{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:09:43Z","timestamp":1791212983366,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T00:00:00Z","timestamp":1196121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1007\/s00109-007-0280-4","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T12:35:52Z","timestamp":1196080552000},"page":"1317-1324","source":"Crossref","is-referenced-by-count":133,"title":["Hypoxia and chronic lung disease"],"prefix":"10.1007","volume":"85","author":[{"given":"Rubin M.","family":"Tuder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong H.","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhunia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Fijalkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,11,27]]},"reference":[{"key":"280_CR1","volume-title":"Design and structure of human lung in Pulmonary diseases and disorders","author":"ER Weibel","year":"1980","unstructured":"Weibel ER (1980) Design and structure of human lung in Pulmonary diseases and disorders. McGrow-Hill Book Company, New York"},{"key":"280_CR2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2006.01.010","volume":"4","author":"L Liu","year":"2006","unstructured":"Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC (2006) Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 4:521\u2013531","journal-title":"Mol Cell"},{"key":"280_CR3","first-page":"1426","volume":"12","author":"R Kulshreshtha","year":"2007","unstructured":"Kulshreshtha R, Ferracin M, Negrini M, Calin GA, Davuluri RV, Ivan M (2007) Regulation of microRNA expression: the hypoxic component. Cell Cycle 12:1426\u20131431","journal-title":"Cell Cycle"},{"key":"280_CR4","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/MCB.01395-06","volume":"5","author":"R Kulshreshtha","year":"2007","unstructured":"Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, gosto-Perez FJ, Davuluri R, Liu CG, Croce CM, Negrini M, Calin GA, Ivan M (2007) A microRNA signature of hypoxia. Mol Cell Biol 5:1859\u20131867","journal-title":"Mol Cell Biol"},{"key":"280_CR5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF03401744","volume":"6","author":"JL Arbiser","year":"1998","unstructured":"Arbiser JL, Klauber N, Rohan RM, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR (1998) Curcumin is an in vivo inhibitor of angiogenesis. Mol Med 6:376","journal-title":"Mol Med"},{"key":"280_CR6","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1038\/sj.onc.1209913","volume":"46","author":"OA Kent","year":"2006","unstructured":"Kent OA, Mendell JT (2006) A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes. Oncogene 46:6188\u20136196","journal-title":"Oncogene"},{"key":"280_CR7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","volume":"5824","author":"A Rodriguez","year":"2007","unstructured":"Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van DS, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A (2007) Requirement of bic\/microRNA-155 for normal immune function. Science 5824:608\u2013611","journal-title":"Science"},{"key":"280_CR8","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1073\/pnas.95.14.8298","volume":"14","author":"SF Yan","year":"1998","unstructured":"Yan SF, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Mibrandt J, Pinsky D, Kisiel W, Stern D (1998) Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci USA 14:8298","journal-title":"Proc Natl Acad Sci USA"},{"key":"280_CR9","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI119337","volume":"7","author":"CA Lawson","year":"1997","unstructured":"Lawson CA, Yan SD, Yan SF, Liao H, Zhou YS, Sobel J, Kisiel W, Stern DM, Pinsky DJ (1997) Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J Clin Invest 7:1729\u20131738","journal-title":"J Clin Invest"},{"key":"280_CR10","doi-asserted-by":"crossref","first-page":"L167","DOI":"10.1152\/ajplung.00185.2004","volume":"1","author":"M Tuyl van","year":"2005","unstructured":"van Tuyl M, Liu J, Wang J, Kuliszewski M, Tibboel D, Post M (2005) Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung. Am J Physiol Lung Cell Mol Physiol 1:L167\u2013L178","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s001090050231","volume":"6","author":"E Maltepe","year":"1998","unstructured":"Maltepe E, Simon MC (1998) Oxygen, genes, and development: an analysis of the role of hypoxic gene regulation during murine vascular development. J Mol Med 6:391\u2013401","journal-title":"J Mol Med"},{"key":"280_CR12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/dbio.1997.8513","volume":"2","author":"A Tufro-McReddie","year":"1997","unstructured":"Tufro-McReddie A, Norwood VF, Aylor KW, Botkin SJ, Carey RM, Gomez RA (1997) Oxygen regulates vascular endothelial growth factor-mediated vasculogenesis and tubulogenesis. Dev Biol 2:139\u2013149","journal-title":"Dev Biol"},{"key":"280_CR13","first-page":"133","volume":"28","author":"SA Gebb","year":"2003","unstructured":"Gebb SA, Jones PL (2003) Hypoxia and lung branching morphogenesis. Adv Exp Med Biol 28:133\u2013137","journal-title":"Adv Exp Med Biol"},{"key":"280_CR14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0092-8674(00)81652-9","volume":"2","author":"J Jarecki","year":"1999","unstructured":"Jarecki J, Johnson E, Krasnow MA (1999) Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF. Cell 2:211\u2013220","journal-title":"Cell"},{"key":"280_CR15","first-page":"374","volume":"3","author":"A Minchenko","year":"1994","unstructured":"Minchenko A, Bauer T, Salceda S, Caro J (1994) Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 3:374\u2013379","journal-title":"Lab Invest"},{"key":"280_CR16","doi-asserted-by":"crossref","first-page":"L600","DOI":"10.1152\/ajplung.2000.279.3.L600","volume":"3","author":"M Jakkula","year":"2000","unstructured":"Jakkula M, Le Cras TD, Gebb S, Hirth KP, Tuder RM, Voelkel NF, Abman SH (2000) Inhibition of angiogenesis decreases alveolarization in the developing rat lung. Am J Physiol, Lung Cell Mol Physiol 3:L600\u2013L607","journal-title":"Am J Physiol, Lung Cell Mol Physiol"},{"key":"280_CR17","doi-asserted-by":"crossref","first-page":"L465","DOI":"10.1152\/ajplung.1993.264.5.L465","volume":"5","author":"MJ Acarregui","year":"1993","unstructured":"Acarregui MJ, Snyder JM, Mendelson CR (1993) Oxygen modulates the differentiation of human fetal lung in vitro and its responsiveness to cAMP. Am J Physiol Lung Cell Mol Physiol 5:L465\u2013L474","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR18","doi-asserted-by":"crossref","first-page":"L557","DOI":"10.1152\/ajplung.00486.2006","volume":"3","author":"FA Groenman","year":"2007","unstructured":"Groenman FA, Rutter M, Wang J, Caniggia I, Tibboel D, Post M (2007) Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. Am J Physiol Lung Cell Mol Physiol 3:L557\u2013L567","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR19","doi-asserted-by":"crossref","first-page":"L167","DOI":"10.1152\/ajplung.00185.2004","volume":"1","author":"M Tuyl van","year":"2005","unstructured":"van Tuyl M, Liu J, Wang J, Kuliszewski M, Tibboel D, Post M (2005) Role of oxygen and vascular development in epithelial branching morphogenesis of the developing mouse lung. Am J Physiol Lung Cell Mol Physiol 1:L167\u2013L178","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nm721","volume":"7","author":"V Compernolle","year":"2002","unstructured":"Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P (2002) Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 7:702\u2013710","journal-title":"Nat Med"},{"key":"280_CR21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1097-0177(199803)211:3<215::AID-AJA3>3.0.CO;2-K","volume":"211","author":"X Zeng","year":"1998","unstructured":"Zeng X, Wert SE, Federici R, Peters KG, Whitsett JA (1998) VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis. Dev Dyn 211:215\u2013227","journal-title":"Dev Dyn"},{"key":"280_CR22","doi-asserted-by":"crossref","first-page":"L880","DOI":"10.1152\/ajplung.00213.2005","volume":"5","author":"Q Zhang","year":"2006","unstructured":"Zhang Q, Moe OW, Garcia JA, Hsia CCW (2006) Regulated expression of hypoxia-inducible factors during postnatal and postpneumonectomy lung growth. Am J Physiol Lung Cell Mol Physiol 5:L880\u2013L889","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.taap.2004.07.008","volume":"2","author":"TM Asikainen","year":"2005","unstructured":"Asikainen TM, White CW (2005) Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD. Toxicol Appl Pharmacol 2:177\u2013188","journal-title":"Toxicol Appl Pharmacol"},{"key":"280_CR24","doi-asserted-by":"crossref","first-page":"L1345","DOI":"10.1152\/ajplung.00372.2006","volume":"6","author":"TR Grover","year":"2007","unstructured":"Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW (2007) Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am J Physiol Lung Cell Mol Physiol 6:L1345\u2013L1351","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR25","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1164\/ajrccm.164.10.2012036","volume":"1","author":"P Lassus","year":"2001","unstructured":"Lassus P, Turanlahti M, Heikkila P, Andersson LC, Nupponen I, Sarnesto A, Andersson S (2001) Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 10 Pt 1:1981\u20131987","journal-title":"Am J Respir Crit Care Med 10 Pt"},{"key":"280_CR26","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1164\/ajrccm.164.10.2101140","volume":"1","author":"AJ Bhatt","year":"2001","unstructured":"Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM (2001) Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 10 Pt 1:1971\u20131980","journal-title":"Am J Respir Crit Care Med 10 Pt"},{"key":"280_CR27","doi-asserted-by":"crossref","first-page":"L811","DOI":"10.1152\/ajplung.00325.2001","volume":"4","author":"WM Maniscalco","year":"2002","unstructured":"Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H (2002) Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol 4:L811\u2013L823","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR28","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.freeradbiomed.2004.12.004","volume":"8","author":"TM Asikainen","year":"2005","unstructured":"Asikainen TM, Ahmad A, Schneider BK, Ho WB, Arend M, Brenner M, Gunzler V, White CW (2005) Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells. Free Radic Biol Med 8:1002\u20131013","journal-title":"Free Radic Biol Med"},{"key":"280_CR29","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1096\/fj.06-5887fje","volume":"10","author":"TM Asikainen","year":"2006","unstructured":"Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW (2006) Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J 10:1698\u20131700","journal-title":"FASEB J"},{"key":"280_CR30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1748-1716.1946.tb00389.x","volume":"12","author":"US Euler","year":"1946","unstructured":"von Euler US, Liljsjestrand G (1946) Observations of the pulmonary arterial blood pressure on the cat. Acta Physiol Scand 12:301\u2013320","journal-title":"Acta Physiol Scand"},{"key":"280_CR31","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cardiores.2006.04.009","volume":"4","author":"N Weissmann","year":"2006","unstructured":"Weissmann N, Sommer N, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F (2006) Oxygen sensors in hypoxic pulmonary vasoconstriction. Cardiovasc Res 4:620\u2013629","journal-title":"Cardiovasc Res"},{"key":"280_CR32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cardiores.2006.07.025","volume":"1","author":"HA Ghofrani","year":"2006","unstructured":"Ghofrani HA, Voswinckel R, Reichenberger F, Weissmann N, Schermuly RT, Seeger W, Grimminger F (2006) Hypoxia- and non-hypoxia-related pulmonary hypertension\u2014established and new therapies. Cardiovasc Res 1:30\u201340","journal-title":"Cardiovasc Res"},{"key":"280_CR33","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.acra.2006.02.055","volume":"7","author":"RB Easley","year":"2006","unstructured":"Easley RB, Fuld MK, Fernandez-Bustamante A, Hoffman EA, Simon BA (2006) Mechanism of hypoxemia in acute lung injury evaluated by multidetector-row CT. Acad Radiol 7:916\u2013921","journal-title":"Acad Radiol"},{"key":"280_CR34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.7326\/0003-4819-145-7-200610030-00015","volume":"7","author":"ER Swenson","year":"2006","unstructured":"Swenson ER (2006) Hypoxic lung whiteout: further clearing but more questions from on high. Ann Intern Med 7:550\u2013552","journal-title":"Ann Intern Med"},{"key":"280_CR35","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1073\/pnas.161272598","volume":"15","author":"T Minamino","year":"2001","unstructured":"Minamino T, Christou H, Hsieh CM, Li Y, Dhawan V, Abraham NJ, Perrella MA, Mitsialis SA, Kourembanas S (2001) Targeted expression of hemeoxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci USA 15:8798\u20138803","journal-title":"Proc Natl Acad Sci USA"},{"key":"280_CR36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1513\/pats.200603-086MS","volume":"6","author":"EA Hoffman","year":"2006","unstructured":"Hoffman EA, Simon BA, McLennan G (2006) State of the art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc 6:519\u2013532","journal-title":"Proc Am Thorac Soc"},{"key":"280_CR37","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI11144","volume":"6","author":"NF Voelkel","year":"2000","unstructured":"Voelkel NF, Tuder RM (2000) Hypoxia-induced pulmonary vascular remodeling\u2014a model for what human disease. J Clin Invest 6:733\u2013738","journal-title":"J Clin Invest"},{"key":"280_CR38","first-page":"51","volume":"1","author":"B Meyrick","year":"1979","unstructured":"Meyrick B, Reid L (1979) Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall. Am J Pathol 1:51\u201370","journal-title":"Am J Pathol"},{"key":"280_CR39","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.CIR.0000102381.57477.50","volume":"2","author":"R Budhiraja","year":"2004","unstructured":"Budhiraja R, Tuder RM, Hassoun PM (2004) Endothelial dysfunction in pulmonary hypertension. Circulation 2:159\u2013165","journal-title":"Circulation"},{"key":"280_CR40","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1165\/rcmb.F307","volume":"5","author":"A Zaiman","year":"2005","unstructured":"Zaiman A, Fijalkowska I, Hassoun PM, Tuder RM (2005) One hundred years of research in the pathogenesis of pulmonary hypertension. Am J Respir Cell Mol Biol 5:425\u2013431","journal-title":"Am J Respir Cell Mol Biol"},{"key":"280_CR41","first-page":"225S","volume":"3","author":"NF Voelkel","year":"1999","unstructured":"Voelkel NF, Cool CD, Lee SD, Wright L, Geraci MW, Tuder RM (1999) Primary pulmonary hypertension between inflammation and cancer. Chest Suppl 3:225S\u2013230S","journal-title":"Chest Suppl"},{"key":"280_CR42","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1161\/CIRCULATIONAHA.105.609008","volume":"22","author":"S Bonnet","year":"2006","unstructured":"Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL (2006) An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 22:2630\u20132641","journal-title":"Circulation"},{"key":"280_CR43","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/01.RES.0000024689.07590.C2","volume":"12","author":"ED Michelakis","year":"2002","unstructured":"Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, Archer SL (2002) Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circulation Research 12:1307\u20131315","journal-title":"Circulation Research"},{"key":"280_CR44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/pupt.1998.0107","volume":"10","author":"HL Reeve","year":"1997","unstructured":"Reeve HL, Archer SL, Weir EK (1997) Ion channels in the pulmonary vasculature. Pulm Pharmacol Ther 10:243\u2013252","journal-title":"Pulm Pharmacol Ther"},{"key":"280_CR45","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI23203","volume":"6","author":"MS McMurtry","year":"2005","unstructured":"McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED (2005) Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest 6:1479\u20131491","journal-title":"J Clin Invest"},{"key":"280_CR46","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1172\/JCI5912","volume":"5","author":"AY Yu","year":"1999","unstructured":"Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. J Clin Invest 5:691\u2013696","journal-title":"J Clin Invest"},{"key":"280_CR47","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI15496","volume":"10","author":"K Brusselmans","year":"2003","unstructured":"Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P (2003) Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 10:1519\u20131527","journal-title":"J Clin Invest"},{"key":"280_CR48","doi-asserted-by":"crossref","first-page":"L202","DOI":"10.1152\/ajplung.2001.281.1.L202","volume":"1","author":"LA Shimoda","year":"2001","unstructured":"Shimoda LA, Manalo DJ, Sham JSK, Semenza GL, Sylvester JT (2001) Partial HIF-1{alpha} deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol, Lung Cell Mol Physiol 1:L202\u2013L208","journal-title":"Am J Physiol, Lung Cell Mol Physiol"},{"key":"280_CR49","doi-asserted-by":"crossref","first-page":"L941","DOI":"10.1152\/ajplung.00528.2005","volume":"5","author":"LA Shimoda","year":"2006","unstructured":"Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL (2006) HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol, Lung Cell Mol Physiol 5:L941\u2013L949","journal-title":"Am J Physiol, Lung Cell Mol Physiol"},{"key":"280_CR50","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1161\/01.RES.0000227551.68124.98","volume":"12","author":"J Wang","year":"2006","unstructured":"Wang J, Weigand L, Lu W, Sylvester JT, Semenza L, Shimoda LA (2006) Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circ Res 12:1528\u20131537","journal-title":"Circ Res"},{"key":"280_CR51","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1172\/JCI10230","volume":"11","author":"BL Fanburg","year":"2000","unstructured":"Fanburg BL, Lee SL (2000) A role for the serotonin transporter in hypoxia-induced pulmonary hypertension. J Clin Invest 11:1521\u20131523","journal-title":"J Clin Invest"},{"key":"280_CR52","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1172\/JCI8678","volume":"11","author":"S Eddahibi","year":"2000","unstructured":"Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, Adnot S (2000) Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 11:1555\u20131562","journal-title":"J Clin Invest"},{"key":"280_CR53","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nm764","volume":"10","author":"JM Launay","year":"2002","unstructured":"Launay JM, Herve P, Peoc'h K, Tournois C, Callebert J, Nebigil CG, Etienne N, Drouet L, Humbert M, Simonneau G, Maroteaux L (2002) Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med 10:1129\u20131135","journal-title":"Nat Med"},{"key":"280_CR54","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/path.953","volume":"3","author":"RM Tuder","year":"2001","unstructured":"Tuder RM, Chacon M, Alger L, Wang J, Taraseviciene-Stewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, Voelkel NF (2001) Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 3:367\u2013374","journal-title":"J Pathol"},{"key":"280_CR55","doi-asserted-by":"crossref","first-page":"L548","DOI":"10.1152\/ajplung.00428.2006","volume":"3","author":"FA Masri","year":"2007","unstructured":"Masri FA, Xu W, Comhair SAA, Asosingh K, Koo M, Vasanji A, Drazba J, Anand-Apte B, Erzurum SC (2007) Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension. Am J Physiol, Lung Cell Mol Physiol 3:L548\u2013L554","journal-title":"Am J Physiol, Lung Cell Mol Physiol"},{"key":"280_CR56","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1073\/pnas.0605080104","volume":"4","author":"W Xu","year":"2007","unstructured":"Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, Janocha AJ, Masri FA, Arroliga AC, Jennings C, Dweik RA, Tuder RM, Stuehr DJ, Erzurum SC (2007) Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci USA 4:1342\u20131347","journal-title":"Proc Natl Acad Sci USA"},{"key":"280_CR57","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.00-0343com","volume":"2","author":"L Taraseviciene-Stewart","year":"2001","unstructured":"Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon GG, Waltenberger J, Voelkel NF, Tuder RM (2001) Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. Faseb J 2:427\u2013438","journal-title":"Faseb J"},{"key":"280_CR58","doi-asserted-by":"crossref","first-page":"L1241","DOI":"10.1152\/ajplung.00239.2004","volume":"6","author":"H Beppu","year":"2004","unstructured":"Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD (2004) BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Amer J Physiol -Lung Cell M PH 6:L1241\u2013L1247","journal-title":"Amer J Physiol -Lung Cell M PH"},{"key":"280_CR59","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00048.2006","volume":"3","author":"T Yoshida","year":"2007","unstructured":"Yoshida T, Tuder RM (2007) Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol Rev 3:1047\u20131082","journal-title":"Physiol Rev"},{"key":"280_CR60","doi-asserted-by":"crossref","first-page":"L209","DOI":"10.1152\/ajplung.00185.2005","volume":"2","author":"NF Voelkel","year":"2006","unstructured":"Voelkel NF, Vandivier RW, Tuder RM (2006) Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 2:L209\u2013L221","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"280_CR61","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1096\/fj.02-0172fje","volume":"9","author":"SE Michaud","year":"2003","unstructured":"Michaud SE, Menard C, Guy LG, Gennaro G, Rivard A (2003) Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure: impairment of the HIF-1alpha\/VEGF pathway. Faseb J 9:1150\u20131152","journal-title":"Faseb J"},{"key":"280_CR62","doi-asserted-by":"crossref","first-page":"551a","DOI":"10.1513\/pats.200603-084MS","volume":"6","author":"T Yoshida","year":"2006","unstructured":"Yoshida T, Rangasamy T, Biswal S, Petrache I, Mett I, Feinstein E, Tuder RM (2006) Role of RTP801, a suppressor of the mTOR pathway, in cigarette smoke-induced pulmonary injury in mice. Proc Am Thorac Soc 6:551a\u2013552a","journal-title":"Proc Am Thorac Soc"},{"key":"280_CR63","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/thx.2005.042994","volume":"7","author":"JL Wright","year":"2005","unstructured":"Wright JL, Levy RD, Churg A (2005) Pulmonary hypertension in chronic obstructive pulmonary disease: current theories of pathogenesis and their implications for treatment. Thorax 7:605\u2013609","journal-title":"Thorax"},{"key":"280_CR64","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1164\/rccm.200507-1161WS","volume":"4","author":"TL Croxton","year":"2006","unstructured":"Croxton TL, Bailey WC, for the NHLBI Working Group on Long-term Oxygen Treatment in COPD (2006) Long-term oxygen treatment in chronic obstructive pulmonary disease: recommendations for future research: An NHLBI Workshop Report. Am J Respir Crit Care Med 4(373\u2013378)","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-007-0280-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-007-0280-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-007-0280-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T04:28:44Z","timestamp":1558585724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-007-0280-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,27]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["280"],"URL":"https:\/\/doi.org\/10.1007\/s00109-007-0280-4","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,27]]}}}