{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:21:28Z","timestamp":1793506888387,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T00:00:00Z","timestamp":1312675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s00109-011-0796-5","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T02:13:19Z","timestamp":1312596799000},"page":"1241-1251","source":"Crossref","is-referenced-by-count":44,"title":["Lymphocyte \u03b1-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses"],"prefix":"10.1007","volume":"89","author":[{"given":"Shu-Jung","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Pin","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Min-Shan","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Lun","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shean-Jaw","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Shin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Shan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Pin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chin","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,7]]},"reference":[{"key":"796_CR1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/art.11441","volume":"50","author":"WH Wang","year":"2004","unstructured":"Wang WH, Chang SJ, Wang TN, Cheng LS, Feng YP, Chen CJ, Huang CH, Ko YC (2004) Complex segregation and linkage analysis of familial gout in Taiwanese aborigines. Arthritis Rheum 50:242\u2013246. doi: 10.1002\/art.11441","journal-title":"Arthritis Rheum"},{"key":"796_CR2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1086\/423429","volume":"75","author":"LS Cheng","year":"2004","unstructured":"Cheng LS, Chiang SL, Tu HP, Chang SJ, Wang TN, Ko AM, Chakraborty R, Ko YC (2004) Genomewide scan for gout in Taiwanese aborigines reveals linkage to chromosome 4q25. Am J Hum Genet 75:498\u2013503. doi: 10.1086\/423429","journal-title":"Am J Hum Genet"},{"key":"796_CR3","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1016\/S0960-9822(99)80006-2","volume":"9","author":"AG Ryazanov","year":"1999","unstructured":"Ryazanov AG, Pavur KS, Dorovkov MV (1999) Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol 9:R43\u2013R45","journal-title":"Curr Biol"},{"key":"796_CR4","doi-asserted-by":"crossref","first-page":"25637","DOI":"10.1074\/jbc.M502265200","volume":"280","author":"M Heine","year":"2005","unstructured":"Heine M, Cramm-Behrens CI, Ansari A, Chu HP, Ryazanov AG, Naim HY, Jacob R (2005) Alpha-kinase 1, a new component in apical protein transport. J Biol Chem 280:25637\u201325643. doi: 10.1074\/jbc.M502265200","journal-title":"J Biol Chem"},{"key":"796_CR5","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1016\/S0002-9343(97)89546-0","volume":"100","author":"HR Schumacher","year":"1996","unstructured":"Schumacher HR (1996) Crystal-induced arthritis: an overview. Am J Med 100:46S\u201352S","journal-title":"Am J Med"},{"key":"796_CR6","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/art.20438","volume":"50","author":"JD Bieber","year":"2004","unstructured":"Bieber JD, Terkeltaub RA (2004) Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum 50:2400\u20132414. doi: 10.1002\/art.20438","journal-title":"Arthritis Rheum"},{"key":"796_CR7","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI115142","volume":"87","author":"FS Giovine di","year":"1991","unstructured":"di Giovine FS, Malawista SE, Thornton E, Duff GW (1991) Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest 87:1375\u20131381. doi: 10.1172\/JCI115142","journal-title":"J Clin Invest"},{"key":"796_CR8","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T","volume":"43","author":"R Liu","year":"2000","unstructured":"Liu R, O\u2019Connell M, Johnson K, Pritzker K, Mackman N, Terkeltaub R (2000) Extracellular signal-regulated kinase 1\/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis Rheum 43:1145\u20131155. doi: 10.1002\/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T","journal-title":"Arthritis Rheum"},{"key":"796_CR9","doi-asserted-by":"crossref","first-page":"52797","DOI":"10.1074\/jbc.M403823200","volume":"279","author":"M Jaramillo","year":"2004","unstructured":"Jaramillo M, Godbout M, Naccache PH, Olivier M (2004) Signaling events involved in macrophage chemokine expression in response to monosodium urate crystals. J Biol Chem 279:52797\u201352805. doi: 10.1074\/jbc.M403823200","journal-title":"J Biol Chem"},{"key":"796_CR10","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","volume":"20","author":"SL Wallace","year":"1977","unstructured":"Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, Yu TF (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20:895\u2013900","journal-title":"Arthritis Rheum"},{"key":"796_CR11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJMoa035700","volume":"350","author":"HK Choi","year":"2004","unstructured":"Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (2004) Purine-rich foods, dairy and protein intake, and the risk of gout in men. N Engl J Med 350:1093\u20131103. doi: 10.1056\/NEJMoa035700","journal-title":"N Engl J Med"},{"key":"796_CR12","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1158\/1078-0432.CCR-10-0138","volume":"16","author":"SS Jiang","year":"2010","unstructured":"Jiang SS, Fang WT, Hou YH, Huang SF, Yen BL, Chang JL, Li SM, Liu HP, Liu YL, Huang CT et al (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin Cancer Res 16:4363\u20134373. doi: 10.1158\/1078-0432.CCR-10-0138","journal-title":"Clin Cancer Res"},{"key":"796_CR13","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1093\/nar\/gkn234","volume":"36","author":"LH Ding","year":"2008","unstructured":"Ding LH, Xie Y, Park S, Xiao G, Story MD (2008) Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology. Nucleic Acids Res 36:e58. doi: 10.1093\/nar\/gkn234","journal-title":"Nucleic Acids Res"},{"key":"796_CR14","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/art.10326","volume":"46","author":"C Schiltz","year":"2002","unstructured":"Schiltz C, Liote F, Prudhommeaux F, Meunier A, Champy R, Callebert J, Bardin T (2002) Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events. Arthritis Rheum 46:1643\u20131650. doi: 10.1002\/art.10326","journal-title":"Arthritis Rheum"},{"key":"796_CR15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237\u2013241. doi: 10.1038\/nature04516","journal-title":"Nature"},{"key":"796_CR16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-143-7-200510040-00009","volume":"143","author":"HK Choi","year":"2005","unstructured":"Choi HK, Mount DB, Reginato AM (2005) Pathogenesis of gout. Ann Intern Med 143:499\u2013516","journal-title":"Ann Intern Med"},{"key":"796_CR17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jbspin.2004.12.010","volume":"72","author":"R Liu-Bryan","year":"2005","unstructured":"Liu-Bryan R, Liote F (2005) Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling. Joint Bone Spine 72:295\u2013302. doi: 10.1016\/j.jbspin.2004.12.010","journal-title":"Joint Bone Spine"},{"key":"796_CR18","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/1529-0131(200008)43:8<1779::AID-ANR14>3.0.CO;2-2","volume":"43","author":"DR Yagnik","year":"2000","unstructured":"Yagnik DR, Hillyer P, Marshall D, Smythe CD, Krausz T, Haskard DO, Landis RC (2000) Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in gout. Arthritis Rheum 43:1779\u20131789. doi: 10.1002\/1529-0131(200008)43:8<1779::AID-ANR14>3.0.CO;2-2","journal-title":"Arthritis Rheum"},{"key":"796_CR19","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1002\/art.10614","volume":"46","author":"RC Landis","year":"2002","unstructured":"Landis RC, Yagnik DR, Florey O, Philippidis P, Emons V, Mason JC, Haskard DO (2002) Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. Arthritis Rheum 46:3026\u20133033. doi: 10.1002\/art.10614","journal-title":"Arthritis Rheum"},{"key":"796_CR20","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.177.9.6370","volume":"177","author":"P Scott","year":"2006","unstructured":"Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R (2006) Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J Immunol 177:6370\u20136378","journal-title":"J Immunol"},{"key":"796_CR21","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1002\/art.22938","volume":"56","author":"RM Pope","year":"2007","unstructured":"Pope RM, Tschopp J (2007) The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum 56:3183\u20133188. doi: 10.1002\/art.22938","journal-title":"Arthritis Rheum"},{"key":"796_CR22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","volume":"60","author":"WJ Martin","year":"2009","unstructured":"Martin WJ, Walton M, Harper J (2009) Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum 60:281\u2013289. doi: 10.1002\/art.24185","journal-title":"Arthritis Rheum"},{"key":"796_CR23","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.30249","volume":"63","author":"WJ Martin","year":"2011","unstructured":"Martin WJ, Shaw O, Liu X, Steiger S, Harper JL (2011) Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. Arthritis Rheum 63:1322\u20131332. doi: 10.1002\/art.30249","journal-title":"Arthritis Rheum"},{"key":"796_CR24","doi-asserted-by":"crossref","first-page":"50643","DOI":"10.1074\/jbc.C400441200","volume":"279","author":"MV Dorovkov","year":"2004","unstructured":"Dorovkov MV, Ryazanov AG (2004) Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem 279:50643\u201350646. doi: 10.1074\/jbc.C400441200","journal-title":"J Biol Chem"},{"key":"796_CR25","first-page":"321","volume":"35","author":"LV Riazanova","year":"2001","unstructured":"Riazanova LV, Pavur KS, Petrov AN, Dorovkov MV, Riazanov AG (2001) Novel type of signaling molecules: protein kinases covalently linked to ion channels. Mol Biol (Mosk) 35:321\u2013332","journal-title":"Mol Biol (Mosk)"},{"key":"796_CR26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0014-5793(02)02299-8","volume":"514","author":"AG Ryazanov","year":"2002","unstructured":"Ryazanov AG (2002) Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett 514:26\u201329","journal-title":"FEBS Lett"},{"key":"796_CR27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1189\/jlb.70.6.961","volume":"70","author":"R Liu","year":"2001","unstructured":"Liu R, Aupperle K, Terkeltaub R (2001) Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. J Leukoc Biol 70:961\u2013968","journal-title":"J Leukoc Biol"},{"key":"796_CR28","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.4049\/jimmunol.145.10.3391","volume":"145","author":"JS Bomalaski","year":"1990","unstructured":"Bomalaski JS, Baker DG, Brophy LM, Clark MA (1990) Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein. J Immunol 145:3391\u20133397","journal-title":"J Immunol"},{"key":"796_CR29","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1182\/blood.V86.9.3567.bloodjournal8693567","volume":"86","author":"M Gaudry","year":"1995","unstructured":"Gaudry M, Gilbert C, Barabe F, Poubelle PE, Naccache PH (1995) Activation of Lyn is a common element of the stimulation of human neutrophils by soluble and particulate agonists. Blood 86:3567\u20133574","journal-title":"Blood"},{"key":"796_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-12-1","volume":"12","author":"M Chen","year":"2011","unstructured":"Chen M, Xu R (2011) Motor coordination deficits in Alpk1 mutant mice with the inserted piggyBac transposon. BMC Neurosci 12:1. doi: 10.1186\/1471-2202-12-1","journal-title":"BMC Neurosci"},{"key":"796_CR31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","volume":"417","author":"A Enomoto","year":"2002","unstructured":"Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T et al (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447\u2013452. doi: 10.1038\/nature742","journal-title":"Nature"},{"key":"796_CR32","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1083\/jcb.200701144","volume":"177","author":"RE McConnell","year":"2007","unstructured":"McConnell RE, Tyska MJ (2007) Myosin-1a powers the sliding of apical membrane along microvillar actin bundles. J Cell Biol 177:671\u2013681. doi: 10.1083\/jcb.200701144","journal-title":"J Cell Biol"},{"key":"796_CR33","doi-asserted-by":"crossref","first-page":"C20","DOI":"10.1152\/ajpcell.00368.2004","volume":"288","author":"B Brone","year":"2005","unstructured":"Brone B, Eggermont J (2005) PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes. Am J Physiol Cell Physiol 288:C20\u2013C29. doi: 10.1152\/ajpcell.00368.2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"796_CR34","doi-asserted-by":"crossref","first-page":"45942","DOI":"10.1074\/jbc.M406724200","volume":"279","author":"N Anzai","year":"2004","unstructured":"Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K et al (2004) The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus. J Biol Chem 279:45942\u201345950. doi: 10.1074\/jbc.M406724200","journal-title":"J Biol Chem"},{"key":"796_CR35","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1681\/ASN.2006090980","volume":"18","author":"R Cunningham","year":"2007","unstructured":"Cunningham R, Brazie M, Kanumuru S, Xiaofei E, Biswas R, Wang F, Steplock D, Wade JB, Anzai N, Endou H et al (2007) Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol 18:1419\u20131425. doi: 10.1681\/ASN.2006090980","journal-title":"J Am Soc Nephrol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-011-0796-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-011-0796-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-011-0796-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T11:31:36Z","timestamp":1686223896000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-011-0796-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,7]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["796"],"URL":"https:\/\/doi.org\/10.1007\/s00109-011-0796-5","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,7]]}}}