{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:44:06Z","timestamp":1779241446255,"version":"3.51.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00109-010-0697-z","type":"journal-article","created":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T12:04:24Z","timestamp":1289822664000},"page":"321-329","source":"Crossref","is-referenced-by-count":36,"title":["Hematopoietic colony-stimulating factors: new players in tumor\u2013nerve interactions"],"prefix":"10.1007","volume":"89","author":[{"given":"Sebastian","family":"St\u00f6sser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schweizerhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohini","family":"Kuner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"697_CR1","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(99)01310-0","volume":"353","author":"RK Portenoy","year":"1999","unstructured":"Portenoy RK, Lesage P (1999) Management of cancer pain. Lancet 353:1695\u20131700. doi: 10.1016\/S0140-6736(99)01310-0","journal-title":"Lancet"},{"key":"697_CR2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nrn1914","volume":"7","author":"PW Mantyh","year":"2006","unstructured":"Mantyh PW (2006) Cancer pain and its impact on diagnosis, survival and quality of life. Nat Rev Neurosci 7:797\u2013809. doi: 10.1038\/nrn1914","journal-title":"Nat Rev Neurosci"},{"key":"697_CR3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/0470867639.ch15","volume":"260","author":"PW Mantyh","year":"2004","unstructured":"Mantyh PW, Hunt SP (2004) Mechanisms that generate and maintain bone cancer pain. Novartis Found Symp 260:221\u2013238, discussion 238\u2013240, 277\u2013229","journal-title":"Novartis Found Symp"},{"key":"697_CR4","doi-asserted-by":"crossref","first-page":"9355","DOI":"10.1523\/JNEUROSCI.21-23-09355.2001","volume":"21","author":"PW Wacnik","year":"2001","unstructured":"Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, Wilcox GL (2001) Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain. J Neurosci 21:9355\u20139366","journal-title":"J Neurosci"},{"key":"697_CR5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nri2356","volume":"8","author":"JA Hamilton","year":"2008","unstructured":"Hamilton JA (2008) Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 8:533\u2013544. doi: 10.1038\/nri2356","journal-title":"Nat Rev Immunol"},{"key":"697_CR6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nm.1976","volume":"15","author":"M Schweizerhof","year":"2009","unstructured":"Schweizerhof M, Stosser S, Kurejova M, Njoo C, Gangadharan V, Agarwal N, Schmelz M, Bali KK, Michalski CW, Brugger S, Dickenson A, Simone DA, Kuner R (2009) Hematopoietic colony-stimulating factors mediate tumor-nerve interactions and bone cancer pain. Nat Med 15:802\u2013807. doi: 10.1038\/nm.1976","journal-title":"Nat Med"},{"key":"697_CR7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0167-5699(91)90067-4","volume":"12","author":"G Vairo","year":"1991","unstructured":"Vairo G, Hamilton JA (1991) Signalling through CSF receptors. Immunol Today 12:362\u2013369","journal-title":"Immunol Today"},{"key":"697_CR8","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMra052706","volume":"354","author":"K Kaushansky","year":"2006","unstructured":"Kaushansky K (2006) Lineage-specific hematopoietic growth factors. N Engl J Med 354:2034\u20132045. doi: 10.1056\/NEJMra052706","journal-title":"N Engl J Med"},{"key":"697_CR9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuron.2007.07.008","volume":"55","author":"T Hucho","year":"2007","unstructured":"Hucho T, Levine JD (2007) Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 55:365\u2013376. doi: 10.1016\/j.neuron.2007.07.008","journal-title":"Neuron"},{"key":"697_CR10","doi-asserted-by":"crossref","first-page":"C558","DOI":"10.1152\/ajpcell.00113.2004","volume":"287","author":"X Jin","year":"2004","unstructured":"Jin X, Morsy N, Winston J, Pasricha PJ, Garrett K, Akbarali HI (2004) Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. Am J Physiol Cell Physiol 287:C558\u2013C563. doi: 10.1152\/ajpcell.00113.2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"697_CR11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284. doi: 10.1016\/j.cell.2009.09.028","journal-title":"Cell"},{"key":"697_CR12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cyto.2008.03.002","volume":"42","author":"AD Panopoulos","year":"2008","unstructured":"Panopoulos AD, Watowich SS (2008) Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine 42:277\u2013288. doi: 10.1016\/j.cyto.2008.03.002","journal-title":"Cytokine"},{"key":"697_CR13","first-page":"1165","volume":"231","author":"K Balonov","year":"2006","unstructured":"Balonov K, Khodorova A, Strichartz GR (2006) Tactile allodynia initiated by local subcutaneous endothelin-1 is prolonged by activation of TRPV-1 receptors. Exp Biol Med Maywood 231:1165\u20131170","journal-title":"Exp Biol Med Maywood"},{"key":"697_CR14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.brainresrev.2008.12.006","volume":"60","author":"GY Wong","year":"2009","unstructured":"Wong GY, Gavva NR (2009) Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. Brain Res Rev 60:267\u2013277. doi: 10.1016\/j.brainresrev.2008.12.006","journal-title":"Brain Res Rev"},{"key":"697_CR15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pain.2005.06.024","volume":"117","author":"K Bolcskei","year":"2005","unstructured":"Bolcskei K, Helyes Z, Szabo A, Sandor K, Elekes K, Nemeth J, Almasi R, Pinter E, Petho G, Szolcsanyi J (2005) Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain 117:368\u2013376. doi: 10.1016\/j.pain.2005.06.024","journal-title":"Pain"},{"key":"697_CR16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/jpet.104.082487","volume":"314","author":"A Szabo","year":"2005","unstructured":"Szabo A, Helyes Z, Sandor K, Bite A, Pinter E, Nemeth J, Banvolgyi A, Bolcskei K, Elekes K, Szolcsanyi J (2005) Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice. J Pharmacol Exp Ther 314:111\u2013119. doi: 10.1124\/jpet.104.082487","journal-title":"J Pharmacol Exp Ther"},{"key":"697_CR17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pain.2008.01.024","volume":"136","author":"NR Gavva","year":"2008","unstructured":"Gavva NR, Treanor JJ, Garami A, Fang L, Surapaneni S, Akrami A, Alvarez F, Bak A, Darling M, Gore A, Jang GR, Kesslak JP, Ni L, Norman MH, Palluconi G, Rose MJ, Salfi M, Tan E, Romanovsky AA, Banfield C, Davar G (2008) Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 136:202\u2013210. doi: 10.1016\/j.pain.2008.01.024","journal-title":"Pain"},{"key":"697_CR18","doi-asserted-by":"crossref","first-page":"9512","DOI":"10.1523\/JNEUROSCI.2160-06.2006","volume":"26","author":"T Miao","year":"2006","unstructured":"Miao T, Wu D, Zhang Y, Bo X, Subang MC, Wang P, Richardson PM (2006) Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons. J Neurosci 26:9512\u20139519. doi: 10.1523\/JNEUROSCI.2160-06.2006","journal-title":"J Neurosci"},{"key":"697_CR19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/REVNEURO.2008.19.4-5.341","volume":"19","author":"S Dziennis","year":"2008","unstructured":"Dziennis S, Alkayed NJ (2008) Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Rev Neurosci 19:341\u2013361","journal-title":"Rev Neurosci"},{"key":"697_CR20","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/16040","volume":"2","author":"RR Ji","year":"1999","unstructured":"Ji RR, Baba H, Brenner GJ, Woolf CJ (1999) Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 2:1114\u20131119. doi: 10.1038\/16040","journal-title":"Nat Neurosci"},{"key":"697_CR21","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.1523\/JNEUROSCI.2893-04.2004","volume":"24","author":"ZY Zhuang","year":"2004","unstructured":"Zhuang ZY, Xu H, Clapham DE, Ji RR (2004) Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J Neurosci 24:8300\u20138309. doi: 10.1523\/JNEUROSCI.2893-04.2004","journal-title":"J Neurosci"},{"key":"697_CR22","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1460-9568.2005.04011.x","volume":"21","author":"S Pezet","year":"2005","unstructured":"Pezet S, Spyropoulos A, Williams RJ, McMahon SB (2005) Activity-dependent phosphorylation of Akt\/PKB in adult DRG neurons. Eur J Neurosci 21:1785\u20131797. doi: 10.1111\/j.1460-9568.2005.04011.x","journal-title":"Eur J Neurosci"},{"key":"697_CR23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V83.5.1299.1299","volume":"83","author":"A al-Aoukaty","year":"1994","unstructured":"al-Aoukaty A, Giaid A, Sinoff C, Ho AD, Maghazachi AA (1994) Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes. Blood 83:1299\u20131309","journal-title":"Blood"},{"key":"697_CR24","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/brain\/awn060","volume":"131","author":"S Wang","year":"2008","unstructured":"Wang S, Dai Y, Fukuoka T, Yamanaka H, Kobayashi K, Obata K, Cui X, Tominaga M, Noguchi K (2008) Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain 131:1241\u20131251. doi: 10.1093\/brain\/awn060","journal-title":"Brain"},{"key":"697_CR25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0306-4522(91)90255-M","volume":"44","author":"YO Taiwo","year":"1991","unstructured":"Taiwo YO, Levine JD (1991) Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience 44:131\u2013135","journal-title":"Neuroscience"},{"key":"697_CR26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0090-6980(79)90103-5","volume":"18","author":"SH Ferreira","year":"1979","unstructured":"Ferreira SH, Nakamura M (1979) I - Prostaglandin hyperalgesia, a cAMP\/Ca2+ dependent process. Prostaglandins 18:179\u2013190","journal-title":"Prostaglandins"},{"key":"697_CR27","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0896-6273(02)00802-4","volume":"35","author":"G Bhave","year":"2002","unstructured":"Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, RWt G (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35:721\u2013731","journal-title":"Neuron"},{"issue":"Pt 2","key":"697_CR28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1469-7793.1999.0433v.x","volume":"516","author":"EM Fitzgerald","year":"1999","unstructured":"Fitzgerald EM, Okuse K, Wood JN, Dolphin AC, Moss SJ (1999) cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. J Physiol 516(Pt 2):433\u2013446","journal-title":"J Physiol"},{"key":"697_CR29","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1073\/pnas.2032100100","volume":"100","author":"G Bhave","year":"2003","unstructured":"Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, RWt G (2003) Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci USA 100:12480\u201312485. doi: 10.1073\/pnas.2032100100","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1744-8069-4-42","volume":"4","author":"DH Woo","year":"2008","unstructured":"Woo DH, Jung SJ, Zhu MH, Park CK, Kim YH, Oh SB, Lee CJ (2008) Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). Mol Pain 4:42. doi: 10.1186\/1744-8069-4-42","journal-title":"Mol Pain"},{"key":"697_CR31","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1083646","volume":"300","author":"ED Prescott","year":"2003","unstructured":"Prescott ED, Julius D (2003) A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300:1284\u20131288. doi: 10.1126\/science.1083646","journal-title":"Science"},{"key":"697_CR32","doi-asserted-by":"crossref","first-page":"25665","DOI":"10.1074\/jbc.M311515200","volume":"279","author":"C Morenilla-Palao","year":"2004","unstructured":"Morenilla-Palao C, Planells-Cases R, Garcia-Sanz N, Ferrer-Montiel A (2004) Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. J Biol Chem 279:25665\u201325672. doi: 10.1074\/jbc.M311515200","journal-title":"J Biol Chem"},{"key":"697_CR33","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1182\/blood.V80.4.1045.1045","volume":"80","author":"M Nishimura","year":"1992","unstructured":"Nishimura M, Kaku K, Azuno Y, Okafuji K, Inoue Y, Kaneko T (1992) Stimulation of phosphoinositol turnover and protein kinase C activation by granulocyte-macrophage colony-stimulating factor in HL-60 cells. Blood 80:1045\u20131051","journal-title":"Blood"},{"key":"697_CR34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.intimp.2004.04.001","volume":"4","author":"HK Kang","year":"2004","unstructured":"Kang HK, Lee HY, Lee YN, Jo EJ, Kim JI, Kim GY, Park YM, Min DS, Yano A, Kwak JY, Bae YS (2004) Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells. Int Immunopharmacol 4:911\u2013920. doi: 10.1016\/j.intimp.2004.04.001","journal-title":"Int Immunopharmacol"},{"key":"697_CR35","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0006-291X(91)91411-5","volume":"179","author":"N Veis","year":"1991","unstructured":"Veis N, Hamilton JA (1991) GM-CSF and IL-3 stimulate diacylglycerol generation in murine bone marrow-derived macrophages. Biochem Biophys Res Commun 179:586\u2013591","journal-title":"Biochem Biophys Res Commun"},{"key":"697_CR36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1042\/bj2440683","volume":"244","author":"SW Evans","year":"1987","unstructured":"Evans SW, Rennick D, Farrar WL (1987) Identification of a signal-transduction pathway shared by haematopoietic growth factors with diverse biological specificity. Biochem J 244:683\u2013691","journal-title":"Biochem J"},{"key":"697_CR37","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1021\/bi00160a002","volume":"31","author":"GT Baxter","year":"1992","unstructured":"Baxter GT, Miller DL, Kuo RC, Wada HG, Owicki JC (1992) PKC epsilon is involved in granulocyte-macrophage colony-stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments. Biochemistry 31:10950\u201310954","journal-title":"Biochemistry"},{"key":"697_CR38","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.C200104200","volume":"277","author":"M Numazaki","year":"2002","unstructured":"Numazaki M, Tominaga T, Toyooka H, Tominaga M (2002) Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem 277:13375\u201313378. doi: 10.1074\/jbc.C200104200","journal-title":"J Biol Chem"},{"key":"697_CR39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0896-6273(00)80837-5","volume":"24","author":"SG Khasar","year":"1999","unstructured":"Khasar SG, Lin YH, Martin A, Dadgar J, McMahon T, Wang D, Hundle B, Aley KO, Isenberg W, McCarter G, Green PG, Hodge CW, Levine JD, Messing RO (1999) A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron 24:253\u2013260","journal-title":"Neuron"},{"key":"697_CR40","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1523\/JNEUROSCI.0285-05.2005","volume":"25","author":"TB Hucho","year":"2005","unstructured":"Hucho TB, Dina OA, Levine JD (2005) Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci 25:6119\u20136126. doi: 10.1523\/JNEUROSCI.0285-05.2005","journal-title":"J Neurosci"},{"key":"697_CR41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/jphysiol.2007.135616","volume":"584","author":"C Wang","year":"2007","unstructured":"Wang C, Gu Y, Li GW, Huang LY (2007) A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats. J Physiol 584:191\u2013203. doi: 10.1113\/jphysiol.2007.135616","journal-title":"J Physiol"},{"key":"697_CR42","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1073\/pnas.91.11.4683","volume":"91","author":"SJ Corey","year":"1994","unstructured":"Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ (1994) Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci USA 91:4683\u20134687","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1998.9441","volume":"251","author":"AC Ward","year":"1998","unstructured":"Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (1998) The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor. Biochem Biophys Res Commun 251:117\u2013123. doi: 10.1006\/bbrc.1998.9441","journal-title":"Biochem Biophys Res Commun"},{"key":"697_CR44","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1046\/j.1365-2141.2000.02412.x","volume":"111","author":"N Kroger","year":"2000","unstructured":"Kroger N, Renges H, Kruger W, Gutensohn K, Loliger C, Carrero I, Cortes L, Zander AR (2000) A randomized comparison of once versus twice daily recombinant human granulocyte colony-stimulating factor (filgrastim) for stem cell mobilization in healthy donors for allogeneic transplantation. Br J Haematol 111:761\u2013765","journal-title":"Br J Haematol"},{"key":"697_CR45","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/sj.bmt.1701977","volume":"24","author":"J Rubia de la","year":"1999","unstructured":"de la Rubia J, Martinez C, Solano C, Brunet S, Cascon P, Arrieta R, Alegre A, Bargay J, de Arriba F, Canizo C, Lopez J, Serrano D, Verdeguer A, Torrabadella M, Diaz MA, Insunza A, de la Serna J, Espigado I, Petit J, Martinez M, Benlloch L, Sanz M (1999) Administration of recombinant human granulocyte colony-stimulating factor to normal donors: results of the Spanish National Donor Registry. Spanish Group of Allo-PBT. Bone Marrow Transplant 24:723\u2013728. doi: 10.1038\/sj.bmt.1701977","journal-title":"Bone Marrow Transplant"},{"key":"697_CR46","first-page":"339","volume":"15","author":"S Placido De","year":"1999","unstructured":"De Placido S, Lauria R, Carlomagno C, Perrone F, De Laurentiis M, Gallo C, Martignetti A, Bellelli T, Limite G, Petrella G, Bianco AR (1999) The impact of schedule on acute toxicity and dose-intensity of high-dose chemotherapy with epirubicin and cyclophosphamide plus colony stimulating factors in advanced breast cancer. Int J Oncol 15:339\u2013346","journal-title":"Int J Oncol"},{"key":"697_CR47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1365-2141.1994.tb05110.x","volume":"88","author":"MA Bonilla","year":"1994","unstructured":"Bonilla MA, Dale D, Zeidler C, Last L, Reiter A, Ruggeiro M, Davis M, Koci B, Hammond W, Gillio A et al (1994) Long-term safety of treatment with recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) in patients with severe congenital neutropenias. Br J Haematol 88:723\u2013730","journal-title":"Br J Haematol"},{"key":"697_CR48","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1537-2995.1999.39499235675.x","volume":"39","author":"MK Froberg","year":"1999","unstructured":"Froberg MK, Garg UC, Stroncek DF, Geis M, McCullough J, Brown DM (1999) Changes in serum osteocalcin and bone-specific alkaline phosphatase are associated with bone pain in donors receiving granulocyte-colony-stimulating factor for peripheral blood stem and progenitor cell collection. Transfusion 39:410\u2013414","journal-title":"Transfusion"},{"key":"697_CR49","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1210\/jcem-66-5-951","volume":"66","author":"RJ Duda Jr","year":"1988","unstructured":"Duda RJ Jr, O'Brien JF, Katzmann JA, Peterson JM, Mann KG, Riggs BL (1988) Concurrent assays of circulating bone Gla-protein and bone alkaline phosphatase: effects of sex, age, and metabolic bone disease. J Clin Endocrinol Metab 66:951\u2013957","journal-title":"J Clin Endocrinol Metab"},{"key":"697_CR50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrc747","volume":"2","author":"PW Mantyh","year":"2002","unstructured":"Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP (2002) Molecular mechanisms of cancer pain. Nat Rev Cancer 2:201\u2013209. doi: 10.1038\/nrc747","journal-title":"Nat Rev Cancer"},{"key":"697_CR51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3959(98)00135-3","volume":"78","author":"F Fulfaro","year":"1998","unstructured":"Fulfaro F, Casuccio A, Ticozzi C, Ripamonti C (1998) The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials. Pain 78:157\u2013169","journal-title":"Pain"},{"key":"697_CR52","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jpain.2008.02.004","volume":"9","author":"B Carvalho","year":"2008","unstructured":"Carvalho B, Clark DJ, Angst MS (2008) Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and substance P in incisional wounds and serum following cesarean delivery. J Pain 9:650\u2013657. doi: 10.1016\/j.jpain.2008.02.004","journal-title":"J Pain"},{"key":"697_CR53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pain.2008.02.028","volume":"139","author":"MS Angst","year":"2008","unstructured":"Angst MS, Clark JD, Carvalho B, Tingle M, Schmelz M, Yeomans DC (2008) Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: a microdialysis study. Pain 139:15\u201327. doi: 10.1016\/j.pain.2008.02.028","journal-title":"Pain"},{"key":"697_CR54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1744-8069-4-7","volume":"4","author":"D Liang","year":"2008","unstructured":"Liang D, Shi X, Qiao Y, Angst MS, Yeomans DC, Clark JD (2008) Chronic morphine administration enhances nociceptive sensitivity and local cytokine production after incision. Mol Pain 4:7. doi: 10.1186\/1744-8069-4-7","journal-title":"Mol Pain"},{"key":"697_CR55","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","volume":"85","author":"M Feldmann","year":"1996","unstructured":"Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85:307\u2013310","journal-title":"Cell"},{"key":"697_CR56","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/art.27186","volume":"62","author":"H Kokkonen","year":"2010","unstructured":"Kokkonen H, Soderstrom I, Rocklov J, Hallmans G, Lejon K, Rantapaa Dahlqvist S (2010) Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum 62:383\u2013391. doi: 10.1002\/art.27186","journal-title":"Arthritis Rheum"},{"key":"697_CR57","first-page":"2336","volume":"31","author":"CA Hitchon","year":"2004","unstructured":"Hitchon CA, Alex P, Erdile LB, Frank MB, Dozmorov I, Tang Y, Wong K, Centola M, El-Gabalawy HS (2004) A distinct multicytokine profile is associated with anti-cyclical citrullinated peptide antibodies in patients with early untreated inflammatory arthritis. J Rheumatol 31:2336\u20132346","journal-title":"J Rheumatol"},{"key":"697_CR58","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/ar318","volume":"3","author":"AD Cook","year":"2001","unstructured":"Cook AD, Braine EL, Campbell IK, Rich MJ, Hamilton JA (2001) Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res 3:293\u2013298","journal-title":"Arthritis Res"},{"key":"697_CR59","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1182\/blood-2008-02-139535","volume":"112","author":"JL Eyles","year":"2008","unstructured":"Eyles JL, Hickey MJ, Norman MU, Croker BA, Roberts AW, Drake SF, James WG, Metcalf D, Campbell IK, Wicks IP (2008) A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis. Blood 112:5193\u20135201. doi: 10.1182\/blood-2008-02-139535","journal-title":"Blood"},{"key":"697_CR60","doi-asserted-by":"crossref","first-page":"11398","DOI":"10.1073\/pnas.0404328101","volume":"101","author":"KE Lawlor","year":"2004","unstructured":"Lawlor KE, Campbell IK, Metcalf D, O'Donnell K, van Nieuwenhuijze A, Roberts AW, Wicks IP (2004) Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Proc Natl Acad Sci USA 101:11398\u201311403. doi: 10.1073\/pnas.0404328101","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR61","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrrheum.2009.178","volume":"5","author":"AL Cornish","year":"2009","unstructured":"Cornish AL, Campbell IK, McKenzie BS, Chatfield S, Wicks IP (2009) G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol 5:554\u2013559. doi: 10.1038\/nrrheum.2009.178","journal-title":"Nat Rev Rheumatol"},{"key":"697_CR62","doi-asserted-by":"crossref","first-page":"13473","DOI":"10.1523\/JNEUROSCI.1822-09.2009","volume":"29","author":"M Andratsch","year":"2009","unstructured":"Andratsch M, Mair N, Constantin CE, Scherbakov N, Benetti C, Quarta S, Vogl C, Sailer CA, Uceyler N, Brockhaus J, Martini R, Sommer C, Zeilhofer HU, Muller W, Kuner R, Davis JB, Rose-John S, Kress M (2009) A key role for gp130 expressed on peripheral sensory nerves in pathological pain. J Neurosci 29:13473\u201313483. doi: 10.1523\/JNEUROSCI.1822-09.2009","journal-title":"J Neurosci"},{"key":"697_CR63","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/74999","volume":"6","author":"P Honore","year":"2000","unstructured":"Honore P, Luger NM, Sabino MA, Schwei MJ, Rogers SD, Mach DB, O'Keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW (2000) Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med 6:521\u2013528","journal-title":"Nat Med"},{"key":"697_CR64","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuroscience.2004.12.035","volume":"132","author":"PW Wacnik","year":"2005","unstructured":"Wacnik PW, Eikmeier LJ, Simone DA, Wilcox GL, Beitz AJ (2005) Nociceptive characteristics of tumor necrosis factor-alpha in naive and tumor-bearing mice. Neuroscience 132:479\u2013491","journal-title":"Neuroscience"},{"key":"697_CR65","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1523\/JNEUROSCI.4476-07.2008","volume":"28","author":"CE Constantin","year":"2008","unstructured":"Constantin CE, Mair N, Sailer CA, Andratsch M, Xu ZZ, Blumer MJ, Scherbakov N, Davis JB, Bluethmann H, Ji RR, Kress M (2008) Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci 28:5072\u20135081. doi: 10.1523\/JNEUROSCI.4476-07.2008","journal-title":"J Neurosci"},{"key":"697_CR66","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1073\/pnas.85.23.9253","volume":"85","author":"S Dedhar","year":"1988","unstructured":"Dedhar S, Gaboury L, Galloway P, Eaves C (1988) Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. Proc Natl Acad Sci USA 85:9253\u20139257","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR67","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2249.1991.tb05695.x","volume":"85","author":"VA Danis","year":"1991","unstructured":"Danis VA, Franic GM, Rathjen DA, Brooks PM (1991) Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes. Clin Exp Immunol 85:143\u2013150","journal-title":"Clin Exp Immunol"},{"key":"697_CR68","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1172\/JCI113971","volume":"83","author":"WD Xu","year":"1989","unstructured":"Xu WD, Firestein GS, Taetle R, Kaushansky K, Zvaifler NJ (1989) Cytokines in chronic inflammatory arthritis. II Granulocyte macrophage colony stimulating factor rheumatoid synovial effusions. J Clin Invest 83:876\u2013882","journal-title":"J Clin Invest"},{"key":"697_CR69","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1182\/blood.V72.4.1368.1368","volume":"72","author":"SD Sisson","year":"1988","unstructured":"Sisson SD, Dinarello CA (1988) Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte-macrophage colony-stimulating factor. Blood 72:1368\u20131374","journal-title":"Blood"},{"key":"697_CR70","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/eji.1830190135","volume":"19","author":"W Seelentag","year":"1989","unstructured":"Seelentag W, Mermod JJ, Vassalli P (1989) Interleukin 1 and tumor necrosis factor-alpha additively increase the levels of granulocyte-macrophage and granulocyte colony-stimulating factor (CSF) mRNA in human fibroblasts. Eur J Immunol 19:209\u2013212","journal-title":"Eur J Immunol"},{"key":"697_CR71","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrc990","volume":"3","author":"J Nelson","year":"2003","unstructured":"Nelson J, Bagnato A, Battistini B, Nisen P (2003) The endothelin axis: emerging role in cancer. Nat Rev Cancer 3:110\u2013116. doi: 10.1038\/nrc990","journal-title":"Nat Rev Cancer"},{"key":"697_CR72","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1046\/j.1365-2567.1998.00614.x","volume":"95","author":"B Salh","year":"1998","unstructured":"Salh B, Hoeflick K, Kwan W, Pelech S (1998) Granulocyte-macrophage colony-stimulating factor and interleukin-3 potentiate interferon-gamma-mediated endothelin production by human monocytes: role of protein kinase C. Immunology 95:473\u2013479","journal-title":"Immunology"},{"key":"697_CR73","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cellimm.2005.08.032","volume":"235","author":"JL Owen","year":"2005","unstructured":"Owen JL, Lopez DM, Grosso JF, Guthrie KM, Herbert LM, Torroella-Kouri M, Iragavarapu-Charyulu V (2005) The expression of CCL2 by T lymphocytes of mammary tumor bearers: role of tumor-derived factors. Cell Immunol 235:122\u2013135","journal-title":"Cell Immunol"},{"key":"697_CR74","doi-asserted-by":"crossref","first-page":"10289","DOI":"10.1523\/JNEUROSCI.2851-07.2007","volume":"27","author":"IA Khasabova","year":"2007","unstructured":"Khasabova IA, Stucky CL, Harding-Rose C, Eikmeier L, Beitz AJ, Coicou LG, Hanson AE, Simone DA, Seybold VS (2007) Chemical interactions between fibrosarcoma cancer cells and sensory neurons contribute to cancer pain. J Neurosci 27:10289\u201310298","journal-title":"J Neurosci"},{"key":"697_CR75","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cell.2008.05.053","volume":"134","author":"G Hansen","year":"2008","unstructured":"Hansen G, Hercus TR, McClure BJ, Stomski FC, Dottore M, Powell J, Ramshaw H, Woodcock JM, Xu Y, Guthridge M, McKinstry WJ, Lopez AF, Parker MW (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134:496\u2013507","journal-title":"Cell"},{"key":"697_CR76","doi-asserted-by":"crossref","first-page":"5838","DOI":"10.1073\/pnas.91.13.5838","volume":"91","author":"TR Hercus","year":"1994","unstructured":"Hercus TR, Bagley CJ, Cambareri B, Dottore M, Woodcock JM, Vadas MA, Shannon MF, Lopez AF (1994) Specific human granulocyte-macrophage colony-stimulating factor antagonists. Proc Natl Acad Sci USA 91:5838\u20135842","journal-title":"Proc Natl Acad Sci USA"},{"key":"697_CR77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00280-002-0474-y","volume":"50","author":"IN Olver","year":"2002","unstructured":"Olver IN, Hercus T, Lopez A, Vadas M, Somogyi AA, Doyle I, Foster DJ, Keefe D, Taylor A, Brown M, To LB, Cole J, Rawling T, Cambareri B, Myers M, Olszewski N, Bastiras S, Senn C, Hey A, Verma M, Wigley P (2002) A phase I study of the GM-CSF antagonist E21R. Cancer Chemother Pharmacol 50:171\u2013178. doi: 10.1007\/s00280-002-0474-y","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00109-010-0697-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:10:00Z","timestamp":1711955400000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-010-0697-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,16]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["697"],"URL":"https:\/\/doi.org\/10.1007\/s00109-010-0697-z","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,16]]}}}