{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:43:13Z","timestamp":1787654593358,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:00:00Z","timestamp":1461715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC100-2314-B-182A-028-MY3"],"award-info":[{"award-number":["NSC100-2314-B-182A-028-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX104-10436SI"],"award-info":[{"award-number":["NHRI-EX104-10436SI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG8A4022, CMRPG8B0872, CLRPG8B0042"],"award-info":[{"award-number":["CMRPG8A4022, CMRPG8B0872, CLRPG8B0042"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s00109-016-1422-3","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T02:26:51Z","timestamp":1461724011000},"page":"755-769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis"],"prefix":"10.1007","volume":"94","author":[{"given":"Jih-Yang","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chih","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,27]]},"reference":[{"key":"1422_CR1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2012-201575","volume":"72","author":"D Felson","year":"2013","unstructured":"Felson D, Niu J, Sack B, Aliabadi P, McCullough C, Nevitt MC (2013) Progression of osteoarthritis as a state of inertia. Ann Rheum Dis 72:924\u2013929","journal-title":"Ann Rheum Dis"},{"key":"1422_CR2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as organ. Arthritis Rheum 64:1697\u20131707","journal-title":"Arthritis Rheum"},{"key":"1422_CR3","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","volume":"20","author":"BJ Lange-Brokaar de","year":"2012","unstructured":"de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, Huizinga TW, Kloppenburg M (2012) Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthr Cartil 20:1484\u20131499","journal-title":"Osteoarthr Cartil"},{"key":"1422_CR4","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1073\/pnas.1319569111","volume":"111","author":"CJ O\u2019Conor","year":"2014","unstructured":"O\u2019Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F (2014) TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proc Natl Acad Sci U S A 111:1316\u20131321","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1422_CR5","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.37965","volume":"65","author":"KL Culley","year":"2013","unstructured":"Culley KL, Hui W, Barter MJ, Davidson RK, Swingler TE, Destrument AP, Scott ST, Dowell ST, Fenwick S, Rowan AD et al (2013) Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. Arthritis Rheum 65:1822\u20131830","journal-title":"Arthritis Rheum"},{"key":"1422_CR6","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/art.37996","volume":"65","author":"YM Bastinaansen-Jenniskens","year":"2013","unstructured":"Bastinaansen-Jenniskens YM, Wei W, Feijt C, Waarsing JH, Verhaar JA, Zuurmond AM, Hanemaaijer R, Stoop R, van Osch GJ (2013) Stimulation of fibrotic processes by the infrapatellar fat pad in cultured synoviocytes from patients with osteoarthritis: a possible role for prostaglandin f2\u03b1. Arthritis Rheum 65:2070\u20132080","journal-title":"Arthritis Rheum"},{"key":"1422_CR7","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1002\/art.34645","volume":"64","author":"T Weng","year":"2012","unstructured":"Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen L (2012) Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice. Arthritis Rheum 64:3982\u20133992","journal-title":"Arthritis Rheum"},{"key":"1422_CR8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature13614","volume":"514","author":"JB Arlet","year":"2014","unstructured":"Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S et al (2014) HSP70 sequestration by \u03b1-globin promotes ineffective erythropoiesis in \u03b2-thalassaemia. Nature 514:242\u2013246","journal-title":"Nature"},{"key":"1422_CR9","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1172\/JCI71919","volume":"124","author":"L Winter","year":"2014","unstructured":"Winter L, Staszewska I, Mihailovska E, Fischer I, Goldmann WH, Schr\u00f6der R, Wiche G (2014) Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle. J Clin Invest 124:1144\u20131157","journal-title":"J Clin Invest"},{"key":"1422_CR10","doi-asserted-by":"crossref","first-page":"12998","DOI":"10.1073\/pnas.1205854109","volume":"109","author":"A Ghosh","year":"2012","unstructured":"Ghosh A, Stuehr DJ (2012) Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. Proc Natl Acad Sci U S A 109:12998\u201313003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1422_CR11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077788","volume":"8","author":"T Koya","year":"2013","unstructured":"Koya T, Nishizawa S, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, Egawa T, Nakai A, Sugiura T et al (2013) Heat shock transcription factor-1 deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. PLoS One 8, e77788","journal-title":"PLoS One"},{"key":"1422_CR12","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1206803109","volume":"109","author":"MJ Herwijnen van","year":"2012","unstructured":"van Herwijnen MJ, Wieten L, van der Zee R, van Kooten PJ, Wagenaar-Hilbers JP, Hoek A, den Braber I, Anderton SM, Singh M, Meiring HD et al (2012) Regulatory T cells that recognize a ubiquitous stress-induced self-antigen are long-lived suppressors of autoimmune arthritis. Proc Natl Acad Sci U S A 109:14134\u201314139","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1422_CR13","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/art.38000","volume":"65","author":"M Siebelt","year":"2013","unstructured":"Siebelt M, Jahr H, Groen HC, Sandker M, Waarsing JH, Kops N, M\u00fcller C, van Eden W, de Jong M, Weinans H (2013) Hsp90 inhibition protects against biomechanically induced osteoarthritis. Arthritis Rheum 65:2102\u20132112","journal-title":"Arthritis Rheum"},{"key":"1422_CR14","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1084\/jem.20111783","volume":"209","author":"SA Yoo","year":"2012","unstructured":"Yoo SA, You D, Yoon HJ, Kim DH, Kim HS, Lee K, Ahn JH, Hwang D, Lee AS, Kim KJ et al (2012) A novel pathogenic role of the ER chaperone GRP78\/BiP in rheumatoid arthritis. J Exp Med 209:871\u2013886","journal-title":"J Exp Med"},{"key":"1422_CR15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/jor.22623","volume":"32","author":"S Tsuchida","year":"2014","unstructured":"Tsuchida S, Arai Y, Takahashi KA, Kishida T, Terauchi R, Honjo K, Nakagawa S, Inoue H, Ikoma K, Ueshima K et al (2014) HIF-1\u03b1-induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions. J Orthop Res 32:975\u2013980","journal-title":"J Orthop Res"},{"key":"1422_CR16","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.joca.2009.10.008","volume":"18","author":"S Lambrecht","year":"2010","unstructured":"Lambrecht S, Dhaenens M, Almqvist F, Verdonk P, Verbruggen G, Deforce D, Elewaut D (2010) Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock protein in chondrocyte homeostasis. Osteoarthr Cartil 18:440\u2013446","journal-title":"Osteoarthr Cartil"},{"key":"1422_CR17","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/ard.2008.092288","volume":"68","author":"Z Fan","year":"2009","unstructured":"Fan Z, Tardif G, Hum D, Duval N, Pelletier JP, Martel-Pelletier J (2009) HSP90(beta) and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritis chondrocytes. Ann Rheum Dis 68:976\u2013982","journal-title":"Ann Rheum Dis"},{"key":"1422_CR18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s12192-010-0194-x","volume":"15","author":"JH Christensen","year":"2010","unstructured":"Christensen JH, Nielsen MN, Hansen J, F\u00fcchtbauer A, F\u00fcchtbauer EM, West M, Corydon TJ, Gregersen N, Bross P (2010) Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice. Cell Stress Chaperones 15:851\u2013863","journal-title":"Cell Stress Chaperones"},{"key":"1422_CR19","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1172\/JCI67615","volume":"123","author":"A Kleninridders","year":"2013","unstructured":"Kleninridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR (2013) Leptin regulation of HSP60 impacts hypothalamic insulin signaling. J Clin Invest 123:4667\u20134680","journal-title":"J Clin Invest"},{"key":"1422_CR20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/jbmr.271","volume":"26","author":"J Suwanwela","year":"2011","unstructured":"Suwanwela J, Farber CR, Haung BL, Song B, Pan C, Lyons KM, Lusis AJ (2011) Systems genetics analysis of mouse chondrocyte differentiation. J Bone Miner Res 26:747\u2013760","journal-title":"J Bone Miner Res"},{"key":"1422_CR21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bone.2013.10.003","volume":"58","author":"M Romanello","year":"2014","unstructured":"Romanello M, Piatkowska E, Antoniali G, Cesaratto L, Vascotto C, Iozzo RV, Delneri D, Brancia FL (2014) Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment. Bone 58:81\u201391","journal-title":"Bone"},{"key":"1422_CR22","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1136\/annrheumdis-2011-201131","volume":"71","author":"E Zonneveld-Huijssoon","year":"2012","unstructured":"Zonneveld-Huijssoon E, van Wijk F, Roord S, Delemarre E, Meerding J, de Jager W, Klein M, Raz R, Albani S, Kuis W et al (2012) TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis. Ann Rheum Dis 71:1706\u20131715","journal-title":"Ann Rheum Dis"},{"key":"1422_CR23","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bone.2011.08.006","volume":"49","author":"FS Wang","year":"2011","unstructured":"Wang FS, Wu RW, Yeh DW, Chen MW, Ke HC, Wu SL, Ko JY (2011) Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival. Bone 49:1080\u20131089","journal-title":"Bone"},{"key":"1422_CR24","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1002\/art.34602","volume":"64","author":"LH Weng","year":"2012","unstructured":"Weng LH, Ko JY, Wang CJ, Sun YC, Wang FS (2012) Dkk-1 promotes angiogenic responses and cartilage matrix proteinase secretion in synovial fibroblasts from osteoarthritic joints. Arthritis Rheum 64:3267\u20133277","journal-title":"Arthritis Rheum"},{"key":"1422_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/gene.20038","volume":"39","author":"YC Hsiao","year":"2004","unstructured":"Hsiao YC, Chang HH, Tsai CY, Jong TJ, Horng LS, Lin SF, Tsai TF (2004) Coat color-tagged green mouse with EGFP expressed from the RNA polymerase II promoter. Genesis 39:122\u2013129","journal-title":"Genesis"},{"key":"1422_CR26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/ard.2010.134619","volume":"70","author":"M Daans","year":"2011","unstructured":"Daans M, Luyten FP, Lories RJ (2011) GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes. Ann Rheum Dis 70:208\u2013213","journal-title":"Ann Rheum Dis"},{"key":"1422_CR27","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1021\/bc2002727","volume":"22","author":"K Licha","year":"2011","unstructured":"Licha K, Welker P, Weinhart M, Wegner N, Kern S, Reichert S, Gemeinhardt I, Weissbach C, Ebert B, Haag R et al (2011) Fluorescence imaging with multifunctional polyglycerol sulfates: novel polymeric near-IR probes targeting inflammation. Bioconjug Chem 22:2453\u20132460","journal-title":"Bioconjug Chem"},{"key":"1422_CR28","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.4049\/jimmunol.1103826","volume":"189","author":"CL Chang","year":"2012","unstructured":"Chang CL, Hsu YT, Wu CC, Yang YC, Wang C, Wu TC, Hung CF (2012) Immune mechanism of the anittumor effects generated by bortezomib. J Immunol 189:3209\u20133220","journal-title":"J Immunol"},{"key":"1422_CR29","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrcardio.2014.91","volume":"11","author":"G Wick","year":"2014","unstructured":"Wick G, Jakic B, Buszko M, Wick MC, Grundtman C (2014) The role of heat shock proteins in atherosclerosis. Nat Rev Cardiol 11:516\u2013529","journal-title":"Nat Rev Cardiol"},{"key":"1422_CR30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/art.24152","volume":"60","author":"S Lambrecht","year":"2009","unstructured":"Lambrecht S, Verbruggen G, Elewaut D, Deforce D (2009) Differential expression of alphaB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis. Arthritis Rheum 60:179\u2013188","journal-title":"Arthritis Rheum"},{"key":"1422_CR31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jor.21535","volume":"30","author":"S Fujita","year":"2012","unstructured":"Fujita S, Arai Y, Nakagawa S, Takahashi KA, Terauchi R, Inoue A, Tonomura H, Hiraoka M, Inoue H, Tsuchida S et al (2012) Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoathritis model. J Orthop Res 30:401\u2013407","journal-title":"J Orthop Res"},{"key":"1422_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.12.014","author":"EW Bradley","year":"2015","unstructured":"Bradley EW, Carpio LR, McGee-Lawrence ME, Castillejo Becerra C, Amanatulla DF, Ta LE, Otero M, Goldring MB, Kakar S, Westendorf JJ (2015) Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demthylation in human osteoarthritis. Osteoarthr Cartil. doi: 10.1016\/j.joca.2015.12.014","journal-title":"Osteoarthr Cartil"},{"key":"1422_CR33","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1002\/art.38713","volume":"66","author":"MD Rushton","year":"2014","unstructured":"Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J (2014) Characterization of the cartilage DNA methylation in knee and hip osteoarthritis. Arthritis Rheumatol 66:2450\u20132460","journal-title":"Arthritis Rheumatol"},{"key":"1422_CR34","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/art.39182","volume":"67","author":"Y Wang","year":"2015","unstructured":"Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R (2015) Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor \u03b3 coactivator 1\u03b1. Arthritis Rheum 67:2141\u20132153","journal-title":"Arthritis Rheum"},{"key":"1422_CR35","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1136\/annrheumdis-2014-205980","volume":"73","author":"W Hollanders den","year":"2014","unstructured":"den Hollanders W, Ramos YF, Bos SD, Bomer N, van der Breggen R, Lakenberg N, de Dijcker WJ, Duijnisveld BJ, Slagboom PE, Nelissen RG et al (2014) Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches. Ann Rheum Dis 73:2208\u20132212","journal-title":"Ann Rheum Dis"},{"key":"1422_CR36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2011) Role of proinflammatiory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7:33\u201342","journal-title":"Nat Rev Rheumatol"},{"key":"1422_CR37","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI66938","volume":"123","author":"JW Leavenworth","year":"2013","unstructured":"Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H (2013) Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest 123:1382\u20131389","journal-title":"J Clin Invest"},{"key":"1422_CR38","volume":"5","author":"SC Liu","year":"2014","unstructured":"Liu SC, Chuang SM, Hsu CJ, Tsai CH, Wang SW, Tang CH (2014) CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis 5, e1485","journal-title":"Cell Death Dis"},{"key":"1422_CR39","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.stem.2009.01.015","volume":"4","author":"S Koelling","year":"2009","unstructured":"Koelling S, Kruegel J, Irmer M, Path JR, Sadowski B, Miro X, Miosge N (2009) Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 4:324\u2013335","journal-title":"Cell Stem Cell"},{"key":"1422_CR40","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/annrheumdis-2013-204962","volume":"74","author":"M Radwan","year":"2015","unstructured":"Radwan M, Wilkinson DJ, Hui W, Destrument A, Charlton SH, Barter MJ, Gibson B, Coulombe J, Gray DA, Rowan AD et al (2015) Protection against murine osteoarthritis by inhibition of the 26 proteasome and lysine-48 linked ubiquitination. Ann Rheum Dis 74:1580\u20131587","journal-title":"Ann Rheum Dis"},{"key":"1422_CR41","doi-asserted-by":"crossref","first-page":"35138","DOI":"10.1074\/jbc.M113.486795","volume":"288","author":"T Hattori","year":"2013","unstructured":"Hattori T, Kishino T, Stephen S, Eberspaecher H, Maki S, Takigawa M, de Crombrugghe B, Yasuda H (2013) E6-AP\/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein. J Biol Chem 288:35138\u201335148","journal-title":"J Biol Chem"},{"key":"1422_CR42","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/carcin\/bgp087","volume":"30","author":"YP Tsai","year":"2009","unstructured":"Tsai YP, Yang MH, Huang CH, Chang SY, Chen PM, Liu CJ, Teng SC, Wu KJ (2009) Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis 30:1049\u20131057","journal-title":"Carcinogenesis"},{"key":"1422_CR43","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1073\/pnas.1217692110","volume":"110","author":"Y Yang","year":"2013","unstructured":"Yang Y, Fiskus W, Yang B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN (2013) Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A 110:6841\u20136846","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1422_CR44","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.joca.2014.11.006","volume":"23","author":"Y Li","year":"2015","unstructured":"Li Y, Wang Y, Chubinskaya S, Schoeberl B, Florine E, Kopesky P, Grodzinsky AJ (2015) Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis. Osteoarthr Cartil 23:266\u2013274","journal-title":"Osteoarthr Cartil"},{"key":"1422_CR45","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/art.38357","volume":"66","author":"FS Loffredo","year":"2014","unstructured":"Loffredo FS, Pancoast JR, Cai L, Vannelli T, Dong JZ, Lee RT, Patwari P (2014) Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor in a rat model of osteoarthritis. Arthritis Rheumatol 66:1247\u20131255","journal-title":"Arthritis Rheumatol"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1422-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-016-1422-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-016-1422-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T22:04:40Z","timestamp":1567807480000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-016-1422-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,27]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["1422"],"URL":"https:\/\/doi.org\/10.1007\/s00109-016-1422-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,27]]}}}