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The genetic study was approved by the Ethics Committee of the Hospital Josep Trueta (Girona, Spain), also following the Helsinki II declaration. All subjects gave their written informed consent before participating in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}