{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:55:57Z","timestamp":1778612157633,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00109-014-1242-2","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T04:45:47Z","timestamp":1419828347000},"page":"559-572","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma"],"prefix":"10.1007","volume":"93","author":[{"given":"Cindrilla","family":"Chumduri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Gillissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Milojkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Overkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Pott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter T.","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"1242_CR1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.semcancer.2009.07.002","volume":"19","author":"GW Bornkamm","year":"2009","unstructured":"Bornkamm GW (2009) Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue. Sem Can Biol 19:351\u2013365","journal-title":"Sem Can Biol"},{"key":"1242_CR2","doi-asserted-by":"crossref","first-page":"10411","DOI":"10.1073\/pnas.93.19.10411","volume":"93","author":"A Polack","year":"1996","unstructured":"Polack A, Hortnagel K, Pajic A, Christoph B, Baier B, Falk M, Mautner J, Geltinger C, Bornkamm GW, Kempkes B (1996) c-myc activation renders proliferation of Epstein-Barr virus (EBV)-transformed cells independent of EBV nuclear antigen 2 and latent membrane protein 1. PNAS 93:10411\u201310416","journal-title":"PNAS"},{"key":"1242_CR3","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2174\/156652408785747988","volume":"8","author":"EV Prochownik","year":"2008","unstructured":"Prochownik EV (2008) c-Myc: linking transformation and genomic instability. Curr Mol Med 8:446\u2013458","journal-title":"Curr Mol Med"},{"key":"1242_CR4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674","journal-title":"Cell"},{"key":"1242_CR5","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1038\/sj.onc.1205497","volume":"21","author":"C Haefen von","year":"2002","unstructured":"von Haefen C, Wieder T, Gillissen B, Starck L, Graupner V, Dorken B, Daniel PT (2002) Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells. Oncogene 21:4009\u20134019","journal-title":"Oncogene"},{"key":"1242_CR6","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1093\/emboj\/cdg343","volume":"22","author":"B Gillissen","year":"2003","unstructured":"Gillissen B, Essmann F, Graupner V, Starck L, Radetzki S, Dorken B, Schulze-Osthoff K, Daniel PT (2003) Induction of cell death by the BH3-only Bcl-2 homolog Nbk\/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J 22:3580\u20133590","journal-title":"EMBO J"},{"key":"1242_CR7","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1083\/jcb.200703040","volume":"179","author":"B Gillissen","year":"2007","unstructured":"Gillissen B, Essmann F, Hemmati PG, Richter A, Richter A, Oztop I, Chinnadurai G, Dorken B, Daniel PT (2007) Mcl-1 determines the Bax dependency of Nbk\/Bik-induced apoptosis. J Cell Biol 179:701\u2013715","journal-title":"J Cell Biol"},{"key":"1242_CR8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/cdd.2010.179","volume":"18","author":"V Graupner","year":"2012","unstructured":"Graupner V, Alexander E, Overkamp T, Rothfuss O, De Laurenzi V, Gillissen BF, Daniel PT, Schulze-Osthoff K, Essmann F (2012) Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ 18:1130\u20131139","journal-title":"Cell Death Differ"},{"key":"1242_CR9","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1182\/blood.V94.3.1100.415a16_1100_1107","volume":"94","author":"PT Daniel","year":"1999","unstructured":"Daniel PT, Pun KT, Ritschel S, Sturm I, Holler J, Dorken B, Brown R (1999) Expression of the death gene Bik\/Nbk promotes sensitivity to drug-induced apoptosis in corticosteroid-resistant T-cell lymphoma and prevents tumor growth in severe combined immunodeficient mice. Blood 94:1100\u20131107","journal-title":"Blood"},{"key":"1242_CR10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/ncb2057","volume":"12","author":"Y Zaltsman","year":"2010","unstructured":"Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F et al (2010) MTCH2\/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12:553\u2013562","journal-title":"Nat Cell Biol"},{"key":"1242_CR11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0065-230X(06)97005-5","volume":"97","author":"PH Krammer","year":"2007","unstructured":"Krammer PH, Kaminski M, Kiessling M, Gulow K (2007) No life without death. Adv Can Res 97:111\u2013138","journal-title":"Adv Can Res"},{"key":"1242_CR12","doi-asserted-by":"crossref","first-page":"17343","DOI":"10.1074\/jbc.M111.314898","volume":"287","author":"A Muer","year":"2012","unstructured":"Muer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dorken B, Daniel PT, Hemmati P (2012) p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. J Biol Chem 287:17343\u201317352","journal-title":"J Biol Chem"},{"key":"1242_CR13","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1038\/emboj.2011.307","volume":"30","author":"A Strasser","year":"2011","unstructured":"Strasser A, Cory S, Adams JM (2011) Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J 30:3667\u20133683","journal-title":"EMBO J"},{"key":"1242_CR14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/10428190310001595713","volume":"45","author":"JP Doucet","year":"2004","unstructured":"Doucet JP, Hussain A, Al-Rasheed M, Gaidano G, Gutierrez MI, Magrath I, Bhatia K (2004) Differences in the expression of apoptotic proteins in Burkitt's lymphoma cell lines: potential models for screening apoptosis-inducing agents. Leuk Lymphoma 45:357\u2013362","journal-title":"Leuk Lymphoma"},{"key":"1242_CR15","first-page":"5824","volume":"54","author":"S Fan","year":"1994","unstructured":"Fan S, el-Deiry WS, Bae I, Freeman J, Jondle D, Bhatia K, Fornace AJ Jr, Magrath I, Kohn KW, O'Connor PM (1994) p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 54:5824\u20135830","journal-title":"Cancer Res"},{"key":"1242_CR16","first-page":"696","volume":"59","author":"MI Gutierrez","year":"1999","unstructured":"Gutierrez MI, Cherney B, Hussain A, Mostowski H, Tosato G, Magrath I, Bhatia K (1999) Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis. Cancer Res 59:696\u2013703","journal-title":"Cancer Res"},{"key":"1242_CR17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/312196b0","volume":"312","author":"JR McIntosh","year":"1984","unstructured":"McIntosh JR (1984) Cell biology. Microtubule catastrophe. Nature 312:196\u2013197","journal-title":"Nature"},{"key":"1242_CR18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/030089160909500401","volume":"95","author":"J Portugal","year":"2009","unstructured":"Portugal J, Bataller M, Mansilla S (2009) Cell death pathways in response to antitumor therapy. Tumori 95:409\u2013421","journal-title":"Tumori"},{"key":"1242_CR19","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/sj.onc.1207528","volume":"23","author":"M Castedo","year":"2004","unstructured":"Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G (2004) Cell death by mitotic catastrophe: a molecular definition. Oncogene 23:2825\u20132837","journal-title":"Oncogene"},{"key":"1242_CR20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/carcin\/bgh296","volume":"26","author":"JW Shay","year":"2005","unstructured":"Shay JW, Wright WE (2005) Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26:867\u2013874","journal-title":"Carcinogenesis"},{"key":"1242_CR21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cellbi.2005.10.005","volume":"29","author":"J Erenpreisa","year":"2005","unstructured":"Erenpreisa J, Kalejs M, Cragg MS (2005) Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution. Cell Biol Int 29:1012\u20131018","journal-title":"Cell Biol Int"},{"key":"1242_CR22","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1074\/jbc.M511333200","volume":"281","author":"MR Bhonde","year":"2006","unstructured":"Bhonde MR, Hanski ML, Budczies J, Cao M, Gillissen B, Moorthy D, Simonetta F, Scherubl H, Truss M, Hagemeier C et al (2006) DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis. J Biol Chem 281:8675\u20138685","journal-title":"J Biol Chem"},{"key":"1242_CR23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/sj.onc.1209017","volume":"25","author":"MR Bhonde","year":"2006","unstructured":"Bhonde MR, Hanski ML, Notter M, Gillissen BF, Daniel PT, Zeitz M, Hanski C (2006) Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth. Oncogene 25:165\u2013175","journal-title":"Oncogene"},{"key":"1242_CR24","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1038\/onc.2008.193","volume":"27","author":"PG Hemmati","year":"2008","unstructured":"Hemmati PG, Normand G, Gillissen B, Wendt J, Dorken B, Daniel PT (2008) Cooperative effect of p21Cip1\/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF. Oncogene 27:6707\u20136719","journal-title":"Oncogene"},{"key":"1242_CR25","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1038\/sj.onc.1208579","volume":"24","author":"PG Hemmati","year":"2005","unstructured":"Hemmati PG, Normand G, Verdoodt B, von Haefen C, Hasenjager A, Guner D, Wendt J, Dorken B, Daniel PT (2005) Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells. Oncogene 24:4114\u20134128","journal-title":"Oncogene"},{"key":"1242_CR26","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1074\/jbc.M412330200","volume":"280","author":"G Normand","year":"2005","unstructured":"Normand G, Hemmati PG, Verdoodt B, von Haefen C, Wendt J, Guner D, May E, Dorken B, Daniel PT (2005) p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity. J Biol Chem 280:7118\u20137130","journal-title":"J Biol Chem"},{"key":"1242_CR27","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1365-2141.2011.08877.x","volume":"156","author":"DC Linch","year":"2012","unstructured":"Linch DC (2012) Burkitt lymphoma in adults. Br J Haematol 156:693\u2013703","journal-title":"Br J Haematol"},{"key":"1242_CR28","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1182\/blood.V97.5.1378","volume":"97","author":"T Wieder","year":"2001","unstructured":"Wieder T, Essmann F, Prokop A, Schmelz K, Schulze-Osthoff K, Beyaert R, Dorken B, Daniel PT (2001) Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95\/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 97:1378\u20131387","journal-title":"Blood"},{"key":"1242_CR29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1182\/blood-2009-07-230730","volume":"115","author":"AM Jabbour","year":"2010","unstructured":"Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN et al (2010) Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood 115:344\u2013352","journal-title":"Blood"},{"key":"1242_CR30","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1038\/sj.onc.1206280","volume":"22","author":"C Haefen von","year":"2003","unstructured":"von Haefen C, Wieder T, Essmann F, Schulze-Osthoff K, Dorken B, Daniel PT (2003) Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3\/-8-driven mitochondrial amplification loop. Oncogene 22:2236\u20132247","journal-title":"Oncogene"},{"key":"1242_CR31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1634\/theoncologist.11-4-375","volume":"11","author":"JA Ferry","year":"2006","unstructured":"Ferry JA (2006) Burkitt's lymphoma: clinicopathologic features and differential diagnosis. Oncologist 11:375\u2013383","journal-title":"Oncologist"},{"key":"1242_CR32","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1038\/sj.emboj.7601127","volume":"25","author":"M Castedo","year":"2006","unstructured":"Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P, Pequignot MO, Casares N, Valent A, Mouhamad S et al (2006) Apoptosis regulation in tetraploid cancer cells. EMBO J 25:2584\u20132595","journal-title":"EMBO J"},{"key":"1242_CR33","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1073\/pnas.80.10.2926","volume":"80","author":"FM Davis","year":"1983","unstructured":"Davis FM, Tsao TY, Fowler SK, Rao PN (1983) Monoclonal antibodies to mitotic cells. PNAS 80:2926\u20132930","journal-title":"PNAS"},{"key":"1242_CR34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-385524-4.00002-7","volume":"111","author":"GL Kelly","year":"2011","unstructured":"Kelly GL, Strasser A (2011) The essential role of evasion from cell death in cancer. Adv Cancer Res 111:39\u201396","journal-title":"Adv Cancer Res"},{"key":"1242_CR35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/jb\/mvi029","volume":"137","author":"Y Morizane","year":"2005","unstructured":"Morizane Y, Honda R, Fukami K, Yasuda H (2005) X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac\/DIABLO. J Biochem 137:125\u2013132","journal-title":"J Biochem"},{"key":"1242_CR36","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1200\/JCO.2000.18.21.3707","volume":"18","author":"JL Hecht","year":"2000","unstructured":"Hecht JL, Aster JC (2000) Molecular biology of Burkitt's lymphoma. J Clin Oncol 18:3707\u20133721","journal-title":"J Clin Oncol"},{"key":"1242_CR37","unstructured":"Perkins AS, Friedberg JW (2008) Burkitt lymphoma in adults. Am Soc Hematol Educ Program :341-348"},{"key":"1242_CR38","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/j.1460-2075.1991.tb07837.x","volume":"10","author":"PJ Farrell","year":"1991","unstructured":"Farrell PJ, Allan GJ, Shanahan F, Vousden KH, Crook T (1991) p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J 10:2879\u20132887","journal-title":"EMBO J"},{"key":"1242_CR39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1040-8428(98)00023-7","volume":"29","author":"CE Gidding","year":"1999","unstructured":"Gidding CE, Kellie SJ, Kamps WA, de Graaf SS (1999) Vincristine revisited. Crit Rev Oncol Hematol 29:267\u2013287","journal-title":"Crit Rev Oncol Hematol"},{"key":"1242_CR40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jcb.240580206","volume":"58","author":"KL King","year":"1995","unstructured":"King KL, Cidlowski JA (1995) Cell cycle and apoptosis: common pathways to life and death. J Cell Biochem 58:175\u2013180","journal-title":"J Cell Biochem"},{"key":"1242_CR41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0027-5107(95)00164-6","volume":"349","author":"EI Miranda","year":"1996","unstructured":"Miranda EI, Santana C, Rojas E, Hernandez S, Ostrosky-Wegman P, Garcia-Carranca A (1996) Induced mitotic death of HeLa cells by abnormal expression of c-H-ras. Mutat Res 349:173\u2013182","journal-title":"Mutat Res"},{"key":"1242_CR42","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cellbi.2005.10.008","volume":"29","author":"J Erenpreisa","year":"2005","unstructured":"Erenpreisa J, Kalejs M, Ianzini F, Kosmacek EA, Mackey MA, Emzinsh D, Cragg MS, Ivanov A, Illidge TM (2005) Segregation of genomes in polyploid tumour cells following mitotic catastrophe. Cell Biol Int 29:1005\u20131011","journal-title":"Cell Biol Int"},{"key":"1242_CR43","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/cbr.2008.0471","volume":"23","author":"D Eriksson","year":"2008","unstructured":"Eriksson D, Blomberg J, Lindgren T, Lofroth PO, Johansson L, Riklund K, Stigbrand T (2008) Iodine-131 induces mitotic catastrophes and activates apoptotic pathways in HeLa Hep2 cells. Cancer Biother Radiopharm 23:541\u2013549","journal-title":"Cancer Biother Radiopharm"},{"key":"1242_CR44","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1128\/MCB.20.4.1344-1360.2000","volume":"20","author":"M Wade","year":"2000","unstructured":"Wade M, Allday MJ (2000) Epstein-Barr virus suppresses a G(2)\/M checkpoint activated by genotoxins. Mol Cell Biol 20:1344\u20131360","journal-title":"Mol Cell Biol"},{"key":"1242_CR45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/cbt.3.1.683","volume":"3","author":"AR Jazirehi","year":"2004","unstructured":"Jazirehi AR, Bonavida B (2004) Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 3:71\u201384","journal-title":"Mol Cancer Ther"},{"key":"1242_CR46","first-page":"1109","volume":"57","author":"AM Ibrado","year":"1997","unstructured":"Ibrado AM, Liu L, Bhalla K (1997) Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells. Cancer Res 57:1109\u20131115","journal-title":"Cancer Res"},{"issue":"2","key":"1242_CR47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bcp.2011.10.008","volume":"83","author":"R Chu","year":"2012","unstructured":"Chu R, Terrano DT, Chambers TC (2012) Cdk1\/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochem Pharmacol 83(2):199\u2013206","journal-title":"Biochem Pharmacol"},{"issue":"14","key":"1242_CR48","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/emboj.2010.112","volume":"29","author":"ME Harley","year":"2010","unstructured":"Harley ME, Allan LA, Sanderson HS, Clarke PR (2010) Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO J 29(14):2407\u20132420","journal-title":"EMBO J"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-014-1242-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-014-1242-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-014-1242-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T12:21:17Z","timestamp":1598617277000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-014-1242-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["1242"],"URL":"https:\/\/doi.org\/10.1007\/s00109-014-1242-2","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]}}}