{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:28:06Z","timestamp":1789385286652,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s00109-014-1217-3","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T19:21:33Z","timestamp":1415992893000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Molecular signaling of the HMGB1\/RAGE axis contributes to cholesteatoma pathogenesis"],"prefix":"10.1007","volume":"93","author":[{"given":"Miroslaw J.","family":"Szczepanski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Luczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Olszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Molinska-Glura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Zagor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Krzeski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Skarzynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Misiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Dzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikolaj","family":"Bilusiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kopec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Leszczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henryk","family":"Witmanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa L.","family":"Whiteside","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"1217_CR1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","volume":"30","author":"H Kumar","year":"2011","unstructured":"Kumar H, Kawai T, Akira S (2011) Pathogen recognition by the innate immune system. Int Rev Immunol 30:16\u201334","journal-title":"Int Rev Immunol"},{"key":"1217_CR2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-065X.2008.00731.x","volume":"227","author":"NW Palm","year":"2009","unstructured":"Palm NW, Medzhitov R (2009) Pattern recognition receptors and control of adaptive immunity. Immunol Rev 227:221\u2013233","journal-title":"Immunol Rev"},{"key":"1217_CR3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-065X.2007.00579.x","volume":"220","author":"MT Lotze","year":"2007","unstructured":"Lotze MT, Zeh HJ, Rubartelli A, Sparvero LJ, Amoscato AA, Washburn NR, Devera ME, Liang X, Tor M, Billiar T (2007) The grateful dead: damage-associated molecular pattern molecules and reduction\/oxidation regulate immunity. Immunol Rev 220:60\u201381","journal-title":"Immunol Rev"},{"key":"1217_CR4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri1372","volume":"4","author":"SY Seong","year":"2004","unstructured":"Seong SY, Matzinger P (2004) Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 4:469\u2013478","journal-title":"Nat Rev Immunol"},{"key":"1217_CR5","first-page":"68","volume":"4","author":"G Li","year":"2013","unstructured":"Li G, Liang X, Lotze MT (2013) HMGB1: the central cytokine for all lymphoid cells. Front Immunol 4:68","journal-title":"Front Immunol"},{"key":"1217_CR6","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2174\/156652407783220750","volume":"7","author":"H Rauvala","year":"2007","unstructured":"Rauvala H, Rouhiainen A (2007) RAGE as a receptor of HMGB1 (Amphoterin): roles in health and disease. Curr Mol Med 7:725\u2013734","journal-title":"Curr Mol Med"},{"key":"1217_CR7","first-page":"740","volume":"25","author":"MM Steenvoorden","year":"2007","unstructured":"Steenvoorden MM, Toes RE, Ronday HK, Huizinga TW, Degroot J (2007) RAGE activation induces invasiveness of RA fibroblast-like synoviocytes in vitro. Clin Exp Rheumatol 25:740\u2013742","journal-title":"Clin Exp Rheumatol"},{"key":"1217_CR8","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1159\/000327992","volume":"33","author":"J Kim","year":"2011","unstructured":"Kim J, Sohn E, Kim CS, Jo K, Kim JS (2011) The role of high-mobility group box-1 protein in the development of diabetic nephropathy. Am J Nephrol 33:524\u2013529","journal-title":"Am J Nephrol"},{"key":"1217_CR9","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.1002253","volume":"186","author":"Y Yamamoto","year":"2011","unstructured":"Yamamoto Y, Harashima A, Saito H, Tsuneyama K, Munesue S, Motoyoshi S, Han D, Watanabe T, Asano M, Takasawa S et al (2011) Septic shock is associated with receptor for advanced glycation end products ligation of LPS. J Immunol 186:3248\u20133257","journal-title":"J Immunol"},{"key":"1217_CR10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00405-003-0623-x","volume":"261","author":"E Olszewska","year":"2004","unstructured":"Olszewska E, Wagner M, Bernal-Sprekelsen M, Ebmeyer J, Dazert S, Hildmann H, Sudhoff H (2004) Etiopathogenesis of cholesteatoma. Eur Arch Otorhinolaryngol 261:6\u201324","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1217_CR11","first-page":"7","volume":"19","author":"AP Albino","year":"1998","unstructured":"Albino AP, Kimmelman CP, Parisier SC (1998) Cholesteatoma: a molecular and cellular puzzle. Am J Otol 19:7\u201319","journal-title":"Am J Otol"},{"key":"1217_CR12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.18388\/abp.2007_3258","volume":"54","author":"E Olszewska","year":"2007","unstructured":"Olszewska E, Olszewski S, Borzym-Kluczyk M, Zwierz K (2007) Role of N-acetyl-beta-d-hexosaminidase in cholesteatoma tissue. Acta Biochim Pol 54:365\u2013370","journal-title":"Acta Biochim Pol"},{"key":"1217_CR13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02630748","volume":"254","author":"J Bujia","year":"1997","unstructured":"Bujia J, Kim C, Ostos-Aumente P, Lopez-Villarejo J, Kastenbauer E (1997) Enhanced epithelial proliferation due to elevated levels of interleukin-1 receptors in middle ear cholesteatomas. Eur Arch Otorhinolaryngol 254:6\u20138","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1217_CR14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s001060050138","volume":"45","author":"H Sudhoff","year":"1997","unstructured":"Sudhoff H, Borkowski G, Bujia J, Hildmann H, Fisseler-Eckhoff A (1997) Immunohistochemical studies with middle ear mucosal remnants in cholesteatoma. HNO 45:630\u2013635","journal-title":"HNO"},{"key":"1217_CR15","first-page":"793","volume":"21","author":"H Sudhoff","year":"2000","unstructured":"Sudhoff H, Dazert S, Gonzales AM, Borkowski G, Park SY, Baird A, Hildmann H, Ryan AF (2000) Angiogenesis and angiogenic growth factors in middle ear cholesteatoma. Am J Otol 21:793\u2013798","journal-title":"Am J Otol"},{"key":"1217_CR16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/00016488209130853","volume":"93","author":"MD McGinn","year":"1982","unstructured":"McGinn MD, Chole RA, Henry KR (1982) Cholesteatoma. Experimental induction in the Mongolian Gerbil, Meriones Unguiculaus. Acta Otolaryngol 93:61\u201367","journal-title":"Acta Otolaryngol"},{"key":"1217_CR17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/mlg.0b013e318031d09d","volume":"117","author":"G Choufani","year":"2007","unstructured":"Choufani G, Roper N, Delbrouck C, Hassid S, Gabius HJ (2007) Animal model for cholesteatoma induced in the gerbil: will the profiles of differentiation\/growth-regulatory markers be similar to the clinical situation? Laryngoscope 117:706\u2013711","journal-title":"Laryngoscope"},{"key":"1217_CR18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.oraloncology.2012.08.005","volume":"49","author":"MJ Szczepanski","year":"2013","unstructured":"Szczepanski MJ et al (2013) PRAME expression in head and neck cancer correlates with markers of poor prognosis and might help in selecting candidates for retinoid chemoprevention in pre-malignant lesions. Oral Oncol 49:144\u2013151","journal-title":"Oral Oncol"},{"key":"1217_CR19","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00405-006-0215-7","volume":"264","author":"M Szczepanski","year":"2007","unstructured":"Szczepanski M, Stelmachowska M, Stryczynski L, Golusinski W, Samara H, Mozer-Lisewska I, Zeromski J (2007) Assessment of expression of toll-like receptors 2, 3 and 4 in laryngeal carcinoma. Eur Arch Otorhinolaryngol 264:525\u2013530","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1217_CR20","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1158\/0008-5472.CAN-08-3838","volume":"69","author":"MJ Szczepanski","year":"2009","unstructured":"Szczepanski MJ, Czystowska M, Szajnik M, Harasymczuk M, Boyiadzis M, Kruk-Zagajewska A, Szyfter W, Zeromski J, Whiteside TL (2009) Triggering of Toll-like receptor 4 expressed on human head and neck squamous cell carcinoma promotes tumor development and protects the tumor from immune attack. Cancer Res 69:3105\u20133113","journal-title":"Cancer Res"},{"key":"1217_CR21","doi-asserted-by":"crossref","first-page":"9292","DOI":"10.1074\/jbc.M109.093955","volume":"285","author":"J Pi","year":"2010","unstructured":"Pi J, Leung L, Xue P, Wang W, Hou Y, Liu D, Yehuda-Shnaidman E, Lee C, Lau J, Kurtz TW et al (2010) Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J Biol Chem 285:9292\u20139300","journal-title":"J Biol Chem"},{"key":"1217_CR22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00405-006-0030-1","volume":"263","author":"M Szczepanski","year":"2006","unstructured":"Szczepanski M, Szyfter W, Jenek R, Wrobel M, Lisewska IM, Zeromski J (2006) Toll-like receptors 2, 3 and 4 (TLR-2, TLR-3 and TLR-4) are expressed in the microenvironment of human acquired cholesteatoma. Eur Arch Otorhinolaryngol 263:603\u2013607","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1217_CR23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00405-005-1026-y","volume":"263","author":"E Olszewska","year":"2006","unstructured":"Olszewska E, Chodynicki S, Chyczewski L (2006) Apoptosis in the pathogenesis of cholesteatoma in adults. Eur Arch Otorhinolaryngol 263:409\u2013413","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"1217_CR24","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/sj.jid.5701212","volume":"128","author":"S Straino","year":"2008","unstructured":"Straino S et al (2008) High-mobility group box 1 protein in human and murine skin: involvement in wound healing. J Invest Dermatol 128:1545\u20131553","journal-title":"J Invest Dermatol"},{"key":"1217_CR25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","volume":"28","author":"GP Sims","year":"2010","unstructured":"Sims GP, Rowe DC, Rietdijk ST, Herbst R, Coyle AJ (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 28:367\u2013388","journal-title":"Annu Rev Immunol"},{"key":"1217_CR26","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cellsig.2013.06.013","volume":"25","author":"J Xie","year":"2013","unstructured":"Xie J, Mendez JD, Mendez-Valenzuela V, Aguilar-Hernandez MM (2013) Cellular signaling of the receptor for advanced glycation and products (RAGE). Cell Signal 25:2185\u20132197","journal-title":"Cell Signal"},{"key":"1217_CR27","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00018-002-8491-x","volume":"59","author":"LG Bucciarelli","year":"2002","unstructured":"Bucciarelli LG et al (2002) RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease. Cell Mol Life Sci 59:1117\u20131128","journal-title":"Cell Mol Life Sci"},{"key":"1217_CR28","doi-asserted-by":"crossref","first-page":"L566","DOI":"10.1152\/ajplung.00233.2002","volume":"284","author":"N Mukaida","year":"2003","unstructured":"Mukaida N (2003) Pathophysiological roles of interleukin-8\/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 284:L566\u2013L577","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1217_CR29","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1182\/blood-2011-10-386011","volume":"119","author":"E Dejean","year":"2012","unstructured":"Dejean E, Foisseau M, Lagarrigue F, Lamant L, Prade N, Marfak A, Delsol G, Giuriato S, Gaits-Iacovoni F, Meggetto F (2012) ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8\/CXCL8 production by keratinocytes through NF-kappaB activation. Blood 119:4698\u20134707","journal-title":"Blood"},{"key":"1217_CR30","doi-asserted-by":"crossref","first-page":"768","DOI":"10.2741\/s185","volume":"3","author":"Z Zhou","year":"2011","unstructured":"Zhou Z, Xiong WC (2011) RAGE and its ligands in bone metabolism. Front Biosci (Schol Ed) 3:768\u2013776","journal-title":"Front Biosci (Schol Ed)"},{"key":"1217_CR31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.archoralbio.2011.08.001","volume":"57","author":"Y Ito","year":"2012","unstructured":"Ito Y et al (2012) Involvement of HMGB1 and RAGE in IL-1beta-induced gingival inflammation. Arch Oral Biol 57:73\u201380","journal-title":"Arch Oral Biol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-014-1217-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-014-1217-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-014-1217-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T21:09:11Z","timestamp":1598476151000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-014-1217-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["1217"],"URL":"https:\/\/doi.org\/10.1007\/s00109-014-1217-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}