{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:11:14Z","timestamp":1785006674966,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T00:00:00Z","timestamp":1428710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s00109-015-1281-3","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:26:42Z","timestamp":1428625602000},"page":"609-618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress"],"prefix":"10.1007","volume":"93","author":[{"given":"Ilayaraja","family":"Muthuramu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhul","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Nefyodova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Debasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa","family":"Van Horenbeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"De Geest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,11]]},"reference":[{"issue":"6","key":"1281_CR1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ehj.2004.01.008","volume":"25","author":"J Sundstrom","year":"2004","unstructured":"Sundstrom J, Sullivan L, Selhub J, Benjamin EJ, D\u2019Agostino RB, Jacques PF, Rosenberg IH, Levy D, Wilson PW, Vasan RS (2004) Relations of plasma homocysteine to left ventricular structure and function: the Framingham Heart Study. Eur Heart J 25(6):523\u2013530","journal-title":"Eur Heart J"},{"issue":"2","key":"1281_CR2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/CIRCULATIONAHA.106.633750","volume":"115","author":"K Nasir","year":"2007","unstructured":"Nasir K, Tsai M, Rosen BD, Fernandes V, Bluemke DA, Folsom AR, Lima JA (2007) Elevated homocysteine is associated with reduced regional left ventricular function: the Multi-Ethnic Study of Atherosclerosis. Circulation 115(2):180\u2013187","journal-title":"Circulation"},{"key":"1281_CR3","author":"L Ruhui","year":"2014","unstructured":"Ruhui L, Jinfa J, Jiahong X, Wenlin M (2014) Influence of hyperhomocysteinemia on left ventricular diastolic function in Chinese patients with hypertension. Herz. doi: 10.1007\/s00059-014-4098-x","journal-title":"Herz"},{"issue":"4","key":"1281_CR4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1536\/ihj.52.224","volume":"52","author":"T Washio","year":"2011","unstructured":"Washio T, Nomoto K, Watanabe I, Tani S, Nagao K, Hirayama A (2011) Relationship between plasma homocysteine levels and congestive heart failure in patients with acute myocardial infarction. Homocysteine and congestive heart failure. Int Heart J 52(4):224\u2013228","journal-title":"Int Heart J"},{"issue":"10","key":"1281_CR5","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.289.10.1251","volume":"289","author":"RS Vasan","year":"2003","unstructured":"Vasan RS, Beiser A, D\u2019Agostino RB, Levy D, Selhub J, Jacques PF, Rosenberg IH, Wilson PW (2003) Plasma homocysteine and risk for congestive heart failure in adults without prior myocardial infarction. JAMA 289(10):1251\u20131257","journal-title":"JAMA"},{"issue":"3","key":"1281_CR6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000095344","volume":"107","author":"HT May","year":"2007","unstructured":"May HT, Alharethi R, Anderson JL, Muhlestein JB, Reyna SP, Bair TL, Horne BD, Kfoury AG, Carlquist JF, Renlund DG (2007) Homocysteine levels are associated with increased risk of congestive heart failure in patients with and without coronary artery disease. Cardiology 107(3):178\u2013184","journal-title":"Cardiology"},{"issue":"3","key":"1281_CR7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.yjmcc.2011.12.009","volume":"52","author":"X Wang","year":"2012","unstructured":"Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J (2012) Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol 52(3):753\u2013760","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"1281_CR8","doi-asserted-by":"crossref","first-page":"H890","DOI":"10.1152\/ajpheart.00099.2008","volume":"295","author":"KS Moshal","year":"2008","unstructured":"Moshal KS, Tipparaju SM, Vacek TP, Kumar M, Singh M, Frank IE, Patibandla PK, Tyagi N, Rai J, Metreveli N et al (2008) Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 295(2):H890\u2013H897","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1\u20132","key":"1281_CR9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-010-0612-5","volume":"347","author":"L Raaf","year":"2011","unstructured":"Raaf L, Noll C, Cherifi Mel H, Samuel JL, Delcayre C, Delabar JM, Benazzoug Y, Janel N (2011) Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats. Mol Cell Biochem 347(1\u20132):63\u201370","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"1281_CR10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcb.21982","volume":"106","author":"S Kundu","year":"2009","unstructured":"Kundu S, Kumar M, Sen U, Mishra PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi SC (2009) Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS\/CBS double knockout mice. J Cell Biochem 106(1):119\u2013126","journal-title":"J Cell Biochem"},{"issue":"5","key":"1281_CR11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063710","volume":"8","author":"I Muthuramu","year":"2013","unstructured":"Muthuramu I, Jacobs F, Singh N, Gordts SC, De Geest B (2013) Selective homocysteine lowering gene transfer improves infarct healing, attenuates remodelling, and enhances diastolic function after myocardial infarction in mice. PLoS One 8(5), e63710. doi: 10.1371\/journal.pone.0063710","journal-title":"PLoS One"},{"issue":"1","key":"1281_CR12","doi-asserted-by":"crossref","first-page":"H620","DOI":"10.1152\/ajpheart.01236.2006","volume":"293","author":"ES Buys","year":"2007","unstructured":"Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S et al (2007) Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol 293(1):H620\u2013H627","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"1281_CR13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00109-011-0778-7","volume":"89","author":"F Jacobs","year":"2011","unstructured":"Jacobs F, Van Craeyveld E, Muthuramu I, Gordts SC, Emmerechts J, Hoylaerts M, Herijgers P, De Geest B (2011) Correction of endothelial dysfunction after selective homocysteine lowering gene therapy reduces arterial thrombogenicity but has no effect on atherogenesis. J Mol Med 89(10):1051\u20131058","journal-title":"J Mol Med"},{"issue":"8","key":"1281_CR14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.gt.3303096","volume":"15","author":"F Jacobs","year":"2008","unstructured":"Jacobs F, Snoeys J, Feng Y, Van Craeyveld E, Lievens J, Armentano D, Cheng SH, De Geest B (2008) Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer. Gene Ther 15(8):594\u2013603","journal-title":"Gene Ther"},{"issue":"22","key":"1281_CR15","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/sj.gt.3301824","volume":"9","author":"S Linthout Van","year":"2002","unstructured":"Van Linthout S, Lusky M, Collen D, De Geest B (2002) Persistent hepatic expression of human apo A-I after transfer with a helper-virus independent adenoviral vector. Gene Ther 9(22):1520\u20131528","journal-title":"Gene Ther"},{"issue":"10","key":"1281_CR16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046849","volume":"7","author":"SC Gordts","year":"2012","unstructured":"Gordts SC, Van Craeyveld E, Muthuramu I, Singh N, Jacobs F, De Geest B (2012) Lipid lowering and HDL raising gene transfer increase endothelial progenitor cells, enhance myocardial vascularity, and improve diastolic function. PLoS One 7(10), e46849. doi: 10.1371\/journal.pone.0046849","journal-title":"PLoS One"},{"issue":"8","key":"1281_CR17","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/gt.2011.147","volume":"19","author":"E Craeyveld Van","year":"2012","unstructured":"Van Craeyveld E, Jacobs F, Gordts SC, De Geest B (2012) Low-density lipoprotein receptor gene transfer in hypercholesterolemic mice improves cardiac function after myocardial infarction. Gene Ther 19(8):860\u2013871","journal-title":"Gene Ther"},{"issue":"6","key":"1281_CR18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00109-011-0722-x","volume":"89","author":"E Craeyveld Van","year":"2011","unstructured":"Van Craeyveld E, Gordts SC, Nefyodova E, Jacobs F, De Geest B (2011) Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies. J Mol Med 89(6):555\u2013567","journal-title":"J Mol Med"},{"issue":"3","key":"1281_CR19","doi-asserted-by":"crossref","first-page":"H1261","DOI":"10.1152\/ajpheart.00108.2003","volume":"285","author":"P Hu","year":"2003","unstructured":"Hu P, Zhang D, Swenson L, Chakrabarti G, Abel ED, Litwin SE (2003) Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol 285(3):H1261\u2013H1269","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"1281_CR20","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/bph.12328","volume":"170","author":"S Yasuno","year":"2013","unstructured":"Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T et al (2013) Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Br J Pharmacol 170(7):1384\u20131395","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1281_CR21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI108079","volume":"56","author":"W Grossman","year":"1975","unstructured":"Grossman W, Jones D, McLaurin LP (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56(1):56\u201364","journal-title":"J Clin Invest"},{"issue":"5 Suppl 2","key":"1281_CR22","doi-asserted-by":"crossref","first-page":"II21","DOI":"10.1002\/clc.4960161406","volume":"16","author":"JN Cohn","year":"1993","unstructured":"Cohn JN (1993) Post-MI remodeling. Clin Cardiol 16(5 Suppl 2):II21\u2013II24","journal-title":"Clin Cardiol"},{"issue":"3","key":"1281_CR23","doi-asserted-by":"crossref","first-page":"H1003","DOI":"10.1152\/ajpheart.00896.2008","volume":"297","author":"CJ Barrick","year":"2009","unstructured":"Barrick CJ, Dong A, Waikel R, Corn D, Yang F, Threadgill DW, Smyth SS (2009) Parent-of-origin effects on cardiac response to pressure overload in mice. Am J Physiol Heart Circ Physiol 297(3):H1003\u2013H1009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"1281_CR24","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7(8):589\u2013600","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1281_CR25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/hc0102.101365","volume":"105","author":"G Esposito","year":"2002","unstructured":"Esposito G, Rapacciuolo A, Naga Prasad SV, Takaoka H, Thomas SA, Koch WJ, Rockman HA (2002) Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105(1):85\u201392","journal-title":"Circulation"},{"issue":"23","key":"1281_CR26","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","volume":"19","author":"OF Bueno","year":"2000","unstructured":"Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF et al (2000) The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J 19(23):6341\u20136350","journal-title":"EMBO J"},{"issue":"5","key":"1281_CR27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-114-5-345","volume":"114","author":"MJ Koren","year":"1991","unstructured":"Koren MJ, Devereux RB, Casale PN, Savage DD, Laragh JH (1991) Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann Intern Med 114(5):345\u2013352","journal-title":"Ann Intern Med"},{"issue":"17","key":"1281_CR28","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/eurheartj\/ehi290","volume":"26","author":"M Kupari","year":"2005","unstructured":"Kupari M, Turto H, Lommi J (2005) Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure? Eur Heart J 26(17):1790\u20131796","journal-title":"Eur Heart J"},{"issue":"12","key":"1281_CR29","first-page":"1633","volume":"45","author":"W Herrmann","year":"2007","unstructured":"Herrmann W, Herrmann M, Joseph J, Tyagi SC (2007) Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review. Clin Chem Lab Med 45(12):1633\u20131644","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"1281_CR30","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ijcard.2012.03.047","volume":"167","author":"RM Gueant Rodriguez","year":"2013","unstructured":"Gueant Rodriguez RM, Spada R, Pooya S, Jeannesson E, Moreno Garcia MA, Anello G, Bosco P, Elia M, Romano A, Alberto JM et al (2013) Homocysteine predicts increased NT-pro-BNP through impaired fatty acid oxidation. Int J Cardiol 167(3):768\u2013775","journal-title":"Int J Cardiol"},{"issue":"6","key":"1281_CR31","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1159\/000109148","volume":"27","author":"A Sirker","year":"2007","unstructured":"Sirker A, Zhang M, Murdoch C, Shah AM (2007) Involvement of NADPH oxidases in cardiac remodelling and heart failure. Am J Nephrol 27(6):649\u2013660","journal-title":"Am J Nephrol"},{"issue":"11","key":"1281_CR32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/eurheartj\/14.11.1493","volume":"14","author":"J McMurray","year":"1993","unstructured":"McMurray J, Chopra M, Abdullah I, Smith WE, Dargie HJ (1993) Evidence of oxidative stress in chronic heart failure in humans. Eur Heart J 14(11):1493\u20131498","journal-title":"Eur Heart J"},{"issue":"3","key":"1281_CR33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1527-5299.2002.00717.x","volume":"8","author":"D Sorescu","year":"2002","unstructured":"Sorescu D, Griendling KK (2002) Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest Heart Fail 8(3):132\u2013140","journal-title":"Congest Heart Fail"},{"issue":"16","key":"1281_CR34","doi-asserted-by":"crossref","first-page":"15518","DOI":"10.1074\/jbc.M501452200","volume":"280","author":"DE Handy","year":"2005","unstructured":"Handy DE, Zhang Y, Loscalzo J (2005) Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem 280(16):15518\u201315525","journal-title":"J Biol Chem"},{"issue":"2","key":"1281_CR35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/CIRCULATIONAHA.106.652693","volume":"115","author":"N Suematsu","year":"2007","unstructured":"Suematsu N, Ojaimi C, Kinugawa S, Wang Z, Xu X, Koller A, Recchia FA, Hintze TH (2007) Hyperhomocysteinemia alters cardiac substrate metabolism by impairing nitric oxide bioavailability through oxidative stress. Circulation 115(2):255\u2013262","journal-title":"Circulation"},{"issue":"1","key":"1281_CR36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12012-010-9094-7","volume":"11","author":"J Kolling","year":"2011","unstructured":"Kolling J, Scherer EB, da Cunha AA, da Cunha MJ, Wyse AT (2011) Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid. Cardiovasc Toxicol 11(1):67\u201373","journal-title":"Cardiovasc Toxicol"},{"issue":"8","key":"1281_CR37","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1161\/01.STR.0000131749.81508.18","volume":"35","author":"S Dayal","year":"2004","unstructured":"Dayal S, Arning E, Bottiglieri T, Boger RH, Sigmund CD, Faraci FM, Lentz SR (2004) Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke; J Cereb Circ 35(8):1957\u20131962","journal-title":"Stroke; J Cereb Circ"},{"issue":"4","key":"1281_CR38","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1172\/JCI8342","volume":"106","author":"RT Eberhardt","year":"2000","unstructured":"Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI et al (2000) Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest 106(4):483\u2013491","journal-title":"J Clin Invest"},{"issue":"3","key":"1281_CR39","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12013-009-9063-6","volume":"55","author":"PK Mishra","year":"2009","unstructured":"Mishra PK, Tyagi N, Kundu S, Tyagi SC (2009) MicroRNAs are involved in homocysteine-induced cardiac remodeling. Cell Biochem Biophys 55(3):153\u2013162","journal-title":"Cell Biochem Biophys"},{"issue":"3","key":"1281_CR40","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/01.ATV.0000061735.85377.40","volume":"23","author":"Z Ungvari","year":"2003","unstructured":"Ungvari Z, Csiszar A, Edwards JG, Kaminski PM, Wolin MS, Kaley G, Koller A (2003) Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol 23(3):418\u2013424","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"1281_CR41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.108.183475","volume":"104","author":"LH Xie","year":"2009","unstructured":"Xie LH, Chen F, Karagueuzian HS, Weiss JN (2009) Oxidative-stress-induced afterdepolarizations and calmodulin kinase II signaling. Circ Res 104(1):79\u201386","journal-title":"Circ Res"},{"issue":"3","key":"1281_CR42","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","volume":"133","author":"JR Erickson","year":"2008","unstructured":"Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O\u2019Donnell SE, Aykin-Burns N et al (2008) A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell 133(3):462\u2013474","journal-title":"Cell"},{"issue":"9","key":"1281_CR43","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","volume":"97","author":"I Cucoranu","year":"2005","unstructured":"Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D (2005) NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97(9):900\u2013907","journal-title":"Circ Res"},{"issue":"1-2","key":"1281_CR44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11010-008-9803-8","volume":"317","author":"W Zhao","year":"2008","unstructured":"Zhao W, Zhao T, Chen Y, Ahokas RA, Sun Y (2008) Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats. Mol Cell Biochem 317(1-2):43\u201350","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"1281_CR45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.114.011079","volume":"131","author":"QD Zhao","year":"2015","unstructured":"Zhao QD, Viswanadhapalli S, Williams P, Shi Q, Tan C, Yi X, Bhandari B, Abboud HE (2015) NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt\/mTOR and NFkappaB signaling pathways. Circulation 131(7):643\u2013655","journal-title":"Circulation"},{"issue":"2","key":"1281_CR46","doi-asserted-by":"crossref","first-page":"H816","DOI":"10.1152\/ajpheart.01348.2007","volume":"295","author":"S Dayal","year":"2008","unstructured":"Dayal S, Rodionov RN, Arning E, Bottiglieri T, Kimoto M, Murry DJ, Cooke JP, Faraci FM, Lentz SR (2008) Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 295(2):H816\u2013H825","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"24","key":"1281_CR47","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/01.CIR.99.24.3092","volume":"99","author":"A Ito","year":"1999","unstructured":"Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99(24):3092\u20133095","journal-title":"Circulation"},{"issue":"8","key":"1281_CR48","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.CIR.0000027109.14149.67","volume":"106","author":"KY Lin","year":"2002","unstructured":"Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H, Reaven GM, Cooke JP (2002) Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 106(8):987\u2013992","journal-title":"Circulation"},{"issue":"21","key":"1281_CR49","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","volume":"104","author":"MC Stuhlinger","year":"2001","unstructured":"Stuhlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP (2001) Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 104(21):2569\u20132575","journal-title":"Circulation"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-015-1281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-015-1281-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-015-1281-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T06:01:48Z","timestamp":1566540108000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-015-1281-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["1281"],"URL":"https:\/\/doi.org\/10.1007\/s00109-015-1281-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,11]]}}}