med (Lausanne)"},{"key":"2138_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/rheumatology\/kex036","volume":"57","author":"K Takase-Minegishi","year":"2018","unstructured":"Takase-Minegishi\u00a0K, Horita\u00a0N, Kobayashi\u00a0K, Yoshimi\u00a0R, Kirino\u00a0Y, Ohno\u00a0S et\u00a0al (2018) Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis. Rheumatology (Oxford) 57:49\u201358","journal-title":"Rheumatology (Oxford)"},{"key":"2138_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1824-z","volume":"21","author":"S Ohrndorf","year":"2019","unstructured":"Ohrndorf\u00a0S, Boer\u00a0AC, Boeters\u00a0DM, Ten Brinck\u00a0RM, Burmester\u00a0GR, Kortekaas\u00a0MC et\u00a0al (2019) Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia. Arthritis Res Ther 21:59","journal-title":"Arthritis Res Ther"},{"key":"2138_CR17","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1136\/annrheumdis-2012-203158","volume":"72","author":"AN Colebatch","year":"2013","unstructured":"Colebatch\u00a0AN, Edwards\u00a0CJ, \u00d8stergaard\u00a0M, van der Heijde\u00a0D, Balint\u00a0PV, D\u2019Agostino\u00a0MA et\u00a0al (2013) EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 72:804\u2013814","journal-title":"Ann Rheum Dis"},{"key":"2138_CR18","unstructured":"Smolen JS, Edwards CJ, Konzett V, Laskou F, Aletaha D, Caporali R, et\u00a0al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update. Annals of the Rheumatic Diseases 2026:S0003496726000750."},{"key":"2138_CR19","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1093\/rheumatology\/keab570","volume":"61","author":"V Huss","year":"2022","unstructured":"Huss\u00a0V, Bower\u00a0H, Wadstr\u00f6m\u00a0H, Frisell\u00a0T, Askling\u00a0J, the ARTIS group et\u00a0al (2022) Short- and longer-term cancer risks with biologic and targeted synthetic disease-modifying antirheumatic drugs as used against rheumatoid arthritis in clinical practice. Rheumatology 61:1810\u20131818","journal-title":"Rheumatology"},{"key":"2138_CR20","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0140-6736(23)02649-1","volume":"403","author":"AP Cope","year":"2024","unstructured":"Cope\u00a0AP, Jasenecova\u00a0M, Vasconcelos\u00a0JC, Filer\u00a0A, Raza\u00a0K, Qureshi\u00a0S et\u00a0al (2024) Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. The Lancet 403:838\u2013849","journal-title":"The Lancet"},{"key":"2138_CR21","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/S0140-6736(23)02650-8","volume":"403","author":"J Rech","year":"2024","unstructured":"Rech\u00a0J, Tascilar\u00a0K, Hagen\u00a0M, Kleyer\u00a0A, Manger\u00a0B, Schoenau\u00a0V et\u00a0al (2024) Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial. The Lancet 403:850\u2013859","journal-title":"The Lancet"},{"key":"2138_CR22","doi-asserted-by":"publisher","first-page":"e171","DOI":"10.1016\/S2665-9913(25)00371-6","volume":"8","author":"AP Cope","year":"2026","unstructured":"Cope\u00a0AP, Jasenecova\u00a0M, Vasconcelos\u00a0JC, Qureshi\u00a0S, Van Schie\u00a0KA, Filer\u00a0A et\u00a0al (2026) Long-term outcomes of abatacept in individuals at risk of developing rheumatoid arthritis (ALTO): a randomised, double-blind, placebo-controlled trial. The Lancet Rheumatology 8:e171\u2013e180","journal-title":"The Lancet Rheumatology"},{"key":"2138_CR23","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1093\/rheumatology\/keaf077","volume":"64","author":"FN Albach","year":"2025","unstructured":"Albach\u00a0FN, Minopoulou\u00a0I, Wilhelm\u00a0A, Biesen\u00a0R, Kleyer\u00a0A, Wiebe\u00a0E et\u00a0al (2025) Targeting autoimmunity with CD19-CAR T\u2011cell therapy: efficacy and seroconversion in diffuse systemic sclerosis and rheumatoid arthritis. Rheumatology (Oxford) 64:4075\u20134077","journal-title":"Rheumatology (Oxford)"},{"key":"2138_CR24","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/s41422-024-01068-2","volume":"35","author":"Y Li","year":"2025","unstructured":"Li\u00a0Y, Li\u00a0S, Zhao\u00a0X, Sheng\u00a0J, Xue\u00a0L, Schett\u00a0G et\u00a0al (2025) Fourth-generation chimeric antigen receptor T\u2011cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis. Cell Res 35:220\u2013223","journal-title":"Cell Res"},{"key":"2138_CR25","doi-asserted-by":"crossref","unstructured":"Albach FN, Minopoulou I, Wilhelm A, Kleyer A, Wiebe E, Fleischmann A, et\u00a0al. Rapid and profound treatment response of difficult-to-treat rheumatoid arthritis to CD19 CAR T\u2011cell therapy. EULAR Rheumatology Open 2025. Available at: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S3050708125000710. Accessed March\u00a030, 2026.","DOI":"10.1016\/j.ero.2025.08.008"},{"key":"2138_CR26","unstructured":"Anon. Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation - PubMed. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/33615723\/. Accessed March\u00a012, 2026."},{"key":"2138_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20016-x","volume":"12","author":"S Moshayedi","year":"2022","unstructured":"Moshayedi\u00a0S, Tasorian\u00a0B, Almasi-Hashiani\u00a0A (2022) The prevalence of osteoporosis in rheumatoid arthritis patient: a\u00a0systematic review and meta-analysis. Sci Rep 12:15844","journal-title":"Sci Rep"},{"key":"2138_CR28","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1136\/annrheumdis-2022-222339","volume":"81","author":"E Wiebe","year":"2022","unstructured":"Wiebe\u00a0E, Huscher\u00a0D, Schaumburg\u00a0D, Palmowski\u00a0A, Hermann\u00a0S, Buttgereit\u00a0T et\u00a0al (2022) Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease. Ann Rheum Dis 81:1313\u20131322","journal-title":"Ann Rheum Dis"},{"key":"2138_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/S2215-0366(18)30255-4","volume":"6","author":"L Nerurkar","year":"2019","unstructured":"Nerurkar\u00a0L, Siebert\u00a0S, McInnes\u00a0IB, Cavanagh\u00a0J (2019) Rheumatoid arthritis and depression: an inflammatory perspective. Lancet Psychiatry 6:164\u2013173","journal-title":"Lancet Psychiatry"}],"container-title":["Die Innere Medizin"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-026-02138-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00108-026-02138-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00108-026-02138-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:28:26Z","timestamp":1782736106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00108-026-02138-w"}},"subtitle":["\u00dcberblick f\u00fcr die internistische Praxis","Overview for internal medicine practice"],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2138"],"URL":"https:\/\/doi.org\/10.1007\/s00108-026-02138-w","relation":{},"ISSN":["2731-7080","2731-7099"],"issn-type":[{"value":"2731-7080","type":"print"},{"value":"2731-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"30 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.\u00a0Meerkatt, D.\u00a0Simon und E.\u00a0Wiebe geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}