{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:57:05Z","timestamp":1771383425092,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770090"],"award-info":[{"award-number":["81770090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470274"],"award-info":[{"award-number":["81470274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00109-018-01741-1","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T03:23:58Z","timestamp":1551756238000},"page":"619-631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interleukin-26 upregulates interleukin-22 production by human CD4+ T cells in tuberculous pleurisy"],"prefix":"10.1007","volume":"97","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ran","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Shan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Lin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Chu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-3017","authenticated-orcid":false,"given":"Qiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"1741_CR1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S1359-6101(02)00012-6","volume":"13","author":"SV Kotenko","year":"2002","unstructured":"Kotenko SV (2002) The family of IL-10-related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev 13:223\u2013240","journal-title":"Cytokine Growth Factor Rev"},{"key":"1741_CR2","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.intimp.2004.01.004","volume":"4","author":"H Fickenscher","year":"2004","unstructured":"Fickenscher H, Pirzer H (2004) Interleukin-26. Int Immunopharmacol 4:609\u2013613","journal-title":"Int Immunopharmacol"},{"key":"1741_CR3","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.4049\/jimmunol.172.4.2006","volume":"172","author":"F Sheikh","year":"2004","unstructured":"Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A et al (2004) Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. J Immunol 172:2006\u20132010","journal-title":"J Immunol"},{"key":"1741_CR4","doi-asserted-by":"publisher","first-page":"33343","DOI":"10.1074\/jbc.M405000200","volume":"279","author":"S H\u00f6r","year":"2004","unstructured":"H\u00f6r S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H (2004) The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. J Biol Chem 279:33343\u201333351","journal-title":"J Biol Chem"},{"key":"1741_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000434646","volume":"8","author":"S Tengvall","year":"2016","unstructured":"Tengvall S, Che KF, Lind\u00e9n A (2016) Interleukin-26: an emerging player in host defense and inflammation. J Innate Immun 8:15\u201322","journal-title":"J Innate Immun"},{"key":"1741_CR6","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/ni.3211","volume":"16","author":"S Meller","year":"2015","unstructured":"Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T et al (2015) T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol 16:970\u2013979","journal-title":"Nat Immunol"},{"key":"1741_CR7","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1164\/rccm.201404-0689OC","volume":"190","author":"KF Che","year":"2014","unstructured":"Che KF, Tengvall S, Lev\u00e4nen B, Silverpil E, Smith ME, Awad M, Vikstr\u00f6m M, Palmberg L, Qvarfordt I, Sk\u00f6ld M et al (2014) Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization. Am J Respir Crit Care Med 190:1022\u20131031","journal-title":"Am J Respir Crit Care Med"},{"key":"1741_CR8","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1136\/gut.2007.130112","volume":"58","author":"J Dambacher","year":"2009","unstructured":"Dambacher J, Beigel F, Zitzmann K, De Toni EN, G\u00f6ke B, Diepolder HM, Auernhammer CJ, Brand S (2009) The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 58:1207\u20131217","journal-title":"Gut"},{"key":"1741_CR9","doi-asserted-by":"publisher","first-page":"e1001395","DOI":"10.1371\/journal.pbio.1001395","volume":"10","author":"M Corvaisier","year":"2012","unstructured":"Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barr\u00e9 B, Audran M, Bouvard B, Saint-Andr\u00e9 JP, Jeannin P (2012) IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol 10:e1001395","journal-title":"PLoS Biol"},{"key":"1741_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.imlet.2017.08.008","volume":"190","author":"W Kaabachi","year":"2017","unstructured":"Kaabachi W, Bouali E, Berra\u00efes A, Dhifallh IB, Hamdi B, Hamzaoui K, Hamzaoui A (2017) Interleukin-26 is overexpressed in Beh\u00e7et\u2019s disease and enhances Th17 related-cytokines. Immunol Lett 190:177\u2013184","journal-title":"Immunol Lett"},{"key":"1741_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/imm.12371","volume":"144","author":"JM Guerra-Laso","year":"2015","unstructured":"Guerra-Laso JM, Raposo-Garc\u00eda S, Garc\u00eda-Garc\u00eda S, Diez-Tasc\u00f3n C, Rivero-Lezcano OM (2015) Microarray analysis of Mycobacterium tuberculosis-infected monocytes reveals IL26 as a new candidate gene for tuberculosis susceptibility. Immunology 144:291\u2013301","journal-title":"Immunology"},{"key":"1741_CR12","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1056\/NEJMcp010731","volume":"346","author":"RW Light","year":"2002","unstructured":"Light RW (2002) Clinical practice. Pleural effusion. N Engl J Med 346:1971\u20131977","journal-title":"N Engl J Med"},{"key":"1741_CR13","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1128\/CVI.05214-11","volume":"18","author":"ZJ Ye","year":"2011","unstructured":"Ye ZJ, Zhou Q, Du RH, Li X, Huang B, Shi HZ (2011) Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion. Clin Vaccine Immunol 18:1608\u20131615","journal-title":"Clin Vaccine Immunol"},{"key":"1741_CR14","doi-asserted-by":"publisher","first-page":"e31710","DOI":"10.1371\/journal.pone.0031710","volume":"7","author":"ZJ Ye","year":"2012","unstructured":"Ye ZJ, Yuan ML, Zhou Q, Du RH, Yang WB, Xiong XZ, Zhang JC, Wu C, Qin SM, Shi HZ (2012) Differentiation and recruitment of Th9 cells stimulated by pleural mesothelial cells in human Mycobacterium tuberculosis infection. PLoS One 7:e31710","journal-title":"PLoS One"},{"key":"1741_CR15","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1164\/rccm.201107-1198OC","volume":"185","author":"ZJ Ye","year":"2012","unstructured":"Ye ZJ, Zhou Q, Yuan ML, Du RH, Yang WB, Xiong XZ, Huang B, Shi HZ (2012) Differentiation and recruitment of Th22 cells stimulated by pleural mesothelial cells in tuberculous pleurisy. Am J Respir Crit Care Med 185:660\u2013669","journal-title":"Am J Respir Crit Care Med"},{"key":"1741_CR16","doi-asserted-by":"publisher","first-page":"e40450","DOI":"10.1371\/journal.pone.0040450","volume":"7","author":"WB Yang","year":"2012","unstructured":"Yang WB, Liang QL, Ye ZJ, Niu CM, Ma WL, Xiong XZ, Du RH, Zhou Q, Zhang JC, Shi HZ (2012) Cell origins and diagnostic accuracy of interleukin 27 in pleural effusions. PLoS One 7:e40450","journal-title":"PLoS One"},{"key":"1741_CR17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.tube.2014.07.003","volume":"94","author":"H Xia","year":"2014","unstructured":"Xia H, Ye ZJ, Zhou Q, You WJ, Cui A, Wang XJ, Zhai K, Jin XG, Tong ZH, Shi HZ (2014) IL-27 and IL-27-producing CD4(+) T cells in human tuberculous pleural effusion. Tuberculosis (Edinb) 94:579\u2013588","journal-title":"Tuberculosis (Edinb)"},{"key":"1741_CR18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cytogfr.2010.09.001","volume":"21","author":"RP Donnelly","year":"2010","unstructured":"Donnelly RP, Sheikh F, Dickensheets H, Savan R, Young HA, Walter MR (2010) Interleukin-26: an IL-10-related cytokine produced by Th17 cells. Cytokine Growth Factor Rev 21:393\u2013401","journal-title":"Cytokine Growth Factor Rev"},{"key":"1741_CR19","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.4049\/jimmunol.168.11.5397","volume":"168","author":"K Wolk","year":"2002","unstructured":"Wolk K, Kunz S, Asadullah K, Sabat R (2002) Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 168:5397\u20135402","journal-title":"J Immunol"},{"key":"1741_CR20","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/ni1497","volume":"8","author":"NJ Wilson","year":"2007","unstructured":"Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F et al (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8:950\u2013957","journal-title":"Nat Immunol"},{"key":"1741_CR21","doi-asserted-by":"publisher","first-page":"7423","DOI":"10.4049\/jimmunol.180.11.7423","volume":"180","author":"J P\u00e8ne","year":"2008","unstructured":"P\u00e8ne J, Chevalier S, Preisser L, V\u00e9n\u00e9reau E, Guilleux MH, Ghannam S, Mol\u00e8s JP, Danger Y, Ravon E, Lesaux S et al (2008) Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 180:7423\u20137430","journal-title":"J Immunol"},{"key":"1741_CR22","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1136\/thoraxjnl-2016-209718","volume":"73","author":"W Wang","year":"2018","unstructured":"Wang W, Zhou Q, Zhai K, Wang Y, Liu JY, Wang XJ, Wang Z, Zhang JC, Tong ZH, Shi HZ et al (2018) Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis. Thorax 73:240\u2013247","journal-title":"Thorax"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-01741-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-018-01741-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-01741-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T19:08:06Z","timestamp":1583262486000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-018-01741-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1741"],"URL":"https:\/\/doi.org\/10.1007\/s00109-018-01741-1","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]},"assertion":[{"value":"11 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology approved the study protocol.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}