{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:28:14Z","timestamp":1779924494651,"version":"3.53.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (CN)","doi-asserted-by":"publisher","award":["30873088"],"award-info":[{"award-number":["30873088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (CN)","doi-asserted-by":"publisher","award":["81272450"],"award-info":[{"award-number":["81272450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (CN)","doi-asserted-by":"publisher","award":["81402196"],"award-info":[{"award-number":["81402196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (CN)","doi-asserted-by":"publisher","award":["81401989"],"award-info":[{"award-number":["81401989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Gongdong Province","award":["S2012010008995"],"award-info":[{"award-number":["S2012010008995"]}]},{"name":"Doctoral Fund of Ministry of Education of China","award":["20124423110003"],"award-info":[{"award-number":["20124423110003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00109-016-1417-0","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T14:47:48Z","timestamp":1460126868000},"page":"1129-1141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer"],"prefix":"10.1007","volume":"94","author":[{"given":"Guopei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"issue":"2","key":"1417_CR1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69\u201390","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"1417_CR2","first-page":"1008","volume":"21","author":"H Hua","year":"2002","unstructured":"Hua H, Zeng ZY, Zhao H, Chen FJ, Guo ZM, Xu GP, Zhang Q (2002) Influence of induction chemotherapy on long-time effect of patients with tongue squamous cell carcinoma. Ai Zheng 21(9):1008\u20131011","journal-title":"Ai Zheng"},{"issue":"15","key":"1417_CR3","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1158\/1078-0432.CCR-05-0285","volume":"11","author":"P S\u00e8ve","year":"2005","unstructured":"S\u00e8ve P, Isaac S, Tr\u00e9dan O, Souquet PJ, Pach\u00e9co Y, P\u00e9rol M, Lafan\u00e9ch\u00e8re L, Penet A, Peiller EL, Dumontet C (2005) Expression of class III {beta}-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy. Clin Cancer Res 11(15):5481\u20135486","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1417_CR4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/0008-5472.CAN-07-3063","volume":"68","author":"K Yamauchi","year":"2008","unstructured":"Yamauchi K, Yang M, Hayashi K, Jiang P, Yamamoto N, Tsuchiya H, Tomita K, Moossa AR, Bouvet M, Hoffman RM (2008) Induction of cancer metastasis by cyclophosphamide pretreatment of host mice: an opposite effect of chemotherapy. Cancer Res 68(2):516\u2013520","journal-title":"Cancer Res"},{"issue":"4\u20135","key":"1417_CR5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.drup.2009.07.001","volume":"12","author":"HJ Broxterman","year":"2009","unstructured":"Broxterman HJ, Gotink KJ, Verheul HM (2009) Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Update 12(4\u20135):114\u2013126","journal-title":"Drug Resist Update"},{"issue":"3","key":"1417_CR6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.drup.2010.02.001","volume":"13","author":"FH Sarkar","year":"2010","unstructured":"Sarkar FH, Li Y, Wang Z, Kong D, Ali S (2010) Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Update 13(3):57\u201366","journal-title":"Drug Resist Update"},{"issue":"3","key":"1417_CR7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","volume":"11","author":"J Winter","year":"2009","unstructured":"Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11(3):228\u2013234","journal-title":"Nat Cell Biol"},{"issue":"4","key":"1417_CR8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.cell.2009.02.005","volume":"136","author":"A Ventura","year":"2009","unstructured":"Ventura A, Jacks T (2009) MicroRNAs and cancer: short RNAs go a long way. Cell 136(4):586\u2013591","journal-title":"Cell"},{"issue":"1","key":"1417_CR9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2008.09.086","volume":"377","author":"Y Fujita","year":"2008","unstructured":"Fujita Y, Kojima K, Hamada N, Ohhashi R, Akao Y, Nozawa Y, Deguchi T, Ito M (2008) Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun 377(1):114\u2013119","journal-title":"Biochem Biophys Res Commun"},{"issue":"1\u20132","key":"1417_CR10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1582-4934.2009.00964.x","volume":"14","author":"W Rui","year":"2010","unstructured":"Rui W, Bing F, Hai-Zhu S, Wei D, Long-Bang C (2010) Identification of microRNA profiles in docetaxelresistant human non-small cell lung carcinoma cells (SPC-A1). J Cell Mol Med 14(1\u20132):206\u2013214","journal-title":"J Cell Mol Med"},{"issue":"16","key":"1417_CR11","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1158\/1078-0432.CCR-08-2245","volume":"15","author":"L Adam","year":"2009","unstructured":"Adam L, Zhong M, Choi W, Qi W, Nicoloso M, Arora A, Calin G, Wang H, Siefker-Radtke A, McConkey D et al (2009) miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res 15(16):5060\u20135072","journal-title":"Clin Cancer Res"},{"issue":"21","key":"1417_CR12","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1111\/j.1742-4658.2010.07836.x","volume":"277","author":"G Zheng","year":"2010","unstructured":"Zheng G, Zhou M, Ou X, Peng B, Yu Y, Kong F, Ouyang Y, He Z (2010) Identification of carbonic anhydrase9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells. FEBS J 277(21):4506\u20134518","journal-title":"FEBS J"},{"issue":"9","key":"1417_CR13","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.18632\/oncotarget.3165","volume":"6","author":"G Zheng","year":"2015","unstructured":"Zheng G, Jia X, Peng C, Deng Y, Yin J, Zhang Z, Li N, Deng M, Liu X, Liu H et al (2015) The miR-491-3p\/mTORC2\/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer. Oncotarget 6(9):6931\u20136943","journal-title":"Oncotarget"},{"issue":"2","key":"1417_CR14","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2007.05.022","volume":"133","author":"F Meng","year":"2007","unstructured":"Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133(2):647\u2013658","journal-title":"Gastroenterology"},{"issue":"8","key":"1417_CR15","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.18632\/oncotarget.3465","volume":"6","author":"LJ Wang","year":"2015","unstructured":"Wang LJ, He CC, Sui X, Cai MJ, Zhou CY, Ma JL, Wu L, Wang H, Han SX, Zhu Q (2015) MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN. Oncotarget 6(8):5932\u20135946","journal-title":"Oncotarget"},{"issue":"15","key":"1417_CR16","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","volume":"27","author":"IA Asangani","year":"2008","unstructured":"Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, Allgayer H (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 27(15):2128\u20132136","journal-title":"Oncogene"},{"issue":"49","key":"1417_CR17","doi-asserted-by":"crossref","first-page":"21098","DOI":"10.1073\/pnas.1015541107","volume":"107","author":"N Valeri","year":"2010","unstructured":"Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T et al (2010) MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA 107(49):21098\u201321103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1417_CR18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.febslet.2010.12.027","volume":"585","author":"H Bai","year":"2011","unstructured":"Bai H, Xu R, Cao Z, Wei D, Wang C (2011) Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line. FEBS Lett 585(2):402\u2013408","journal-title":"FEBS Lett"},{"issue":"21","key":"1417_CR19","doi-asserted-by":"crossref","first-page":"19127","DOI":"10.1074\/jbc.M110.216887","volume":"286","author":"C Gong","year":"2011","unstructured":"Gong C, Yao Y, Wang Y, Liu B, Wu W, Chen J, Su F, Yao H, Song E (2011) Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer. J Biol Chem 286(21):19127\u201319137","journal-title":"J Biol Chem"},{"issue":"12","key":"1417_CR20","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1158\/1078-0432.CCR-08-3053","volume":"15","author":"J Li","year":"2099","unstructured":"Li J, Huang H, Sun L, Yang M, Pan C, Chen W, Wu D, Lin Z, Zeng C, Yao Y et al (2099) MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res 15(12):3998\u20134008","journal-title":"Clin Cancer Res"},{"issue":"4","key":"1417_CR21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/onc.2011.263","volume":"31","author":"L Sun","year":"2012","unstructured":"Sun L, Yao Y, Liu B, Lin Z, Lin L, Yang M, Zhang W, Chen W, Pan C, Liu Q et al (2012) MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene 31(4):432\u2013445","journal-title":"Oncogene"},{"issue":"3","key":"1417_CR22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.lungcan.2010.10.005","volume":"72","author":"RM Berg van den","year":"2011","unstructured":"van den Berg RM, Snijders PJ, Gr\u00fcnberg K, Kooi C, Spreeuwenberg MD, Meijer CJ, Postmus PE, Smit EF, Steenbergen RD (2011) Comprehensive CADM1 promoter methylation analysis in NSCLC and normal lung specimens. Lung Cancer 72(3):316\u2013321","journal-title":"Lung Cancer"},{"issue":"3","key":"1417_CR23","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12282-011-0272-7","volume":"19","author":"Y Takahashi","year":"2012","unstructured":"Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F et al (2012) Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer. Breast Cancer 19(3):242\u2013252","journal-title":"Breast Cancer"},{"issue":"4","key":"1417_CR24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.2367","volume":"215","author":"RM Overmeer","year":"2008","unstructured":"Overmeer RM, Henken FE, Snijders PJ, Claassen-Kramer D, Berkhof J, Helmerhorst TJ, Heideman DA, Wilting SM, Murakami Y, Ito A et al (2008) Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol 215(4):388\u2013397","journal-title":"J Pathol"},{"issue":"5","key":"1417_CR25","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s13277-012-0396-1","volume":"33","author":"QJ Li","year":"2012","unstructured":"Li QJ, Zhou L, Yang F, Wang GX, Zheng H, Wang DS, He Y, Dou KF (2012) MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells. Tumour Biol 33(5):1455\u20131465","journal-title":"Tumour Biol"},{"issue":"45","key":"1417_CR26","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1038\/sj.onc.1205825","volume":"21","author":"Y Murakami","year":"2002","unstructured":"Murakami Y (2002) Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer. Oncogene 21(45):6936\u20136948","journal-title":"Oncogene"},{"issue":"2","key":"1417_CR27","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.25695","volume":"56","author":"PJ Chen","year":"2012","unstructured":"Chen PJ, Yeh SH, Liu WH, Lin CC, Huang HC, Chen CL, Chen DS, Chen PJ (2012) Androgen pathway stimulates microRNA-216a transcription to suppress the tumor suppressor in lung cancer-1 gene in early hepatocarcinogenesis. Hepatology 56(2):632\u2013643","journal-title":"Hepatology"},{"issue":"2","key":"1417_CR28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cellsig.2014.11.011","volume":"27","author":"P Wang","year":"2015","unstructured":"Wang P, Liu YH, Yao YL, Li Z, Li ZQ, Ma J, Xue YX (2015) Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. Cell Signal 27(2):275\u2013282","journal-title":"Cell Signal"},{"issue":"2","key":"1417_CR29","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.18632\/oncotarget.2859","volume":"6","author":"M Zhou","year":"2015","unstructured":"Zhou M, Zeng J, Wang X, Wang X, Huang T, Fu Y, Sun T, Jia J, Chen C (2015) Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia. Oncotarget 6(2):1249\u20131261","journal-title":"Oncotarget"},{"issue":"2","key":"1417_CR30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.canlet.2010.01.015","volume":"293","author":"E Bell","year":"2010","unstructured":"Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA (2010) MYCN oncoprotein targets and their therapeutic potential. Cancer Lett 293(2):144\u2013157","journal-title":"Cancer Lett"},{"issue":"12","key":"1417_CR31","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/nrc2231","volume":"8","author":"N Meyer","year":"2008","unstructured":"Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8(12):976\u2013990","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"1417_CR32","doi-asserted-by":"crossref","first-page":"a014415","DOI":"10.1101\/cshperspect.a014415","volume":"3","author":"M Huang","year":"2013","unstructured":"Huang M, Weiss WA (2013) Neuroblastoma and MYCN. Cold Spring Harb Perspect Med 3(10):a014415","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"115","key":"1417_CR33","doi-asserted-by":"crossref","first-page":"115ra3","DOI":"10.1126\/scitranslmed.3002977","volume":"4","author":"YH Chanthery","year":"2012","unstructured":"Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK et al (2012) Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med 4(115):115ra3","journal-title":"Sci Transl Med"},{"issue":"9","key":"1417_CR34","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/onc.2009.429","volume":"29","author":"P Mestdagh","year":"2010","unstructured":"Mestdagh P, Fredlund E, Pattyn F, Schulte JH, Muth D, Vermeulen J, Kumps C, Schlierf S, De Preter K, Van Roy N et al (2010) MYCN\/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN\/c-MYC-activated tumors. Oncogene 29(9):1394\u20131404","journal-title":"Oncogene"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1417-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-016-1417-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1417-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1417-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:27:52Z","timestamp":1558571272000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-016-1417-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["1417"],"URL":"https:\/\/doi.org\/10.1007\/s00109-016-1417-0","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}