{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:44Z","timestamp":1790009564701,"version":"4.0.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T00:00:00Z","timestamp":1315612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00109-011-0812-9","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T13:24:58Z","timestamp":1315574698000},"page":"119-126","source":"Crossref","is-referenced-by-count":23,"title":["Blood coagulation factor XII\u2014a neglected player in stroke pathophysiology"],"prefix":"10.1007","volume":"90","author":[{"given":"Mirko","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Nieswandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kleinschnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,10]]},"reference":[{"key":"812_CR1","unstructured":"Eurostat (2011) Absolute number of causes of death in Europe (27 member states). European Commission, . http:\/\/epp.eurostat.ec.europa.eu"},{"key":"812_CR2","unstructured":"WHO (2008) The global burden of disease: 2004 update (edited by WHO). World Health Organization, Geneva"},{"key":"812_CR3","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/STROKEAHA.110.599712","volume":"42","author":"AE Kunst","year":"2011","unstructured":"Kunst AE, Amiri M, Janssen F (2011) The decline in stroke mortality: exploration of future trends in 7 Western European countries. Stroke 42:2126\u20132130","journal-title":"Stroke"},{"key":"812_CR4","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1161\/CIR.0b013e3182009701","volume":"123","author":"VL Roger","year":"2011","unstructured":"Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES (2011) Heart disease and stroke statistics\u20142011 update: a report from the American Heart Association. Circulation 123:e18\u2013e209","journal-title":"Circulation"},{"key":"812_CR5","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","volume":"333","author":"The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group","year":"1995","unstructured":"The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581\u20131587","journal-title":"N Engl J Med"},{"key":"812_CR6","unstructured":"Hacke W (2008) Leitlinie der DGN 2008\u2014Akuttherapie des isch\u00e4mischen Schlaganfalls DGN. http:\/\/www.dgn.org\/images\/stories\/dgn\/leitlinien\/LL2008\/ll08kap_023.pdf"},{"key":"812_CR7","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T et al (2008) Thrombolysis with alteplase 3 to 4.5\u00a0hours after acute ischemic stroke. N Engl J Med 359:1317\u20131329","journal-title":"N Engl J Med"},{"key":"812_CR8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/STROKEAHA.107.497115","volume":"39","author":"WS Smith","year":"2008","unstructured":"Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S et al (2008) Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke 39:1205\u20131212","journal-title":"Stroke"},{"key":"812_CR9","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/archneur.65.8.1024","volume":"65","author":"LG Stead","year":"2008","unstructured":"Stead LG, Gilmore RM, Bellolio MF, Rabinstein AA, Decker WW (2008) Percutaneous clot removal devices in acute ischemic stroke: a systematic review and meta-analysis. Arch Neurol 65:1024\u20131030","journal-title":"Arch Neurol"},{"key":"812_CR10","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.282.21.2003","volume":"282","author":"A Furlan","year":"1999","unstructured":"Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: A randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 282:2003\u20132011","journal-title":"JAMA"},{"key":"812_CR11","unstructured":"Gubitz G, Counsell C, Sandercock P, Signorini D (2000) Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev (2):CD000024"},{"key":"812_CR12","doi-asserted-by":"crossref","unstructured":"Gubitz G, Sandercock P, Counsell C (2004) Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev (3):CD000024","DOI":"10.1002\/14651858.CD000024.pub2"},{"key":"812_CR13","doi-asserted-by":"crossref","unstructured":"Sandercock PA, Counsell C, Kamal AK (2008) Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev (4):CD000024","DOI":"10.1002\/14651858.CD000024.pub3"},{"key":"812_CR14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1474-4422(10)70038-7","volume":"9","author":"GJ Hankey","year":"2010","unstructured":"Hankey GJ, Eikelboom JW (2010) Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events. Lancet Neurol 9:273\u2013284","journal-title":"Lancet Neurol"},{"key":"812_CR15","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0140-6736(99)04407-4","volume":"354","author":"GJ Hankey","year":"1999","unstructured":"Hankey GJ, Warlow CP (1999) Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populations. Lancet 354:1457\u20131463","journal-title":"Lancet"},{"key":"812_CR16","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/europace\/euq350","volume":"12","author":"AJ Camm","year":"2010","unstructured":"Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B et al (2010) Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 12:1360\u20131420","journal-title":"Europace"},{"key":"812_CR17","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","volume":"361","author":"SJ Connolly","year":"2009","unstructured":"Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J et al (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139\u20131151","journal-title":"N Engl J Med"},{"key":"812_CR18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrcardio.2010.206","volume":"8","author":"SJ Connolly","year":"2011","unstructured":"Connolly SJ (2011) Atrial fibrillation in 2010: advances in treatment and management. Nat Rev Cardiol 8:67\u201368","journal-title":"Nat Rev Cardiol"},{"key":"812_CR19","doi-asserted-by":"crossref","unstructured":"Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP et al (2011) Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation. N Engl J Med 2011 Aug 10. [Epub ahead of print]","DOI":"10.1056\/NEJMoa1009638"},{"key":"812_CR20","unstructured":"Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A et al (2011) Apixaban versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med 2011 Aug 27 [Epub ahead of print]"},{"key":"812_CR21","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1182\/blood-2008-04-144758","volume":"112","author":"G Stoll","year":"2008","unstructured":"Stoll G, Kleinschnitz C, Nieswandt B (2008) Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment. Blood 112:3555\u20133562","journal-title":"Blood"},{"key":"812_CR22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1749-6632.2010.05730.x","volume":"1207","author":"G Stoll","year":"2010","unstructured":"Stoll G, Kleinschnitz C, Nieswandt B (2010) Combating innate inflammation: a new paradigm for acute treatment of stroke. Ann NY Acad Sci 1207:149\u2013154","journal-title":"Ann NY Acad Sci"},{"key":"812_CR23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2040-7378-1-8","volume":"1","author":"S Braeuninger","year":"2009","unstructured":"Braeuninger S, Kleinschnitz C (2009) Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems. Exp Transl Stroke Med 1:8","journal-title":"Exp Transl Stroke Med"},{"key":"812_CR24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/01616412.1997.11740874","volume":"19","author":"WM Clark","year":"1997","unstructured":"Clark WM, Lessov NS, Dixon MP, Eckenstein F (1997) Monofilament intraluminal middle cerebral artery occlusion in the mouse. Neurol Res 19:641\u2013648","journal-title":"Neurol Res"},{"key":"812_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3995\/jstroke.8.1","volume":"8","author":"J Koizumi","year":"1986","unstructured":"Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischemic brain edema. I: A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke 8:1\u20138","journal-title":"Jpn J Stroke"},{"key":"812_CR26","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/ana.10380","volume":"52","author":"CS Kidwell","year":"2002","unstructured":"Kidwell CS, Saver JL, Starkman S, Duckwiler G, Jahan R, Vespa P, Villablanca JP, Liebeskind DS, Gobin YP, Vinuela F et al (2002) Late secondary ischemic injury in patients receiving intraarterial thrombolysis. Ann Neurol 52:698\u2013703","journal-title":"Ann Neurol"},{"key":"812_CR27","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/CIRCULATIONAHA.107.691279","volume":"115","author":"C Kleinschnitz","year":"2007","unstructured":"Kleinschnitz C, Pozgajova M, Pham M, Bendszus M, Nieswandt B, Stoll G (2007) Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb\/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation 115:2323\u20132330","journal-title":"Circulation"},{"key":"812_CR28","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.neuroimage.2009.11.061","volume":"49","author":"M Pham","year":"2010","unstructured":"Pham M, Kleinschnitz C, Helluy X, Bartsch AJ, Austinat M, Behr VC, Renne T, Nieswandt B, Stoll G, Bendszus M (2010) Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI. Neuroimage 49:2907\u20132914","journal-title":"Neuroimage"},{"key":"812_CR29","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/01.STR.31.6.1402","volume":"31","author":"T Abumiya","year":"2000","unstructured":"Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF, Pierschbacher MD, del Zoppo GJ (2000) Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke 31:1402\u20131410","journal-title":"Stroke"},{"key":"812_CR30","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI3338","volume":"102","author":"TF Choudhri","year":"1998","unstructured":"Choudhri TF, Hoh BL, Zerwes HG, Prestigiacomo CJ, Kim SC, Connolly ES Jr, Kottirsch G, Pinsky DJ (1998) Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb\/IIIa receptor-mediated platelet aggregation. J Clin Invest 102:1301\u20131310","journal-title":"J Clin Invest"},{"key":"812_CR31","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/01.STR.22.10.1276","volume":"22","author":"GJ Zoppo del","year":"1991","unstructured":"del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM (1991) Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke 22:1276\u20131283","journal-title":"Stroke"},{"key":"812_CR32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/01.STR.11.5.517","volume":"11","author":"U Ito","year":"1980","unstructured":"Ito U, Ohno K, Yamaguchi T, Tomita H, Inaba Y, Kashima M (1980) Transient appearance of \u201cno-reflow\u201d phenomenon in Mongolian gerbils. Stroke 11:517\u2013521","journal-title":"Stroke"},{"key":"812_CR33","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.STR.25.9.1847","volume":"25","author":"Y Okada","year":"1994","unstructured":"Okada Y, Copeland BR, Fitridge R, Koziol JA, del Zoppo GJ (1994) Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion. Stroke 25:1847\u20131853","journal-title":"Stroke"},{"key":"812_CR34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1097\/01.WCB.0000078322.96027.78","volume":"23","author":"GJ Zoppo del","year":"2003","unstructured":"del Zoppo GJ, Mabuchi T (2003) Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab 23:879\u2013894","journal-title":"J Cereb Blood Flow Metab"},{"key":"812_CR35","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1126\/science.145.3638.1310","volume":"145","author":"EW Davie","year":"1964","unstructured":"Davie EW, Ratnoff OD (1964) Waterfall sequence for intrinsic blood clotting. Science 145:1310\u20131312","journal-title":"Science"},{"key":"812_CR36","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/202498a0","volume":"202","author":"RG Macfarlane","year":"1964","unstructured":"Macfarlane RG (1964) An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 202:498\u2013499","journal-title":"Nature"},{"key":"812_CR37","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1160\/TH04-10-0650","volume":"93","author":"G Mariani","year":"2005","unstructured":"Mariani G, Herrmann FH, Dolce A, Batorova A, Etro D, Peyvandi F, Wulff K, Schved JF, Auerswald G, Ingerslev J et al (2005) Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. Thromb Haemost 93:481\u2013487","journal-title":"Thromb Haemost"},{"key":"812_CR38","first-page":"704","volume":"89","author":"M Giansily-Blaizot","year":"2004","unstructured":"Giansily-Blaizot M, Verdier R, Biron-Adreani C, Schved JF, Bertrand MA, Borg JY, Le Cam-Duchez V, Briquel ME, Chambost H, Pouymayou K et al (2004) Analysis of biological phenotypes from 42 patients with inherited factor VII deficiency: can biological tests predict the bleeding risk? Haematologica 89:704\u2013709","journal-title":"Haematologica"},{"key":"812_CR39","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/36862","volume":"390","author":"ED Rosen","year":"1997","unstructured":"Rosen ED, Chan JC, Idusogie E, Clotman F, Vlasuk G, Luther T, Jalbert LR, Albrecht S, Zhong L, Lissens A et al (1997) Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature 390:290\u2013294","journal-title":"Nature"},{"key":"812_CR40","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1073\/pnas.93.13.6258","volume":"93","author":"TH Bugge","year":"1996","unstructured":"Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmback K, Danton MJ, Colbert MC, Witte DP, Fujikawa K, Davie EW et al (1996) Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci USA 93:6258\u20136263","journal-title":"Proc Natl Acad Sci USA"},{"key":"812_CR41","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1073\/pnas.0608647104","volume":"104","author":"C Kannemeier","year":"2007","unstructured":"Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, Song Y, Tzima E, Kennerknecht E, Niepmann M et al (2007) Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci USA 104:6388\u20136393","journal-title":"Proc Natl Acad Sci USA"},{"key":"812_CR42","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2009.11.001","volume":"139","author":"F Muller","year":"2009","unstructured":"Muller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, Schmidbauer S, Gahl WA, Morrissey JH, Renne T (2009) Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139:1143\u20131156","journal-title":"Cell"},{"key":"812_CR43","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/0002-9343(57)90383-2","volume":"23","author":"RT Jim","year":"1957","unstructured":"Jim RT, Goldfein S (1957) Hageman trait (Hageman factor deficiency). Am J Med 23:824\u2013831","journal-title":"Am J Med"},{"key":"812_CR44","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1182\/blood.V11.8.745.745","volume":"11","author":"B Ramot","year":"1956","unstructured":"Ramot B, Singer K, Heller P, Zimmerman HJ (1956) Hageman factor (HF) deficiency. Blood 11:745\u2013752","journal-title":"Blood"},{"key":"812_CR45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-0038-1650025","volume":"43","author":"OD Ratnoff","year":"1980","unstructured":"Ratnoff OD (1980) A quarter century with Mr Hageman. Thromb Haemost 43:95\u201398","journal-title":"Thromb Haemost"},{"key":"812_CR46","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1172\/JCI103109","volume":"34","author":"OD Ratnoff","year":"1955","unstructured":"Ratnoff OD, Colopy JE (1955) A familial hemorrhagic trait associated with a deficiency of a clot-promoting fraction of plasma. J Clin Invest 34:602\u2013613","journal-title":"J Clin Invest"},{"key":"812_CR47","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.20050664","volume":"202","author":"T Renne","year":"2005","unstructured":"Renne T, Pozgajova M, Gruner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B (2005) Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 202:271\u2013281","journal-title":"J Exp Med"},{"key":"812_CR48","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1084\/jem.20052458","volume":"203","author":"C Kleinschnitz","year":"2006","unstructured":"Kleinschnitz C, Stoll G, Bendszus M, Schuh K, Pauer HU, Burfeind P, Renne C, Gailani D, Nieswandt B, Renne T (2006) Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med 203:513\u2013518","journal-title":"J Exp Med"},{"key":"812_CR49","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/CIRCULATIONAHA.109.924761","volume":"121","author":"I Hagedorn","year":"2010","unstructured":"Hagedorn I, Schmidbauer S, Pleines I, Kleinschnitz C, Kronthaler U, Stoll G, Dickneite G, Nieswandt B (2010) Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. Circulation 121:1510\u20131517","journal-title":"Circulation"},{"key":"812_CR50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.190.1.91","volume":"190","author":"TF Choudhri","year":"1999","unstructured":"Choudhri TF, Hoh BL, Prestigiacomo CJ, Huang J, Kim LJ, Schmidt AM, Kisiel W, Connolly ES Jr, Pinsky DJ (1999) Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage. J Exp Med 190:91\u201399","journal-title":"J Exp Med"},{"key":"812_CR51","doi-asserted-by":"crossref","first-page":"5260","DOI":"10.1073\/pnas.74.12.5260","volume":"74","author":"B Osterud","year":"1977","unstructured":"Osterud B, Rapaport SI (1977) Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA 74:5260\u20135264","journal-title":"Proc Natl Acad Sci USA"},{"key":"812_CR52","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.20060217","volume":"203","author":"RW Colman","year":"2006","unstructured":"Colman RW (2006) Are hemostasis and thrombosis two sides of the same coin? J Exp Med 203:493\u2013495","journal-title":"J Exp Med"},{"key":"812_CR53","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm0710-759","volume":"16","author":"CT Esmon","year":"2010","unstructured":"Esmon CT (2010) Far from the heart: counteracting coagulation. Nat Med 16:759\u2013760","journal-title":"Nat Med"},{"key":"812_CR54","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1161\/ATVBAHA.107.155952","volume":"27","author":"D Gailani","year":"2007","unstructured":"Gailani D, Renne T (2007) Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol 27:2507\u20132513","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"812_CR55","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/j.1538-7836.2007.02687.x","volume":"5","author":"JW Govers-Riemslag","year":"2007","unstructured":"Govers-Riemslag JW, Smid M, Cooper JA, Bauer KA, Rosenberg RD, Hack CE, Hamulyak K, Spronk HM, Miller GJ, ten Cate H (2007) The plasma kallikrein\u2013kinin system and risk of cardiovascular disease in men. J Thromb Haemost 5:1896\u20131903","journal-title":"J Thromb Haemost"},{"key":"812_CR56","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1161\/CIRCULATIONAHA.110.943738","volume":"122","author":"B Siegerink","year":"2010","unstructured":"Siegerink B, Govers-Riemslag JW, Rosendaal FR, Ten Cate H, Algra A (2010) Intrinsic coagulation activation and the risk of arterial thrombosis in young women: results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) case\u2013control study. Circulation 122:1854\u20131861","journal-title":"Circulation"},{"key":"812_CR57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1177\/107602960501100313","volume":"11","author":"A Girolami","year":"2005","unstructured":"Girolami A, Gavasso S, Pacquola E, Cabrio L, Lombardi AM, Girolami B (2005) Comparable levels of activity and antigen in factor XII deficiency: a study of 21 homozygotes and 58 heterozygotes. Clin Appl Thromb Hemost 11:335\u2013338","journal-title":"Clin Appl Thromb Hemost"},{"key":"812_CR58","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1182\/blood-2007-10-120139","volume":"111","author":"O Salomon","year":"2008","unstructured":"Salomon O, Steinberg DM, Koren-Morag N, Tanne D, Seligsohn U (2008) Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. Blood 111:4113\u20134117","journal-title":"Blood"},{"key":"812_CR59","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MOH.0b013e328309ec85","volume":"15","author":"F Muller","year":"2008","unstructured":"Muller F, Renne T (2008) Novel roles for factor XII-driven plasma contact activation system. Curr Opin Hematol 15:516\u2013521","journal-title":"Curr Opin Hematol"},{"key":"812_CR60","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/STROKEAHA.108.526673","volume":"40","author":"M Austinat","year":"2009","unstructured":"Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, Stoll G, Renne T, Kleinschnitz C (2009) Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema. Stroke 40:285\u2013293","journal-title":"Stroke"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-011-0812-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-011-0812-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-011-0812-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T12:52:19Z","timestamp":1592916739000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-011-0812-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,10]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["812"],"URL":"https:\/\/doi.org\/10.1007\/s00109-011-0812-9","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,10]]}}}