{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:03:09Z","timestamp":1791356589516,"version":"4.3.1"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,1,19]],"date-time":"2013-01-19T00:00:00Z","timestamp":1358553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s00109-013-0998-0","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T09:47:43Z","timestamp":1358502463000},"page":"297-309","source":"Crossref","is-referenced-by-count":221,"title":["Vascular remodeling in pulmonary hypertension"],"prefix":"10.1007","volume":"91","author":[{"given":"Larissa A.","family":"Shimoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Laurie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,19]]},"reference":[{"key":"998_CR1","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"N Galie","year":"2009","unstructured":"Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS et al (2009) Guidelines for the diagnosis and treatment of pulmonary hypertension: the Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30:2493\u20132537","journal-title":"Eur Heart J"},{"key":"998_CR2","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jacc.2009.04.011","volume":"54","author":"DB Badesch","year":"2009","unstructured":"Badesch DB, Champion HC, Sanchez MA, Hoeper MM, Loyd JE, Manes A, McGoon M, Naeije R, Olschewski H, Oudiz RJ et al (2009) Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol 54:S55\u2013S66","journal-title":"J Am Coll Cardiol"},{"key":"998_CR3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1172\/JCI11144","volume":"106","author":"NF Voelkel","year":"2000","unstructured":"Voelkel NF, Tuder RM (2000) Hypoxia-induced pulmonary vascular remodeling: a model for what human disease? J Clin Invest 106:733\u2013738","journal-title":"J Clin Invest"},{"key":"998_CR4","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","volume":"297","author":"KR Stenmark","year":"2009","unstructured":"Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF (2009) Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 297:L1013\u2013L1032","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1055\/s-0029-1233307","volume":"30","author":"RM Tuder","year":"2009","unstructured":"Tuder RM (2009) Pathology of pulmonary arterial hypertension. Semin Respir Crit Care Med 30:376\u2013385","journal-title":"Semin Respir Crit Care Med"},{"key":"998_CR6","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1097\/PCC.0b013e3181c76db3","volume":"11","author":"KR Stenmark","year":"2010","unstructured":"Stenmark KR, Rabinovitch M (2010) Emerging therapies for the treatment of pulmonary hypertension. Pediatr Crit Care Med 11:S85\u2013S90","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"998_CR7","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1378\/chest.07-1246","volume":"132","author":"CT-J Gan","year":"2007","unstructured":"Gan CT-J, Lankhaar J-W, Westerhof N, Marcus JT, Becker A, Twisk JWR, Boonstra A, Postmus PE, Vonk-Noordegraaf A (2007) Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension. Chest 132(6):1906\u20131912","journal-title":"Chest"},{"key":"998_CR8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jacc.2005.09.054","volume":"47","author":"S Mahapatra","year":"2006","unstructured":"Mahapatra S, Nishimura RA, Sorajja P, Cha S, McGoon MD (2006) Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertension. J Am Coll Cardiol 47:799\u2013803","journal-title":"J Am Coll Cardiol"},{"key":"998_CR9","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1152\/japplphysiol.00533.2010","volume":"110","author":"RR Vanderpool","year":"2011","unstructured":"Vanderpool RR, Kim AR, Molthen R, Chesler NC (2011) Effects of acute Rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function. J Appl Physiol 110:188\u2013198","journal-title":"J Appl Physiol"},{"key":"998_CR10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.RES.0000174287.17953.83","volume":"97","author":"J-M Hyvelin","year":"2005","unstructured":"Hyvelin J-M, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P (2005) Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 97:185\u2013191","journal-title":"Circ Res"},{"key":"998_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1161\/01.RES.00000175934.68087.29","volume":"97","author":"KR Stenmark","year":"2005","unstructured":"Stenmark KR, McMurtry IF (2005) Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res 97:95\u201398","journal-title":"Circ Res"},{"key":"998_CR12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-1-60761-500-2_19","volume":"661","author":"IV McMurtry","year":"2010","unstructured":"McMurtry IV, Abe K, Ota H, Fagan KA, Oka M (2010) Rho kinase-mediated vasoconstriction in pulmonary hypertension. Adv Exp Med Biol 661:299\u2013308","journal-title":"Adv Exp Med Biol"},{"key":"998_CR13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1542\/peds.34.4.568","volume":"34","author":"D Penaloza","year":"1964","unstructured":"Penaloza D, Arias-Stella J, Sime F, Recavarren S, Marticorena E (1964) The heart and pulmonary circulation in children at high altitudes: physiological, anatomical, and clinical observations. Pediatrics 34:568\u2013582","journal-title":"Pediatrics"},{"key":"998_CR14","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/jappl.1956.9.3.328","volume":"9","author":"A Rotta","year":"1956","unstructured":"Rotta A, Canepa A, Hurtado A, Velasquez T, Chavez R (1956) Pulmonary circulation at sea level and at high altitudes. J Appl Physiol 9:328\u2013336","journal-title":"J Appl Physiol"},{"key":"998_CR15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0002-9149(65)90025-1","volume":"16","author":"R Pryor","year":"1965","unstructured":"Pryor R, Weaver WF, Blount SG (1965) Electrocardiographic observation of 493 residents living at high altitude (10,150 feet). Am J Cardiol 16:494\u2013499","journal-title":"Am J Cardiol"},{"key":"998_CR16","first-page":"447","volume":"71","author":"RL Naeye","year":"1961","unstructured":"Naeye RL (1961) Hypoxemia and pulmonary hypertension. A study of the pulmonary vasculature. Arch Pathol 71:447\u2013452","journal-title":"Arch Pathol"},{"key":"998_CR17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1161\/01.RES.16.1.33","volume":"16","author":"RL Naeye","year":"1965","unstructured":"Naeye RL (1965) Children at high altitude: pulmonary and renal abnormalities. Circ Res 16:33\u201338","journal-title":"Circ Res"},{"key":"998_CR18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/01.CIR.28.5.915","volume":"28","author":"J Arias-Stella","year":"1963","unstructured":"Arias-Stella J, Saldana M (1963) The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28:915\u2013925","journal-title":"Circulation"},{"key":"998_CR19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/thx.36.8.599","volume":"36","author":"D Heath","year":"1981","unstructured":"Heath D, Smith P, Rios Dalenz J, Williams D, Harris P (1981) Small pulmonary arteries in some natives of La Paz, Bolivia. Thorax 36:599\u2013604","journal-title":"Thorax"},{"key":"998_CR20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1152\/jappl.1993.74.1.312","volume":"74","author":"BM Groves","year":"1993","unstructured":"Groves BM, Droma T, Sutton JR, McCullough RG, McCullough RE, Zhuang J, Rapmund G, Sun S, Janes C, Moore LG (1993) Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658\u00a0m. J Appl Physiol 74:312\u2013318","journal-title":"J Appl Physiol"},{"key":"998_CR21","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1164\/ajrccm\/145.5.1201","volume":"145","author":"ML Gupta","year":"1992","unstructured":"Gupta ML, Rao KS, Anand IS, Banerjee AK, Boparai MS (1992) Lack of smooth muscle in the small pulmonary arteries of the native Ladakhi. Is the Himalayan highlander adapted? Am Rev Respir Dis 145:1201\u20131204","journal-title":"Am Rev Respir Dis"},{"key":"998_CR22","first-page":"65","volume":"66","author":"M Wilkinson","year":"1988","unstructured":"Wilkinson M, Langhorne CA, Heath D, Barer GR, Howard P (1988) A pathophysiological study of 10 cases of hypoxic cor pulmonale. Q J Med 66:65\u201385","journal-title":"Q J Med"},{"key":"998_CR23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1164\/ajrccm.149.2.8306040","volume":"149","author":"JA Barber\u00e0","year":"1994","unstructured":"Barber\u00e0 JA, Riverola A, Roca J, Ramirez J, Wagner PD, Ros D, Wiggs BR, Rodriguez-Roisin R (1994) Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease. Am J Respir Crit Care Med 149:423\u2013429","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00175982","volume":"170","author":"JL Wright","year":"1992","unstructured":"Wright JL, Petty T, Thurlbeck WM (1992) Analysis of the structure of the muscular pulmonary arteries in patients with pulmonary hypertension and COPD: National Institutes of Health nocturnal oxygen therapy trial. Lung 170:109\u2013124","journal-title":"Lung"},{"key":"998_CR25","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1183\/09031936.02.00245902","volume":"19","author":"S Santos","year":"2002","unstructured":"Santos S, Peinado VI, Ram\u00edrez J, Melgosa T, Roca J, Rodriguez-Roisin R, Barber\u00e0 JA (2002) Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J 19:632\u2013638","journal-title":"Eur Respir J"},{"key":"998_CR26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4103\/2045-8932.87295","volume":"3","author":"N Voelkel","year":"2011","unstructured":"Voelkel N, Mizuno S, Gomez-Arroyo J (2011) COPD\/emphysema: the vascular story. Pulm Circ 3:320","journal-title":"Pulm Circ"},{"key":"998_CR27","first-page":"3","volume":"204","author":"GH Glover","year":"1915","unstructured":"Glover GH, Newsom IE (1915) Brisket disease: dropsy of high altitudes. Colo Agric Exp Station 204:3\u201324","journal-title":"Colo Agric Exp Station"},{"key":"998_CR28","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1152\/japplphysiol.01017.2004","volume":"98","author":"J Rhodes","year":"2005","unstructured":"Rhodes J (2005) Comparative physiology of hypoxic pulmonary hypertension: historical clues from brisket disease. J Appl Physiol 98:1092\u20131100","journal-title":"J Appl Physiol"},{"key":"998_CR29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1152\/jappl.1987.62.2.821","volume":"62","author":"KR Stenmark","year":"1987","unstructured":"Stenmark KR, Fasules J, Hyde DM, Voelkel NF, Henson J, Tucker A, Wilson H, Reeves JT (1987) Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300\u00a0m. J Appl Physiol 62:821\u2013830","journal-title":"J Appl Physiol"},{"key":"998_CR30","first-page":"H818","volume":"236","author":"M Rabinovitch","year":"1979","unstructured":"Rabinovitch M, Gamble WJ, Nadas AS, Miettinen OS, Reid L (1979) Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol 236:H818\u2013H827","journal-title":"Am J Physiol"},{"key":"998_CR31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1152\/japplphysiol.00274.2007","volume":"103","author":"M Rabinovitch","year":"2007","unstructured":"Rabinovitch M, Chesler N, Molthen RC (2007) Point:counterpoint: chronic hypoxia-induced pulmonary hypertension does\/does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1449\u20131451","journal-title":"J Appl Physiol"},{"key":"998_CR32","first-page":"542","volume":"57","author":"A Hislop","year":"1976","unstructured":"Hislop A, Reid L (1976) New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 57:542\u2013554","journal-title":"Br J Exp Pathol"},{"key":"998_CR33","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1152\/japplphysiol.00739.2007","volume":"103","author":"JT Berg","year":"2007","unstructured":"Berg JT (2007) Chronic hypoxia-induced pulmonary hypertension does\/does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1455","journal-title":"J Appl Physiol"},{"key":"998_CR34","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/japplphysiol.00274.2007a","volume":"103","author":"P Mcloughlin","year":"2007","unstructured":"Mcloughlin P, Mcmurtry I (2007) Counterpoint: chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature. J Appl Physiol 103:1451\u20131453, discussion 1453\u20131454","journal-title":"J Appl Physiol"},{"key":"998_CR35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.2002.030676","volume":"547","author":"K Howell","year":"2003","unstructured":"Howell K, Preston RJ, McLoughlin P (2003) Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation. J Physiol 547:133\u2013145","journal-title":"J Physiol"},{"key":"998_CR36","doi-asserted-by":"crossref","first-page":"L580","DOI":"10.1152\/ajplung.00281.2007","volume":"293","author":"NR Bauer","year":"2007","unstructured":"Bauer NR, Moore TM, McMurtry IF (2007) Rodent models of PAH: are we there yet? Am J Physiol Lung Cell Mol Physiol 293:L580\u2013L582","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1465-9921-8-15","volume":"8","author":"R Paddenberg","year":"2007","unstructured":"Paddenberg R, Stieger P, Von Lilien A-L, Faulhammer P, Goldenberg A, Tillmanns HH, Kummer W, Braun-Dullaeus RC (2007) Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice. Respir Res 8:15","journal-title":"Respir Res"},{"key":"998_CR38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/01.RES.0000243584.45145.3f","volume":"99","author":"KR Stenmark","year":"2006","unstructured":"Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99:675\u2013691","journal-title":"Circ Res"},{"key":"998_CR39","first-page":"377","volume":"73","author":"RS Jaenke","year":"1973","unstructured":"Jaenke RS, Alexander AF (1973) Fine structural alterations of bovine peripheral pulmonary arteries in hypoxia-induced hypertension. Am J Pathol 73:377\u2013398","journal-title":"Am J Pathol"},{"key":"998_CR40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0034-5687(01)00217-1","volume":"127","author":"T Nagaoka","year":"2001","unstructured":"Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y (2001) Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 127:53\u201360","journal-title":"Respir Physiol"},{"key":"998_CR41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1164\/ajrccm\/145.4_Pt_1.793","volume":"145","author":"K Sato","year":"1992","unstructured":"Sato K, Webb S, Tucker A, Rabinovitch M, O\u2019Brien RF, McMurtry IF, Stelzner TJ (1992) Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Respir Dis 145:793\u2013797","journal-title":"Am Rev Respir Dis"},{"key":"998_CR42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1096\/fj.00-0343com","volume":"15","author":"L Taraseviciene-Stewart","year":"2001","unstructured":"Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF, Tuder RM (2001) Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 15:427\u2013438","journal-title":"FASEB J"},{"key":"998_CR43","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/CIRCULATIONAHA.109.927681","volume":"121","author":"K Abe","year":"2010","unstructured":"Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, Voelkel NF, McMurtry IF, Oka M (2010) Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation 121:2747\u20132754","journal-title":"Circulation"},{"key":"998_CR44","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1164\/rccm.201103-0412OC","volume":"184","author":"L Ciuclan","year":"2012","unstructured":"Ciuclan L, Bonneau O, Hussey M, Duggan N, Holmes AM, Good R, Stringer R, Jones P, Morrell NW, Jarai G et al (2012) A novel murine model of severe pulmonary arterial hypertension. Am J Respir Crit Care Med 184:1171\u20131182","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR45","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/thx.22.2.176","volume":"22","author":"JM Kay","year":"1967","unstructured":"Kay JM, Harris P, Heath D (1967) Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax 22:176\u2013179","journal-title":"Thorax"},{"key":"998_CR46","doi-asserted-by":"crossref","first-page":"L977","DOI":"10.1152\/ajplung.00362.2011","volume":"302","author":"J Gomez-Arroyo","year":"2012","unstructured":"Gomez-Arroyo J, Saleem SJ, Mizuno S, Syed AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D et al (2012) A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Am J Physiol Lung Cell Mol Physiol 302:L977\u2013L991","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR47","first-page":"H692","volume":"239","author":"B Meyrick","year":"1980","unstructured":"Meyrick B, Gamble W, Reid L (1980) Development of Crotalaria pulmonary hypertension: hemodynamic and structural study. Am J Physiol 239:H692\u2013H702","journal-title":"Am J Physiol"},{"key":"998_CR48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1172\/JCI118809","volume":"98","author":"Y Tanaka","year":"1996","unstructured":"Tanaka Y, Schuster DP, Davis EC, Patterson GA, Botney MD (1996) The role of vascular injury and hemodynamics in rat pulmonary artery remodeling. J Clin Invest 98:434\u2013442","journal-title":"J Clin Invest"},{"key":"998_CR49","first-page":"1019","volume":"151","author":"K Okada","year":"1997","unstructured":"Okada K, Tanaka Y, Bernstein M, Zhang W, Patterson GA, Botney MD (1997) Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol 151:1019\u20131025","journal-title":"Am J Pathol"},{"key":"998_CR50","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-1-60761-500-2_20","volume":"661","author":"MR Maclean","year":"2010","unstructured":"Maclean MR, Dempsie Y (2010) The serotonin hypothesis of pulmonary hypertension revisited. Adv Exp Med Biol 661:309\u2013322","journal-title":"Adv Exp Med Biol"},{"key":"998_CR51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.bjp.0703314","volume":"130","author":"MR MacLean","year":"2000","unstructured":"MacLean MR, Alexander D, Stirrat A, Gallagher M, Douglas SA, Ohlstein EH, Morecroft I, Polland K (2000) Contractile responses to human urotensin-II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat. Br J Pharmacol 130:201\u2013204","journal-title":"Br J Pharmacol"},{"key":"998_CR52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/01.RES.84.3.329","volume":"84","author":"S Eddahibi","year":"1999","unstructured":"Eddahibi S, Fabre V, Boni C, Martres MP, Raffestin B, Hamon M, Adnot S (1999) Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 84:329\u2013336","journal-title":"Circ Res"},{"key":"998_CR53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/cvr\/cvq408","volume":"90","author":"K White","year":"2011","unstructured":"White K, Dempsie Y, Nilsen M, Wright AF, Loughlin L, MacLean MR (2011) The serotonin transporter, gender, and 17\u03b2 oestradiol in the development of pulmonary arterial hypertension. Cardiovasc Res 90:373\u2013382","journal-title":"Cardiovasc Res"},{"key":"998_CR54","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cytogfr.2010.06.001","volume":"21","author":"JW Lowery","year":"2010","unstructured":"Lowery JW, de Caestecker MP (2010) BMP signaling in vascular development and disease. Cytokine Growth Factor Rev 21:287\u2013298","journal-title":"Cytokine Growth Factor Rev"},{"key":"998_CR55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cytogfr.2009.10.007","volume":"20","author":"C Sieber","year":"2009","unstructured":"Sieber C, Kopf J, Hiepen C, Knaus P (2009) Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev 20:343\u2013355","journal-title":"Cytokine Growth Factor Rev"},{"key":"998_CR56","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1086\/303059","volume":"67","author":"Z Deng","year":"2000","unstructured":"Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ et al (2000) Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 67:737\u2013744","journal-title":"Am J Hum Genet"},{"key":"998_CR57","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/s-2005-916150","volume":"26","author":"CG Elliott","year":"2005","unstructured":"Elliott CG (2005) Genetics of pulmonary arterial hypertension: current and future implications. Semin Respir Crit Care Med 26:365\u2013371","journal-title":"Semin Respir Crit Care Med"},{"key":"998_CR58","doi-asserted-by":"crossref","first-page":"278","DOI":"10.7326\/0003-4819-148-4-200802190-00006","volume":"148","author":"JH Newman","year":"2008","unstructured":"Newman JH, Phillips JA, Loyd JE (2008) Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann Intern Med 148:278\u2013283","journal-title":"Ann Intern Med"},{"key":"998_CR59","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1378\/chest.08-1341","volume":"134","author":"RJ Davies","year":"2008","unstructured":"Davies RJ, Morrell NW (2008) Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor. Chest 134:1271\u20131277","journal-title":"Chest"},{"key":"998_CR60","doi-asserted-by":"crossref","first-page":"L1241","DOI":"10.1152\/ajplung.00239.2004","volume":"287","author":"H Beppu","year":"2004","unstructured":"Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD (2004) BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol 287:L1241\u2013L1247","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR61","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCULATIONAHA.104.492488","volume":"112","author":"Y Song","year":"2005","unstructured":"Song Y, Jones JE, Beppu H, Keaney JF, Loscalzo J, Zhang Y-Y (2005) Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation 112:553\u2013562","journal-title":"Circulation"},{"key":"998_CR62","doi-asserted-by":"crossref","first-page":"L98","DOI":"10.1152\/ajplung.00034.2007","volume":"294","author":"DB Frank","year":"2008","unstructured":"Frank DB, Lowery J, Anderson L, Brink M, Reese J, de Caestecker M (2008) Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. Am J Physiol Lung Cell Mol Physiol 294:L98\u2013L109","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR63","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/01.RES.0000126047.82846.20","volume":"94","author":"J West","year":"2004","unstructured":"West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, Hoedt-Miller M, Tada Y, Ozimek J, Tuder R et al (2004) Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 94:1109\u20131114","journal-title":"Circ Res"},{"key":"998_CR64","first-page":"H907","volume":"242","author":"H Suzuki","year":"1982","unstructured":"Suzuki H, Twarog BM (1982) Membrane properties of smooth muscle cells in pulmonary hypertensive rats. Am J Physiol 242:H907\u2013H915","journal-title":"Am J Physiol"},{"issue":"5","key":"998_CR65","doi-asserted-by":"crossref","first-page":"C951","DOI":"10.1152\/ajpcell.00512.2010","volume":"300","author":"LA Shimoda","year":"2011","unstructured":"Shimoda LA, Polak J (2011) Theme: Hypoxia. Hypoxia and ion channel function. Am J Physiol Cell Physiol 300(5):C951\u2013C967","journal-title":"Am J Physiol Cell Physiol"},{"key":"998_CR66","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/01.CIR.98.14.1400","volume":"98","author":"JX Yuan","year":"1998","unstructured":"Yuan JX, Aldinger AM, Juhaszova M, Wang J, Conte JV Jr, Gaine SP, Orens JB, Rubin LJ (1998) Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation 98:1400\u20131406","journal-title":"Circulation"},{"issue":"Suppl 1","key":"998_CR67","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1038\/sj.bjp.0707635","volume":"153","author":"ED Burg","year":"2008","unstructured":"Burg ED, Remillard CV, Yuan JX (2008) Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications. Br J Pharmacol 153(Suppl 1):S99\u2013S111","journal-title":"Br J Pharmacol"},{"key":"998_CR68","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/hc0202.101974","volume":"105","author":"ED Michelakis","year":"2002","unstructured":"Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL (2002) Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 105:244\u2013250","journal-title":"Circulation"},{"key":"998_CR69","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1161\/CIRCULATIONAHA.105.609008","volume":"113","author":"S Bonnet","year":"2006","unstructured":"Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thebaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS et al (2006) An abnormal mitochondrial-hypoxia inducible factor-1a-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113:2630\u20132641","journal-title":"Circulation"},{"key":"998_CR70","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(05)78495-6","volume":"351","author":"XJ Yuan","year":"1998","unstructured":"Yuan XJ, Wang J, Juhaszova M, Gaine SP, Rubin LJ (1998) Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet 351:726\u2013727","journal-title":"Lancet"},{"key":"998_CR71","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.0610467104","volume":"104","author":"S Bonnet","year":"2007","unstructured":"Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED (2007) The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A 104:11418\u201311423","journal-title":"Proc Natl Acad Sci U S A"},{"key":"998_CR72","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/01.CIR.0000062688.76508.B3","volume":"107","author":"ZI Pozeg","year":"2003","unstructured":"Pozeg ZI, Michelakis ED, McMurtry MS, Thebaud B, Wu XC, Dyck JR, Hashimoto K, Wang S, Moudgil R, Harry G et al (2003) In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 107:2037\u20132044","journal-title":"Circulation"},{"key":"998_CR73","doi-asserted-by":"crossref","first-page":"L884","DOI":"10.1152\/ajplung.2000.279.5.L884","volume":"279","author":"LA Shimoda","year":"2000","unstructured":"Shimoda LA, Sham JS, Shimoda TH, Sylvester JT (2000) L-type Ca2+ channels, resting [Ca2+]i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes. Am J Physiol Lung Cell Mol Physiol 279:L884\u2013L894","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR74","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1161\/01.RES.0000227551.68124.98","volume":"98","author":"J Wang","year":"2006","unstructured":"Wang J, Weigand L, Lu W, Sylvester JT, Semenza GL, Shimoda LA (2006) Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells. Circ Res 98:1528\u20131537","journal-title":"Circ Res"},{"key":"998_CR75","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.RES.0000138952.16382.ad","volume":"95","author":"MJ Lin","year":"2004","unstructured":"Lin MJ, Leung GP, Zhang WM, Yang XR, Yip KP, Tse CM, Sham JS (2004) Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res 95:496\u2013505","journal-title":"Circ Res"},{"key":"998_CR76","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199207093270203","volume":"327","author":"S Rich","year":"1992","unstructured":"Rich S, Kaufmann E, Levy PS (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76\u201381","journal-title":"N Engl J Med"},{"key":"998_CR77","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1161\/CIRCULATIONAHA.104.488486","volume":"111","author":"O Sitbon","year":"2005","unstructured":"Sitbon O, Humbert M, Jais X, Ioos V, Hamid AM, Provencher S, Garcia G, Parent F, Herve P, Simonneau G (2005) Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation 111:3105\u20133111","journal-title":"Circulation"},{"key":"998_CR78","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.1633724100","volume":"100","author":"S Bonnet","year":"2003","unstructured":"Bonnet S, Dumas-de-La-Roque E, Begueret H, Marthan R, Fayon M, Dos Santos P, Savineau JP, Baulieu EE (2003) Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc Natl Acad Sci U S A 100:9488\u20139493","journal-title":"Proc Natl Acad Sci U S A"},{"key":"998_CR79","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/01.RES.0000145360.16770.9f","volume":"95","author":"MS McMurtry","year":"2004","unstructured":"McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95:830\u2013840","journal-title":"Circ Res"},{"key":"998_CR80","doi-asserted-by":"crossref","first-page":"H746","DOI":"10.1152\/ajpheart.2001.280.2.H746","volume":"280","author":"VA Golovina","year":"2001","unstructured":"Golovina VA, Platoshyn O, Bailey CL, Wang J, Limsuwan A, Sweeney M, Rubin LJ, Yuan JX (2001) Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation. Am J Physiol Heart Circ Physiol 280:H746\u2013H755","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"998_CR81","first-page":"44","volume":"19","author":"JW Landsberg","year":"2004","unstructured":"Landsberg JW, Yuan JX (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 19:44\u201350","journal-title":"News Physiol Sci"},{"key":"998_CR82","doi-asserted-by":"crossref","first-page":"L343","DOI":"10.1152\/ajplung.00130.2012","volume":"303","author":"K Leggett","year":"2012","unstructured":"Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer KS, King LS, Myers AC, Sylvester JT, Sidhaye VK et al (2012) Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol 303:L343\u2013L353","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR83","doi-asserted-by":"crossref","first-page":"C77","DOI":"10.1152\/ajpcell.00247.2011","volume":"302","author":"XR Liu","year":"2012","unstructured":"Liu XR, Zhang MF, Yang N, Liu Q, Wang RX, Cao YN, Yang XR, Sham JS, Lin MJ (2012) Enhanced store-operated Ca2+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. Am J Physiol Cell Physiol 302:C77\u2013C87","journal-title":"Am J Physiol Cell Physiol"},{"key":"998_CR84","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/2045-8932.78106","volume":"1","author":"MY Song","year":"2011","unstructured":"Song MY, Makino A, Yuan JX (2011) STIM2 contributes to enhanced store-operated Ca entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Pulm Circ 1:84\u201394","journal-title":"Pulm Circ"},{"key":"998_CR85","doi-asserted-by":"crossref","first-page":"L1128","DOI":"10.1152\/ajplung.00396.2011","volume":"302","author":"T Luke","year":"2012","unstructured":"Luke T, Maylor J, Undem C, Sylvester JT, Shimoda LA (2012) Kinase dependent activation of voltage-gated Ca2+ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 302:L1128\u2013L1139","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR86","doi-asserted-by":"crossref","first-page":"L915","DOI":"10.1152\/ajplung.90286.2008","volume":"295","author":"SD Hirenallur","year":"2008","unstructured":"Hirenallur SD, Haworth ST, Leming JT, Chang J, Hernandez G, Gordon JB, Rusch NJ (2008) Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 295:L915\u2013L924","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR87","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000163066.07472.ff","volume":"96","author":"DM Rodman","year":"2005","unstructured":"Rodman DM, Reese K, Harral J, Fouty B, Wu S, West J, Hoedt-Miller M, Tada Y, Li KX, Cool C et al (2005) Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res 96:864\u2013872","journal-title":"Circ Res"},{"key":"998_CR88","doi-asserted-by":"crossref","first-page":"18887","DOI":"10.1074\/jbc.M311274200","volume":"279","author":"C Hisatsune","year":"2004","unstructured":"Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279:18887\u201318894","journal-title":"J Biol Chem"},{"key":"998_CR89","doi-asserted-by":"crossref","first-page":"37974","DOI":"10.1074\/jbc.M503646200","volume":"280","author":"AF Odell","year":"2005","unstructured":"Odell AF, Scott JL, Van Helden DF (2005) EGF induces tyrosine phosphorylation, membrane insertion and activation of transient receptor potential channel 4. J Biol Chem 280:37974\u201337987","journal-title":"J Biol Chem"},{"key":"998_CR90","doi-asserted-by":"crossref","first-page":"L674","DOI":"10.1152\/ajplung.00141.2007","volume":"293","author":"J Wang","year":"2007","unstructured":"Wang J, Weigand L, Foxson J, Shimoda LA, Sylvester JT (2007) Ca2+ signaling in hypoxic pulmonary vasoconstriction: effects of myosin light chain and Rho kinase antagonists. Am J Physiol Lung Cell Mol Physiol 293:L674\u2013L685","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR91","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1073\/pnas.0405908101","volume":"101","author":"Y Yu","year":"2004","unstructured":"Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, Yuan JX (2004) Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A 101:13861\u201313866","journal-title":"Proc Natl Acad Sci U S A"},{"key":"998_CR92","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1164\/rccm.200312-1668OC","volume":"170","author":"N Kunichika","year":"2004","unstructured":"Kunichika N, Landsberg JW, Yu Y, Kunichika H, Thistlethwaite PA, Rubin LJ, Yuan JX (2004) Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med 170:1101\u20131107","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR93","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/CIRCULATIONAHA.108.782458","volume":"119","author":"Y Yu","year":"2009","unstructured":"Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY et al (2009) A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 119:2313\u20132322","journal-title":"Circulation"},{"key":"998_CR94","doi-asserted-by":"crossref","first-page":"C114","DOI":"10.1152\/ajpcell.00629.2008","volume":"298","author":"W Lu","year":"2010","unstructured":"Lu W, Ran P, Zhang D, Peng G, Li B, Zhong N, Wang J (2010) Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol 298:C114\u2013C123","journal-title":"Am J Physiol Cell Physiol"},{"key":"998_CR95","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1164\/rccm.200411-1587OC","volume":"172","author":"J Wharton","year":"2005","unstructured":"Wharton J, Strange JW, Moller GM, Growcott EJ, Ren X, Franklyn AP, Phillips SC, Wilkins MR (2005) Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am J Respir Crit Care Med 172:105\u2013113","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR96","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/ATVBAHA.112.300121","volume":"33","author":"J Yang","year":"2013","unstructured":"Yang J, Li X, Al-Lamki R, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW (2013) Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 33:34\u201342","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"998_CR97","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/sj.bjp.0706408","volume":"146","author":"C Guilluy","year":"2005","unstructured":"Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guerin P, Sagan C, Pacaud P, Loirand G (2005) Inhibition of RhoA\/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 146:1010\u20131018","journal-title":"Br J Pharmacol"},{"key":"998_CR98","doi-asserted-by":"crossref","first-page":"H1546","DOI":"10.1152\/ajpheart.00944.2011","volume":"302","author":"FK Kuhr","year":"2012","unstructured":"Kuhr FK, Smith KA, Song MY, Levitan I, Yuan JX-J (2012) New mechanisms of pulmonary arterial hypertension: role of Ca2+ signaling. Am J Physiol Heart Circ Physiol 302:H1546\u2013H1562","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"998_CR99","doi-asserted-by":"crossref","first-page":"L861","DOI":"10.1152\/ajplung.00201.2010","volume":"299","author":"J Sarkar","year":"2010","unstructured":"Sarkar J, Gou D, Turaka P, Viktorova E, Ramchandran R, Raj JU (2010) MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol 299:L861\u2013L871","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR100","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCRESAHA.112.264473","volume":"110","author":"B Wojciak-Stothard","year":"2012","unstructured":"Wojciak-Stothard B, Zhao L, Oliver E, Dubois O, Wu Y, Kardassis D, Vasilaki E, Huang M, Mitchell JA, Harrington LS et al (2012) Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia. Circ Res 110:1423\u20131434","journal-title":"Circ Res"},{"key":"998_CR101","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00424-012-1136-5","volume":"464","author":"E Martin","year":"2012","unstructured":"Martin E, Dahan D, Cardouat G, Gillibert-Duplantier J, Marthan R, Savineau JP, Ducret T (2012) Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells. Pflugers Arch 464:261\u2013272","journal-title":"Pflugers Arch"},{"key":"998_CR102","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nature03460","volume":"434","author":"S Saadoun","year":"2005","unstructured":"Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786\u2013792","journal-title":"Nature"},{"key":"998_CR103","doi-asserted-by":"crossref","first-page":"e6167","DOI":"10.1371\/journal.pone.0006167","volume":"4","author":"E Monzani","year":"2009","unstructured":"Monzani E, Bazzotti R, Perego C, La Porta CA (2009) AQP1 is not only a water channel: it contributes to cell migration through Lin7\/beta-catenin. PLoS One 4:e6167","journal-title":"PLoS One"},{"key":"998_CR104","doi-asserted-by":"crossref","first-page":"L1233","DOI":"10.1152\/ajplung.00445.2002","volume":"285","author":"I Fantozzi","year":"2003","unstructured":"Fantozzi I, Zhang S, Platoshyn O, Remillard CV, Cowling RT, Yuan JX (2003) Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285:L1233\u2013L1245","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR105","doi-asserted-by":"crossref","first-page":"L1135","DOI":"10.1152\/ajplung.00432.2006","volume":"293","author":"ML Paffett","year":"2007","unstructured":"Paffett ML, Naik JS, Resta TC, Walker BR (2007) Reduced store-operated Ca2+ entry in pulmonary endothelial cells from chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 293:L1135\u2013L1142","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR106","doi-asserted-by":"crossref","first-page":"L264","DOI":"10.1152\/ajplung.2001.280.2.L264","volume":"280","author":"JA Madden","year":"2001","unstructured":"Madden JA, Ray DE, Keller PA, Kleinman JG (2001) Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia. Am J Physiol Lung Cell Mol Physiol 280:L264\u2013L271","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR107","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1165\/ajrcmb\/5.6.586","volume":"5","author":"DA Quinn","year":"1991","unstructured":"Quinn DA, Honeyman TW, Joseph PM, Thompson BT, Hales CA, Scheid CR (1991) Contribution of Na+\/H+ exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 5:586\u2013591","journal-title":"Am J Respir Cell Mol Biol"},{"key":"998_CR108","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1165\/ajrcmb.14.2.8630263","volume":"14","author":"DA Quinn","year":"1996","unstructured":"Quinn DA, Dahlberg CG, Bonventre JP, Scheid CR, Honeyman T, Joseph PM, Thompson BT, Hales CA (1996) The role of Na+\/H+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol 14:139\u2013145","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"998_CR109","doi-asserted-by":"crossref","first-page":"L867","DOI":"10.1152\/ajplung.00455.2004","volume":"289","author":"EJ Rios","year":"2005","unstructured":"Rios EJ, Fallon M, Wang J, Shimoda LA (2005) Chronic hypoxia elevates intracellular pH and activates Na+\/H+ exchange in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 289(5):L867\u2013L874","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR110","doi-asserted-by":"crossref","first-page":"L941","DOI":"10.1152\/ajplung.00528.2005","volume":"291","author":"LA Shimoda","year":"2006","unstructured":"Shimoda LA, Fallon M, Pisarcik S, Wang J, Semenza GL (2006) HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 291:L941\u2013L949","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR111","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1164\/ajrccm.157.4.9704106","volume":"157","author":"DA Quinn","year":"1998","unstructured":"Quinn DA, Du HK, Thompson BT, Hales CA (1998) Amiloride analogs inhibit chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med 157:1263\u20131268","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR112","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1164\/rccm.200710-1522OC","volume":"177","author":"L Yu","year":"2008","unstructured":"Yu L, Quinn DA, Garg HG, Hales CA (2008) Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling. Am J Respir Crit Care Med 177:1276\u20131284","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR113","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1165\/rcmb.2011-0032OC","volume":"45","author":"L Yu","year":"2011","unstructured":"Yu L, Hales CA (2011) Silencing of NHE1 attenuates PASMC proliferation, hypertrophy and migration via E2F1. Am J Respir Cell Mol Biol 45:923\u2013930","journal-title":"Am J Respir Cell Mol Biol"},{"key":"998_CR114","first-page":"L442","volume":"275","author":"MV Cutaia","year":"1998","unstructured":"Cutaia MV, Parks N, Centracchio J, Rounds S, Yip KP, Sun AM (1998) Effect of hypoxic exposure on Na+\/H+ antiport activity, isoform expression, and localization in endothelial cells. Am J Physiol 275:L442\u2013L451","journal-title":"Am J Physiol"},{"key":"998_CR115","first-page":"L789","volume":"268","author":"PG Phillips","year":"1995","unstructured":"Phillips PG, Birnby LM, Narendran A (1995) Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells. Am J Physiol 268:L789\u2013L800","journal-title":"Am J Physiol"},{"key":"998_CR116","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S1097-2765(00)00139-8","volume":"6","author":"SP Denker","year":"2000","unstructured":"Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL (2000) Direct binding of the Na\u2013H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H+ translocation. Mol Cell 6:1425\u20131436","journal-title":"Mol Cell"},{"key":"998_CR117","doi-asserted-by":"crossref","first-page":"1023.4","DOI":"10.1096\/fasebj.24.1_supplement.1023.24","volume":"24","author":"J Maylor","year":"2010","unstructured":"Maylor J, Lu W, Pisarcik S, Walker J, Undem C, Myers A, Shimoda L (2010) Reciprocal regulation of Na+\/H+ exchanger isoform 1 and Na+\/H+ exchange regulatory factor 1 in hypoxic pulmonary arterial smooth muscle cells. FASEB J 24:1023.4, Abstract","journal-title":"FASEB J"},{"key":"998_CR118","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.athoracsur.2007.10.054","volume":"85","author":"RM Mentzer Jr","year":"2008","unstructured":"Mentzer RM Jr, Bartels C, Bolli R, Boyce S, Buckberg GD, Chaitman B, Haverich A, Knight J, Menasche P, Myers ML et al (2008) Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg 85:1261\u20131270","journal-title":"Ann Thorac Surg"},{"key":"998_CR119","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.yjmcc.2008.09.715","volume":"46","author":"E Murphy","year":"2009","unstructured":"Murphy E, Allen DG (2009) Why did the NHE inhibitor clinical trials fail? J Mol Cell Cardiol 46:137\u2013141","journal-title":"J Mol Cell Cardiol"},{"key":"998_CR120","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.RES.0000261658.12024.18","volume":"100","author":"M Oka","year":"2007","unstructured":"Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Burns N, Voelkel NF, McMurtry IF (2007) Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res 100:923\u2013929","journal-title":"Circ Res"},{"key":"998_CR121","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.coph.2009.02.006","volume":"9","author":"JPT Ward","year":"2009","unstructured":"Ward JPT, Mcmurtry IF (2009) Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem. Curr Opin Pharmacol 9:287\u2013296","journal-title":"Curr Opin Pharmacol"},{"key":"998_CR122","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pbiomolbio.2012.05.009","volume":"109","author":"AL Firth","year":"2012","unstructured":"Firth AL, Choi I-W, Park WS (2012) Animal models of pulmonary hypertension: Rho kinase inhibition. Prog Biophys Mol Biol 109:67\u201375","journal-title":"Prog Biophys Mol Biol"},{"key":"998_CR123","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/bjp.2008.239","volume":"155","author":"M Oka","year":"2008","unstructured":"Oka M, Fagan KA, Jones PL, McMurtry IF (2008) Therapeutic potential of RhoA\/Rho kinase inhibitors in pulmonary hypertension. Br J Pharmacol 155:444\u2013454","journal-title":"Br J Pharmacol"},{"key":"998_CR124","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1165\/rcmb.2006-0360OC","volume":"37","author":"X Yang","year":"2007","unstructured":"Yang X, Lee PJ, Long L, Trembath RC, Morrell NW (2007) BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. Am J Respir Cell Mol Biol 37:598\u2013605","journal-title":"Am J Respir Cell Mol Biol"},{"key":"998_CR125","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.RES.0000258492.96097.47","volume":"100","author":"WT Gerthoffer","year":"2007","unstructured":"Gerthoffer WT (2007) Mechanisms of vascular smooth muscle cell migration. Circ Res 100:607\u2013621","journal-title":"Circ Res"},{"key":"998_CR126","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/01.RES.0000141428.53262.a4","volume":"95","author":"Y Liu","year":"2004","unstructured":"Liu Y, Suzuki YJ, Day RM, Fanburg BL (2004) Rho kinase-induced nuclear translocation of ERK1\/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 95:579\u2013586","journal-title":"Circ Res"},{"key":"998_CR127","doi-asserted-by":"crossref","first-page":"e46303","DOI":"10.1371\/journal.pone.0046303","volume":"7","author":"C Undem","year":"2012","unstructured":"Undem C, Rios EJ, Maylor J, Shimoda LA (2012) Endothelin-1 augments Na+\/H+ exchange activity in murine pulmonary arterial smooth muscle cells via Rho kinase. PLoS One 7:e46303","journal-title":"PLoS One"},{"key":"998_CR128","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/hrt.2003.029470","volume":"91","author":"Y Fukumoto","year":"2005","unstructured":"Fukumoto Y, Matoba T, Ito A, Tanaka H, Kishi T, Hayashidani S, Abe K, Takeshita A, Shimokawa H (2005) Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 91:391\u2013392","journal-title":"Heart"},{"key":"998_CR129","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1253\/circj.70.174","volume":"70","author":"K Ishikura","year":"2006","unstructured":"Ishikura K, Yamada N, Ito M, Ota S, Nakamura M, Isaka N, Nakano T (2006) Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 70:174\u2013178","journal-title":"Circ J"},{"key":"998_CR130","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1164\/rccm.200405-637OC","volume":"171","author":"T Nagaoka","year":"2005","unstructured":"Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M (2005) Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171:494\u2013499","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR131","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00380-009-1176-8","volume":"25","author":"H Fujita","year":"2010","unstructured":"Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, Shimokawa H (2010) Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Hear Vessel 25:144\u2013149","journal-title":"Hear Vessel"},{"key":"998_CR132","doi-asserted-by":"crossref","first-page":"L656","DOI":"10.1152\/ajplung.00090.2003","volume":"287","author":"KA Fagan","year":"2004","unstructured":"Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF (2004) Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287:L656\u2013L664","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR133","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.RES.0000111804.34509.94","volume":"94","author":"K Abe","year":"2004","unstructured":"Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K et al (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 94:385\u2013393","journal-title":"Circ Res"},{"key":"998_CR134","doi-asserted-by":"crossref","first-page":"L1105","DOI":"10.1152\/ajplung.00411.2006","volume":"292","author":"RE Girgis","year":"2007","unstructured":"Girgis RE, Mozammel S, Champion HC, Li D, Peng X, Shimoda LA, Tuder RM, Johns RA, Hassoun PM (2007) Regression of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Lung Cell Mol Physiol 292:L1105\u2013L1110","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR135","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/hc3201.094152","volume":"104","author":"NW Morrell","year":"2001","unstructured":"Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-\u03b21 and bone morphogenetic proteins. Circulation 104:790\u2013795","journal-title":"Circulation"},{"key":"998_CR136","doi-asserted-by":"crossref","first-page":"C1370","DOI":"10.1152\/ajpcell.00040.2010","volume":"299","author":"W Lu","year":"2010","unstructured":"Lu W, Ran P, Zhang D, Lai N, Zhong N, Wang J (2010) Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol 299:C1370\u2013C1378","journal-title":"Am J Physiol Cell Physiol"},{"key":"998_CR137","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.RES.0000166926.54293.68","volume":"96","author":"X Yang","year":"2005","unstructured":"Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW (2005) Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res 96:1053\u20131063","journal-title":"Circ Res"},{"key":"998_CR138","doi-asserted-by":"crossref","first-page":"R833","DOI":"10.1152\/ajpregu.00534.2009","volume":"298","author":"L Anderson","year":"2010","unstructured":"Anderson L, Lowery JW, Frank DB, Novitskaya T, Jones M, Mortlock DP, Chandler RL, de Caestecker MP (2010) Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol 298:R833\u2013R842","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"998_CR139","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.RES.0000181152.65534.07","volume":"97","author":"DB Frank","year":"2005","unstructured":"Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP (2005) Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res 97:496\u2013504","journal-title":"Circ Res"},{"key":"998_CR140","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1056\/NEJMoa021650","volume":"348","author":"L Du","year":"2003","unstructured":"Du L, Sullivan CC, Chu D, Cho AJ, Kido M, Wolf PL, Yuan JX, Deutsch R, Jamieson SW, Thistlethwaite PA (2003) Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 348:500\u2013509","journal-title":"N Engl J Med"},{"key":"998_CR141","doi-asserted-by":"crossref","first-page":"L450","DOI":"10.1152\/ajplung.00206.2005","volume":"290","author":"H Takahashi","year":"2006","unstructured":"Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y (2006) Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290:L450\u2013L458","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"998_CR142","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/01.RES.0000200180.01710.e6","volume":"98","author":"K Teichert-Kuliszewska","year":"2006","unstructured":"Teichert-Kuliszewska K, Kutryk MJ, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, Granton J, Stewart DJ (2006) Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res 98:209\u2013217","journal-title":"Circ Res"},{"key":"998_CR143","doi-asserted-by":"crossref","first-page":"33134","DOI":"10.1074\/jbc.M111.274100","volume":"286","author":"A Gangopahyay","year":"2011","unstructured":"Gangopahyay A, Oran M, Bauer EM, Wertz JW, Comhair SA, Erzurum SC, Bauer PM (2011) Bone morphogenetic protein receptor II is a novel mediator of endothelial nitric-oxide synthase activation. J Biol Chem 286:33134\u201333140","journal-title":"J Biol Chem"},{"key":"998_CR144","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbrc.2005.10.187","volume":"339","author":"H Hu","year":"2006","unstructured":"Hu H, Sung A, Zhao G, Shi L, Qiu D, Nishimura T, Kao PN (2006) Simvastatin enhances bone morphogenetic protein receptor type II expression. Biochem Biophys Res Commun 339:59\u201364","journal-title":"Biochem Biophys Res Commun"},{"key":"998_CR145","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1097\/00004872-198812040-00056","volume":"6","author":"M Yanagisawa","year":"1988","unstructured":"Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T (1988) A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J Hypertens Suppl 6:S188\u2013S191","journal-title":"J Hypertens Suppl"},{"key":"998_CR146","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.phrs.2011.03.003","volume":"63","author":"D Shao","year":"2011","unstructured":"Shao D, Park JE, Wort SJ (2011) The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol Res 63:504\u2013511","journal-title":"Pharmacol Res"},{"key":"998_CR147","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1569-9048(02)00052-6","volume":"132","author":"LA Shimoda","year":"2002","unstructured":"Shimoda LA, Sham JS, Liu Q, Sylvester JT (2002) Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1? Respir Physiol Neurobiol 132:93\u2013106","journal-title":"Respir Physiol Neurobiol"},{"key":"998_CR148","doi-asserted-by":"crossref","first-page":"L309","DOI":"10.1152\/ajplung.00091.2007","volume":"294","author":"EM Whitman","year":"2008","unstructured":"Whitman EM, Pisarcik S, Luke T, Fallon M, Wang J, Sylvester JT, Semenza GL, Shimoda LA (2008) Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes. Am J Physiol Lung Cell Mol Physiol 294:L309\u2013L318","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"Suppl 2","key":"998_CR149","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2362.2009.02120.x","volume":"39","author":"NJ Davie","year":"2009","unstructured":"Davie NJ, Schermuly RT, Weissmann N, Grimminger F, Ghofrani HA (2009) The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies. Eur J Clin Investig 39(Suppl 2):38\u201349","journal-title":"Eur J Clin Investig"},{"key":"998_CR150","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/bjp.2008.310","volume":"155","author":"KM Mair","year":"2008","unstructured":"Mair KM, MacLean MR, Morecroft I, Dempsie Y, Palmer TM (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. Br J Pharmacol 155:606\u2013616","journal-title":"Br J Pharmacol"},{"key":"998_CR151","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/MCB.12.12.5447","volume":"12","author":"GL Semenza","year":"1992","unstructured":"Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12:5447\u20135454","journal-title":"Mol Cell Biol"},{"key":"998_CR152","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1513\/pats.200404-029MS","volume":"2","author":"GL Semenza","year":"2005","unstructured":"Semenza GL (2005) Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proc Am Thorac Soc 2:68\u201370","journal-title":"Proc Am Thorac Soc"},{"key":"998_CR153","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/physrev.00030.2011","volume":"92","author":"NR Prabhakar","year":"2012","unstructured":"Prabhakar NR, Semenza GL (2012) Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev 92:967\u20131003","journal-title":"Physiol Rev"},{"key":"998_CR154","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1172\/JCI5912","volume":"103","author":"AY Yu","year":"1999","unstructured":"Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT et al (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1\u03b1. J Clin Invest 103:691\u2013696","journal-title":"J Clin Invest"},{"key":"998_CR155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1164\/rccm.201009-1393PP","volume":"183","author":"LA Shimoda","year":"2011","unstructured":"Shimoda LA, Semenza GL (2011) HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. Am J Respir Crit Care Med 183:152\u2013156","journal-title":"Am J Respir Crit Care Med"},{"key":"998_CR156","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1152\/japplphysiol.00843.2012","volume":"113","author":"LA Shimoda","year":"2012","unstructured":"Shimoda LA (2012) 55th Bowditch lecture: effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. J Appl Physiol 113:1343\u20131352","journal-title":"J Appl Physiol"},{"key":"998_CR157","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1101\/gad.12.2.149","volume":"12","author":"NV Iyer","year":"1998","unstructured":"Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY et al (1998) Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1\u03b1. Genes Dev 12:149\u2013162","journal-title":"Genes Dev"},{"key":"998_CR158","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI15496","volume":"111","author":"K Brusselmans","year":"2003","unstructured":"Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P (2003) Heterozygous deficiency of hypoxia-inducible factor-2\u03b1 protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J Clin Invest 111:1519\u20131527","journal-title":"J Clin Invest"},{"key":"998_CR159","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-60761-500-2_14","volume":"661","author":"LA Shimoda","year":"2010","unstructured":"Shimoda LA (2010) Hypoxic regulation of ion channels and transporters in pulmonary vascular smooth muscle. Adv Exp Med Biol 661:221\u2013235","journal-title":"Adv Exp Med Biol"},{"key":"998_CR160","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1073\/pnas.1120385109","volume":"109","author":"EM Abud","year":"2012","unstructured":"Abud EM, Maylor J, Undem C, Punjabi A, Zaiman AL, Myers AC, Sylvester JT, Semenza GL, Shimoda LA (2012) Digoxin inhibits development of hypoxic pulmonary hypertension in mice. Proc Natl Acad Sci U S A 109:1239\u20131244","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-0998-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-013-0998-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-0998-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T01:57:41Z","timestamp":1644112661000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-013-0998-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,19]]},"references-count":160,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["998"],"URL":"https:\/\/doi.org\/10.1007\/s00109-013-0998-0","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,19]]}}}