{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:43:16Z","timestamp":1762098196365},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2004,8,7]],"date-time":"2004-08-07T00:00:00Z","timestamp":1091836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1007\/s00109-004-0569-5","type":"journal-article","created":{"date-parts":[[2004,8,6]],"date-time":"2004-08-06T14:50:38Z","timestamp":1091803838000},"page":"696-705","source":"Crossref","is-referenced-by-count":21,"title":["Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA"],"prefix":"10.1007","volume":"82","author":[{"given":"Stefan","family":"Wieczorek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jagiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Arning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Dahmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg T.","family":"Epplen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,8,7]]},"reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00004691-200103000-00002","volume":"18","author":"Overeem","year":"2001","unstructured":"Overeem S, Mignot E, van Dijk JG, Lammers GJ (2001) Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J Clin Neurophysiol 18:78?105","journal-title":"J Clin Neurophysiol"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","volume":"98","author":"Chemelli","year":"1999","unstructured":"Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98:437?451","journal-title":"Cell"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)81965-0","volume":"98","author":"Lin","year":"1999","unstructured":"Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, de Jong PJ, Nishino S, Mignot E (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98:365?376","journal-title":"Cell"},{"key":"CR4","doi-asserted-by":"crossref","unstructured":"Billiard M, Pasquie-Magnetto V, Heckman M, Carlander B, Besset A, Zachariev Z, Eliaou JF, Malafosse A (1994) Family studies in narcolepsy. Sleep 17 [8 Suppl]:S54?S59","DOI":"10.1093\/sleep\/17.suppl_8.S54"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1212\/WNL.56.1.115","volume":"56","author":"Gencik","year":"2001","unstructured":"Gencik M, Dahmen N, Wieczorek S, Kasten M, Bierbrauer J, Anghelescu I, Szegedi A, Menezes Saecker AM, Epplen JT (2001) A prepro-orexin gene polymorphism is associated with narcolepsy. Neurology 56:115?117","journal-title":"Neurology"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","volume":"6","author":"Peyron","year":"2000","unstructured":"Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6:991?997","journal-title":"Nat Med"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(99)05582-8","volume":"355","author":"Nishino","year":"2000","unstructured":"Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355:39?40","journal-title":"Lancet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","volume":"18","author":"Peyron","year":"1998","unstructured":"Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996?10015","journal-title":"J Neurosci"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1750-3639.2003.tb00033.x","volume":"13","author":"Thannickal","year":"2003","unstructured":"Thannickal TC, Siegel JM, Nienhuis R, Moore RY (2003) Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. Brain Pathol 13:340?351","journal-title":"Brain Pathol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.genom.4.070802.110432","volume":"4","author":"Chabas","year":"2003","unstructured":"Chabas D, Taheri S, Renier C, Mignot E (2003) The genetics of narcolepsy. Annu Rev Genomics Hum Genet 4:459?483","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00439-004-1092-z","volume":"114","author":"Jagiello","year":"2004","unstructured":"Jagiello P, Gencik M, Arning L, Wieczorek S, Kunstmann E, Csernok E, Gross WL, Epplen JT (2004) New genomic region for Wegener?s granulomatosis as revealed by an extended association screen with 202 apoptosis related genes. Hum Genet 114:468?477","journal-title":"Hum Genet"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1210\/rp.58.1.131","volume":"58","author":"Hayashi","year":"2003","unstructured":"Hayashi T, Faustman DL (2003) Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. Recent Prog Horm Res 58:131?153","journal-title":"Recent Prog Horm Res"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1523\/JNEUROSCI.23-08-03555.2003","volume":"23","author":"Zeitzer","year":"2003","unstructured":"Zeitzer JM, Buckmaster CL, Parker KJ, Hauck CM, Lyons DM, Mignot E (2003) Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness. J Neurosci 23:3555?3560","journal-title":"J Neurosci"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1210\/jcem.87.2.8246","volume":"87","author":"Kok","year":"2002","unstructured":"Kok SW, Meinders AE, Overeem S, Lammers GJ, Roelfsema F, Frolich M, Pijl H (2002) Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans. J Clin Endocrinol Metab 87:805?809","journal-title":"J Clin Endocrinol Metab"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"E641","DOI":"10.1152\/ajpendo.00421.2002","volume":"284","author":"Overeem","year":"2003","unstructured":"Overeem S, Kok SW, Lammers GJ, Vein AA, Frolich M, Meinders AE, Roelfsema F, Pijl H (2003) Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events. Am J Physiol Endocrinol Metab 284:E641?647","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nn944","volume":"Suppl","author":"Mignot","year":"2002","unstructured":"Mignot E, Taheri S, Nishino S (2002) Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci 5 Suppl:1071?1075","journal-title":"Nat Neurosci 5"},{"key":"CR17","first-page":"341","volume":"41","author":"Epplen","year":"1997","unstructured":"Epplen C, Jackel S, Santos EJ, D?Souza M, Poehlau D, Dotzauer B, Sindern E, Haupts M, Rude KP, Weber F, Stover J, Poser S, Gehler W, Malin JP, Przuntek H, Epplen JT. (1997) Genetic predisposition to multiple sclerosis as revealed by immunoprinting. Ann Neurol 1997 41:341?352","journal-title":"Ann Neurol 1997"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215","journal-title":"Nucleic Acids Res"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1034\/j.1399-0039.2003.00068.x","volume":"61","author":"Wieczorek","year":"2003","unstructured":"Wieczorek S, Gencik M, Rujescu D, Tonn P, Giegling I, Epplen JT, Dahmen N. (2003) TNFA promoter polymorphisms and narcolepsy. Tissue Antigens 2003 61:437?442","journal-title":"Tissue Antigens 2003"},{"key":"CR20","first-page":"1817","volume":"60","author":"Eisensehr","year":"2003","unstructured":"Eisensehr I, Linke R, Tatsch K, von Lindeiner H, Kharraz B, Gildehaus FJ, Eberle R, Pollmacher T, Schuld A, Noachtar S (2003) Alteration of the striatal dopaminergic system in human narcolepsy. Neurology 2003 60:1817?1819","journal-title":"Neurology 2003"},{"key":"CR21","doi-asserted-by":"crossref","unstructured":"G\u00f6dde R, Nigmatova V, Jagiello P, Sindern E, Haupts M, Schimrigk S et al. (2004) Refining the results of a whole-genome screen based on 4666 microsatellite markers for defining predisposition factors for multiple sclerosis. Electrophoresis (in press)","DOI":"10.1002\/elps.200405929"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0895-4356(00)00314-0","volume":"54","author":"Bender","year":"2001","unstructured":"Bender R, Lange S (2001) Adjusting for multiple testing?when and how? J Clin Epidemiol 54:343?349","journal-title":"J Clin Epidemiol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1073\/pnas.93.14.7063","volume":"93","author":"Wang","year":"1996","unstructured":"Wang HG, Takayama S, Rapp UR, Reed JC (1996) Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci USA 93:7063?7068","journal-title":"Proc Natl Acad Sci USA"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0301-0082(96)00064-0","volume":"51","author":"Maitre","year":"1997","unstructured":"Maitre M (1997) The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog Neurobiol 51:337?361","journal-title":"Prog Neurobiol"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1011031014433","volume":"21","author":"Budingen","year":"2001","unstructured":"Budingen HC von, Tanuma N, Villoslada P, Ouallet JC, Hauser SL, Genain CP (2001) Immune responses against the myelin\/oligodendrocyte glycoprotein in experimental autoimmune demyelination. J Clin Immunol 21:155?170","journal-title":"J Clin Immunol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0165-5728(02)00361-2","volume":"133","author":"Gomez-Lira","year":"2002","unstructured":"Gomez-Lira M, Moretto G, Bonamini D, Benedetti MD, Pignatti PF, Rizzuto N, Salviati A (2002) Myelin oligodendrocyte glycoprotein polymorphisms and multiple sclerosis. J Neuroimmunol 133:241?243","journal-title":"J Neuroimmunol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0198-8859(95)91033-T","volume":"43","author":"Roth","year":"1995","unstructured":"Roth MP, Dolbois L, Borot N, Amadou C, Clanet M, Pontarotti P, Coppin H (1995) Three highly polymorphic microsatellites at the human myelin oligodendrocyte glycoprotein locus, 100 kb telomeric to HLA-F. Characterization and relation to HLA haplotypes. Hum Immunol 43:276?282","journal-title":"Hum Immunol"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0306-4530(03)00095-7","volume":"29","author":"Lechin","year":"2004","unstructured":"Lechin F, Pardey-Maldonado B, Van Der Dijs B, Benaim M, Baez S, Orozco B, Lechin AE (2004) Circulating neurotransmitters during the different wake-sleep stages in normal subjects. Psychoneuroendocrinology 29:669?685","journal-title":"Psychoneuroendocrinology"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(02)02698-7","volume":"943","author":"Kantor","year":"2002","unstructured":"Kantor S, Jakus R, Bodizs R, Halasz P, Bagdy G (2002) Acute and long-term effects of the 5-HT2 receptor antagonist ritanserin on EEG power spectra, motor activity, and sleep: changes at the light-dark phase shift. Brain Res 943:105?111","journal-title":"Brain Res"},{"key":"CR30","first-page":"1084","volume":"59","author":"Kato","year":"1996","unstructured":"Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y (1996) Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Am J Hum Genet 59:1084?1090","journal-title":"Am J Hum Genet"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1523\/JNEUROSCI.23-01-00007.2003","volume":"23","author":"Korotkova","year":"2003","unstructured":"Korotkova TM, Sergeeva OA, Eriksson KS, Haas HL, Brown RE (2003) Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins\/hypocretins. J Neurosci 23:7?11","journal-title":"J Neurosci"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1097\/00001756-199911260-00046","volume":"10","author":"Honda","year":"1999","unstructured":"Honda K, Riehl J, Mignot E, Nishino S (1999) Dopamine D3 agonists into the substantia nigra aggravate cataplexy but do not modify sleep. Neuroreport 10:3717?3724","journal-title":"Neuroreport"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.mp.4000911","volume":"6","author":"Dauvilliers","year":"2001","unstructured":"Dauvilliers Y, Neidhart E, Lecendreux M, Billiard M, Tafti M (2001) MAO-A COMT polymorphisms gene effects in narcolepsy. Mol Psychiatry 6:367?372","journal-title":"Mol Psychiatry"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-004-0569-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-004-0569-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-004-0569-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:21:59Z","timestamp":1558585319000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-004-0569-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,7]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["569"],"URL":"https:\/\/doi.org\/10.1007\/s00109-004-0569-5","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,7]]}}}