{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:41:31Z","timestamp":1793018491022,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s00109-013-1104-3","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T08:55:06Z","timestamp":1385456106000},"page":"291-303","source":"Crossref","is-referenced-by-count":45,"title":["Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma"],"prefix":"10.1007","volume":"92","author":[{"given":"Ziqiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlai","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangxue","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"1104_CR1","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1016\/S0021-9258(18)47567-9","volume":"262","author":"S Ferrari","year":"1987","unstructured":"Ferrari S, Calabretta B, deRiel J, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel B, Gurrieri F, Baserga R (1987) Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem 262:8325\u20138332","journal-title":"J Biol Chem"},{"key":"1104_CR2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0969-2126(02)00740-2","volume":"10","author":"LR Otterbein","year":"2002","unstructured":"Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CLA, Dominguez R (2002) Crystal structures of S100A6 in the Ca2+-free and Ca2+-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Structure 10:557\u2013567","journal-title":"Structure"},{"key":"1104_CR3","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(01)00046-2","volume":"33","author":"R Donato","year":"2001","unstructured":"Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637\u2013668","journal-title":"Int J Biochem Cell Biol"},{"key":"1104_CR4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0968-0004(96)10020-7","volume":"21","author":"BW Sch\u00e4fer","year":"1996","unstructured":"Sch\u00e4fer BW, Heizmann CW (1996) The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 21:134\u2013140","journal-title":"Trends Biochem Sci"},{"key":"1104_CR5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/jcb.10398","volume":"88","author":"EC Breen","year":"2003","unstructured":"Breen EC, Tang K (2003) Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro. J Cell Biochem 88:848\u2013854","journal-title":"J Cell Biochem"},{"key":"1104_CR6","doi-asserted-by":"crossref","first-page":"30174","DOI":"10.1074\/jbc.M805318200","volume":"283","author":"JN Tsoporis","year":"2008","unstructured":"Tsoporis JN, Izhar S, Parker TG (2008) Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-\u03b1. J Biol Chem 283:30174\u201330183","journal-title":"J Biol Chem"},{"key":"1104_CR7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-4827(92)90191-A","volume":"200","author":"J Ku\u017anicki","year":"1992","unstructured":"Ku\u017anicki J, Kordowska J, Puzianowska M, Wo\u017aniewicz B (1992) Calcyclin as a marker of human epithelial cells and fibroblasts. Exp Cell Res 200:425\u2013430","journal-title":"Exp Cell Res"},{"key":"1104_CR8","first-page":"172","volume":"6","author":"K Komatsu","year":"2000","unstructured":"Komatsu K, Andoh A, Ishiguro S, Suzuki N, Hunai H, Kobune-Fujiwara Y, Kameyama M, Miyoshi J, Akedo H, Nakamura H (2000) Increased expression of S100A6 (Calcyclin), a calcium-binding protein of the S100 family, in human colorectal adenocarcinomas. Clin Cancer Res 6:172\u2013177","journal-title":"Clin Cancer Res"},{"key":"1104_CR9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2559.2005.02097.x","volume":"46","author":"SS Cross","year":"2005","unstructured":"Cross SS, Hamdy FC, Deloulme JC, Rehman I (2005) Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathol 46:256\u2013269","journal-title":"Histopathol"},{"key":"1104_CR10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1365-2559.2005.02137.x","volume":"46","author":"Y Ito","year":"2005","unstructured":"Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, Matsuzuka F, Kakudo K, Kuma K, Miyauchi A (2005) Expression of S100A2 and S100A6 in thyroid carcinomas. Histopathol 46:569\u2013575","journal-title":"Histopathol"},{"key":"1104_CR11","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1158\/0008-5472.CAN-04-4311","volume":"65","author":"D Vimalachandran","year":"2005","unstructured":"Vimalachandran D, Greenhalf W, Thompson C, L\u00fcttges J, Prime W, Campbell F, Dodson A, Watson R, Crnogorac-Jurcevic T, Lemoine N (2005) High nuclear S100A6 (Calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Res 65:3218\u20133225","journal-title":"Cancer Res"},{"key":"1104_CR12","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.lungcan.2008.06.003","volume":"63","author":"L Petris De","year":"2009","unstructured":"De Petris L, Orre LM, Kanter L, Pernemalm M, Koyi H, Lewensohn R, Lehti\u00f6 J (2009) Tumor expression of S100A6 correlates with survival of patients with stage I non-small-cell lung cancer. Lung Cancer (Amsterdam, Netherlands) 63:410\u2013417","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"key":"1104_CR13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/sj.bjc.6605289","volume":"101","author":"T Nedjadi","year":"2009","unstructured":"Nedjadi T, Kitteringham N, Campbell F, Jenkins R, Park B, Navarro P, Ashcroft F, Tepikin A, Neoptolemos J, Costello E (2009) S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer 101:1145\u20131154","journal-title":"Br J Cancer"},{"key":"1104_CR14","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2353\/ajpath.2010.091217","volume":"177","author":"XH Wang","year":"2010","unstructured":"Wang XH, Zhang LH, Zhong XY, Xing XF, Liu YQ, Niu ZJ, Peng Y, Du H, Zhang GG, Hu Y (2010) S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer. Am J Pathol 177:586\u2013597","journal-title":"Am J Pathol"},{"key":"1104_CR15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.canlet.2005.02.015","volume":"229","author":"HH Luu","year":"2005","unstructured":"Luu HH, Zhou L, Haydon RC, Deyrup AT, Montag AG, Huo D, Heck R, Heizmann CW, Peabody TD, Simon MA (2005) Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. Cancer Lett 229:135\u2013148","journal-title":"Cancer Lett"},{"key":"1104_CR16","doi-asserted-by":"crossref","first-page":"31317","DOI":"10.1074\/jbc.M703951200","volume":"282","author":"E Leclerc","year":"2007","unstructured":"Leclerc E, Fritz G, Weibel M, Heizmann CW, Galichet A (2007) S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains. J Biol Chem 282:31317\u201331331","journal-title":"J Biol Chem"},{"key":"1104_CR17","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1158\/1078-0432.CCR-05-0092","volume":"11","author":"T Arumugam","year":"2005","unstructured":"Arumugam T, Simeone DM, Van Golen K, Logsdon CD (2005) S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res 11:5356\u20135364","journal-title":"Clin Cancer Res"},{"key":"1104_CR18","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1074\/jbc.M310124200","volume":"279","author":"T Arumugam","year":"2004","unstructured":"Arumugam T, Simeone DM, Schmidt AM, Logsdon CD (2004) S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem 279:5059\u20135065","journal-title":"J Biol Chem"},{"key":"1104_CR19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/0008-5472.CAN-11-3843","volume":"73","author":"T Hibino","year":"2013","unstructured":"Hibino T, Sakaguchi M, Miyamoto S, Yamamoto M, Motoyama A, Hosoi J, Shimokata T, Ito T, Tsuboi R, Huh N (2013) S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis. Cancer Res 73:172\u2013183","journal-title":"Cancer Res"},{"key":"1104_CR20","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/pr8008622","volume":"8","author":"A Tong","year":"2009","unstructured":"Tong A, Gou L, Lau QC, Chen B, Zhao X, Li J, Tang H, Chen L, Tang M, Huang C et al (2009) Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein. J Proteome Res 8:1037\u20131046","journal-title":"J Proteome Res"},{"key":"1104_CR21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","volume":"45","author":"JF Perz","year":"2006","unstructured":"Perz JF, Armstrong GL, Farrington LA, Hutin YJF, Bell BP (2006) The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Hepatol 45:529\u2013538","journal-title":"J Hepatol"},{"key":"1104_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3748\/wjg.14.1","volume":"14","author":"M H\u00f6pfner","year":"2008","unstructured":"H\u00f6pfner M, Schuppan D, Scher\u00fcbl H (2008) Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer. World J Gastroenterol 14:1\u201314","journal-title":"World J Gastroenterol"},{"key":"1104_CR23","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/hep.22580","volume":"48","author":"RN Aravalli","year":"2008","unstructured":"Aravalli RN, Steer CJ, Cressman ENK (2008) Molecular mechanisms of hepatocellular carcinoma. Hepatol 48:2047\u20132063","journal-title":"Hepatol"},{"key":"1104_CR24","doi-asserted-by":"crossref","first-page":"e3767","DOI":"10.1371\/journal.pone.0003767","volume":"3","author":"C Melle","year":"2008","unstructured":"Melle C, Ernst G, Schimmel B, Bleul A, Von Eggeling F (2008) Colon-derived liver metastasis, colorectal carcinoma, and hepatocellular carcinoma can be discriminated by the Ca2+-binding proteins S100A6 and S100A11. PLoS One 3:e3767","journal-title":"PLoS One"},{"key":"1104_CR25","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1158\/1078-0432.CCR-05-0714","volume":"11","author":"K Ohuchida","year":"2005","unstructured":"Ohuchida K, Mizumoto K, Ishikawa N, Fujii K, Konomi H, Nagai E, Yamaguchi K, Tsuneyoshi M, Tanaka M (2005) The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target. Clin Cancer Res 11:7785\u20137793","journal-title":"Clin Cancer Res"},{"key":"1104_CR26","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.surg.2010.12.007","volume":"149","author":"Z Hua","year":"2011","unstructured":"Hua Z, Chen J, Sun B, Zhao G, Zhang Y, Fong Y, Jia Z, Yao L (2011) Specific expression of osteopontin and S100A6 in hepatocellular carcinoma. Surgery 149:783\u2013791","journal-title":"Surgery"},{"key":"1104_CR27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S1386-6346(02)00008-6","volume":"23","author":"JW Kim","year":"2002","unstructured":"Kim JW, Kim JH, Yoon SY, Joo JH, Lee Y, Lee KS, Chung JH, Choe IS (2002) S100A6 protein as a marker for differential diagnosis of cholangiocarcinoma from hepatocellular carcinoma. Hepatol Res 23:274\u2013286","journal-title":"Hepatol Res"},{"key":"1104_CR28","doi-asserted-by":"crossref","first-page":"17109","DOI":"10.1074\/jbc.M111.326975","volume":"287","author":"H Chen","year":"2012","unstructured":"Chen H, Yuan Y, Zhang C, Luo A, Ding F, Ma J, Yang S, Tian Y, Tong T, Zhan Q (2012) Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. J Biol Chem 287:17109\u201317119","journal-title":"J Biol Chem"},{"key":"1104_CR29","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1091\/mbc.E10-09-0739","volume":"22","author":"U Sack","year":"2011","unstructured":"Sack U, Walther W, Scudiero D, Selby M, Aumann J, Lemos C, Fichtner I, Schlag PM, Shoemaker RH, Stein U (2011) S100A4-induced cell motility and metastasis is restricted by the Wnt\/\u03b2-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell 22:3344\u20133354","journal-title":"Mol Biol Cell"},{"key":"1104_CR30","doi-asserted-by":"crossref","first-page":"15330","DOI":"10.1074\/jbc.M112.349787","volume":"287","author":"M Du","year":"2012","unstructured":"Du M, Wang G, Ismail TM, Gross S, Fernig DG, Barraclough R, Rudland PS, Du M, Wang G, Ismail TM (2012) S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration. J Biol Chem 287:15330\u201315344","journal-title":"J Biol Chem"},{"key":"1104_CR31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.febslet.2010.12.037","volume":"585","author":"A Voss","year":"2011","unstructured":"Voss A, Bode G, Sopalla C, Benedyk M, Varga G, B\u00f6hm M, Nacken W, Kerkhoff C (2011) Expression of S100A8\/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation. FEBS Lett 585:440\u2013446","journal-title":"FEBS Lett"},{"key":"1104_CR32","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s10350-006-0850-5","volume":"50","author":"MK Fuentes","year":"2007","unstructured":"Fuentes MK, Nigavekar SS, Arumugam T, Logsdon CD, Schmidt AM, Park JC, Huang EH (2007) RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. Dis Colon Rectum 50:1230\u20131240","journal-title":"Dis Colon Rectum"},{"key":"1104_CR33","doi-asserted-by":"crossref","first-page":"10921","DOI":"10.1021\/bi801233z","volume":"47","author":"YT Lee","year":"2008","unstructured":"Lee YT, Dimitrova YN, Schneider G, Ridenour WB, Bhattacharya S, Soss SE, Caprioli RM, Filipek A, Chazin WJ (2008) Structure of the S100A6 complex with a fragment from the c-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition. Biochemistry 47:10921\u201310932","journal-title":"Biochemistry"},{"key":"1104_CR34","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.4161\/cc.4.11.2129","volume":"4","author":"SY Fuchs","year":"2005","unstructured":"Fuchs SY, Ougolkov AV, Spiegelman VS, Minamoto T (2005) Oncogenic \u03b2-catenin signaling networks in colorectal cancer. Cell Cycle 4:1522\u20131539","journal-title":"Cell Cycle"},{"key":"1104_CR35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrc839","volume":"2","author":"I Vivanco","year":"2002","unstructured":"Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase\u2013AKT pathway in human cancer. Nat Rev Cancer 2:489\u2013501","journal-title":"Nat Rev Cancer"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1104-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-013-1104-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-013-1104-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:24:02Z","timestamp":1647527042000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-013-1104-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["1104"],"URL":"https:\/\/doi.org\/10.1007\/s00109-013-1104-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}