{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:22:17Z","timestamp":1781036537970,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T00:00:00Z","timestamp":1202860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1007\/s00109-008-0312-8","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T12:29:50Z","timestamp":1202819390000},"page":"457-469","source":"Crossref","is-referenced-by-count":34,"title":["A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin"],"prefix":"10.1007","volume":"86","author":[{"given":"Navin K.","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Olwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Mcelligott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Butini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Campiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Clive","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M.","family":"Zisterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lawler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Volkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,2,13]]},"reference":[{"key":"312_CR1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1126\/science.1070051","volume":"296","author":"MJ Miller","year":"2002","unstructured":"Miller MJ, Wei SH, Parker I, Cahalan MD (2002) Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296:1869\u20131873","journal-title":"Science"},{"key":"312_CR2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/205887a0","volume":"205","author":"W McFarland","year":"1965","unstructured":"McFarland W, Heilman DH (1965) Lymphocyte foot appendage: its role in lymphocyte function and in immunological reactions. Nature 205:887\u2013888","journal-title":"Nature"},{"key":"312_CR3","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.4049\/jimmunol.175.12.7811","volume":"175","author":"BSEDE Homasany","year":"2005","unstructured":"Homasany BSEDE, Volkov Y, Takahashi M, Ono Y, Keryer G, Delouvee A, Looby E, Long A, Kelleher D (2005) The scaffolding protein CG-NAP\/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells. J Immunol 175:7811\u20137818","journal-title":"J Immunol"},{"key":"312_CR4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nature02238","volume":"427","author":"TR Mempel","year":"2004","unstructured":"Mempel TR, Henrickson SE, Von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427:154\u2013159","journal-title":"Nature"},{"key":"312_CR5","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1073\/pnas.2628040100","volume":"100","author":"MJ Miller","year":"2003","unstructured":"Miller MJ, Wei SH, Cahalan MD, Parker I (2003) Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc Natl Acad Sci USA 100:2604\u20132609","journal-title":"Proc Natl Acad Sci USA"},{"key":"312_CR6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/88700","volume":"2","author":"Y Volkov","year":"2001","unstructured":"Volkov Y, Long A, McGrath S, Eidhin DNi, Kelleher D (2001) Crucial importance of PKC-\u03b2(I) in LFA-1-mediated locomotion of activated T cells. Nat Immunol 2:508\u2013514","journal-title":"Nat Immunol"},{"key":"312_CR7","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1242\/jcs.00876","volume":"116","author":"N Hogg","year":"2003","unstructured":"Hogg N, Laschinger M, Giles K, McDowall A (2003) T-cell integrins: more than just sticking points. J Cell Sci 116:4695\u20134705","journal-title":"J Cell Sci"},{"key":"312_CR8","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.4049\/jimmunol.161.12.6487","volume":"161","author":"Y Volkov","year":"1998","unstructured":"Volkov Y, Long A, Kelleher D (1998) Inside the crowling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isozymes \u03b2(I) and \u03b4. J Immunol 161:6487\u20136495","journal-title":"J Immunol"},{"key":"312_CR9","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.170.5.1697","volume":"170","author":"A Kupfer","year":"1989","unstructured":"Kupfer A, Singer SJ (1989) The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose. J Exp Med 170:1697\u20131713","journal-title":"J Exp Med"},{"key":"312_CR10","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1083\/jcb.102.3.1118","volume":"102","author":"GG Gundersen","year":"1986","unstructured":"Gundersen GG, Bulinski JC (1986) Distribution of tyrosinated and nontyrosinated alpha-tubulin during mitosis. J Cell Biol 102:1118\u20131126","journal-title":"J Cell Biol"},{"key":"312_CR11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tcb.2004.12.006","volume":"15","author":"T Watanabe","year":"2005","unstructured":"Watanabe T, Noritake J, Kaibuchi K (2005) Regulation of microtubule in cell migration. TRENDS Cell Biol 15:76\u201383","journal-title":"TRENDS Cell Biol"},{"key":"312_CR12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1023\/B:MCBI.0000012834.43990.b6","volume":"258","author":"S Belmadani","year":"2004","unstructured":"Belmadani S, Pous C, Fischmeister R, Mery PF (2004) Post-translational modifications of tubulin and microtubule stability in adult rat ventricular myocytes and immortalized HL-1 cardiomyocytes. Mol Cell Biochem 258:35\u201348","journal-title":"Mol Cell Biochem"},{"key":"312_CR13","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/328676a0","volume":"328","author":"JC Bulinski","year":"1987","unstructured":"Bulinski JC, Gundersen GG, Webster DR (1987) A function for tubulin tyrosination. Nature 328:676\u2013676","journal-title":"Nature"},{"key":"312_CR14","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1056\/NEJMoa021007","volume":"348","author":"SJ Park","year":"2003","unstructured":"Park SJ, Shim WH, Ho DS, Raizner AE, Park SW, Hong MK, Lee CW, Choi D, Jang Y, Lam R, Weissman NJ, Mintz GS (2003) A paclitaxel-eluting stent for the prevention of coronary restenosis. N Engl J Med 348:1537\u20131545","journal-title":"N Engl J Med"},{"key":"312_CR15","first-page":"1357","volume":"5","author":"LM Greene","year":"2005","unstructured":"Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM (2005) The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo. Oncology Reports 5:1357\u20131363","journal-title":"Oncology Reports"},{"key":"312_CR16","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/jpet.106.116640","volume":"321","author":"LM Greene","year":"2007","unstructured":"Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM (2007) STI-571 enhances the apoptotic efficacy of PBOX-6, a novel microtubule-targeting agent, in both STI-571-sensitive and STI-571-resistant Bcr-Abl-positive human chronic myeloid leukemia cells. J Pharmacol Exp Ther 321:288\u2013297","journal-title":"J Pharmacol Exp Ther"},{"key":"312_CR17","doi-asserted-by":"crossref","first-page":"18383","DOI":"10.1074\/jbc.M112058200","volume":"277","author":"MM McGee","year":"2002","unstructured":"McGee MM, Campiani G, Ramunno A, Nacci V, Lawler M, Williams DC, Zisterer DM (2002) Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells. J Biol Chem 277:18383\u201318389","journal-title":"J Biol Chem"},{"key":"312_CR18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-5793(02)02440-7","volume":"515","author":"MM McGee","year":"2002","unstructured":"McGee MM, Hyland E, Campiani G, Ramunn A, Nacci V, Zisterer DM (2002) Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Lett 515:66\u201370","journal-title":"FEBS Lett"},{"key":"312_CR19","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1124\/jpet.104.067561","volume":"310","author":"MM McGee","year":"2004","unstructured":"McGee MM, Greene LM, Ledwidge S, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM (2004) Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl] oxy]\u20136-(2-naphthyl) pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in leukemia cells occur via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL. J Pharmacol Exp Ther 310:1084\u20131095","journal-title":"J Pharmacol Exp Ther"},{"key":"312_CR20","first-page":"48","volume":"293","author":"DM Zisterer","year":"2000","unstructured":"Zisterer DM, Campiani G, Nacci V, Williams DC (2000) Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther 293:48\u201359","journal-title":"J Pharmacol Exp Ther"},{"key":"312_CR21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1124\/mol.105.021204","volume":"70","author":"JM Mulligan","year":"2006","unstructured":"Mulligan JM, Greene LM, Cloonan S, McGee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM (2006) Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol 70:60\u201370","journal-title":"Mol Pharmacol"},{"key":"312_CR22","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1021\/jm960251b","volume":"39","author":"G Campiani","year":"1996","unstructured":"Campiani G, Nacci V, Fiorini I, DeFilippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T (1996) Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific \u201cperipheral-type\u201d benzodiazepine receptor ligands. J Med Chem 39:3435\u20133450","journal-title":"J Med Chem"},{"key":"312_CR23","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4049\/jimmunol.156.5.1810","volume":"156","author":"MP Stewart","year":"1996","unstructured":"Stewart MP, Cabanas C, Hogg N (1996) T cell adhesion to intracellular adhesion molecule-1 (ICAM-1) is controlled by cell spreading and the activation of integrin LFA-1. J Immunol 156:1810\u20131817","journal-title":"J Immunol"},{"key":"312_CR24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/intimm\/dxh225","volume":"17","author":"A Fanning","year":"2005","unstructured":"Fanning A, Volkov Y, Freely M, Kelleher D, Long A (2005) CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes. Int Immunol 17:449\u2013458","journal-title":"Int Immunol"},{"key":"312_CR25","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/sj.bjp.0706002","volume":"143","author":"NK Verma","year":"2004","unstructured":"Verma NK, Singh J, Dey CS (2004) PPAR\u03b3 expression modulates insulin sensitivity in C2C12 skeletal muscle cells. Br J Pharmacol 143:1006\u20131013","journal-title":"Br J Pharmacol"},{"key":"312_CR26","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1016\/S0021-9258(19)67891-9","volume":"266","author":"AM Minotti","year":"1991","unstructured":"Minotti AM, Barlow SB, Cabral F (1991) Resistance to antimitotic drugs in Chinese hamster ovary cells correlates with changes in the level of polymerized tubulin. J Biol Chem 266:3987\u20133994","journal-title":"J Biol Chem"},{"key":"312_CR27","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nrm1260","volume":"4","author":"S Westermann","year":"2003","unstructured":"Westermann S, Weber K (2003) Post-translational modifications regulate microtubule function. Nat Rev Mol Cell Biol 4:938\u2013947","journal-title":"Nat Rev Mol Cell Biol"},{"key":"312_CR28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1242\/jcs.92.1.57","volume":"92","author":"DR Webster","year":"1989","unstructured":"Webster DR, Borisy GG (1989) Microtubules are acetylated in domains that turn over slowly. J Cell Sci 92:57\u201365","journal-title":"J Cell Sci"},{"key":"312_CR29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0092-8674(84)90273-3","volume":"38","author":"GG Gundersen","year":"1984","unstructured":"Gundersen GG, Kalnoski MH, Bulinski JC (1984) Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo. Cell 38:779\u2013789","journal-title":"Cell"},{"key":"312_CR30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1200\/JCO.1999.17.3.1061","volume":"17","author":"C Dumontet","year":"1999","unstructured":"Dumontet C, Sikiec BI (1999) Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J Clin Oncol 17:1061\u20131070","journal-title":"J Clin Oncol"},{"key":"312_CR31","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.103.5.1883","volume":"103","author":"G Geuens","year":"1986","unstructured":"Geuens G, Gundersen GG, Nuydens R, Cornelissen F, Bulinski JC, DeBrabander M (1986) Ultrastructural colocalization of tyrosinated and detyrosinated alphatubulin in interphase and mitotic cells. J Cell Biol 103:1883\u20131893","journal-title":"J Cell Biol"},{"key":"312_CR32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0074-7696(08)62138-5","volume":"178","author":"RF Luduena","year":"1998","unstructured":"Luduena RF (1998) Multiple forms of tubulin: different gene products and covalent modifications. Int Rev Cytol 178:207\u2013275","journal-title":"Int Rev Cytol"},{"key":"312_CR33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0955-0674(99)80010-6","volume":"11","author":"GG Gundersen","year":"1999","unstructured":"Gundersen GG, Cook TA (1999) Microtubules and signal transduction. Curr Opin Cell Biol 11:81\u201394","journal-title":"Curr Opin Cell Biol"},{"key":"312_CR34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1091\/mbc.10.4.1105","volume":"10","author":"G Kreitzer","year":"1999","unstructured":"Kreitzer G, Liao G, Gundersen GG (1999) Detyrosination of tubulin regulates the interaction of intermediate filaments with microtubules in vivo via a kinesin-dependent mechanism. Mol Biol Cell 10:1105\u20131118","journal-title":"Mol Biol Cell"},{"key":"312_CR35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1183\/09031936.00154206","volume":"30","author":"T Mirzapoiazova","year":"2007","unstructured":"Mirzapoiazova T, Kolosova IA, Moreno L, Sammani S, Garcia JGN, Verin AD (2007) Suppression of endotoxin-induced inflammation by taxol. Eur Respir J 30:429\u2013435","journal-title":"Eur Respir J"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-008-0312-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-008-0312-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-008-0312-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T13:07:26Z","timestamp":1684242446000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-008-0312-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,13]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["312"],"URL":"https:\/\/doi.org\/10.1007\/s00109-008-0312-8","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,13]]}}}