{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:47:47Z","timestamp":1783975667725,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,1,17]],"date-time":"2006-01-17T00:00:00Z","timestamp":1137456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1007\/s00109-005-0002-8","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T16:01:06Z","timestamp":1137427266000},"page":"126-131","source":"Crossref","is-referenced-by-count":9,"title":["Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth"],"prefix":"10.1007","volume":"84","author":[{"given":"David M.","family":"Flavell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T. E.","family":"Wootton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul G.","family":"Myerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"World","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dudley J.","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve E.","family":"Humphries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa J.","family":"Talmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh E.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,1,17]]},"reference":[{"key":"2_CR1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/01.CIR.102.4.470","volume":"102","author":"BH Lorell","year":"2000","unstructured":"Lorell BH, Carabello BA (2000) Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 102:470\u2013479","journal-title":"Circulation"},{"key":"2_CR2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-108-1-7","volume":"108","author":"D Levy","year":"1988","unstructured":"Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP (1988) Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study. Ann Intern Med 108:7\u201313","journal-title":"Ann Intern Med"},{"key":"2_CR3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-114-5-345","volume":"114","author":"MJ Koren","year":"1991","unstructured":"Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH (1991) Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 114:345\u2013352","journal-title":"Ann Intern Med"},{"key":"2_CR4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/A:1007887020332","volume":"14","author":"MN Sack","year":"2000","unstructured":"Sack MN, Harrington LS, Jonassen AK, Mjos OD, Yellon DM (2000) Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats. Cardiovasc Drugs Ther 14:31\u201339","journal-title":"Cardiovasc Drugs Ther"},{"key":"2_CR5","first-page":"H742","volume":"267","author":"MF Allard","year":"1994","unstructured":"Allard MF, Schonekess BO, Henning SL, English DR, Lopaschuk GD (1994) Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol 267:H742\u2013H750","journal-title":"Am J Physiol"},{"key":"2_CR6","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1152\/physrev.00012.2002","volume":"82","author":"D Fatkin","year":"2002","unstructured":"Fatkin D, Graham RM (2002) Molecular mechanisms of inherited cardiomyopathies. Physiol Rev 82:945\u2013980","journal-title":"Physiol Rev"},{"key":"2_CR7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0005-2760(93)90196-G","volume":"1169","author":"S Enerback","year":"1993","unstructured":"Enerback S, Gimble JM (1993) Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. Biochim Biophys Acta 1169:107\u2013125","journal-title":"Biochim Biophys Acta"},{"key":"2_CR8","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1161\/01.ATV.14.9.1445","volume":"14","author":"KD O'Brien","year":"1994","unstructured":"O'Brien KD, Ferguson M, Gordon D, Deeb SS, Chait A (1994) Lipoprotein lipase is produced by cardiac myocytes rather than interstitial cells in human myocardium. Arterioscler Thromb 14:1445\u20131451","journal-title":"Arterioscler Thromb"},{"key":"2_CR9","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1194\/jlr.R200015-JLR200","volume":"43","author":"M Merkel","year":"2002","unstructured":"Merkel M, Eckel RH, Goldberg IJ (2002) Lipoprotein lipase: genetics, lipid uptake, and regulation. J Lipid Res 43:1997\u20132006","journal-title":"J Lipid Res"},{"key":"2_CR10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1161\/01.RES.78.1.8","volume":"78","author":"H Masuzaki","year":"1996","unstructured":"Masuzaki H, Jingami H, Matsuoka N et al (1996) Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart. Circ Res 78:8\u201314","journal-title":"Circ Res"},{"key":"2_CR11","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0008-6363(96)00201-5","volume":"33","author":"N Sambandam","year":"1997","unstructured":"Sambandam N, Chen X, Cam MC, Rodrigues B (1997) Cardiac lipoprotein lipase in the spontaneously hypertensive rat. Cardiovasc Res 33:460\u2013468","journal-title":"Cardiovasc Res"},{"key":"2_CR12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0005-2760(98)00170-2","volume":"1436","author":"ND Vaziri","year":"1999","unstructured":"Vaziri ND, Liang K, Barton CH (1999) Effect of increased afterload on cardiac lipoprotein lipase and VLDL receptor expression. Biochim Biophys Acta 1436:577\u2013584","journal-title":"Biochim Biophys Acta"},{"key":"2_CR13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0005-2760(96)00059-8","volume":"1302","author":"H Zhang","year":"1996","unstructured":"Zhang H, Henderson H, Gagne SE et al (1996) Common sequence variants of lipoprotein lipase: standardized studies of in vitro expression and catalytic function. Biochim Biophys Acta 1302:159\u2013166","journal-title":"Biochim Biophys Acta"},{"key":"2_CR14","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1161\/01.CIR.99.22.2901","volume":"99","author":"HH Wittrup","year":"1999","unstructured":"Wittrup HH, Tybjaerg-Hansen A, Nordestgaard BG (1999) Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis. Circulation 99:2901\u20132907","journal-title":"Circulation"},{"key":"2_CR15","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI118648","volume":"97","author":"DA Wu","year":"1996","unstructured":"Wu DA, Bu X, Warden CH et al (1996) Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest 97:2111\u20132118","journal-title":"J Clin Invest"},{"key":"2_CR16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/hy1001.092617","volume":"38","author":"H Allayee","year":"2001","unstructured":"Allayee H, de Bruin TW, Michelle DK et al (2001) Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension 38:773\u2013778","journal-title":"Hypertension"},{"key":"2_CR17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00439-004-1108-8","volume":"115","author":"W Yang","year":"2004","unstructured":"Yang W, Huang J, Ge D et al (2004) Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees. Hum Genet 115:8\u201312","journal-title":"Hum Genet"},{"key":"2_CR18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1034\/j.1399-0004.2001.600407.x","volume":"60","author":"SM Clee","year":"2001","unstructured":"Clee SM, Loubser O, Collins J, Kastelein JJ, Hayden MR (2001) The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease. Clin Genet 60:293\u2013300","journal-title":"Clin Genet"},{"key":"2_CR19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1097\/00004872-200018120-00011","volume":"18","author":"C Sass","year":"2000","unstructured":"Sass C, Herbeth B, Siest G, Visvikis S (2000) Lipoprotein lipase (C\/G)447 polymorphism and blood pressure in the Stanislas Cohort. J Hypertens 18:1775\u20131781","journal-title":"J Hypertens"},{"key":"2_CR20","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1161\/01.CIR.94.12.3239","volume":"94","author":"DL Sprecher","year":"1996","unstructured":"Sprecher DL, Harris BV, Stein EA, Bellet PS, Keilson LM, Simbartl LA (1996) Higher triglycerides, lower high-density lipoprotein cholesterol, and higher systolic blood pressure in lipoprotein lipase-deficient heterozygotes. A preliminary report. Circulation 94:3239\u20133245","journal-title":"Circulation"},{"key":"2_CR21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1161\/01.HYP.34.1.18","volume":"34","author":"JM Hagberg","year":"1999","unstructured":"Hagberg JM, Ferrell RE, Dengel DR, Wilund KR (1999) Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent. Hypertension 34:18\u201323","journal-title":"Hypertension"},{"key":"2_CR22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1161\/01.CIR.96.3.741","volume":"96","author":"HE Montgomery","year":"1997","unstructured":"Montgomery HE, Clarkson P, Dollery CM et al (1997) Association of angiotensin-converting enzyme gene I\/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96:741\u2013747","journal-title":"Circulation"},{"key":"2_CR23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.CIR.103.2.226","volume":"103","author":"SG Myerson","year":"2001","unstructured":"Myerson SG, Montgomery HE, Whittingham M et al (2001) Left ventricular hypertrophy with exercise and the angiotensin converting enzyme gene I\/D polymorphism: a randomised controlled trial with losartan. Circulation 103:226\u2013230","journal-title":"Circulation"},{"key":"2_CR24","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(01)06273-0","volume":"358","author":"D Brull","year":"2001","unstructured":"Brull D, Dhamrait S, Myerson S et al (2001) Bradykinin B2BKR receptor polymorphism and left-ventricular growth response. Lancet 358:1155\u20131156","journal-title":"Lancet"},{"key":"2_CR25","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/hc0802.104535","volume":"105","author":"Y Jamshidi","year":"2002","unstructured":"Jamshidi Y, Montgomery HE, Hense HW et al (2002) Peroxisome proliferator-activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension. Circulation 105:950\u2013955","journal-title":"Circulation"},{"key":"2_CR26","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1006\/jmcc.2002.2061","volume":"34","author":"BN Finck","year":"2002","unstructured":"Finck BN, Kelly DP (2002) Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. J Mol Cell Cardiol 34:1249\u20131257","journal-title":"J Mol Cell Cardiol"},{"key":"2_CR27","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.ATV.18.4.526","volume":"18","author":"SE Humphries","year":"1998","unstructured":"Humphries SE, Nicaud V, Margalef J, Tiret L, Talmud PJ (1998) Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arterioscler Thromb Vasc Biol 18:526\u2013534","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2_CR28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/abio.1994.1507","volume":"222","author":"IN Day","year":"1994","unstructured":"Day IN, Humphries SE (1994) Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose. Anal Biochem 222:389\u2013395","journal-title":"Anal Biochem"},{"key":"2_CR29","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-2275(20)42003-6","volume":"37","author":"K Schoonjans","year":"1996","unstructured":"Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907\u2013925","journal-title":"J Lipid Res"},{"key":"2_CR30","doi-asserted-by":"crossref","first-page":"H1055","DOI":"10.1152\/ajpheart.00925.2003","volume":"287","author":"Y Burelle","year":"2004","unstructured":"Burelle Y, Wambolt RB, Grist M et al (2004) Regular exercise is associated with a protective metabolic phenotype in the rat heart. Am J Physiol Heart Circ Physiol 287:H1055\u2013H1063","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2_CR31","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/0026-0495(95)90081-0","volume":"44","author":"JM Ong","year":"1995","unstructured":"Ong JM, Simsolo RB, Saghizadeh M, Goers JW, Kern PA (1995) Effects of exercise training and feeding on lipoprotein lipase gene expression in adipose tissue, heart, and skeletal muscle of the rat. Metabolism 44:1596\u20131605","journal-title":"Metabolism"},{"key":"2_CR32","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2337\/diabetes.53.1.214","volume":"53","author":"MO Goodarzi","year":"2004","unstructured":"Goodarzi MO, Guo X, Taylor KD et al (2004) Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes 53:214\u2013220","journal-title":"Diabetes"},{"key":"2_CR33","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1073\/pnas.121164498","volume":"98","author":"JK Kim","year":"2001","unstructured":"Kim JK, Fillmore JJ, Chen Y et al (2001) Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA 98:7522\u20137527","journal-title":"Proc Natl Acad Sci USA"},{"key":"2_CR34","first-page":"4284","volume":"83","author":"RA Phillips","year":"1998","unstructured":"Phillips RA, Krakoff LR, Dunaif A, Finegood DT, Gorlin R, Shimabukuro S (1998) Relation among left ventricular mass, insulin resistance, and blood pressure in nonobese subjects. J Clin Endocrinol Metab 83:4284\u20134288","journal-title":"J Clin Endocrinol Metab"},{"key":"2_CR35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00000441-200208000-00005","volume":"324","author":"CL Davis","year":"2002","unstructured":"Davis CL, Kapuku G, Snieder H, Kumar M, Treiber FA (2002) Insulin resistance syndrome and left ventricular mass in healthy young people. Am J Med Sci 324:72\u201375","journal-title":"Am J Med Sci"},{"key":"2_CR36","doi-asserted-by":"crossref","first-page":"27426","DOI":"10.1074\/jbc.274.39.27426","volume":"274","author":"BA Marshall","year":"1999","unstructured":"Marshall BA, Tordjman K, Host HH et al (1999) Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. J Biol Chem 274:27426\u201327432","journal-title":"J Biol Chem"},{"key":"2_CR37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00125-001-0771-8","volume":"45","author":"B Holzl","year":"2002","unstructured":"Holzl B, Iglseder B, Sandhofer A et al (2002) Insulin sensitivity is impaired in heterozygous carriers of lipoprotein lipase deficiency. Diabetologia 45:378\u2013384","journal-title":"Diabetologia"},{"key":"2_CR38","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1152\/jappl.2001.91.3.1334","volume":"91","author":"C Garenc","year":"2001","unstructured":"Garenc C, Perusse L, Bergeron J et al (2001) Evidence of LPL gene\u2013exercise interaction for body fat and LPL activity: the HERITAGE family study. J Appl Physiol 91:1334\u20131340","journal-title":"J Appl Physiol"},{"key":"2_CR39","first-page":"1351","volume":"98","author":"G Kessler","year":"1997","unstructured":"Kessler G, Friedman J (1997) Metabolism of fatty acids and glucose. Circulation 98:1351","journal-title":"Circulation"},{"key":"2_CR40","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00059-002-2428-x","volume":"27","author":"H Rupp","year":"2002","unstructured":"Rupp H, Zarain-Herzberg A, Maisch B (2002) The use of partial fatty acid oxidation inhibitors for metabolic therapy of angina pectoris and heart failure. Herz 27:621\u2013636","journal-title":"Herz"},{"key":"2_CR41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.HYP.0000047668.48494.39","volume":"41","author":"L Fuentes de las","year":"2003","unstructured":"de las Fuentes L, Herrero P, Peterson LR, Kelly DP, Gropler RJ, Davila-Roman VG (2003) Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart disease. Hypertension 41:83\u201387","journal-title":"Hypertension"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-005-0002-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-005-0002-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-005-0002-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T16:41:54Z","timestamp":1626972114000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-005-0002-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,17]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["2"],"URL":"https:\/\/doi.org\/10.1007\/s00109-005-0002-8","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,17]]}}}