{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:04:40Z","timestamp":1790049880529,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300179"],"award-info":[{"award-number":["81300179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s00109-016-1387-2","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T20:53:30Z","timestamp":1454964810000},"page":"711-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia"],"prefix":"10.1007","volume":"94","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"1387_CR1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cvr\/cvr073","volume":"91","author":"H Kanamori","year":"2011","unstructured":"Kanamori H, Takemura G, Goto K et al (2011) The role of autophagy emerging in postinfarction cardiac remodelling. Cardiovasc Res 91:330\u2013339","journal-title":"Cardiovasc Res"},{"key":"1387_CR2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","volume":"306","author":"T Shintani","year":"2004","unstructured":"Shintani T, Klionsky DJ (2004) Autophagy in health and disease: a double-edged sword. Science 306:990\u2013995","journal-title":"Science"},{"key":"1387_CR3","doi-asserted-by":"crossref","first-page":"H2261","DOI":"10.1152\/ajpheart.01056.2010","volume":"300","author":"H Kanamori","year":"2011","unstructured":"Kanamori H, Takemura G, Goto K et al (2011) Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion. Am J Physiol Heart Circ Physiol 300:H2261\u20132271","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1387_CR4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.4161\/auto.9064","volume":"5","author":"H Zhu","year":"2009","unstructured":"Zhu H, Wu H, Li B et al (2009) Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 5:816\u2013823","journal-title":"Autophagy"},{"key":"1387_CR5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4161\/auto.8.2.18351","volume":"8","author":"G Korkmaz","year":"2012","unstructured":"Korkmaz G, le Sage C, Tekirdag KA et al (2012) miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 8:165\u2013176","journal-title":"Autophagy"},{"key":"1387_CR6","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncomms2090","volume":"3","author":"A Ucar","year":"2012","unstructured":"Ucar A, Gupta SK, Fiedler J et al (2012) The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 3:1078","journal-title":"Nat Commun"},{"key":"1387_CR7","doi-asserted-by":"crossref","first-page":"e50926","DOI":"10.1371\/journal.pone.0050926","volume":"7","author":"G Long","year":"2012","unstructured":"Long G, Wang F, Duan Q et al (2012) Circulating miR-30a, miR-195 and let-7b associated with acute myocardial infarction. PLoS One 7:e50926","journal-title":"PLoS One"},{"key":"1387_CR8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog J, W\u00fcrdinger T, van Rijn S et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470\u20131476","journal-title":"Nat Cell Biol"},{"key":"1387_CR9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","volume":"110","author":"EE Creemers","year":"2012","unstructured":"Creemers EE, Tijsen AJ, Pinto YM (2012) Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res 110:483\u2013495","journal-title":"Circ Res"},{"key":"1387_CR10","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.jacc.2012.08.001","volume":"60","author":"K Thygesen","year":"2012","unstructured":"Thygesen K, Alpert JS, Jaffe AS et al (2012) Third universal definition of myocardial infarction. J Am Coll Cardiol 60:1581\u20131598","journal-title":"J Am Coll Cardiol"},{"key":"1387_CR11","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1182\/blood-2013-05-504597","volume":"122","author":"JA Dubovsky","year":"2013","unstructured":"Dubovsky JA, Chappell DL, Harrington BK et al (2013) Lymphocyte cytosolic protein 1 is a chronic lymphocytic leukemia membrane-associated antigen critical to niche homing. Blood 122:3308\u20133316","journal-title":"Blood"},{"key":"1387_CR12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCRESAHA.108.182535","volume":"104","author":"RF Duisters","year":"2009","unstructured":"Duisters RF, Tijsen AJ, Schroen B et al (2009) miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 104:170\u2013178","journal-title":"Circ Res"},{"key":"1387_CR13","doi-asserted-by":"crossref","first-page":"e53950","DOI":"10.1371\/journal.pone.0053950","volume":"8","author":"W Pan","year":"2013","unstructured":"Pan W, Zhong Y, Cheng C et al (2013) MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One 8:e53950","journal-title":"PLoS One"},{"key":"1387_CR14","author":"P Wang","year":"2015","unstructured":"Wang P, Zhang N, Liang J et al (2015) Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke. J Neurosci Res. doi: 10.1002\/jnr.23637","journal-title":"J Neurosci Res"},{"key":"1387_CR15","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105:10513\u201310518","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1387_CR16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm3335","volume":"13","author":"M Mittelbrunn","year":"2012","unstructured":"Mittelbrunn M, S\u00e1nchez-Madrid F (2012) Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol 13:328\u2013335","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1387_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","volume":"13","author":"KC Vickers","year":"2011","unstructured":"Vickers KC, Palmisano BT, Shoucri BM et al (2011) MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13:423\u2013433","journal-title":"Nat Cell Biol"},{"key":"1387_CR18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","volume":"21","author":"M Simons","year":"2009","unstructured":"Simons M, Raposo G (2009) Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol 21:575\u2013581","journal-title":"Curr Opin Cell Biol"},{"key":"1387_CR19","author":"C Th\u00e9ry","year":"2006","unstructured":"Th\u00e9ry C, Amigorena S, Raposo G et al (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. doi: 10.1002\/0471143030","journal-title":"Curr Protoc Cell Biol"},{"key":"1387_CR20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","volume":"18","author":"H Peinado","year":"2012","unstructured":"Peinado H, Aleckovic M, Lavotshkin S (2012) Melanoma exosomes educate bone marrow progenitor cells toward a prometastatic phenotype through MET. Nat Med 18:883\u2013891","journal-title":"Nat Med"},{"key":"1387_CR21","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1074\/jbc.C113.532267","volume":"289","author":"C Kahlert","year":"2014","unstructured":"Kahlert C, Melo SA, Protopopov A et al (2014) Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J Biol Chem 289:3869\u20133875","journal-title":"J Biol Chem"},{"key":"1387_CR22","doi-asserted-by":"crossref","first-page":"e34653","DOI":"10.1371\/journal.pone.0034653","volume":"7","author":"A Waldenstr\u00f6m","year":"2012","unstructured":"Waldenstr\u00f6m A, Genneb\u00e4ck N, Hellman U et al (2012) Cardiomyocyte microvesicles contain DNA\/RNA and convey biological messages to target cells. PLoS One 7:e34653","journal-title":"PLoS One"},{"key":"1387_CR23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00441-012-1485-6","volume":"352","author":"JC Herve","year":"2013","unstructured":"Herve JC, Derangeon M (2013) Gap-junction-mediated cell-to-cell communication. Cell Tissue Res 352:21\u201331","journal-title":"Cell Tissue Res"},{"key":"1387_CR24","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1126\/science.1313187","volume":"255","author":"SJ Singer","year":"1992","unstructured":"Singer SJ (1992) Intercellular communication and cell-cell adhesion. Science 255:1671\u20131677","journal-title":"Science"},{"key":"1387_CR25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0960-0760(01)00188-1","volume":"80","author":"W Imagawa","year":"2002","unstructured":"Imagawa W, Pedchenko VK, Helber J et al (2002) Hormone\/growth factor interactions mediating epithelial\/stromal communication in mammary gland development and carcinogenesis. J Steroid Biochem Mol Biol 80:213\u2013230","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1387_CR26","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s13277-013-1417-4","volume":"35","author":"WX Chen","year":"2014","unstructured":"Chen WX, Zhong SL, Ji MH et al (2014) MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer. Tumour Biol 35:2883\u20132892","journal-title":"Tumour Biol"},{"key":"1387_CR27","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi H, Ekstrom K, Bossios A et al (2007) Exosome mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654\u2013659","journal-title":"Nat Cell Biol"},{"key":"1387_CR28","doi-asserted-by":"crossref","first-page":"e32765","DOI":"10.1371\/journal.pone.0032765","volume":"7","author":"X Zhang","year":"2012","unstructured":"Zhang X, Wang X, Zhu H et al (2012) Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS ONE 7:e32765","journal-title":"PLoS ONE"},{"key":"1387_CR29","doi-asserted-by":"crossref","first-page":"H954","DOI":"10.1152\/ajpheart.00835.2012","volume":"304","author":"ZA Malik","year":"2013","unstructured":"Malik ZA, Kott KS, Poe AJ et al (2013) Cardiac myocyte exosomes: stability, HSP60, and proteomics. Am J Physiol Heart Circ Physiol 304:H954\u2013965","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1387_CR30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","volume":"200","author":"G Raposo","year":"2013","unstructured":"Raposo G, Stoorvogel W (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200:373\u2013383","journal-title":"J Cell Biol"},{"key":"1387_CR31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","volume":"9","author":"C Thery","year":"2009","unstructured":"Thery C, Ostrowski M, Segura E (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9:581\u2013593","journal-title":"Nat Rev Immunol"},{"key":"1387_CR32","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","volume":"290","author":"DJ Klionsky","year":"2000","unstructured":"Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717\u20131721","journal-title":"Science"},{"key":"1387_CR33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","volume":"10","author":"H Nakatogawa","year":"2009","unstructured":"Nakatogawa H, Suzuki K, Kamada Y et al (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 10:458\u2013467","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1387_CR34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ceb.2009.11.014","volume":"22","author":"Z Yang","year":"2010","unstructured":"Yang Z, Klionsky DJ (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22:124\u2013131","journal-title":"Curr Opin Cell Biol"},{"key":"1387_CR35","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cdd.2010.191","volume":"18","author":"R Kang","year":"2011","unstructured":"Kang R, Zeh HJ, Lotze MT et al (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18:571\u2013580","journal-title":"Cell Death Differ"},{"key":"1387_CR36","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1172\/JCI20039","volume":"112","author":"X Qu","year":"2003","unstructured":"Qu X, Yu J, Bhagat G et al (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112:1809\u20131820","journal-title":"J Clin Invest"},{"key":"1387_CR37","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","volume":"100","author":"Z Yue","year":"2003","unstructured":"Yue Z, Jin SK, Yang CW et al (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 100:15077\u201315082","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1387_CR38","author":"J Xiao","year":"2011","unstructured":"Xiao J, Zhu X, He B et al (2011) MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II. J Biomed Sci. doi: 10.1186\/1423-0127-18-35","journal-title":"J Biomed Sci"},{"key":"1387_CR39","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/leu.2012.65","volume":"26","author":"Y Yu","year":"2012","unstructured":"Yu Y, Yang L, Zhao M et al (2012) Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells. Leukemia 26:1752\u20131760","journal-title":"Leukemia"},{"key":"1387_CR40","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","volume":"8","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Zalckvar E, Kimchi A et al (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741\u2013752","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1387_CR41","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm1574","volume":"13","author":"A Nakai","year":"2007","unstructured":"Nakai A, Yamaguchi O, Takeda T et al (2007) The role of autophagy in myocytes in the basal state and in response to hemodynamic stress. Nat Med 13:619\u2013624","journal-title":"Nat Med"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1387-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-016-1387-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1387-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T06:51:03Z","timestamp":1567579863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-016-1387-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["1387"],"URL":"https:\/\/doi.org\/10.1007\/s00109-016-1387-2","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}