{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:51:05Z","timestamp":1771710665223,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T00:00:00Z","timestamp":1184630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1007\/s00109-007-0233-y","type":"journal-article","created":{"date-parts":[[2007,7,16]],"date-time":"2007-07-16T23:43:47Z","timestamp":1184629427000},"page":"1379-1392","source":"Crossref","is-referenced-by-count":36,"title":["Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro"],"prefix":"10.1007","volume":"85","author":[{"name":"Endocannabinoid Research Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Iuvone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"De Filippis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Bisogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Petrosino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Steardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,7,17]]},"reference":[{"issue":"10","key":"233_CR1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1096\/fj.06-5864fje","volume":"20","author":"JR Richardson","year":"2000","unstructured":"Richardson JR, Caudle WM, Wang M, Dean ED, Pennell KD, Miller GW (2000) Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson\u2019s disease. FASEB J 20(10):1695\u20131697, Aug","journal-title":"FASEB J"},{"issue":"11","key":"233_CR2","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1074\/jbc.M411306200","volume":"280","author":"IS Kil","year":"2005","unstructured":"Kil IS, Park JW (2005) Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation. J Biol Chem 280(11):10846\u201310854, Mar 18","journal-title":"J Biol Chem"},{"key":"233_CR3","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1460-9568.1996.tb01294.x","volume":"8","author":"H Russ","year":"1996","unstructured":"Russ H, Staust K, Martel F, Gliese M, Schomig E (1996) The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur J Neurosci 8:1256\u20131264","journal-title":"Eur J Neurosci"},{"key":"233_CR4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2006.02.029","volume":"1084","author":"W Tripanichkul","year":"2006","unstructured":"Tripanichkul W, Sripanichkulchai K, Finkelstein DI (2006) Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Brain Res 1084:28\u201337","journal-title":"Brain Res"},{"key":"233_CR5","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/70978","volume":"5","author":"GT Liberatore","year":"2005","unstructured":"Liberatore GT, Jackson-Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WG, Dawson VL, Dawson TM, Przedborski S (2005) Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat Med 5:1403\u20131409","journal-title":"Nat Med"},{"key":"233_CR6","first-page":"1763","volume":"22","author":"DC Wu","year":"2005","unstructured":"Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S (2005) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22:1763\u20131771","journal-title":"J Neurosci"},{"issue":"1","key":"233_CR7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/exnr.1998.6993","volume":"156","author":"I Kurkowska-Jastrzebska","year":"1999","unstructured":"Kurkowska-Jastrzebska I, Wronska A, Kohutnicka M, Czlonkowski A, Czlonkowska A (1999) The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse. Exp Neurol 156(1):50\u201361","journal-title":"Exp Neurol"},{"key":"233_CR8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0006-8993(91)91579-P","volume":"542","author":"LJ Eldik Van","year":"1991","unstructured":"Van Eldik LJ, Christie-Pope B, Bolin LM, Shooter EM, Whetsell WO Jr (1991) Neurotrophic activity of S100-beta in cultures of dorsal root ganglia from embryonic chick and fetal rat. Brain Res 542:280\u2013285","journal-title":"Brain Res"},{"issue":"11","key":"233_CR9","first-page":"85","volume":"23","author":"A Kleindienst","year":"2006","unstructured":"Kleindienst A, Ross Bullock M (2006) A critical analysis of the role of the neurotrophic protein S100B in acute brain injury. J Neurotrauma 23(11):85\u2013200","journal-title":"J Neurotrauma"},{"key":"233_CR10","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1046\/j.1471-4159.1997.69062294.x","volume":"69","author":"J Hu","year":"1997","unstructured":"Hu J, Ferreira A, van Eldik L (1997) S100b induces neuronal death through nitric oxide release from astrocytes. J Neurochem 69:2294\u201322301","journal-title":"J Neurochem"},{"key":"233_CR11","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1073\/pnas.86.19.7611","volume":"86","author":"WST Griffin","year":"1989","unstructured":"Griffin WST, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL III, Araoz C (1989) Brain interleukin-1 and S100 immunoreactivity are elevated in Down Syndrome and Alzheimer Disease. Proc Natl Acad Sci USA 86:7611\u20137615","journal-title":"Proc Natl Acad Sci USA"},{"key":"233_CR12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/glia.10225","volume":"42","author":"Y Muramatsu","year":"2003","unstructured":"Muramatsu Y, Kurosaki R, Watanabe H, Michimata M, Matsubara M, Imai Y, Araki T (2003) Density of S100 protein is related to neuronal damage in MPTP treated mice. Glia 42:307\u2013313","journal-title":"Glia"},{"key":"233_CR13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.0022-3042.2001.00716.x","volume":"80","author":"G Marsicano","year":"2002","unstructured":"Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C (2002) Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 80:448\u2013456","journal-title":"J Neurochem"},{"key":"233_CR14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/35097089","volume":"413","author":"D Panikashvili","year":"2001","unstructured":"Panikashvili D, Simeonidou C, Ben-Shabat S, Hanus L, Breuer A, Mechoulam R, Shohami E (2001) An endogenous cannabinoid (2-AG) is neuroprotective after brain injury. Nature 413:527\u2013531","journal-title":"Nature"},{"issue":"5","key":"233_CR15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0705667","volume":"141","author":"L Walter","year":"2004","unstructured":"Walter L, Stella N (2004) Cannabinoids and neuroinflammation. Br J Pharmacol 141(5):775\u2013785, Mar","journal-title":"Br J Pharmacol"},{"key":"233_CR16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1471-4159.1993.tb03232.x","volume":"60","author":"DF Condorelli","year":"1993","unstructured":"Condorelli DF, Dell\u2019Albani P, Amico C, Kaczmarek L, Nicoletti F, Lukasiuk K, Stella AM (1993) Induction of primary response genes by excitatory amino acid receptor agonists in primary astroglial cultures. J Neurochem 60:877\u2013885 Links","journal-title":"J Neurochem"},{"key":"233_CR17","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1523\/JNEUROSCI.23-21-07767.2003","volume":"23","author":"A Franklin","year":"1997","unstructured":"Franklin A, Parmentier-Batteur S, Walter L, Greenberg DA, Stella N (1997) Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J Neurosci 23:7767\u20137775","journal-title":"J Neurosci"},{"key":"233_CR18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.277.5329.1094","volume":"277","author":"M Beltramo","year":"1997","unstructured":"Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277:1094\u20131097","journal-title":"Science"},{"key":"233_CR19","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2174\/1381612003399365","volume":"6","author":"V Marzo Di","year":"2000","unstructured":"Di Marzo V, Bisogno T, De Petrocellis L (2000) Endocannabinoids: new targets for drug development. Curr Pharm Des 6:1361\u20131380","journal-title":"Curr Pharm Des"},{"key":"233_CR20","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.pbb.2005.01.027","volume":"81","author":"T Bisogno","year":"2005","unstructured":"Bisogno T, Ligresti A, Marzo V (2005) The endocannabinoid signalling system: biochemical aspects. Pharmacol Biochem Behav 81:224\u2013238","journal-title":"Pharmacol Biochem Behav"},{"key":"233_CR21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/bbrc.1998.8874","volume":"248","author":"T Bisogno","year":"1998","unstructured":"Bisogno T, Melck D, De Petrocellis L, Bobrov MY, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick WH, Marzo V (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun 248:515\u2013522","journal-title":"Biochem Biophys Res Commun"},{"key":"233_CR22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0009-3084(00)00196-1","volume":"108","author":"L Petrocellis De","year":"2000","unstructured":"De Petrocellis L, Melck D, Bisogno T, Marzo V (2000) Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders. Chem Phys Lipids 108:191\u2013209","journal-title":"Chem Phys Lipids"},{"key":"233_CR23","doi-asserted-by":"crossref","first-page":"39550","DOI":"10.1074\/jbc.M603950200","volume":"281","author":"VD Nair","year":"2006","unstructured":"Nair VD, McNaught KS, Gonzalez-Maeso J, Sealfon SC, Olanow CW (2006) p53 mediates nontranscriptional cell death in dopaminergic cells in response to proteasome inhibition. J Biol Chem 281:39550\u201339560","journal-title":"J Biol Chem"},{"key":"233_CR24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1471-4159.2005.03403.x","volume":"95","author":"HJ Jeon","year":"2005","unstructured":"Jeon HJ, Lee DH, Kang MS, Lee MO, Jung KM, Jung SY, Kim DK (2005) Dopamine release in PC12 cells is mediated by Ca(2+)-dependent production of ceramide via sphingomyelin pathway. J Neurochem 95:811\u2013820","journal-title":"J Neurochem"},{"key":"233_CR25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.molbrainres.2004.10.006","volume":"133","author":"SH Koh","year":"2005","unstructured":"Koh SH, Kwon H, Park KH, Ko JK, Kim JH, Hwang MS, Yum YN, Kim OH, Kim J, Kim HT, Do BR, Kim KS, Kim H, Roh H, Yu HJ, Jung HK, Kim SH (2005) Protective effect of diallyl disulfide on oxidative stress-injured neuronally differentiated PC12 cells. Brain Res Mol Brain Res 133:176\u2013186","journal-title":"Brain Res Mol Brain Res"},{"key":"233_CR26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1046\/j.1471-4159.2001.00465.x","volume":"78","author":"G Esposito","year":"2001","unstructured":"Esposito G, Izzo AA, Di Rosa M, Iuvone T (2001) Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein density in C6 rat glioma cells. J Neurochem 78:835\u2013841","journal-title":"J Neurochem"},{"issue":"260","key":"233_CR27","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"25","author":"G Grynkiewicz","year":"1985","unstructured":"Grynkiewicz G, Poenie M, Tsien RY (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 25(260):3440\u20133450","journal-title":"J Biol Chem"},{"key":"233_CR28","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.0022-3042.2001.00716.x","volume":"80","author":"G Marsicano","year":"2002","unstructured":"Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C (2002) Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 80:448\u2013456","journal-title":"J Neurochem"},{"key":"233_CR29","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1016\/S0021-9258(19)50145-4","volume":"267","author":"SW Barger","year":"1992","unstructured":"Barger SW, Van Eldik LJ (1992) S100beta stimulates calcium fluxes in glial and neuronal cells. J Biol Chem 267:9689\u20139694","journal-title":"J Biol Chem"},{"key":"233_CR30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2005.01.004","volume":"45","author":"Y Hashimotodani","year":"2005","unstructured":"Hashimotodani Y, Ohno-Shosaku T, Tsubokawa H, Ogata H, Emoto K, Maejima T, Araishi K, Shin HS, Kano M (2005) Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. Neuron 45:257\u2013268","journal-title":"Neuron"},{"key":"233_CR31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/bj20031812","volume":"380","author":"A Ligresti","year":"2004","unstructured":"Ligresti A, Morera E, Van Der Stelt M, Monory K, Lutz B, Ortar G, Di Marzo V (2004) Further evidence for the existence of a specific process for the membrane transport of anandamide. Biochem J 380:265\u2013272","journal-title":"Biochem J"},{"key":"233_CR32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1088208","volume":"302","author":"G Marsicano","year":"2003","unstructured":"Marsicano G, Goodenough S, Monory K (2003) CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science 302:84\u201388","journal-title":"Science"},{"key":"233_CR33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/jn.1997.78.1.43","volume":"78","author":"W Twitchell","year":"1997","unstructured":"Twitchell W, Brown S, Mackie K (1997) Cannabinoids inhibit N- and P\/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 78:43\u201350","journal-title":"J Neurophysiol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-007-0233-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-007-0233-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-007-0233-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T17:07:15Z","timestamp":1629392835000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-007-0233-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,17]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["233"],"URL":"https:\/\/doi.org\/10.1007\/s00109-007-0233-y","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,17]]}}}