{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:52:54Z","timestamp":1782269574150,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,9,18]],"date-time":"2010-09-18T00:00:00Z","timestamp":1284768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00109-010-0680-8","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T08:43:24Z","timestamp":1284713004000},"page":"1277-1288","source":"Crossref","is-referenced-by-count":82,"title":["PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)"],"prefix":"10.1007","volume":"88","author":[{"given":"Bjoern F.","family":"Kraemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Schoenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ninci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Bigalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Martinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Daub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Merz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Schwanitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Fiesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lindemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,18]]},"reference":[{"key":"680_CR1","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1182\/blood.V92.11.4446","volume":"92","author":"G Berger","year":"1998","unstructured":"Berger G, Hartwell DW, Wagner DD (1998) P-selectin and platelet clearance. Blood 92:4446\u20134452","journal-title":"Blood"},{"key":"680_CR2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2005.06.015","volume":"122","author":"MM Denis","year":"2005","unstructured":"Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ et al (2005) Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122:379\u2013391","journal-title":"Cell"},{"key":"680_CR3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.200105058","volume":"154","author":"S Lindemann","year":"2001","unstructured":"Lindemann S, Tolley ND, Dixon DA, McIntyre TM, Prescott SM, Zimmerman GA, Weyrich AS (2001) Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 154:485\u2013490","journal-title":"J Cell Biol"},{"key":"680_CR4","doi-asserted-by":"crossref","first-page":"33947","DOI":"10.1074\/jbc.M104281200","volume":"276","author":"S Lindemann","year":"2001","unstructured":"Lindemann S, Tolley ND, Eyre JR, Kraiss LW, Mahoney TM, Weyrich AS (2001) Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem 276:33947\u201333951","journal-title":"J Biol Chem"},{"key":"680_CR5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000096322","volume":"152","author":"M Jakab","year":"2006","unstructured":"Jakab M, Ritter M (2006) Cell volume regulatory ion transport in the regulation of cell migration. Contrib Nephrol 152:161\u2013180","journal-title":"Contrib Nephrol"},{"key":"680_CR6","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.febslet.2008.02.064","volume":"582","author":"EA Papakonstanti","year":"2008","unstructured":"Papakonstanti EA, Stournaras C (2008) Cell responses regulated by early reorganization of actin cytoskeleton. FEBS Lett 582:2120\u20132127","journal-title":"FEBS Lett"},{"key":"680_CR7","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","volume":"302","author":"AJ Ridley","year":"2003","unstructured":"Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR (2003) Cell migration: integrating signals from front to back. Science 302:1704\u20131709","journal-title":"Science"},{"key":"680_CR8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00424-006-0138-6","volume":"453","author":"A Schwab","year":"2007","unstructured":"Schwab A, Nechyporuk-Zloy V, Fabian A, Stock C (2007) Cells move when ions and water flow. Pflugers Arch 453:421\u2013432","journal-title":"Pflugers Arch"},{"key":"680_CR9","first-page":"3","volume-title":"platelets","author":"J Lewin","year":"2002","unstructured":"Lewin J (2002) The evolution of mammalian platelets. In: Michelson ED (ed) platelets. Academic, San Diego, pp 3\u201317"},{"key":"680_CR10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/IAI.20.1.242-247.1978","volume":"20","author":"I Kakoma","year":"1978","unstructured":"Kakoma I, Carson CA, Ristic M, Stephenson EM, Hildebrandt PK, Huxsoll DL (1978) Platelet migration inhibition as an indicator of immunologically mediated target cell injury in canine ehrlichiosis. Infect Immun 20:242\u2013247","journal-title":"Infect Immun"},{"key":"680_CR11","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1172\/JCI107854","volume":"54","author":"FH Valone","year":"1974","unstructured":"Valone FH, Austen KF, Goetzl EJ (1974) Modulation of the random migration of human platelets. J Clin Invest 54:1100\u20131106","journal-title":"J Clin Invest"},{"key":"680_CR12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.exphem.2004.09.010","volume":"33","author":"M Czapiga","year":"2005","unstructured":"Czapiga M, Gao JL, Kirk A, Lekstrom-Himes J (2005) Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. Exp Hematol 33:73\u201384","journal-title":"Exp Hematol"},{"key":"680_CR13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000023944","volume":"116","author":"D Feng","year":"1998","unstructured":"Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM (1998) Platelets exit venules by a transcellular pathway at sites of F-met peptide-induced acute inflammation in guinea pigs. Int Arch Allergy Immunol 116:188\u2013195","journal-title":"Int Arch Allergy Immunol"},{"key":"680_CR14","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1164\/rccm.200702-214OC","volume":"177","author":"SC Pitchford","year":"2008","unstructured":"Pitchford SC, Momi S, Baglioni S, Casali L, Giannini S, Rossi R, Page CP, Gresele P (2008) Allergen induces the migration of platelets to lung tissue in allergic asthma. Am J Respir Crit Care Med 177:604\u2013612","journal-title":"Am J Respir Crit Care Med"},{"key":"680_CR15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/01.RES.86.2.131","volume":"86","author":"S Abi-Younes","year":"2000","unstructured":"Abi-Younes S, Sauty A, Mach F, Sukhova GK, Libby P, Luster AD (2000) The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ Res 86:131\u2013138","journal-title":"Circ Res"},{"key":"680_CR16","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.184.3.1101","volume":"184","author":"CC Bleul","year":"1996","unstructured":"Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA (1996) A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 184:1101\u20131109","journal-title":"J Exp Med"},{"key":"680_CR17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1084\/jem.188.3.539","volume":"188","author":"T Hamada","year":"1998","unstructured":"Hamada T, Mohle R, Hesselgesser J, Hoxie J, Nachman RL, Moore MA, Rafii S (1998) Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. J Exp Med 188:539\u2013548","journal-title":"J Exp Med"},{"key":"680_CR18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q","volume":"32","author":"R Phillips","year":"2002","unstructured":"Phillips R, Ager A (2002) Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells. Eur J Immunol 32:837\u2013847","journal-title":"Eur J Immunol"},{"key":"680_CR19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/FJC.0b013e318093ec8f","volume":"50","author":"H Zheng","year":"2007","unstructured":"Zheng H, Fu G, Dai T, Huang H (2007) Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha\/CXCR4 via PI3K\/Akt\/eNOS signal transduction pathway. J Cardiovasc Pharmacol 50:274\u2013280","journal-title":"J Cardiovasc Pharmacol"},{"key":"680_CR20","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1182\/blood.V96.13.4046","volume":"96","author":"KJ Clemetson","year":"2000","unstructured":"Clemetson KJ, Clemetson JM, Proudfoot AE, Power CA, Baggiolini M, Wells TN (2000) Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Blood 96:4046\u20134054","journal-title":"Blood"},{"key":"680_CR21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.107.714691","volume":"117","author":"K Stellos","year":"2008","unstructured":"Stellos K, Langer H, Daub K, Schoenberger T, Gauss A, Geisler T, Bigalke B, Mueller I, Schumm M, Schaefer I et al (2008) Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation 117:206\u2013215","journal-title":"Circulation"},{"key":"680_CR22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1182\/blood.V97.1.33","volume":"97","author":"E Haddad","year":"2001","unstructured":"Haddad E, Zugaza JL, Louache F, Debili N, Crouin C, Schwarz K, Fischer A, Vainchenker W, Bertoglio J (2001) The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis. Blood 97:33\u201338","journal-title":"Blood"},{"key":"680_CR23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0301-472X(02)00823-8","volume":"30","author":"S Okabe","year":"2002","unstructured":"Okabe S, Fukuda S, Broxmeyer HE (2002) Activation of Wiskott\u2013Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line. Exp Hematol 30:761\u2013766","journal-title":"Exp Hematol"},{"key":"680_CR24","doi-asserted-by":"crossref","first-page":"32531","DOI":"10.1074\/jbc.274.46.32531","volume":"274","author":"HN Higgs","year":"1999","unstructured":"Higgs HN, Pollard TD (1999) Regulation of actin polymerization by Arp2\/3 complex and WASp\/Scar proteins. J Biol Chem 274:32531\u201332534","journal-title":"J Biol Chem"},{"key":"680_CR25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nri884","volume":"2","author":"AJ Thrasher","year":"2002","unstructured":"Thrasher AJ (2002) WASp in immune-system organization and function. Nat Rev Immunol 2:635\u2013646","journal-title":"Nat Rev Immunol"},{"key":"680_CR26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/sj.onc.1206910","volume":"23","author":"AZ Fernandis","year":"2004","unstructured":"Fernandis AZ, Prasad A, Band H, Klosel R, Ganju RK (2004) Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells. Oncogene 23:157\u2013167","journal-title":"Oncogene"},{"key":"680_CR27","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1083\/jcb.200607053","volume":"176","author":"L Primo","year":"2007","unstructured":"Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F (2007) Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol 176:1035\u20131047","journal-title":"J Cell Biol"},{"key":"680_CR28","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1189\/jlb.0208088","volume":"84","author":"TN Hartmann","year":"2008","unstructured":"Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R (2008) A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J Leukoc Biol 84:1130\u20131140","journal-title":"J Leukoc Biol"},{"key":"680_CR29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0014-5793(02)03143-5","volume":"527","author":"S Hatse","year":"2002","unstructured":"Hatse S, Princen K, Bridger G, De Clercq E, Schols D (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 527:255\u2013262","journal-title":"FEBS Lett"},{"key":"680_CR30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0165-6147(84)90444-9","volume":"5","author":"M Ui","year":"1984","unstructured":"Ui M (1984) Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase. Trends Pharmacol Sci 5:277\u2013279","journal-title":"Trends Pharmacol Sci"},{"key":"680_CR31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/blood-2002-10-3260","volume":"103","author":"A Sch\u00e4fer","year":"2004","unstructured":"Sch\u00e4fer A, Schulz C, Eigenthaler M, Fraccarollo D, Kobsar A, Gawaz M, Ertl G, Walter U, Bauersachs J (2004) Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. Blood 103:407\u201312","journal-title":"Blood"},{"key":"680_CR32","doi-asserted-by":"crossref","first-page":"14871","DOI":"10.1016\/S0021-9258(18)48106-9","volume":"262","author":"HS Banga","year":"1987","unstructured":"Banga HS, Walker RK, Winberry LK, Rittenhouse SE (1987) Pertussis toxin can activate human platelets. Comparative effects of holotoxin and its ADP-ribosylating S1 subunit. J Biol Chem 262:14871\u20134","journal-title":"J Biol Chem"},{"key":"680_CR33","first-page":"F931","volume":"273","author":"GG Choudhury","year":"1997","unstructured":"Choudhury GG, Karamitsos C, Hernandez J, Gentilini A, Bardgette J, Abboud HE (1997) PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am J Physiol 273:F931\u2013F938","journal-title":"Am J Physiol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-010-0680-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-010-0680-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-010-0680-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T03:19:05Z","timestamp":1636514345000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-010-0680-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,18]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["680"],"URL":"https:\/\/doi.org\/10.1007\/s00109-010-0680-8","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,18]]}}}