{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:21:58Z","timestamp":1791278518442,"version":"4.1.0"},"reference-count":225,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00109-013-1021-5","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T04:52:22Z","timestamp":1363755142000},"page":"411-429","source":"Crossref","is-referenced-by-count":330,"title":["The metastasis-promoting roles of tumor-associated immune cells"],"prefix":"10.1007","volume":"91","author":[{"given":"Heath A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"1021_CR1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cytogfr.2009.11.002","volume":"21","author":"B Ruffell","year":"2010","unstructured":"Ruffell B, DeNardo DG, Affara NI, Coussens LM (2010) Lymphocytes in cancer development: polarization towards pro-tumor immunity. Cytokine Growth Factor Rev 21:3\u201310","journal-title":"Cytokine Growth Factor Rev"},{"key":"1021_CR2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/jcp.10290","volume":"195","author":"A Garcia-Lora","year":"2003","unstructured":"Garcia-Lora A, Algarra I, Garrido F (2003) MHC class I antigens, immune surveillance, and tumor immune escape. J Cell Physiol 195:346\u2013355","journal-title":"J Cell Physiol"},{"key":"1021_CR3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.coi.2007.02.001","volume":"19","author":"JD Bui","year":"2007","unstructured":"Bui JD, Schreiber RD (2007) Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes? Curr Opin Immunol 19:203\u2013208","journal-title":"Curr Opin Immunol"},{"key":"1021_CR4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrc1782","volume":"6","author":"KE Visser de","year":"2006","unstructured":"de Visser KE, Eichten A, Coussens LM (2006) Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6:24\u201337","journal-title":"Nat Rev Cancer"},{"key":"1021_CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.gde.2007.12.007","volume":"18","author":"S Ostrand-Rosenberg","year":"2008","unstructured":"Ostrand-Rosenberg S (2008) Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev 18:11\u201318","journal-title":"Curr Opin Genet Dev"},{"key":"1021_CR6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","volume":"12","author":"SJ Galli","year":"2011","unstructured":"Galli SJ, Borregaard N, Wynn TA (2011) Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 12:1035\u20131044","journal-title":"Nat Immunol"},{"key":"1021_CR7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.coi.2012.01.014","volume":"24","author":"S Nakayamada","year":"2012","unstructured":"Nakayamada S, Takahashi H, Kanno Y, O\u2019Shea JJ (2012) Helper T cell diversity and plasticity. Curr Opin Immunol 24:297\u2013302","journal-title":"Curr Opin Immunol"},{"key":"1021_CR8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4161\/onci.20068","volume":"1","author":"T Lanca","year":"2012","unstructured":"Lanca T, Silva-Santos B (2012) The split nature of tumor-infiltrating leukocytes: implications for cancer surveillance and immunotherapy. Oncoimmunology 1:717\u2013725","journal-title":"Oncoimmunology"},{"key":"1021_CR9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc2618","volume":"9","author":"JA Joyce","year":"2009","unstructured":"Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239\u2013252","journal-title":"Nat Rev Cancer"},{"key":"1021_CR10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial\u2013mesenchymal transitions in development and disease. Cell 139:871\u2013890","journal-title":"Cell"},{"key":"1021_CR11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2217\/imt.11.113","volume":"3","author":"DB Lowe","year":"2011","unstructured":"Lowe DB, Storkus WJ (2011) Chronic inflammation and immunologic-based constraints in malignant disease. Immunotherapy 3:1265\u20131274","journal-title":"Immunotherapy"},{"key":"1021_CR12","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1002\/ijc.26032","volume":"128","author":"N Erez","year":"2011","unstructured":"Erez N, Coussens LM (2011) Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization. Int J Cancer J Int Du Cancer 128:2536\u20132544","journal-title":"Int J Cancer J Int Du Cancer"},{"key":"1021_CR13","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","volume":"315","author":"HF Dvorak","year":"1986","unstructured":"Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650\u20131659","journal-title":"N Engl J Med"},{"key":"1021_CR14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436\u2013444","journal-title":"Nature"},{"key":"1021_CR15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-009-0161-8","volume":"31","author":"MJ Waldner","year":"2009","unstructured":"Waldner MJ, Neurath MF (2009) Colitis-associated cancer: the role of T cells in tumor development. Semin Immunopathol 31:249\u2013256","journal-title":"Semin Immunopathol"},{"key":"1021_CR16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/1078-0432.CCR-08-0149","volume":"15","author":"BB Aggarwal","year":"2009","unstructured":"Aggarwal BB, Vijayalekshmi RV, Sung B (2009) Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res Off J Am Assoc Cancer Res 15:425\u2013430","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1021_CR17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","volume":"441","author":"M Karin","year":"2006","unstructured":"Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441:431\u2013436","journal-title":"Nature"},{"key":"1021_CR18","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm.2015","volume":"15","author":"S Wu","year":"2009","unstructured":"Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F et al (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses. Nat Med 15:1016\u20131022","journal-title":"Nat Med"},{"key":"1021_CR19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","volume":"357","author":"F Balkwill","year":"2001","unstructured":"Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539\u2013545","journal-title":"Lancet"},{"key":"1021_CR20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883\u2013899","journal-title":"Cell"},{"key":"1021_CR21","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nm1649","volume":"13","author":"L Soucek","year":"2007","unstructured":"Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI (2007) Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13:1211\u20131218","journal-title":"Nat Med"},{"key":"1021_CR22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ccr.2004.09.028","volume":"6","author":"A Sparmann","year":"2004","unstructured":"Sparmann A, Bar-Sagi D (2004) Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell 6:447\u2013458. doi: 10.1016\/j.ccr.2004.09.028","journal-title":"Cancer Cell"},{"key":"1021_CR23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1415","volume":"4","author":"J Vakkila","year":"2004","unstructured":"Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4:641\u2013648","journal-title":"Nat Rev Immunol"},{"key":"1021_CR24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.25.022106.141609","volume":"25","author":"GA Rabinovich","year":"2007","unstructured":"Rabinovich GA, Gabrilovich D, Sotomayor EM (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267\u2013296","journal-title":"Annu Rev Immunol"},{"key":"1021_CR25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","volume":"9","author":"DI Gabrilovich","year":"2009","unstructured":"Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162\u2013174","journal-title":"Nat Rev Immunol"},{"key":"1021_CR26","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s00262-010-0855-8","volume":"CII 59","author":"S Ostrand-Rosenberg","year":"2010","unstructured":"Ostrand-Rosenberg S (2010) Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity. Cancer Immunol Immunother CII 59:1593\u20131600","journal-title":"Cancer Immunol Immunother"},{"key":"1021_CR27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","volume":"431","author":"E Pikarsky","year":"2004","unstructured":"Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y (2004) NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431:461\u2013466","journal-title":"Nature"},{"key":"1021_CR28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nm976","volume":"10","author":"T Wang","year":"2004","unstructured":"Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D et al (2004) Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med 10:48\u201354","journal-title":"Nat Med"},{"key":"1021_CR29","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/nm1325","volume":"11","author":"M Kortylewski","year":"2005","unstructured":"Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mule J, Kerr WG et al (2005) Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 11:1314\u20131321","journal-title":"Nat Med"},{"key":"1021_CR30","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1158\/0008-5472.CAN-10-4316","volume":"71","author":"PB Olkhanud","year":"2011","unstructured":"Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, Wejksza K, Malchinkhuu E, Wersto RP, Biragyn A (2011) Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells. Cancer Res 71:3505\u20133515","journal-title":"Cancer Res"},{"key":"1021_CR31","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1002\/eji.201040736","volume":"40","author":"A Sica","year":"2010","unstructured":"Sica A, Porta C, Riboldi E, Locati M (2010) Convergent pathways of macrophage polarization: the role of B cells. Eur J Immunol 40:2131\u20132133","journal-title":"Eur J Immunol"},{"key":"1021_CR32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2353\/ajpath.2007.060761","volume":"170","author":"MI Harrell","year":"2007","unstructured":"Harrell MI, Iritani BM, Ruddell A (2007) Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis. Am J Pathol 170:774\u2013786","journal-title":"Am J Pathol"},{"key":"1021_CR33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1593\/neo.11756","volume":"13","author":"A Ruddell","year":"2011","unstructured":"Ruddell A, Harrell MI, Furuya M, Kirschbaum SB, Iritani BM (2011) B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma. Neoplasia 13:748\u2013757","journal-title":"Neoplasia"},{"key":"1021_CR34","doi-asserted-by":"crossref","first-page":"e42635","DOI":"10.1371\/journal.pone.0042635","volume":"7","author":"RL Bjordahl","year":"2012","unstructured":"Bjordahl RL, Gapin L, Marrack P, Refaeli Y (2012) iNKT cells suppress the CD8+ T cell response to a murine Burkitt\u2019s-like B cell lymphoma. PLoS One 7:e42635","journal-title":"PLoS One"},{"key":"1021_CR35","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860\u2013867","journal-title":"Nature"},{"key":"1021_CR36","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","volume":"453","author":"J Rius","year":"2008","unstructured":"Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M (2008) NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 453:807\u2013811","journal-title":"Nature"},{"key":"1021_CR37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrc2620","volume":"9","author":"K Polyak","year":"2009","unstructured":"Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265\u2013273","journal-title":"Nat Rev Cancer"},{"key":"1021_CR38","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI39675","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R (2009) EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119:1417\u20131419","journal-title":"J Clin Invest"},{"key":"1021_CR39","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1083\/jcb.200104036","volume":"154","author":"A Stockinger","year":"2001","unstructured":"Stockinger A, Eger A, Wolf J, Beug H, Foisner R (2001) E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 154:1185\u20131196","journal-title":"J Cell Biol"},{"key":"1021_CR40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cell.2004.07.011","volume":"118","author":"Y Kang","year":"2004","unstructured":"Kang Y, Massague J (2004) Epithelial\u2013mesenchymal transitions: twist in development and metastasis. Cell 118:277\u2013279","journal-title":"Cell"},{"key":"1021_CR41","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.oraloncology.2012.06.005","volume":"48","author":"C Zhou","year":"2012","unstructured":"Zhou C, Liu J, Tang Y, Liang X (2012) Inflammation linking EMT and cancer stem cells. Oral Oncol 48:1068\u20131075","journal-title":"Oral Oncol"},{"key":"1021_CR42","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","volume":"331","author":"CL Chaffer","year":"2011","unstructured":"Chaffer CL, Weinberg RA (2011) A perspective on cancer cell metastasis. Science 331:1559\u20131564","journal-title":"Science"},{"key":"1021_CR43","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1038\/onc.2010.215","volume":"29","author":"A Singh","year":"2010","unstructured":"Singh A, Settleman J (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 29:4741\u20134751","journal-title":"Oncogene"},{"key":"1021_CR44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/emmm.200900043","volume":"1","author":"JM Lopez-Novoa","year":"2009","unstructured":"Lopez-Novoa JM, Nieto MA (2009) Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med 1:303\u2013314","journal-title":"EMBO Mol Med"},{"key":"1021_CR45","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.cell.2011.04.029","volume":"145","author":"C Scheel","year":"2011","unstructured":"Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, Kah KJ, Bell G, Guo W, Rubin J, Richardson AL et al (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145:926\u2013940","journal-title":"Cell"},{"key":"1021_CR46","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1101\/gad.10.19.2462","volume":"10","author":"M Oft","year":"1996","unstructured":"Oft M, Peli J, Rudaz C, Schwarz H, Beug H, Reichmann E (1996) TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10:2462\u20132477","journal-title":"Genes Dev"},{"key":"1021_CR47","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1091\/mbc.E02-09-0583","volume":"14","author":"RC Bates","year":"2003","unstructured":"Bates RC, Mercurio AM (2003) Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 14:1790\u20131800","journal-title":"Mol Biol Cell"},{"key":"1021_CR48","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature02962","volume":"431","author":"SS Karhadkar","year":"2004","unstructured":"Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA (2004) Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431:707\u2013712","journal-title":"Nature"},{"key":"1021_CR49","doi-asserted-by":"crossref","unstructured":"Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B et al (2012) CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFalpha. Cell Stem Cell 11:812\u2013824","DOI":"10.1016\/j.stem.2012.08.013"},{"key":"1021_CR50","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2009.03.016","volume":"15","author":"Y Wu","year":"2009","unstructured":"Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP (2009) Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15:416\u2013428","journal-title":"Cancer Cell"},{"key":"1021_CR51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.canlet.2010.03.003","volume":"295","author":"HJ Maier","year":"2010","unstructured":"Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H, Wirth T (2010) NF-kappaB promotes epithelial\u2013mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295:214\u2013228","journal-title":"Cancer Lett"},{"key":"1021_CR52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/ncb1173","volume":"6","author":"BP Zhou","year":"2004","unstructured":"Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial\u2013mesenchymal transition. Nat Cell Biol 6:931\u2013940","journal-title":"Nat Cell Biol"},{"key":"1021_CR53","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1074\/jbc.M707429200","volume":"283","author":"GZ Cheng","year":"2008","unstructured":"Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M, Xu LM, Costanzo C, Cheng JQ, Wang LH (2008) Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem 283:14665\u201314673","journal-title":"J Biol Chem"},{"key":"1021_CR54","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"H Yu","year":"2009","unstructured":"Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9:798\u2013809","journal-title":"Nat Rev Cancer"},{"key":"1021_CR55","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/onc.2009.180","volume":"28","author":"NJ Sullivan","year":"2009","unstructured":"Sullivan NJ, Sasser AK, Axel AE, Vesuna F, Raman V, Ramirez N, Oberyszyn TM, Hall BM (2009) Interleukin-6 induces an epithelial\u2013mesenchymal transition phenotype in human breast cancer cells. Oncogene 28:2940\u20132947","journal-title":"Oncogene"},{"key":"1021_CR56","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ccr.2009.01.023","volume":"15","author":"C Kudo-Saito","year":"2009","unstructured":"Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y (2009) Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 15:195\u2013206","journal-title":"Cancer Cell"},{"key":"1021_CR57","doi-asserted-by":"crossref","unstructured":"Kudo-Saito C, Shirako H, Ohike M, Tsukamoto N, Kawakami Y (2012) CCL2 is critical for immunosuppression to promote cancer metastasis. Clin Exp Metastasis. doi: 10.1007\/s10585-012-9545-6","DOI":"10.1007\/s10585-012-9545-6"},{"key":"1021_CR58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1083\/jcb.200409067","volume":"168","author":"RE Bachelder","year":"2005","unstructured":"Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM (2005) Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial\u2013mesenchymal transition. J Cell Biol 168:29\u201333","journal-title":"J Cell Biol"},{"key":"1021_CR59","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.onc.1209808","volume":"26","author":"HL Chua","year":"2007","unstructured":"Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H (2007) NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 26:711\u2013724","journal-title":"Oncogene"},{"key":"1021_CR60","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1038\/sj.onc.1207990","volume":"23","author":"MJ Barbera","year":"2004","unstructured":"Barbera MJ, Puig I, Dominguez D, Julien-Grille S, Guaita-Esteruelas S, Peiro S, Baulida J, Franci C, Dedhar S, Larue L et al (2004) Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 23:7345\u20137354","journal-title":"Oncogene"},{"key":"1021_CR61","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1038\/sj.onc.1210546","volume":"26","author":"S Julien","year":"2007","unstructured":"Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, Dargemont C, de Herreros AG, Bellacosa A, Larue L (2007) Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26:7445\u20137456","journal-title":"Oncogene"},{"key":"1021_CR62","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1947601910373795","volume":"1","author":"K Lin","year":"2010","unstructured":"Lin K, Baritaki S, Militello L, Malaponte G, Bevelacqua Y, Bonavida B (2010) The role of B-RAF mutations in melanoma and the induction of EMT via dysregulation of the NF-kappaB\/Snail\/RKIP\/PTEN circuit. Genes & Cancer 1:409\u2013420","journal-title":"Genes & Cancer"},{"key":"1021_CR63","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1038\/onc.2009.214","volume":"28","author":"S Baritaki","year":"2009","unstructured":"Baritaki S, Chapman A, Yeung K, Spandidos DA, Palladino M, Bonavida B (2009) Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. Oncogene 28:3573\u20133585","journal-title":"Oncogene"},{"key":"1021_CR64","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/cdd.2010.103","volume":"18","author":"QQ Li","year":"2011","unstructured":"Li QQ, Chen ZQ, Cao XX, Xu JD, Xu JW, Chen YY, Wang WJ, Chen Q, Tang F, Liu XP et al (2011) Involvement of NF-kappaB\/miR-448 regulatory feedback loop in chemotherapy-induced epithelial\u2013mesenchymal transition of breast cancer cells. Cell Death Differ 18:16\u201325","journal-title":"Cell Death Differ"},{"key":"1021_CR65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","volume":"17","author":"TS Blackwell","year":"1997","unstructured":"Blackwell TS, Christman JW (1997) The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 17:3\u20139","journal-title":"Am J Respir Cell Mol Biol"},{"key":"1021_CR66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","volume":"134","author":"J Massague","year":"2008","unstructured":"Massague J (2008) TGFbeta in cancer. Cell 134:215\u2013230","journal-title":"Cell"},{"key":"1021_CR67","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.semcancer.2012.05.004","volume":"22","author":"J Fuxe","year":"2012","unstructured":"Fuxe J, Karlsson MC (2012) TGF-beta-induced epithelial\u2013mesenchymal transition: a link between cancer and inflammation. Semin Cancer Biol 22:455\u2013461","journal-title":"Semin Cancer Biol"},{"key":"1021_CR68","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","volume":"20","author":"M Labelle","year":"2011","unstructured":"Labelle M, Begum S, Hynes RO (2011) Direct signaling between platelets and cancer cells induces an epithelial\u2013mesenchymal-like transition and promotes metastasis. Cancer Cell 20:576\u2013590","journal-title":"Cancer Cell"},{"key":"1021_CR69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","volume":"7","author":"H Yu","year":"2007","unstructured":"Yu H, Kortylewski M, Pardoll D (2007) Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7:41\u201351","journal-title":"Nat Rev Immunol"},{"key":"1021_CR70","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1582-4934.2008.00647.x","volume":"13","author":"DE Sullivan","year":"2009","unstructured":"Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR (2009) TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med 13:1866\u20131876","journal-title":"J Cell Mol Med"},{"key":"1021_CR71","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cell.2009.01.039","volume":"137","author":"M Adorno","year":"2009","unstructured":"Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V et al (2009) A mutant\u2013p53\/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell 137:87\u201398","journal-title":"Cell"},{"key":"1021_CR72","doi-asserted-by":"crossref","first-page":"21113","DOI":"10.1074\/jbc.M211304200","volume":"278","author":"H Peinado","year":"2003","unstructured":"Peinado H, Quintanilla M, Cano A (2003) Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113\u201321123","journal-title":"J Biol Chem"},{"key":"1021_CR73","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1073\/pnas.0913360107","volume":"107","author":"M Graauw de","year":"2010","unstructured":"de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Devedec SE, Smit VT, van der Wal A et al (2010) Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proc Natl Acad Sci USA 107:6340\u20136345","journal-title":"Proc Natl Acad Sci USA"},{"key":"1021_CR74","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1158\/0008-5472.CAN-09-1872","volume":"70","author":"P Papageorgis","year":"2010","unstructured":"Papageorgis P, Lambert AW, Ozturk S, Gao F, Pan H, Manne U, Alekseyev YO, Thiagalingam A, Abdolmaleky HM, Lenburg M et al (2010) Smad signaling is required to maintain epigenetic silencing during breast cancer progression. Cancer Res 70:968\u2013978","journal-title":"Cancer Res"},{"key":"1021_CR75","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1242\/jcs.115.15.3193","volume":"115","author":"AV Bakin","year":"2002","unstructured":"Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL (2002) p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 115:3193\u20133206","journal-title":"J Cell Sci"},{"key":"1021_CR76","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/35087019","volume":"3","author":"R Perlman","year":"2001","unstructured":"Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA (2001) TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 3:708\u2013714","journal-title":"Nat Cell Biol"},{"key":"1021_CR77","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.1073\/pnas.111614398","volume":"98","author":"J Zavadil","year":"2001","unstructured":"Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, Piek E, Bottinger EP (2001) Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci USA 98:6686\u20136691","journal-title":"Proc Natl Acad Sci USA"},{"key":"1021_CR78","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.onc.1206132","volume":"22","author":"M Arsura","year":"2003","unstructured":"Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS et al (2003) Transient activation of NF-kappaB through a TAK1\/IKK kinase pathway by TGF-beta1 inhibits AP-1\/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22:412\u2013425","journal-title":"Oncogene"},{"key":"1021_CR79","first-page":"286","volume":"12","author":"A Chaudhury","year":"2010","unstructured":"Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH (2010) TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. NatureCell Biology 12:286\u2013293","journal-title":"NatureCell Biology"},{"key":"1021_CR80","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1158\/0008-5472.CAN-07-3094","volume":"68","author":"JR Neil","year":"2008","unstructured":"Neil JR, Schiemann WP (2008) Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res 68:1462\u20131470","journal-title":"Cancer Res"},{"key":"1021_CR81","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1038\/sj.onc.1206478","volume":"22","author":"JI Park","year":"2003","unstructured":"Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG (2003) Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene 22:4314\u20134332","journal-title":"Oncogene"},{"key":"1021_CR82","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1038\/onc.2008.346","volume":"27","author":"G Moreno-Bueno","year":"2008","unstructured":"Moreno-Bueno G, Portillo F, Cano A (2008) Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27:6958\u20136969","journal-title":"Oncogene"},{"key":"1021_CR83","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1158\/1535-7163.MCT-09-0832","volume":"9","author":"SA Rajasekaran","year":"2010","unstructured":"Rajasekaran SA, Huynh TP, Wolle DG, Espineda CE, Inge LJ, Skay A, Lassman C, Nicholas SB, Harper JF, Reeves AE et al (2010) Na, K-ATPase subunits as markers for epithelial\u2013mesenchymal transition in cancer and fibrosis. Mol Cancer Ther 9:1515\u20131524","journal-title":"Mol Cancer Ther"},{"key":"1021_CR84","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","volume":"7","author":"H Peinado","year":"2007","unstructured":"Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7:415\u2013428","journal-title":"Nat Rev Cancer"},{"key":"1021_CR85","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/carcin\/bgq108","volume":"31","author":"M Natsuizaka","year":"2010","unstructured":"Natsuizaka M, Ohashi S, Wong GS, Ahmadi A, Kalman RA, Budo D, Klein-Szanto AJ, Herlyn M, Diehl JA, Nakagawa H (2010) Insulin-like growth factor-binding protein-3 promotes transforming growth factor-{beta}1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells. Carcinogenesis 31:1344\u20131353","journal-title":"Carcinogenesis"},{"key":"1021_CR86","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1038\/onc.2010.258","volume":"29","author":"B Kong","year":"2010","unstructured":"Kong B, Michalski CW, Hong X, Valkovskaya N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H et al (2010) AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling. Oncogene 29:5146\u20135158","journal-title":"Oncogene"},{"key":"1021_CR87","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1158\/0008-5472.CAN-10-1354","volume":"70","author":"DS Micalizzi","year":"2010","unstructured":"Micalizzi DS, Wang CA, Farabaugh SM, Schiemann WP, Ford HL (2010) Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res 70:10371\u201310380","journal-title":"Cancer Res"},{"key":"1021_CR88","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/onc.2010.169","volume":"29","author":"J Braun","year":"2010","unstructured":"Braun J, Hoang-Vu C, Dralle H, Huttelmaier S (2010) Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene 29:4237\u20134244","journal-title":"Oncogene"},{"key":"1021_CR89","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","volume":"283","author":"M Korpal","year":"2008","unstructured":"Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial\u2013mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910\u201314914","journal-title":"J Biol Chem"},{"key":"1021_CR90","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ncb1722","volume":"10","author":"PA Gregory","year":"2008","unstructured":"Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10:593\u2013601","journal-title":"Nat Cell Biol"},{"key":"1021_CR91","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1091\/mbc.E11-02-0103","volume":"22","author":"PA Gregory","year":"2011","unstructured":"Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY et al (2011) An autocrine TGF-beta\/ZEB\/miR-200 signaling network regulates establishment and maintenance of epithelial\u2013mesenchymal transition. Mol Biol Cell 22:1686\u20131698","journal-title":"Mol Biol Cell"},{"key":"1021_CR92","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/embor.2008.74","volume":"9","author":"U Burk","year":"2008","unstructured":"Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9:582\u2013589","journal-title":"EMBO Rep"},{"key":"1021_CR93","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1101\/gad.1640608","volume":"22","author":"SM Park","year":"2008","unstructured":"Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894\u2013907","journal-title":"Genes Dev"},{"key":"1021_CR94","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1074\/jbc.M611393200","volume":"282","author":"S Zhu","year":"2007","unstructured":"Zhu S, Si ML, Wu H, Mo YY (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282:14328\u201314336","journal-title":"J Biol Chem"},{"key":"1021_CR95","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1128\/MCB.00941-08","volume":"28","author":"W Kong","year":"2008","unstructured":"Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ (2008) MicroRNA-155 is regulated by the transforming growth factor beta\/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 28:6773\u20136784","journal-title":"Mol Cell Biol"},{"key":"1021_CR96","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/cc.6.1.3669","volume":"6","author":"V Gocheva","year":"2007","unstructured":"Gocheva V, Joyce JA (2007) Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle 6:60\u201364","journal-title":"Cell Cycle"},{"key":"1021_CR97","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cccn.2003.12.016","volume":"342","author":"I Berdowska","year":"2004","unstructured":"Berdowska I (2004) Cysteine proteases as disease markers. Clin Chim Acta Int J Clin Chem 342:41\u201369","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"1021_CR98","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"K Kessenbrock","year":"2010","unstructured":"Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52\u201367","journal-title":"Cell"},{"key":"1021_CR99","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","volume":"121","author":"A Orimo","year":"2005","unstructured":"Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion. Cell 121:335\u2013348","journal-title":"Cell"},{"key":"1021_CR100","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1101\/gad.13.11.1382","volume":"13","author":"LM Coussens","year":"1999","unstructured":"Coussens LM, Raymond WW, Bergers G, Laig-Webster M, Behrendtsen O, Werb Z, Caughey GH, Hanahan D (1999) Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev 13:1382\u20131397","journal-title":"Genes Dev"},{"key":"1021_CR101","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0092-8674(00)00139-2","volume":"103","author":"LM Coussens","year":"2000","unstructured":"Coussens LM, Tinkle CL, Hanahan D, Werb Z (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103:481\u2013490","journal-title":"Cell"},{"key":"1021_CR102","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1593\/neo.07871","volume":"10","author":"JC Pahler","year":"2008","unstructured":"Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE, Hanahan D (2008) Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 10:329\u2013340","journal-title":"Neoplasia"},{"key":"1021_CR103","first-page":"615","volume":"23","author":"M Xiang","year":"2010","unstructured":"Xiang M, Gu Y, Zhao F, Lu H, Chen S, Yin L (2010) Mast cell tryptase promotes breast cancer migration and invasion. Oncol Rep 23:615\u2013619","journal-title":"Oncol Rep"},{"key":"1021_CR104","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2006.01.007","volume":"124","author":"J Condeelis","year":"2006","unstructured":"Condeelis J, Pollard JW (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124:263\u2013266","journal-title":"Cell"},{"key":"1021_CR105","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1158\/0008-5472.CAN-05-4463","volume":"66","author":"O Vasiljeva","year":"2006","unstructured":"Vasiljeva O, Papazoglou A, Kruger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M et al (2006) Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 66:5242\u20135250","journal-title":"Cancer Res"},{"key":"1021_CR106","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000276564","volume":"25","author":"MM Mohamed","year":"2010","unstructured":"Mohamed MM, Cavallo-Medved D, Rudy D, Anbalagan A, Moin K, Sloane BF (2010) Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol 25:315\u2013324","journal-title":"Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol"},{"key":"1021_CR107","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1172\/JCI200317913","volume":"112","author":"Y Li","year":"2003","unstructured":"Li Y, Yang J, Dai C, Wu C, Liu Y (2003) Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112:503\u2013516","journal-title":"J Clin Invest"},{"key":"1021_CR108","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1046\/j.1523-1755.2002.00333.x","volume":"61","author":"F Strutz","year":"2002","unstructured":"Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Muller GA, Neilson EG (2002) Role of basic fibroblast growth factor-2 in epithelial\u2013mesenchymal transformation. Kidney Int 61:1714\u20131728","journal-title":"Kidney Int"},{"key":"1021_CR109","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ng1997","volume":"39","author":"T Kitamura","year":"2007","unstructured":"Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A et al (2007) SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet 39:467\u2013475","journal-title":"Nat Genet"},{"key":"1021_CR110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.1874010","volume":"24","author":"V Gocheva","year":"2010","unstructured":"Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, Berman T, Joyce JA (2010) IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev 24:241\u2013255","journal-title":"Genes Dev"},{"key":"1021_CR111","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4049\/jimmunol.1000413","volume":"185","author":"G Solinas","year":"2010","unstructured":"Solinas G, Schiarea S, Liguori M, Fabbri M, Pesce S, Zammataro L, Pasqualini F, Nebuloni M, Chiabrando C, Mantovani A et al (2010) Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility. J Immunol 185:642\u2013652","journal-title":"J Immunol"},{"key":"1021_CR112","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nature05656","volume":"446","author":"JL Luo","year":"2007","unstructured":"Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446:690\u2013694","journal-title":"Nature"},{"key":"1021_CR113","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/onc.2010.387","volume":"30","author":"L Sevenich","year":"2011","unstructured":"Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Muller S, Follo M, Peters C, Reinheckel T (2011) Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice. Oncogene 30:54\u201364","journal-title":"Oncogene"},{"key":"1021_CR114","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1158\/0008-5472.CAN-07-2048","volume":"67","author":"T Kawakubo","year":"2007","unstructured":"Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama KI, Kadowaki T, Tsukuba T, Yamamoto K (2007) Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface. Cancer Res 67:10869\u201310878","journal-title":"Cancer Res"},{"key":"1021_CR115","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1084\/jem.20090207","volume":"206","author":"L Wang","year":"2009","unstructured":"Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206:1457\u20131464","journal-title":"J Exp Med"},{"key":"1021_CR116","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2009.06.018","volume":"16","author":"DG DeNardo","year":"2009","unstructured":"DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM (2009) CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16:91\u2013102","journal-title":"Cancer Cell"},{"key":"1021_CR117","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature07623","volume":"457","author":"S Kim","year":"2009","unstructured":"Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457:102\u2013106","journal-title":"Nature"},{"key":"1021_CR118","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","volume":"9","author":"DX Nguyen","year":"2009","unstructured":"Nguyen DX, Bos PD, Massague J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9:274\u2013284","journal-title":"Nat Rev Cancer"},{"key":"1021_CR119","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10585-007-9130-6","volume":"25","author":"P Gassmann","year":"2008","unstructured":"Gassmann P, Haier J (2008) The tumor cell\u2013host organ interface in the early onset of metastatic organ colonisation. Clin Exp Metastasis 25:171\u2013181","journal-title":"Clin Exp Metastasis"},{"key":"1021_CR120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccr.2004.08.012","volume":"6","author":"JL Luo","year":"2004","unstructured":"Luo JL, Maeda S, Hsu LC, Yagita H, Karin M (2004) Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell 6:297\u2013305","journal-title":"Cancer Cell"},{"key":"1021_CR121","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nrc2371","volume":"8","author":"JM Pawelek","year":"2008","unstructured":"Pawelek JM, Chakraborty AK (2008) Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. Nat Rev Cancer 8:377\u2013386","journal-title":"Nat Rev Cancer"},{"key":"1021_CR122","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1182\/blood-2004-02-0434","volume":"104","author":"E Camerer","year":"2004","unstructured":"Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR (2004) Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 104:397\u2013401","journal-title":"Blood"},{"key":"1021_CR123","doi-asserted-by":"crossref","first-page":"8613","DOI":"10.1158\/0008-5472.CAN-04-2078","volume":"64","author":"JH Im","year":"2004","unstructured":"Im JH, Fu W, Wang H, Bhatia SK, Hammer DA, Kowalska MA, Muschel RJ (2004) Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res 64:8613\u20138619","journal-title":"Cancer Res"},{"key":"1021_CR124","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1182\/blood-2007-01-065995","volume":"110","author":"JS Palumbo","year":"2007","unstructured":"Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL (2007) Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood 110:133\u2013141","journal-title":"Blood"},{"key":"1021_CR125","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/sj.bjp.0706013","volume":"143","author":"P Jurasz","year":"2004","unstructured":"Jurasz P, Alonso-Escolano D, Radomski MW (2004) Platelet\u2013cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation. Br J Pharmacol 143:819\u2013826","journal-title":"Br J Pharmacol"},{"key":"1021_CR126","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(02)00789-1","volume":"3","author":"GF Nash","year":"2002","unstructured":"Nash GF, Turner LF, Scully MF, Kakkar AK (2002) Platelets and cancer. Lancet Oncol 3:425\u2013430","journal-title":"Lancet Oncol"},{"key":"1021_CR127","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2741\/3261","volume":"14","author":"R Bonecchi","year":"2009","unstructured":"Bonecchi R, Galliera E, Borroni EM, Corsi MM, Locati M, Mantovani A (2009) Chemokines and chemokine receptors: an overview. Front Biosci J Virtual Libr 14:540\u2013551","journal-title":"Front Biosci J Virtual Libr"},{"key":"1021_CR128","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/ijc.24409","volume":"125","author":"B McDonald","year":"2009","unstructured":"McDonald B, Spicer J, Giannais B, Fallavollita L, Brodt P, Ferri LE (2009) Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int J Cancer J Int du Cancer 125:1298\u20131305","journal-title":"Int J Cancer J Int du Cancer"},{"key":"1021_CR129","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/ijc.11297","volume":"106","author":"MJ Slattery","year":"2003","unstructured":"Slattery MJ, Dong C (2003) Neutrophils influence melanoma adhesion and migration under flow conditions. Int J Cancer J International du Cancer 106:713\u2013722","journal-title":"Int J Cancer J International du Cancer"},{"key":"1021_CR130","doi-asserted-by":"crossref","first-page":"C831","DOI":"10.1152\/ajpcell.00439.2004","volume":"288","author":"MJ Slattery","year":"2005","unstructured":"Slattery MJ, Liang S, Dong C (2005) Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation. Am J Physiol Cell Physiol 288:C831\u2013C839","journal-title":"Am J Physiol Cell Physiol"},{"key":"1021_CR131","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1158\/0008-5472.CAN-11-2393","volume":"72","author":"JD Spicer","year":"2012","unstructured":"Spicer JD, McDonald B, Cools-Lartigue JJ, Chow SC, Giannias B, Kubes P, Ferri LE (2012) Neutrophils promote liver metastasis via Mac-1-mediated interactions with circulating tumor cells. Cancer Res 72:3919\u20133927","journal-title":"Cancer Res"},{"key":"1021_CR132","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.acthis.2006.03.008","volume":"108","author":"SB Oppenheimer","year":"2006","unstructured":"Oppenheimer SB (2006) Cellular basis of cancer metastasis: a review of fundamentals and new advances. Acta Histochem 108:327\u2013334","journal-title":"Acta Histochem"},{"key":"1021_CR133","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1158\/0008-5472.CAN-07-1543","volume":"67","author":"TC Wu","year":"2007","unstructured":"Wu TC (2007) The role of vascular cell adhesion molecule-1 in tumor immune evasion. Cancer Res 67:6003\u20136006","journal-title":"Cancer Res"},{"key":"1021_CR134","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1158\/0008-5472.CAN-06-3014","volume":"67","author":"KY Lin","year":"2007","unstructured":"Lin KY, Lu D, Hung CF, Peng S, Huang L, Jie C, Murillo F, Rowley J, Tsai YC, He L et al (2007) Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion. Cancer Res 67:1832\u20131841","journal-title":"Cancer Res"},{"key":"1021_CR135","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ccr.2011.08.025","volume":"20","author":"Q Chen","year":"2011","unstructured":"Chen Q, Zhang XH, Massague J (2011) Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20:538\u2013549","journal-title":"Cancer Cell"},{"key":"1021_CR136","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ccr.2011.11.002","volume":"20","author":"X Lu","year":"2011","unstructured":"Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M, Yan J, Hua Y, Tiede BJ, Haffty BG et al (2011) VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteoclast progenitors. Cancer Cell 20:701\u2013714","journal-title":"Cancer Cell"},{"key":"1021_CR137","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/cdd.2008.190","volume":"16","author":"M Kochetkova","year":"2009","unstructured":"Kochetkova M, Kumar S, McColl SR (2009) Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death Differ 16:664\u2013673","journal-title":"Cell Death Differ"},{"key":"1021_CR138","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1196\/annals.1413.021","volume":"1131","author":"S Das","year":"2008","unstructured":"Das S, Skobe M (2008) Lymphatic vessel activation in cancer. Ann N Y Acad Sci 1131:235\u2013241","journal-title":"Ann N Y Acad Sci"},{"key":"1021_CR139","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2004.05.003","volume":"25","author":"P Saharinen","year":"2004","unstructured":"Saharinen P, Tammela T, Karkkainen MJ, Alitalo K (2004) Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 25:387\u2013395","journal-title":"Trends Immunol"},{"key":"1021_CR140","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10555-006-9036-9","volume":"25","author":"RN Kaplan","year":"2006","unstructured":"Kaplan RN, Psaila B, Lyden D (2006) Bone marrow cells in the \u2018pre-metastatic niche\u2019: within bone and beyond. Cancer Metastasis Rev 25:521\u2013529","journal-title":"Cancer Metastasis Rev"},{"key":"1021_CR141","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nature04186","volume":"438","author":"RN Kaplan","year":"2005","unstructured":"Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA et al (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820\u2013827","journal-title":"Nature"},{"key":"1021_CR142","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1158\/0008-5472.CAN-10-0706","volume":"70","author":"HH Yan","year":"2010","unstructured":"Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, Geng Y, Gray JW, Moses HL, Yang L (2010) Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung. Cancer Res 70:6139\u20136149","journal-title":"Cancer Res"},{"key":"1021_CR143","doi-asserted-by":"crossref","first-page":"5996","DOI":"10.1158\/0008-5472.CAN-08-4619","volume":"69","author":"PB Olkhanud","year":"2009","unstructured":"Olkhanud PB, Baatar D, Bodogai M, Hakim F, Gress R, Anderson RL, Deng J, Xu M, Briest S, Biragyn A (2009) Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells. Cancer Res 69:5996\u20136004","journal-title":"Cancer Res"},{"key":"1021_CR144","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/ncb1507","volume":"8","author":"S Hiratsuka","year":"2006","unstructured":"Hiratsuka S, Watanabe A, Aburatani H, Maru Y (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369\u20131375","journal-title":"Nat Cell Biol"},{"key":"1021_CR145","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ncb1794","volume":"10","author":"S Hiratsuka","year":"2008","unstructured":"Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol 10:1349\u20131355","journal-title":"Nat Cell Biol"},{"key":"1021_CR146","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","volume":"440","author":"JT Erler","year":"2006","unstructured":"Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440:1222\u20131226","journal-title":"Nature"},{"key":"1021_CR147","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10555-010-9224-5","volume":"29","author":"EC Finger","year":"2010","unstructured":"Finger EC, Giaccia AJ (2010) Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev 29:285\u2013293","journal-title":"Cancer Metastasis Rev"},{"key":"1021_CR148","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2004.09.027","volume":"6","author":"YM Li","year":"2004","unstructured":"Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D et al (2004) Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6:459\u2013469","journal-title":"Cancer Cell"},{"key":"1021_CR149","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1158\/0008-5472.CAN-08-1810","volume":"68","author":"F Marchesi","year":"2008","unstructured":"Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P et al (2008) The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 68:9060\u20139069","journal-title":"Cancer Res"},{"key":"1021_CR150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/BD-2007-26106","volume":"26","author":"B Psaila","year":"2006","unstructured":"Psaila B, Kaplan RN, Port ER, Lyden D (2006) Priming the \u2018soil\u2019 for breast cancer metastasis: the pre-metastatic niche. Breast Dis 26:65\u201374","journal-title":"Breast Dis"},{"key":"1021_CR151","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcancer.2011.01.002","volume":"21","author":"H Peinado","year":"2011","unstructured":"Peinado H, Lavotshkin S, Lyden D (2011) The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin Cancer Biol 21:139\u2013146","journal-title":"Semin Cancer Biol"},{"key":"1021_CR152","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2174\/156652411797536705","volume":"11","author":"N Rucci","year":"2011","unstructured":"Rucci N, Sanita P, Angelucci A (2011) Roles of metalloproteases in metastatic niche. Curr Mol Med 11:609\u2013622","journal-title":"Curr Mol Med"},{"key":"1021_CR153","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm1400","volume":"12","author":"DK Jin","year":"2006","unstructured":"Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B et al (2006) Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med 12:557\u2013567","journal-title":"Nat Med"},{"key":"1021_CR154","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1158\/0008-5472.CAN-03-1829","volume":"64","author":"L Mendoza","year":"2004","unstructured":"Mendoza L, Valcarcel M, Carrascal T, Egilegor E, Salado C, Sim BK, Vidal-Vanaclocha F (2004) Inhibition of cytokine-induced microvascular arrest of tumor cells by recombinant endostatin prevents experimental hepatic melanoma metastasis. Cancer Res 64:304\u2013310","journal-title":"Cancer Res"},{"key":"1021_CR155","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12307-008-0011-6","volume":"1","author":"F Vidal-Vanaclocha","year":"2008","unstructured":"Vidal-Vanaclocha F (2008) The prometastatic microenvironment of the liver. Cancer microenviron Off J Int Cancer Microenviron Soc 1:113\u2013129","journal-title":"Cancer microenviron Off J Int Cancer Microenviron Soc"},{"key":"1021_CR156","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0898-6568(03)00113-X","volume":"16","author":"KS Brown","year":"2004","unstructured":"Brown KS, Blair D, Reid SD, Nicholson EK, Harnett MM (2004) FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3\u2032-inositol phosphatase, PTEN. Cell Signal 16:71\u201380","journal-title":"Cell Signal"},{"key":"1021_CR157","doi-asserted-by":"crossref","first-page":"657406","DOI":"10.1155\/2010\/657406","volume":"2010","author":"JF Cohen-Solal","year":"2010","unstructured":"Cohen-Solal JF, Cassard L, Fournier EM, Loncar SM, Fridman WH, Sautes-Fridman C (2010) Metastatic melanomas express inhibitory low affinity fc gamma receptor and escape humoral immunity. Dermatol res pract 2010:657406","journal-title":"Dermatol res pract"},{"key":"1021_CR158","doi-asserted-by":"crossref","first-page":"29087","DOI":"10.1074\/jbc.M109.035899","volume":"284","author":"X Lu","year":"2009","unstructured":"Lu X, Kang Y (2009) Chemokine (C\u2013C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem 284:29087\u201329096","journal-title":"J Biol Chem"},{"key":"1021_CR159","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"GR Mundy","year":"2002","unstructured":"Mundy GR (2002) Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2:584\u2013593","journal-title":"Nat Rev Cancer"},{"key":"1021_CR160","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.ejca.2010.02.026","volume":"46","author":"T Ara","year":"2010","unstructured":"Ara T, Declerck YA (2010) Interleukin-6 in bone metastasis and cancer progression. Eur J Cancer 46:1223\u20131231","journal-title":"Eur J Cancer"},{"key":"1021_CR161","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nm1519","volume":"13","author":"BK Park","year":"2007","unstructured":"Park BK, Zhang H, Zeng Q, Dai J, Keller ET, Giordano T, Gu K, Shah V, Pei L, Zarbo RJ et al (2007) NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med 13:62\u201369","journal-title":"Nat Med"},{"key":"1021_CR162","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s10585-008-9193-z","volume":"25","author":"DP Fitzgerald","year":"2008","unstructured":"Fitzgerald DP, Palmieri D, Hua E, Hargrave E, Herring JM, Qian Y, Vega-Valle E, Weil RJ, Stark AM, Vortmeyer AO et al (2008) Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization. Clin Exp Metastasis 25:799\u2013810","journal-title":"Clin Exp Metastasis"},{"key":"1021_CR163","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ccr.2007.12.003","volume":"13","author":"Y Husemann","year":"2008","unstructured":"Husemann Y, Geigl JB, Schubert F, Musiani P, Meyer M, Burghart E, Forni G, Eils R, Fehm T, Riethmuller G et al (2008) Systemic spread is an early step in breast cancer. Cancer Cell 13:58\u201368","journal-title":"Cancer Cell"},{"key":"1021_CR164","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrc2627","volume":"9","author":"CA Klein","year":"2009","unstructured":"Klein CA (2009) Parallel progression of primary tumours and metastases. Nat Rev Cancer 9:302\u2013312","journal-title":"Nat Rev Cancer"},{"key":"1021_CR165","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrc3125","volume":"11","author":"N Sethi","year":"2011","unstructured":"Sethi N, Kang Y (2011) Unravelling the complexity of metastasis\u2014molecular understanding and targeted therapies. Nat Rev Cancer 11:735\u2013748","journal-title":"Nat Rev Cancer"},{"key":"1021_CR166","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/embor.2012.41","volume":"13","author":"BI Koh","year":"2012","unstructured":"Koh BI, Kang Y (2012) The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells. EMBO Rep 13:412\u2013422","journal-title":"EMBO Rep"},{"key":"1021_CR167","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.pathol.1.110304.100224","volume":"1","author":"TD Tlsty","year":"2006","unstructured":"Tlsty TD, Coussens LM (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1:119\u2013150","journal-title":"Annu Rev Pathol"},{"key":"1021_CR168","doi-asserted-by":"crossref","first-page":"R155","DOI":"10.1186\/bcr3368","volume":"14","author":"CA Fordyce","year":"2012","unstructured":"Fordyce CA, Patten KT, Fessenden TB, Defilippis R, Hwang ES, Zhao J, Tlsty TD (2012) Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes: BCR. Breast Cancer Res 14:R155","journal-title":"Breast Cancer Res"},{"key":"1021_CR169","doi-asserted-by":"crossref","first-page":"e7965","DOI":"10.1371\/journal.pone.0007965","volume":"4","author":"D Liao","year":"2009","unstructured":"Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA (2009) Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS One 4:e7965","journal-title":"PLoS One"},{"key":"1021_CR170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s12015-008-9030-4","volume":"4","author":"J Stagg","year":"2008","unstructured":"Stagg J (2008) Mesenchymal stem cells in cancer. Stem Cell Rev 4:119\u2013124","journal-title":"Stem Cell Rev"},{"key":"1021_CR171","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1158\/1078-0432.CCR-07-0731","volume":"13","author":"RM Dwyer","year":"2007","unstructured":"Dwyer RM, Potter-Beirne SM, Harrington KA, Lowery AJ, Hennessy E, Murphy JM, Barry FP, O\u2019Brien T, Kerin MJ (2007) Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells. Clin cancer res off J Am Assoc Cancer Res 13:5020\u20135027","journal-title":"Clin cancer res off J Am Assoc Cancer Res"},{"key":"1021_CR172","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/stem.559","volume":"29","author":"AH Klopp","year":"2011","unstructured":"Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F 3rd (2011) Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells 29:11\u201319","journal-title":"Stem Cells"},{"key":"1021_CR173","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1634\/stemcells.2007-0737","volume":"26","author":"JY Oh","year":"2008","unstructured":"Oh JY, Kim MK, Shin MS, Lee HJ, Ko JH, Wee WR, Lee JH (2008) The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells 26:1047\u20131055","journal-title":"Stem Cells"},{"key":"1021_CR174","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","volume":"131","author":"B Sacchetti","year":"2007","unstructured":"Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M et al (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131:324\u2013336","journal-title":"Cell"},{"key":"1021_CR175","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/sj.bjc.6604508","volume":"99","author":"BM Beckermann","year":"2008","unstructured":"Beckermann BM, Kallifatidis G, Groth A, Frommhold D, Apel A, Mattern J, Salnikov AV, Moldenhauer G, Wagner W, Diehlmann A et al (2008) VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. Br J Cancer 99:622\u2013631","journal-title":"Br J Cancer"},{"key":"1021_CR176","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","volume":"449","author":"AE Karnoub","year":"2007","unstructured":"Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557\u2013563","journal-title":"Nature"},{"key":"1021_CR177","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1158\/0008-5472.CAN-10-1254","volume":"70","author":"RH Goldstein","year":"2010","unstructured":"Goldstein RH, Reagan MR, Anderson K, Kaplan DL, Rosenblatt M (2010) Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res 70:10044\u201310050","journal-title":"Cancer Res"},{"key":"1021_CR178","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF03256317","volume":"13","author":"L Dunn","year":"2009","unstructured":"Dunn L, Demichele A (2009) Genomic predictors of outcome and treatment response in breast cancer. Mol Diagn Ther 13:73\u201390","journal-title":"Mol Diagn Ther"},{"key":"1021_CR179","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","volume":"21","author":"JK Kolls","year":"2004","unstructured":"Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467\u2013476","journal-title":"Immunity"},{"key":"1021_CR180","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","volume":"25","author":"CT Weaver","year":"2007","unstructured":"Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821\u2013852","journal-title":"Annu Rev Immunol"},{"key":"1021_CR181","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1182\/blood-2002-05-1461","volume":"101","author":"M Numasaki","year":"2003","unstructured":"Numasaki M, Fukushi J, Ono M, Narula SK, Zavodny PJ, Kudo T, Robbins PD, Tahara H, Lotze MT (2003) Interleukin-17 promotes angiogenesis and tumor growth. Blood 101:2620\u20132627","journal-title":"Blood"},{"key":"1021_CR182","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.imlet.2004.01.014","volume":"93","author":"M Numasaki","year":"2004","unstructured":"Numasaki M, Lotze MT, Sasaki H (2004) Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett 93:39\u201343","journal-title":"Immunol Lett"},{"key":"1021_CR183","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.imlet.2004.11.012","volume":"98","author":"H Takahashi","year":"2005","unstructured":"Takahashi H, Numasaki M, Lotze MT, Sasaki H (2005) Interleukin-17 enhances bFGF-, HGF- and VEGF-induced growth of vascular endothelial cells. Immunol Lett 98:189\u2013193","journal-title":"Immunol Lett"},{"key":"1021_CR184","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jaci.2005.10.025","volume":"117","author":"S Letuve","year":"2006","unstructured":"Letuve S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q (2006) IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J Allergy Clin Immunol 117:590\u2013596","journal-title":"J Allergy Clin Immunol"},{"key":"1021_CR185","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3892\/or.2010.1118","volume":"25","author":"T Iida","year":"2011","unstructured":"Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K et al (2011) Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer. Oncol Rep 25:1271\u20131277","journal-title":"Oncol Rep"},{"key":"1021_CR186","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","volume":"115","author":"M Pelletier","year":"2010","unstructured":"Pelletier M, Maggi L, Micheletti A, Lazzeri E, Tamassia N, Costantini C, Cosmi L, Lunardi C, Annunziato F, Romagnani S et al (2010) Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115:335\u2013343","journal-title":"Blood"},{"key":"1021_CR187","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrclinonc.2009.52","volume":"6","author":"VL Heath","year":"2009","unstructured":"Heath VL, Bicknell R (2009) Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 6:395\u2013404","journal-title":"Nat Rev Clin Oncol"},{"key":"1021_CR188","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","volume":"307","author":"RK Jain","year":"2005","unstructured":"Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58\u201362","journal-title":"Science"},{"key":"1021_CR189","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/cncr.24238","volume":"115","author":"CN Qian","year":"2009","unstructured":"Qian CN, Huang D, Wondergem B, Teh BT (2009) Complexity of tumor vasculature in clear cell renal cell carcinoma. Cancer 115:2282\u20132289","journal-title":"Cancer"},{"key":"1021_CR190","doi-asserted-by":"crossref","first-page":"11238","DOI":"10.1158\/0008-5472.CAN-06-1278","volume":"66","author":"EY Lin","year":"2006","unstructured":"Lin EY, Li JF, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue XN, Pollard JW (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66:11238\u201311246","journal-title":"Cancer Res"},{"key":"1021_CR191","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","volume":"8","author":"M Palma De","year":"2005","unstructured":"De Palma M, Venneri MA, Galli R, Sergi Sergi L, Politi LS, Sampaolesi M, Naldini L (2005) Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8:211\u2013226","journal-title":"Cancer Cell"},{"key":"1021_CR192","doi-asserted-by":"crossref","first-page":"12493","DOI":"10.1073\/pnas.0601807103","volume":"103","author":"H Nozawa","year":"2006","unstructured":"Nozawa H, Chiu C, Hanahan D (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 103:12493\u201312498","journal-title":"Proc Natl Acad Sci USA"},{"key":"1021_CR193","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrclinonc.2009.130","volume":"6","author":"SP Ivy","year":"2009","unstructured":"Ivy SP, Wick JY, Kaufman BM (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 6:569\u2013579","journal-title":"Nat Rev Clin Oncol"},{"key":"1021_CR194","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1172\/JCI35213","volume":"118","author":"M Kujawski","year":"2008","unstructured":"Kujawski M, Kortylewski M, Lee H, Herrmann A, Kay H, Yu H (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J Clin Invest 118:3367\u20133377","journal-title":"J Clin Invest"},{"key":"1021_CR195","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nbt1323","volume":"25","author":"F Shojaei","year":"2007","unstructured":"Shojaei F, Wu X, Malik AK, Zhong C, Baldwin ME, Schanz S, Fuh G, Gerber HP, Ferrara N (2007) Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol 25:911\u2013920","journal-title":"Nat Biotechnol"},{"key":"1021_CR196","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1158\/0008-5472.CAN-10-0012","volume":"70","author":"SB Coffelt","year":"2010","unstructured":"Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y et al (2010) Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer Res 70:5270\u20135280","journal-title":"Cancer Res"},{"key":"1021_CR197","doi-asserted-by":"crossref","first-page":"8429","DOI":"10.1158\/0008-5472.CAN-07-1684","volume":"67","author":"CE Lewis","year":"2007","unstructured":"Lewis CE, De Palma M, Naldini L (2007) Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67:8429\u20138432","journal-title":"Cancer Res"},{"key":"1021_CR198","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.ajpath.2011.07.029","volume":"179","author":"A Capobianco","year":"2011","unstructured":"Capobianco A, Monno A, Cottone L, Venneri MA, Biziato D, Di Puppo F, Ferrari S, De Palma M, Manfredi AA, Rovere-Querini P (2011) Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol 179:2651\u20132659","journal-title":"Am J Pathol"},{"key":"1021_CR199","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ccr.2008.09.004","volume":"14","author":"M Palma De","year":"2008","unstructured":"De Palma M, Mazzieri R, Politi LS, Pucci F, Zonari E, Sitia G, Mazzoleni S, Moi D, Venneri MA, Indraccolo S et al (2008) Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 14:299\u2013311","journal-title":"Cancer Cell"},{"key":"1021_CR200","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm1101-1194","volume":"7","author":"D Lyden","year":"2001","unstructured":"Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L et al (2001) Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7:1194\u20131201","journal-title":"Nat Med"},{"key":"1021_CR201","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1158\/1078-0432.CCR-10-0600","volume":"16","author":"S Vallet","year":"2010","unstructured":"Vallet S, Smith MR, Raje N (2010) Novel bone-targeted strategies in oncology. Clin Cancer Res Off J Am Assoc Cancer Res 16:4084\u20134093","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1021_CR202","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10555-010-9229-0","volume":"29","author":"C Dinarello","year":"2010","unstructured":"Dinarello C (2010) Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev 29:317\u2013329","journal-title":"Cancer Metastasis Rev"},{"key":"1021_CR203","first-page":"5","volume":"13","author":"JF Grosso","year":"2013","unstructured":"Grosso JF, Jure-Kunkel MN (2013) CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 13:5","journal-title":"Cancer Immun"},{"key":"1021_CR204","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","volume":"363","author":"FS Hodi","year":"2010","unstructured":"Hodi FS, O\u2019Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711\u2013723","journal-title":"N Engl J Med"},{"key":"1021_CR205","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/CJI.0b013e318247a4e7","volume":"35","author":"J Dulos","year":"2012","unstructured":"Dulos J, Carven GJ, van Boxtel SJ, Evers S, Driessen-Engels LJ, Hobo W, Gorecka MA, de Haan AF, Mulders P, Punt CJ et al (2012) PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. J Immunother 35:169\u2013178","journal-title":"J Immunother"},{"key":"1021_CR206","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/1547691X.2012.678021","volume":"9","author":"E Simeone","year":"2012","unstructured":"Simeone E, Ascierto PA (2012) Immunomodulating antibodies in the treatment of metastatic melanoma: the experience with anti-CTLA-4, anti-CD137, and anti-PD1. J Immunotoxicol 9:241\u2013247","journal-title":"J Immunotoxicol"},{"key":"1021_CR207","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1158\/1078-0432.CCR-11-1595","volume":"17","author":"EJ Lipson","year":"2011","unstructured":"Lipson EJ, Drake CG (2011) Ipilimumab: an anti-CTLA-4 antibody for metastatic melanoma. Clin Cancer Res Off J Am Assoc Cancer Res 17:6958\u20136962","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1021_CR208","doi-asserted-by":"crossref","first-page":"893","DOI":"10.18632\/oncotarget.593","volume":"3","author":"T Karnezis","year":"2012","unstructured":"Karnezis T, Shayan R, Fox S, Achen MG, Stacker SA (2012) The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway. Oncotarget 3:893\u2013906","journal-title":"Oncotarget"},{"key":"1021_CR209","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.2174\/138161212802083680","volume":"18","author":"V Sanz-Motilva","year":"2012","unstructured":"Sanz-Motilva V, Martorell-Calatayud A, Nagore E (2012) Non-steroidal anti-inflammatory drugs and melanoma. Curr Pharm Des 18:3966\u20133978","journal-title":"Curr Pharm Des"},{"key":"1021_CR210","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1056\/NEJMcibr055457","volume":"354","author":"H Clevers","year":"2006","unstructured":"Clevers H (2006) Colon cancer\u2014understanding how NSAIDs work. N Engl J Med 354:761\u2013763","journal-title":"N Engl J Med"},{"key":"1021_CR211","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1158\/1078-0432.CCR-07-0641","volume":"14","author":"DY Lee","year":"2008","unstructured":"Lee DY, Park K, Kim SK, Park RW, Kwon IC, Kim SY, Byun Y (2008) Antimetastatic effect of an orally active heparin derivative on experimentally induced metastasis. Clin Cancer Res Off J Am Assoc Cancer Res 14:2841\u20132849","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1021_CR212","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2045-824X-4-14","volume":"4","author":"MC Schmid","year":"2012","unstructured":"Schmid MC, Varner JA (2012) Myeloid cells in tumor inflammation. Vascular cell 4:14","journal-title":"Vascular cell"},{"key":"1021_CR213","first-page":"4263","volume":"32","author":"D Ilkovitch","year":"2012","unstructured":"Ilkovitch D, Carrio R, Lopez DM (2012) uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation. Anticancer Res 32:4263\u20134270","journal-title":"Anticancer Res"},{"key":"1021_CR214","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/08820139.2012.695417","volume":"41","author":"N Obermajer","year":"2012","unstructured":"Obermajer N, Wong JL, Edwards RP, Odunsi K, Moysich K, Kalinski P (2012) PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells. Immunol Invest 41:635\u2013657","journal-title":"Immunol Invest"},{"key":"1021_CR215","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s00109-012-0916-x","volume":"90","author":"CT Wu","year":"2012","unstructured":"Wu CT, Hsieh CC, Lin CC, Chen WC, Hong JH, Chen MF (2012) Significance of IL-6 in the transition of hormone-resistant prostate cancer and the induction of myeloid-derived suppressor cells. J Mol Med (Berl) 90:1343\u20131355","journal-title":"J Mol Med (Berl)"},{"key":"1021_CR216","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.4049\/jimmunol.1103553","volume":"188","author":"P Jayaraman","year":"2012","unstructured":"Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW et al (2012) Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188:5365\u20135376","journal-title":"J Immunol"},{"key":"1021_CR217","doi-asserted-by":"crossref","first-page":"e1001162","DOI":"10.1371\/journal.pbio.1001162","volume":"9","author":"B Toh","year":"2011","unstructured":"Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, Kato M, Prevost-Blondel A, Thiery JP, Abastado JP (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol 9:e1001162","journal-title":"PLoS Biol"},{"key":"1021_CR218","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4161\/onci.19401","volume":"1","author":"A Facciabene","year":"2012","unstructured":"Facciabene A, Santoro S, Coukos G (2012) Know thy enemy: why are tumor-infiltrating regulatory T cells so deleterious? Oncoimmunology 1:575\u2013577","journal-title":"Oncoimmunology"},{"key":"1021_CR219","doi-asserted-by":"crossref","first-page":"6110","DOI":"10.1158\/1078-0432.CCR-12-2130","volume":"18","author":"DA Wainwright","year":"2012","unstructured":"Wainwright DA, Balyasnikova IV, Chang AL, Ahmed AU, Moon KS, Auffinger B, Tobias AL, Han Y, Lesniak MS (2012) IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clin Cancer Res Off J Am Assoc Cancer Res 18:6110\u20136121","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"1021_CR220","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1158\/0008-5472.CAN-08-2360","volume":"69","author":"M Gobert","year":"2009","unstructured":"Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, Biota C, Doffin AC, Durand I, Olive D et al (2009) Regulatory T cells recruited through CCL22\/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 69:2000\u20132009","journal-title":"Cancer Res"},{"key":"1021_CR221","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ccr.2009.08.014","volume":"16","author":"A Mantovani","year":"2009","unstructured":"Mantovani A (2009) The yin-yang of tumor-associated neutrophils. Cancer Cell 16:173\u2013174","journal-title":"Cancer Cell"},{"key":"1021_CR222","first-page":"83","volume":"152","author":"A Bellocq","year":"1998","unstructured":"Bellocq A, Antoine M, Flahault A, Philippe C, Crestani B, Bernaudin JF, Mayaud C, Milleron B, Baud L, Cadranel J (1998) Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome. Am J Pathol 152:83\u201392","journal-title":"Am J Pathol"},{"key":"1021_CR223","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/carcin\/bgs123","volume":"33","author":"ZG Fridlender","year":"2012","unstructured":"Fridlender ZG, Albelda SM (2012) Tumor-associated neutrophils: friend or foe? Carcinogenesis 33:949\u2013955","journal-title":"Carcinogenesis"},{"key":"1021_CR224","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","volume":"9","author":"NM Bambace","year":"2011","unstructured":"Bambace NM, Holmes CE (2011) The platelet contribution to cancer progression. J Thromb Haemostasis JTH 9:237\u2013249","journal-title":"J Thromb Haemostasis JTH"},{"key":"1021_CR225","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1038\/onc.2010.348","volume":"29","author":"RM Melillo","year":"2010","unstructured":"Melillo RM, Guarino V, Avilla E, Galdiero MR, Liotti F, Prevete N, Rossi FW, Basolo F, Ugolini C, de Paulis A et al (2010) Mast cells have a protumorigenic role in human thyroid cancer. Oncogene 29:6203\u20136215","journal-title":"Oncogene"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1021-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-013-1021-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1021-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T21:07:06Z","timestamp":1745960826000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-013-1021-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":225,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["1021"],"URL":"https:\/\/doi.org\/10.1007\/s00109-013-1021-5","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]}}}