{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:54:42Z","timestamp":1769165682570,"version":"3.49.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T00:00:00Z","timestamp":1547856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST105-2320-B-182-031-MY2"],"award-info":[{"award-number":["MOST105-2320-B-182-031-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2320-B-182-013"],"award-info":[{"award-number":["MOST107-2320-B-182-013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2320-B-264-001-MY2"],"award-info":[{"award-number":["MOST107-2320-B-264-001-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["BMRP098"],"award-info":[{"award-number":["BMRP098"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPD1F0462"],"award-info":[{"award-number":["CMRPD1F0462"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPD1F0622"],"award-info":[{"award-number":["CMRPD1F0622"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00109-018-01740-2","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T13:16:39Z","timestamp":1547903799000},"page":"385-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans"],"prefix":"10.1007","volume":"97","author":[{"given":"Hung-Chi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szecheng J.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Tsun-Yee","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,19]]},"reference":[{"key":"1740_CR1","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","volume":"84","author":"E Beutler","year":"1994","unstructured":"Beutler E (1994) G6PD deficiency. Blood 84:3613\u20133636","journal-title":"Blood"},{"key":"1740_CR2","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3109\/10715762.2014.913788","volume":"48","author":"HY Ho","year":"2014","unstructured":"Ho HY, Cheng ML, Chiu DT (2014) Glucose-6-phosphate dehydrogenase--beyond the realm of red cell biology. Free Radic Res 48:1028\u20131048","journal-title":"Free Radic Res"},{"key":"1740_CR3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/10715762.2016.1223296","volume":"50","author":"HC Yang","year":"2016","unstructured":"Yang HC, Wu YH, Liu HY, Stern A, Chiu DT (2016) What has passed is prolog: new cellular and physiological roles of G6PD. Free Radic Res 50:1047\u20131064","journal-title":"Free Radic Res"},{"key":"1740_CR4","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1093\/emboj\/cdf426","volume":"21","author":"L Longo","year":"2002","unstructured":"Longo L, Vanegas OC, Patel M, Rosti V, Li H, Waka J, Merghoub T, Pandolfi PP, Notaro R, Manova K, Luzzatto L (2002) Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J 21:4229\u20134239","journal-title":"EMBO J"},{"key":"1740_CR5","doi-asserted-by":"publisher","first-page":"e616","DOI":"10.1038\/cddis.2013.132","volume":"4","author":"HC Yang","year":"2013","unstructured":"Yang HC, Chen TL, Wu YH, Cheng KP, Lin YH, Cheng ML, Ho HY, Lo SJ, Chiu DT (2013) Glucose 6-phosphate dehydrogenase deficiency enhances germ cell apoptosis and causes defective embryogenesis in Caenorhabditis elegans. Cell Death Dis 4:e616","journal-title":"Cell Death Dis"},{"key":"1740_CR6","doi-asserted-by":"publisher","first-page":"e2545","DOI":"10.1038\/cddis.2016.463","volume":"8","author":"TL Chen","year":"2017","unstructured":"Chen TL, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern A, Lo SJ, Chiu DT (2017) Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death Dis 8:e2545","journal-title":"Cell Death Dis"},{"key":"1740_CR7","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.exphem.2013.04.002","volume":"41","author":"X Patrinostro","year":"2013","unstructured":"Patrinostro X, Carter ML, Kramer AC, Lund TC (2013) A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish. Exp Hematol 41:697\u2013710.e692","journal-title":"Exp Hematol"},{"key":"1740_CR8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.molcel.2014.05.008","volume":"55","author":"CA Lewis","year":"2014","unstructured":"Lewis CA, Parker SJ, Fiske BP, McCloskey D, Gui DY, Green CR, Vokes NI, Feist AM, Vander Heiden MG, Metallo CM (2014) Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. Mol Cell 55:253\u2013263","journal-title":"Mol Cell"},{"key":"1740_CR9","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature13236","volume":"510","author":"J Fan","year":"2014","unstructured":"Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD (2014) Quantitative flux analysis reveals folate-dependent NADPH production. Nature 510:298\u2013302","journal-title":"Nature"},{"key":"1740_CR10","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/jnci\/djq187","volume":"102","author":"ZJ Reitman","year":"2010","unstructured":"Reitman ZJ, Yan H (2010) Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst 102:932\u2013941","journal-title":"J Natl Cancer Inst"},{"key":"1740_CR11","doi-asserted-by":"publisher","first-page":"30593","DOI":"10.1074\/jbc.M511908200","volume":"281","author":"SM Ronnebaum","year":"2006","unstructured":"Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV (2006) A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem 281:30593\u201330602","journal-title":"J Biol Chem"},{"key":"1740_CR12","doi-asserted-by":"publisher","first-page":"39968","DOI":"10.1074\/jbc.M402260200","volume":"279","author":"HJ Koh","year":"2004","unstructured":"Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, Park JW, Park DC, Song BJ, Veech RL, Song H, Huh TL (2004) Cytosolic NADP+\u2212dependent isocitrate dehydrogenase plays a key role in lipid metabolism. J Biol Chem 279:39968\u201339974","journal-title":"J Biol Chem"},{"key":"1740_CR13","doi-asserted-by":"publisher","first-page":"H1505","DOI":"10.1152\/ajpheart.00287.2002","volume":"283","author":"B Comte","year":"2002","unstructured":"Comte B, Vincent G, Bouchard B, Benderdour M, Des Rosiers C (2002) Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia. Am J Physiol Heart Circ Physiol 283:H1505\u2013H1514","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1740_CR14","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/oxfordjournals.molbev.a025894","volume":"15","author":"A Nekrutenko","year":"1998","unstructured":"Nekrutenko A, Hillis DM, Patton JC, Bradley RD, Baker RJ (1998) Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. Mol Biol Evol 15:1674\u20131684","journal-title":"Mol Biol Evol"},{"key":"1740_CR15","first-page":"730","volume":"3","author":"RA Cairns","year":"2013","unstructured":"Cairns RA, Mak TW (2013) Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cell Biosci 3:730\u2013741","journal-title":"Cell Biosci"},{"key":"1740_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ccr.2010.01.020","volume":"17","author":"PS Ward","year":"2010","unstructured":"Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB (2010) The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17:225\u2013234","journal-title":"Cancer Cell"},{"key":"1740_CR17","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/cdd.2015.38","volume":"22","author":"M Itsumi","year":"2015","unstructured":"Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF, Brenner D, Harris IS, Chio II, Afzal S et al (2015) Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)\/NADPH ratio. Cell Death Differ 22:1837\u20131845","journal-title":"Cell Death Differ"},{"key":"1740_CR18","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1073\/pnas.1618605114","volume":"114","author":"J Ye","year":"2017","unstructured":"Ye J, Gu Y, Zhang F, Zhao Y, Yuan Y, Hao Z, Sheng Y, Li WY, Wakeham A, Cairns RA, Mak TW (2017) IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization. Proc Natl Acad Sci U S A 114:292\u2013297","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1740_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S0891-5849(00)00331-2","volume":"29","author":"HY Ho","year":"2000","unstructured":"Ho HY, Cheng ML, Lu FJ, Chou YH, Stern A, Liang CM, Chiu DT (2000) Enhanced oxidative stress and accelerated cellular senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts. Free Radic Biol Med 29:156\u2013169","journal-title":"Free Radic Biol Med"},{"key":"1740_CR20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2006.09.024","volume":"42","author":"KI Minard","year":"2007","unstructured":"Minard KI, Carroll CA, Weintraub ST, Mc-Alister-Henn L (2007) Changes in disulfide bond content of proteins in a yeast strain lacking major sources of NADPH. Free Radic Biol Med 42:106\u2013117","journal-title":"Free Radic Biol Med"},{"key":"1740_CR21","doi-asserted-by":"publisher","unstructured":"Braeckman BP, Houthoofd K, Vanfleteren JR (2009) Intermediary metabolism. WormBook: 1\u201324. DOI https:\/\/doi.org\/10.1895\/wormbook.1.146.1","DOI":"10.1895\/wormbook.1.146.1"},{"key":"1740_CR22","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.febslet.2008.04.020","volume":"582","author":"HJ Atherton","year":"2008","unstructured":"Atherton HJ, Jones OA, Malik S, Miska EA, Griffin JL (2008) A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse. FEBS Lett 582:1661\u20131666","journal-title":"FEBS Lett"},{"key":"1740_CR23","doi-asserted-by":"publisher","first-page":"3512","DOI":"10.1021\/pr9001806","volume":"8","author":"SL Hughes","year":"2009","unstructured":"Hughes SL, Bundy JG, Want EJ, Kille P, Sturzenbaum SR (2009) The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins. J Proteome Res 8:3512\u20133519","journal-title":"J Proteome Res"},{"key":"1740_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2164-13-36","volume":"13","author":"C Castro","year":"2012","unstructured":"Castro C, Sar F, Shaw WR, Mishima M, Miska EA, Griffin JL (2012) A metabolomic strategy defines the regulation of lipid content and global metabolism by Delta9 desaturases in Caenorhabditis elegans. BMC Genomics 13:36","journal-title":"BMC Genomics"},{"key":"1740_CR25","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s11306-013-0608-8","volume":"10","author":"GJ Patti","year":"2014","unstructured":"Patti GJ, Tautenhahn R, Johannsen D, Kalisiak E, Ravussin E, Bruning JC, Dillin A, Siuzdak G (2014) Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension. Metabolomics 10:737\u2013743","journal-title":"Metabolomics"},{"key":"1740_CR26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.mito.2014.12.004","volume":"20","author":"PG Morgan","year":"2015","unstructured":"Morgan PG, Higdon R, Kolker N, Bauman AT, Ilkayeva O, Newgard CB, Kolker E, Steele LM, Sedensky MM (2015) Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans. Mitochondrion 20:95\u2013102","journal-title":"Mitochondrion"},{"key":"1740_CR27","doi-asserted-by":"publisher","first-page":"26163","DOI":"10.1074\/jbc.M115.662916","volume":"290","author":"W Wang","year":"2015","unstructured":"Wang W, McReynolds MR, Goncalves JF, Shu M, Dhondt I, Braeckman BP, Lange SE, Kho K, Detwiler AC, Pacella MJ et al (2015) Comparative metabolomic profiling reveals that dysregulated glycolysis stemming from lack of salvage NAD+ biosynthesis impairs reproductive development in Caenorhabditis elegans. J Biol Chem 290:26163\u201326179","journal-title":"J Biol Chem"},{"key":"1740_CR28","doi-asserted-by":"publisher","first-page":"447","DOI":"10.18632\/aging.101170","volume":"9","author":"QL Wan","year":"2017","unstructured":"Wan QL, Shi X, Liu J, Ding AJ, Pu YZ, Li Z, Wu GS, Luo HR (2017) Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans. Aging (Albany NY) 9:447\u2013474","journal-title":"Aging (Albany NY)"},{"key":"1740_CR29","doi-asserted-by":"publisher","first-page":"6001","DOI":"10.1242\/dev.01454","volume":"131","author":"MW Davis","year":"2004","unstructured":"Davis MW, Birnie AJ, Chan AC, Page AP, Jorgensen EM (2004) A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Development 131:6001\u20136008","journal-title":"Development"},{"key":"1740_CR30","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1089\/ars.2014.6142","volume":"22","author":"HY Tang","year":"2015","unstructured":"Tang HY, Ho HY, Wu PR, Chen SH, Kuypers FA, Cheng ML, Chiu DT (2015) Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance. Antioxid Redox Signal 22:744\u2013759","journal-title":"Antioxid Redox Signal"},{"key":"1740_CR31","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1016\/j.bcp.2011.07.104","volume":"82","author":"ML Cheng","year":"2011","unstructured":"Cheng ML, Shiao MS, Chiu DT, Weng SF, Tang HY, Ho HY (2011) Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics. Biochem Pharmacol 82:1549\u20131561","journal-title":"Biochem Pharmacol"},{"key":"1740_CR32","doi-asserted-by":"publisher","first-page":"8060","DOI":"10.1038\/ncomms9060","volume":"6","author":"S Penkov","year":"2015","unstructured":"Penkov S, Kaptan D, Erkut C, Sarov M, Mende F, Kurzchalia TV (2015) Integration of carbohydrate metabolism and redox state controls dauer larva formation in Caenorhabditis elegans. Nat Commun 6:8060","journal-title":"Nat Commun"},{"key":"1740_CR33","doi-asserted-by":"publisher","unstructured":"Szewczyk NJ, Kozak E, Conley CA (2003) Chemically defined medium and Caenorhabditis elegans. Bmc Biotechnol 3. DOI Artn 19. Doi https:\/\/doi.org\/10.1186\/1472-6750-3-19","DOI":"10.1186\/1472-6750-3-19"},{"key":"1740_CR34","doi-asserted-by":"publisher","first-page":"17549","DOI":"10.1074\/jbc.M900831200","volume":"284","author":"MC Thein","year":"2009","unstructured":"Thein MC, Winter AD, Stepek G, McCormack G, Stapleton G, Johnstone IL, Page AP (2009) Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. J Biol Chem 284:17549\u201317563","journal-title":"J Biol Chem"},{"key":"1740_CR35","doi-asserted-by":"publisher","first-page":"e1002957","DOI":"10.1371\/journal.pgen.1002957","volume":"8","author":"H Moribe","year":"2012","unstructured":"Moribe H, Konakawa R, Koga D, Ushiki T, Nakamura K, Mekada E (2012) Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. PLoS Genet 8:e1002957","journal-title":"PLoS Genet"},{"key":"1740_CR36","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5483\/BMBRep.2011.44.4.285","volume":"44","author":"Y Li","year":"2011","unstructured":"Li Y, Paik YK (2011) A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans. BMB Rep 44:285\u2013290","journal-title":"BMB Rep"},{"key":"1740_CR37","doi-asserted-by":"publisher","first-page":"32100","DOI":"10.1074\/jbc.M301293200","volume":"278","author":"JA Leopold","year":"2003","unstructured":"Leopold JA, Walker J, Scribner AW, Voetsch B, Zhang YY, Loscalzo AJ, Stanton RC, Loscalzo J (2003) Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem 278:32100\u201332106","journal-title":"J Biol Chem"},{"key":"1740_CR38","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/s12957-015-0733-0","volume":"13","author":"H Pu","year":"2015","unstructured":"Pu H, Zhang Q, Zhao C, Shi L, Wang Y, Wang J, Zhang M (2015) Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma. World J Surg Oncol 13:323","journal-title":"World J Surg Oncol"},{"key":"1740_CR39","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s13277-011-0251-9","volume":"33","author":"J Wang","year":"2012","unstructured":"Wang J, Yuan W, Chen Z, Wu S, Chen J, Ge J, Hou F, Chen Z (2012) Overexpression of G6PD is associated with poor clinical outcome in gastric cancer. Tumour Biol 33:95\u2013101","journal-title":"Tumour Biol"},{"key":"1740_CR40","doi-asserted-by":"publisher","first-page":"8468","DOI":"10.1038\/ncomms9468","volume":"6","author":"X Rao","year":"2015","unstructured":"Rao X, Duan X, Mao W, Li X, Li Z, Li Q, Zheng Z, Xu H, Chen M, Wang PG, Wang Y, Shen B, Yi W (2015) O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth. Nat Commun 6:8468","journal-title":"Nat Commun"},{"key":"1740_CR41","doi-asserted-by":"crossref","first-page":"32375","DOI":"10.18632\/oncotarget.8632","volume":"7","author":"MA Kowalik","year":"2016","unstructured":"Kowalik MA, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, Trevisan E, Angioni MM, Fornari F, Quagliata L, Ledda-Columbano GM, Gramantieri L, Terracciano L, Giordano S, Chiarugi P, Rasola A, Columbano A (2016) Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis. Oncotarget 7:32375\u201332393","journal-title":"Oncotarget"},{"key":"1740_CR42","doi-asserted-by":"publisher","first-page":"32734","DOI":"10.1038\/srep32734","volume":"6","author":"SN Xu","year":"2016","unstructured":"Xu SN, Wang TS, Li X, Wang YP (2016) SIRT2 activates G6PD to enhance NADPH production and promote leukaemia cell proliferation. Sci Rep 6:32734","journal-title":"Sci Rep"},{"key":"1740_CR43","doi-asserted-by":"publisher","first-page":"e5254","DOI":"10.1097\/MD.0000000000005254","volume":"95","author":"MP Dore","year":"2016","unstructured":"Dore MP, Davoli A, Longo N, Marras G, Pes GM (2016) Glucose-6-phosphate dehydrogenase deficiency and risk of colorectal cancer in Northern Sardinia: a retrospective observational study. Medicine (Baltimore) 95:e5254","journal-title":"Medicine (Baltimore)"},{"key":"1740_CR44","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.1007\/s13277-015-4428-5","volume":"37","author":"Y Chen","year":"2016","unstructured":"Chen Y, Xu Q, Ji D, Wei Y, Chen H, Li T, Wan B, Yuan L, Huang R, Chen G (2016) Inhibition of pentose phosphate pathway suppresses acute myelogenous leukemia. Tumour Biol 37:6027\u20136034","journal-title":"Tumour Biol"},{"key":"1740_CR45","doi-asserted-by":"publisher","first-page":"E6669","DOI":"10.1073\/pnas.1603876113","volume":"113","author":"MA Gregory","year":"2016","unstructured":"Gregory MA, D'Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Adane B, Rozhok AI, Kumar A, Kumar V, Pollyea DA et al (2016) ATM\/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A 113:E6669\u2013E6678","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1740_CR46","doi-asserted-by":"publisher","first-page":"6282","DOI":"10.1038\/onc.2017.227","volume":"36","author":"HQ Ju","year":"2017","unstructured":"Ju HQ, Lu YX, Wu QN, Liu J, Zeng ZL, Mo HY, Chen Y, Tian T, Wang Y, Kang TB, Xie D, Zeng MS, Huang P, Xu RH (2017) Disrupting G6PD-mediated redox homeostasis enhances chemosensitivity in colorectal cancer. Oncogene 36:6282\u20136292","journal-title":"Oncogene"},{"key":"1740_CR47","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/neuonc\/nov136","volume":"18","author":"MS Waitkus","year":"2016","unstructured":"Waitkus MS, Diplas BH, Yan H (2016) Isocitrate dehydrogenase mutations in gliomas. Neuro-Oncology 18:16\u201326","journal-title":"Neuro-Oncology"},{"key":"1740_CR48","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/leu.2016.275","volume":"31","author":"BC Medeiros","year":"2017","unstructured":"Medeiros BC, Fathi AT, DiNardo CD, Pollyea DA, Chan SM, Swords R (2017) Isocitrate dehydrogenase mutations in myeloid malignancies. Leukemia 31:272\u2013281","journal-title":"Leukemia"},{"key":"1740_CR49","first-page":"37","volume":"7","author":"H Al-Khallaf","year":"2017","unstructured":"Al-Khallaf H (2017) Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight. Cancer Discov 7:37","journal-title":"Cancer Discov"},{"key":"1740_CR50","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2015.06.017","volume":"59","author":"A Kuehne","year":"2015","unstructured":"Kuehne A, Emmert H, Soehle J, Winnefeld M, Fischer F, Wenck H, Gallinat S, Terstegen L, Lucius R, Hildebrand J, Zamboni N (2015) Acute activation of oxidative pentose phosphate pathway as first-line response to oxidative stress in human skin cells. Mol Cell 59:359\u2013371","journal-title":"Mol Cell"},{"key":"1740_CR51","doi-asserted-by":"publisher","first-page":"10894","DOI":"10.1038\/ncomms10894","volume":"7","author":"S Nobrega-Pereira","year":"2016","unstructured":"Nobrega-Pereira S, Fernandez-Marcos PJ, Brioche T, Gomez-Cabrera MC, Salvador-Pascual A, Flores JM, Vina J, Serrano M (2016) G6PD protects from oxidative damage and improves healthspan in mice. Nat Commun 7:10894","journal-title":"Nat Commun"},{"key":"1740_CR52","doi-asserted-by":"publisher","first-page":"D472","DOI":"10.1093\/nar\/gkl894","volume":"35","author":"LR Girard","year":"2007","unstructured":"Girard LR, Fiedler TJ, Harris TW, Carvalho F, Antoshechkin I, Han M, Sternberg PW, Stein LD, Chalfie M (2007) WormBook: the online review of Caenorhabditis elegans biology. Nucleic Acids Res 35:D472\u2013D475","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-018-01740-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-01740-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-01740-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T23:54:17Z","timestamp":1606089257000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-018-01740-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,19]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["1740"],"URL":"https:\/\/doi.org\/10.1007\/s00109-018-01740-2","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,19]]},"assertion":[{"value":"14 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}