{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:45:17Z","timestamp":1787921117389,"version":"build-2784847793"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T00:00:00Z","timestamp":1532131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T00:00:00Z","timestamp":1532131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM107469"],"award-info":[{"award-number":["R01GM107469"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS106469"],"award-info":[{"award-number":["R21NS106469"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00109-018-1672-3","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T23:01:26Z","timestamp":1532127686000},"page":"873-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Contributions of monocytes to nervous system disorders"],"prefix":"10.1007","volume":"96","author":[{"given":"Juan Mauricio","family":"Garr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-9126","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,21]]},"reference":[{"issue":"3","key":"1672_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1084\/jem.128.3.415","volume":"128","author":"R van Furth","year":"1968","unstructured":"van Furth R, Cohn ZA (1968) The origin and kinetics of mononuclear phagocytes. J Exp Med 128(3):415\u2013435","journal-title":"J Exp Med"},{"issue":"11","key":"1672_CR2","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11(11):762\u2013774","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"1672_CR3","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.bbi.2007.12.008","volume":"22","author":"A Brynskikh","year":"2008","unstructured":"Brynskikh A et al (2008) Adaptive immunity affects learning behavior in mice. Brain Behav Immun 22(6):861\u2013869","journal-title":"Brain Behav Immun"},{"issue":"5","key":"1672_CR4","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1084\/jem.20091419","volume":"207","author":"NC Derecki","year":"2010","unstructured":"Derecki NC et al (2010) Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067\u20131080","journal-title":"J Exp Med"},{"issue":"3","key":"1672_CR5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.bbi.2010.11.009","volume":"25","author":"NC Derecki","year":"2011","unstructured":"Derecki NC, Quinnies KM, Kipnis J (2011) Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice. Brain Behav Immun 25(3):379\u2013385","journal-title":"Brain Behav Immun"},{"issue":"6","key":"1672_CR6","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/nm.4340","volume":"23","author":"JM Garre","year":"2017","unstructured":"Garre JM et al (2017) CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-alpha. Nat Med 23(6):714\u2013722","journal-title":"Nat Med"},{"key":"1672_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","volume":"19","author":"F Geissmann","year":"2003","unstructured":"Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19:71\u201382","journal-title":"Immunity"},{"issue":"6","key":"1672_CR8","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nri3671","volume":"14","author":"F Ginhoux","year":"2014","unstructured":"Ginhoux F, Jung S (2014) Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol 14(6):392\u2013404","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"1672_CR9","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nn.4475","volume":"20","author":"M Prinz","year":"2017","unstructured":"Prinz M, Priller J (2017) The role of peripheral immune cells in the CNS in steady state and disease. Nat Neurosci 20(2):136\u2013144","journal-title":"Nat Neurosci"},{"key":"1672_CR10","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","volume":"317","author":"C Auffray","year":"2007","unstructured":"Auffray C et al (2007) Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science 317:666\u2013670","journal-title":"Science"},{"issue":"4","key":"1672_CR11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41593-018-0100-x","volume":"21","author":"B Ajami","year":"2018","unstructured":"Ajami B et al (2018) Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models. Nat Neurosci 21(4):541\u2013551","journal-title":"Nat Neurosci"},{"key":"1672_CR12","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","volume":"330","author":"F Ginhoux","year":"2010","unstructured":"Ginhoux F et al (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330:841\u2013845","journal-title":"Science"},{"key":"1672_CR13","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","volume":"518","author":"E Gomez Perdiguero","year":"2015","unstructured":"Gomez Perdiguero E et al (2015) Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518:547\u2013551","journal-title":"Nature"},{"issue":"4","key":"1672_CR14","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1073\/pnas.88.4.1541","volume":"88","author":"F Alliot","year":"1991","unstructured":"Alliot F et al (1991) Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc Natl Acad Sci U S A 88(4):1541\u20131545","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1672_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0165-3806(99)00113-3","volume":"117","author":"F Alliot","year":"1999","unstructured":"Alliot F, Godin I, Pessac B (1999) Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res 117(2):145\u2013152","journal-title":"Brain Res Dev Brain Res"},{"issue":"7","key":"1672_CR16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ni.3423","volume":"17","author":"T Goldmann","year":"2016","unstructured":"Goldmann T et al (2016) Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol 17(7):797\u2013805","journal-title":"Nat Immunol"},{"issue":"1","key":"1672_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ni.3341","volume":"17","author":"EG Perdiguero","year":"2016","unstructured":"Perdiguero EG, Geissmann F (2016) The development and maintenance of resident macrophages. Nat Immunol 17(1):2\u20138","journal-title":"Nat Immunol"},{"key":"1672_CR18","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nn.4547","volume":"20","author":"TL Tay","year":"2017","unstructured":"Tay TL, Mai D, Dautzenberg J, Fern\u00e1ndez-Klett F, Lin G, Sagar, Datta M, Drougard A, Stempfl T, Ardura-Fabregat A, Staszewski O, Margineanu A, Sporbert A, Steinmetz LM, Pospisilik JA, Jung S, Priller J, Gr\u00fcn D, Ronneberger O, Prinz M (2017) A new fate mapping system reveals context-dependent random or clonal expansion ofmicroglia. Nat Neurosci 20:793\u2013803","journal-title":"Nat Neurosci"},{"key":"1672_CR19","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nn.4631","volume":"20","author":"P Fuger","year":"2017","unstructured":"Fuger P et al (2017) Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci 20:1371\u20131376","journal-title":"Nat Neurosci"},{"issue":"5757","key":"1672_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.1117729","volume":"311","author":"DK Fogg","year":"2006","unstructured":"Fogg DK et al (2006) A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311(5757):83\u201387","journal-title":"Science"},{"issue":"1","key":"1672_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1084\/jem.20061011","volume":"204","author":"C Varol","year":"2007","unstructured":"Varol C et al (2007) Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171\u2013180","journal-title":"J Exp Med"},{"issue":"8","key":"1672_CR22","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ni.2638","volume":"14","author":"J Hettinger","year":"2013","unstructured":"Hettinger J et al (2013) Origin of monocytes and macrophages in a committed progenitor. Nat Immunol 14(8):821\u2013830","journal-title":"Nat Immunol"},{"issue":"16","key":"1672_CR23","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","volume":"116","author":"L Ziegler-Heitbrock","year":"2010","unstructured":"Ziegler-Heitbrock L et al (2010) Nomenclature of monocytes and dendritic cells in blood. Blood 116(16):e74\u2013e80","journal-title":"Blood"},{"issue":"3","key":"1672_CR24","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.immuni.2010.08.012","volume":"33","author":"J Cros","year":"2010","unstructured":"Cros J et al (2010) Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity 33(3):375\u2013386","journal-title":"Immunity"},{"issue":"9","key":"1672_CR25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nri3265","volume":"12","author":"RM Ransohoff","year":"2012","unstructured":"Ransohoff RM, Engelhardt B (2012) The anatomical and cellular basis of immune surveillance in the central nervous system. Nat Rev Immunol 12(9):623\u2013635","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"1672_CR26","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/ni.3006","volume":"15","author":"B Becher","year":"2014","unstructured":"Becher B et al (2014) High-dimensional analysis of the murine myeloid cell system. Nat Immunol 15(12):1181\u20131189","journal-title":"Nat Immunol"},{"key":"1672_CR27","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.immuni.2017.04.018","volume":"46","author":"A Mildner","year":"2017","unstructured":"Mildner A et al (2017) Genomic characterization of murine monocytes reveals C\/EBP\u03b2 transcription factor dependence of Ly6C(\u2212) cells. Immunity 46:849\u2013862","journal-title":"Immunity"},{"issue":"3","key":"1672_CR28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.immuni.2018.02.014","volume":"48","author":"D Mrdjen","year":"2018","unstructured":"Mrdjen D et al (2018) High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity 48(3):599","journal-title":"Immunity"},{"issue":"11","key":"1672_CR29","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","volume":"20","author":"S Jung","year":"2000","unstructured":"Jung S et al (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106\u20134114","journal-title":"Mol Cell Biol"},{"issue":"11","key":"1672_CR30","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1038\/nn.3531","volume":"16","author":"T Goldmann","year":"2013","unstructured":"Goldmann T et al (2013) A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci 16(11):1618\u20131626","journal-title":"Nat Neurosci"},{"key":"1672_CR31","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","volume":"38","author":"S Yona","year":"2013","unstructured":"Yona S et al (2013) Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38:79\u201391","journal-title":"Immunity"},{"issue":"7","key":"1672_CR32","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1084\/jem.20170355","volume":"214","author":"AA Patel","year":"2017","unstructured":"Patel AA et al (2017) The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. J Exp Med 214(7):1913\u20131923","journal-title":"J Exp Med"},{"issue":"5","key":"1672_CR33","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.4049\/jimmunol.180.5.3019","volume":"180","author":"C Jakubzick","year":"2008","unstructured":"Jakubzick C et al (2008) Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol 180(5):3019\u20133027","journal-title":"J Immunol"},{"issue":"2","key":"1672_CR34","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.neuron.2015.01.026","volume":"86","author":"M Hanoun","year":"2015","unstructured":"Hanoun M et al (2015) Neural regulation of hematopoiesis, inflammation, and cancer. Neuron 86(2):360\u2013373","journal-title":"Neuron"},{"issue":"5","key":"1672_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.gde.2009.08.005","volume":"19","author":"A Wilson","year":"2009","unstructured":"Wilson A, Laurenti E, Trumpp A (2009) Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev 19(5):461\u2013468","journal-title":"Curr Opin Genet Dev"},{"key":"1672_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.neuroscience.2015.01.001","volume":"289","author":"BF Reader","year":"2015","unstructured":"Reader BF et al (2015) Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience 289:429\u2013442","journal-title":"Neuroscience"},{"issue":"6785","key":"1672_CR37","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/35013070","volume":"405","author":"LV Borovikova","year":"2000","unstructured":"Borovikova LV et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785):458\u2013462","journal-title":"Nature"},{"issue":"12","key":"1672_CR38","first-page":"1172","volume":"26","author":"GJ Maestroni","year":"1998","unstructured":"Maestroni GJ et al (1998) Neural and endogenous catecholamines in the bone marrow. Circadian association of norepinephrine with hematopoiesis? Exp Hematol 26(12):1172\u20131177","journal-title":"Exp Hematol"},{"issue":"7186","key":"1672_CR39","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nature06685","volume":"452","author":"S Mendez-Ferrer","year":"2008","unstructured":"Mendez-Ferrer S et al (2008) Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452(7186):442\u2013447","journal-title":"Nature"},{"issue":"6153","key":"1672_CR40","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1126\/science.1240636","volume":"341","author":"KD Nguyen","year":"2013","unstructured":"Nguyen KD et al (2013) Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science 341(6153):1483\u20131488","journal-title":"Science"},{"issue":"12","key":"1672_CR41","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s00018-017-2463-7","volume":"74","author":"L Zuroff","year":"2017","unstructured":"Zuroff L et al (2017) Clearance of cerebral Abeta in Alzheimer's disease: reassessing the role of microglia and monocytes. Cell Mol Life Sci 74(12):2167\u20132201","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"1672_CR42","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1084\/jem.20150479","volume":"212","author":"S Prokop","year":"2015","unstructured":"Prokop S et al (2015) Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J Exp Med 212(11):1811\u20131818","journal-title":"J Exp Med"},{"issue":"1","key":"1672_CR43","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","volume":"43","author":"J Bruttger","year":"2015","unstructured":"Bruttger J et al (2015) Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 43(1):92\u2013106","journal-title":"Immunity"},{"issue":"7","key":"1672_CR44","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"H Keren-Shaul","year":"2017","unstructured":"Keren-Shaul H et al (2017) A unique microglia type associated with restricting development of Alzheimer's disease. Cell 169(7):1276\u20131290 e17","journal-title":"Cell"},{"issue":"4","key":"1672_CR45","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/nm1555","volume":"13","author":"J El Khoury","year":"2007","unstructured":"El Khoury J et al (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13(4):432\u2013438","journal-title":"Nat Med"},{"issue":"Pt 8","key":"1672_CR46","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1093\/brain\/awv150","volume":"138","author":"Y Koronyo","year":"2015","unstructured":"Koronyo Y et al (2015) Therapeutic effects of glatiramer acetate and grafted CD115(+) monocytes in a mouse model of Alzheimer's disease. Brain 138(Pt 8):2399\u20132422","journal-title":"Brain"},{"issue":"6","key":"1672_CR47","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1111\/j.1471-4159.2009.06402.x","volume":"111","author":"M Koronyo-Hamaoui","year":"2009","unstructured":"Koronyo-Hamaoui M et al (2009) Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9. J Neurochem 111(6):1409\u20131424","journal-title":"J Neurochem"},{"issue":"29","key":"1672_CR48","doi-asserted-by":"publisher","first-page":"9651","DOI":"10.1523\/JNEUROSCI.0329-10.2010","volume":"30","author":"L Lebson","year":"2010","unstructured":"Lebson L et al (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J Neurosci 30(29):9651\u20139658","journal-title":"J Neurosci"},{"issue":"31","key":"1672_CR49","doi-asserted-by":"publisher","first-page":"11159","DOI":"10.1523\/JNEUROSCI.6209-10.2011","volume":"31","author":"A Mildner","year":"2011","unstructured":"Mildner A et al (2011) Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease. J Neurosci 31(31):11159\u201311171","journal-title":"J Neurosci"},{"issue":"3","key":"1672_CR50","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.celrep.2013.10.010","volume":"5","author":"JP Michaud","year":"2013","unstructured":"Michaud JP et al (2013) Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3):646\u2013653","journal-title":"Cell Rep"},{"issue":"7","key":"1672_CR51","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nn.3435","volume":"16","author":"EM Bradshaw","year":"2013","unstructured":"Bradshaw EM et al (2013) CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci 16(7):848\u2013850","journal-title":"Nat Neurosci"},{"key":"1672_CR52","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff JJ et al (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2. Sci Transl Med 4:147ra111","journal-title":"Sci Transl Med"},{"issue":"7","key":"1672_CR53","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1084\/jem.20142290","volume":"212","author":"A Aspelund","year":"2015","unstructured":"Aspelund A et al (2015) A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 212(7):991\u2013999","journal-title":"J Exp Med"},{"issue":"7560","key":"1672_CR54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"A Louveau","year":"2015","unstructured":"Louveau A et al (2015) Structural and functional features of central nervous system lymphatic vessels. Nature 523(7560):337\u2013341","journal-title":"Nature"},{"key":"1672_CR55","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","volume":"93","author":"W Peng","year":"2016","unstructured":"Peng W et al (2016) Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease. Neurobiol Dis 93:215\u2013225","journal-title":"Neurobiol Dis"},{"issue":"6","key":"1672_CR56","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/s41593-018-0154-9","volume":"21","author":"S Mostafavi","year":"2018","unstructured":"Mostafavi S et al (2018) A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci 21(6):811\u2013819","journal-title":"Nat Neurosci"},{"issue":"3","key":"1672_CR57","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.immuni.2013.02.012","volume":"38","author":"R Shechter","year":"2013","unstructured":"Shechter R et al (2013) Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 38(3):555\u2013569","journal-title":"Immunity"},{"issue":"43","key":"1672_CR58","doi-asserted-by":"publisher","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","volume":"29","author":"KA Kigerl","year":"2009","unstructured":"Kigerl KA et al (2009) Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 29(43):13435\u201313444","journal-title":"J Neurosci"},{"issue":"27","key":"1672_CR59","doi-asserted-by":"publisher","first-page":"9910","DOI":"10.1523\/JNEUROSCI.2114-11.2011","volume":"31","author":"DJ Donnelly","year":"2011","unstructured":"Donnelly DJ et al (2011) Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo\/iNOS+ macrophages. J Neurosci 31(27):9910\u20139922","journal-title":"J Neurosci"},{"issue":"10","key":"1672_CR60","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.4049\/jimmunol.1700896","volume":"199","author":"HM Makinde","year":"2017","unstructured":"Makinde HM et al (2017) Nonclassical monocytes mediate secondary injury, neurocognitive outcome, and neutrophil infiltration after traumatic brain injury. J Immunol 199(10):3583\u20133591","journal-title":"J Immunol"},{"issue":"2","key":"1672_CR61","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1006\/exnr.1999.7118","volume":"158","author":"PG Popovich","year":"1999","unstructured":"Popovich PG et al (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158(2):351\u2013365","journal-title":"Exp Neurol"},{"issue":"5","key":"1672_CR62","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","volume":"83","author":"A Kroner","year":"2014","unstructured":"Kroner A et al (2014) TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83(5):1098\u20131116","journal-title":"Neuron"},{"issue":"7","key":"1672_CR63","doi-asserted-by":"publisher","first-page":"e1000113","DOI":"10.1371\/journal.pmed.1000113","volume":"6","author":"R Shechter","year":"2009","unstructured":"Shechter R et al (2009) Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 6(7):e1000113","journal-title":"PLoS Med"},{"issue":"34","key":"1672_CR64","doi-asserted-by":"publisher","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","volume":"33","author":"ES Wohleb","year":"2013","unstructured":"Wohleb ES et al (2013) Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J Neurosci 33(34):13820\u201313833","journal-title":"J Neurosci"},{"issue":"10","key":"1672_CR65","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.biopsych.2015.07.010","volume":"79","author":"DB McKim","year":"2016","unstructured":"McKim DB et al (2016) Sympathetic release of splenic monocytes promotes recurring anxiety following repeated social defeat. Biol Psychiatry 79(10):803\u2013813","journal-title":"Biol Psychiatry"},{"issue":"45","key":"1672_CR66","doi-asserted-by":"publisher","first-page":"16136","DOI":"10.1073\/pnas.1415191111","volume":"111","author":"GE Hodes","year":"2014","unstructured":"Hodes GE et al (2014) Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci U S A 111(45):16136\u201316141","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"1672_CR67","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1016\/j.jpsychires.2013.08.020","volume":"47","author":"R Mota","year":"2013","unstructured":"Mota R et al (2013) Interleukin-1beta is associated with depressive episode in major depression but not in bipolar disorder. J Psychiatr Res 47(12):2011\u20132014","journal-title":"J Psychiatr Res"},{"issue":"4","key":"1672_CR68","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.biopsych.2013.07.011","volume":"75","author":"U Meyer","year":"2014","unstructured":"Meyer U (2014) Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry 75(4):307\u2013315","journal-title":"Biol Psychiatry"},{"issue":"6123","key":"1672_CR69","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1126\/science.1228261","volume":"339","author":"S Giovanoli","year":"2013","unstructured":"Giovanoli S et al (2013) Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science 339(6123):1095\u20131099","journal-title":"Science"},{"issue":"6276","key":"1672_CR70","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1126\/science.aad0314","volume":"351","author":"GB Choi","year":"2016","unstructured":"Choi GB et al (2016) The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science 351(6276):933\u2013939","journal-title":"Science"},{"issue":"7673","key":"1672_CR71","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nature23910","volume":"549","author":"S Kim","year":"2017","unstructured":"Kim S et al (2017) Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature 549(7673):528\u2013532","journal-title":"Nature"},{"issue":"49","key":"1672_CR72","doi-asserted-by":"publisher","first-page":"16467","DOI":"10.1523\/JNEUROSCI.2582-14.2014","volume":"34","author":"D Yang","year":"2014","unstructured":"Yang D et al (2014) Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci 34(49):16467\u201316481","journal-title":"J Neurosci"},{"issue":"8","key":"1672_CR73","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1172\/JCI78167","volume":"125","author":"LM Lombardi","year":"2015","unstructured":"Lombardi LM, Baker SA, Zoghbi HY (2015) MECP2 disorders: from the clinic to mice and back. J Clin Invest 125(8):2914\u20132923","journal-title":"J Clin Invest"},{"issue":"163","key":"1672_CR74","doi-asserted-by":"publisher","first-page":"163ra158","DOI":"10.1126\/scitranslmed.3004430","volume":"4","author":"T Yang","year":"2012","unstructured":"Yang T et al (2012) Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses. Sci Transl Med 4(163):163ra158","journal-title":"Sci Transl Med"},{"issue":"4","key":"1672_CR75","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.immuni.2015.03.013","volume":"42","author":"JC Cronk","year":"2015","unstructured":"Cronk JC et al (2015) Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli. Immunity 42(4):679\u2013691","journal-title":"Immunity"},{"key":"1672_CR76","doi-asserted-by":"crossref","unstructured":"Schafer DP et al (2016) Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. Elife 5","DOI":"10.7554\/eLife.15224"},{"issue":"6286","key":"1672_CR77","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","volume":"352","author":"S Hong","year":"2016","unstructured":"Hong S et al (2016) Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science 352(6286):712\u2013716","journal-title":"Science"},{"issue":"7612","key":"1672_CR78","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nature18626","volume":"535","author":"AJ Filiano","year":"2016","unstructured":"Filiano AJ et al (2016) Unexpected role of interferon-gamma in regulating neuronal connectivity and social behaviour. Nature 535(7612):425\u2013429","journal-title":"Nature"},{"issue":"2","key":"1672_CR79","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ni.3656","volume":"18","author":"RS Klein","year":"2017","unstructured":"Klein RS, Garber C, Howard N (2017) Infectious immunity in the central nervous system and brain function. Nat Immunol 18(2):132\u2013141","journal-title":"Nat Immunol"},{"issue":"4","key":"1672_CR80","first-page":"265","volume":"3","author":"MD Brot","year":"1997","unstructured":"Brot MD et al (1997) Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice. J Neuro-Oncol 3(4):265\u2013273","journal-title":"J Neuro-Oncol"},{"issue":"7226","key":"1672_CR81","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature07591","volume":"457","author":"JV Kim","year":"2009","unstructured":"Kim JV et al (2009) Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 457(7226):191\u2013195","journal-title":"Nature"},{"issue":"2","key":"1672_CR82","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1128\/CMR.00046-08","volume":"22","author":"TH Mogensen","year":"2009","unstructured":"Mogensen TH (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22(2):240\u2013273 Table of Contents","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"1672_CR83","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1084\/jem.20160499","volume":"214","author":"Y Wolf","year":"2017","unstructured":"Wolf Y et al (2017) Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med 214(4):905\u2013917","journal-title":"J Exp Med"},{"issue":"37","key":"1672_CR84","doi-asserted-by":"publisher","first-page":"14878","DOI":"10.1523\/JNEUROSCI.1329-13.2013","volume":"33","author":"C D'Mello","year":"2013","unstructured":"D'Mello C et al (2013) P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors. J Neurosci 33(37):14878\u201314888","journal-title":"J Neurosci"},{"issue":"5","key":"1672_CR85","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.immuni.2013.01.012","volume":"38","author":"D Venkatesh","year":"2013","unstructured":"Venkatesh D et al (2013) Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment. Immunity 38(5):1025\u20131037","journal-title":"Immunity"},{"issue":"4","key":"1672_CR86","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.immuni.2016.04.005","volume":"44","author":"T Blank","year":"2016","unstructured":"Blank T et al (2016) Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity 44(4):901\u2013912","journal-title":"Immunity"},{"issue":"7608","key":"1672_CR87","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/nature18283","volume":"534","author":"MJ Vasek","year":"2016","unstructured":"Vasek MJ et al (2016) A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature 534(7608):538\u2013543","journal-title":"Nature"},{"issue":"4","key":"1672_CR88","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.neuron.2014.02.007","volume":"81","author":"A Araque","year":"2014","unstructured":"Araque A et al (2014) Gliotransmitters travel in time and space. Neuron 81(4):728\u2013739","journal-title":"Neuron"},{"issue":"7321","key":"1672_CR89","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nature09612","volume":"468","author":"C Eroglu","year":"2010","unstructured":"Eroglu C, Barres BA (2010) Regulation of synaptic connectivity by glia. Nature 468(7321):223\u2013231","journal-title":"Nature"},{"issue":"7403","key":"1672_CR90","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nature11059","volume":"486","author":"NJ Allen","year":"2012","unstructured":"Allen NJ et al (2012) Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors. Nature 486(7403):410\u2013414","journal-title":"Nature"},{"issue":"3","key":"1672_CR91","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","volume":"96","author":"NJ Allen","year":"2017","unstructured":"Allen NJ, Eroglu C (2017) Cell biology of astrocyte-synapse interactions. Neuron 96(3):697\u2013708","journal-title":"Neuron"},{"issue":"24","key":"1672_CR92","doi-asserted-by":"publisher","first-page":"9321","DOI":"10.1073\/pnas.0603146103","volume":"103","author":"MD Tran","year":"2006","unstructured":"Tran MD, Neary JT (2006) Purinergic signaling induces thrombospondin-1 expression in astrocytes. Proc Natl Acad Sci U S A 103(24):9321\u20139326","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1672_CR93","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuron.2011.02.003","volume":"69","author":"M Santello","year":"2011","unstructured":"Santello M, Bezzi P, Volterra A (2011) TNFalpha controls glutamatergic gliotransmission in the hippocampal dentate gyrus. Neuron 69(5):988\u20131001","journal-title":"Neuron"},{"key":"1672_CR94","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","volume":"163","author":"S Habbas","year":"2015","unstructured":"Habbas S et al (2015) Neuroinflammatory TNF\u03b1 impairs memory via astrocyte signaling. Cell 163:1730\u20131741","journal-title":"Cell"},{"issue":"2","key":"1672_CR95","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41590-017-0021-y","volume":"19","author":"C Garber","year":"2018","unstructured":"Garber C et al (2018) Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1. Nat Immunol 19(2):151\u2013161","journal-title":"Nat Immunol"},{"key":"1672_CR96","doi-asserted-by":"crossref","unstructured":"Garre JM, Bennett MVL (2009) Gap junctions as electrical synapses. (The sticky synapse- Cell Adhesion Molecules and their role in Synapse Formation and Maintenance ): p. Chapter 21. Springer, New York","DOI":"10.1007\/978-0-387-92708-4_21"},{"issue":"5907","key":"1672_CR97","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1126\/science.1164022","volume":"322","author":"N Rouach","year":"2008","unstructured":"Rouach N et al (2008) Astroglial metabolic networks sustain hippocampal synaptic transmission. Science 322(5907):1551\u20131555","journal-title":"Science"},{"issue":"50","key":"1672_CR98","doi-asserted-by":"publisher","first-page":"13781","DOI":"10.1523\/JNEUROSCI.2042-07.2007","volume":"27","author":"MA Retamal","year":"2007","unstructured":"Retamal MA et al (2007) Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci 27(50):13781\u201313792","journal-title":"J Neurosci"},{"issue":"52","key":"1672_CR99","doi-asserted-by":"publisher","first-page":"22659","DOI":"10.1073\/pnas.1013793107","volume":"107","author":"JM Garre","year":"2010","unstructured":"Garre JM et al (2010) FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proc Natl Acad Sci U S A 107(52):22659\u201322664","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"1672_CR100","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/glia.22960","volume":"64","author":"M De Bock","year":"2016","unstructured":"De Bock M et al (2016) Into rather unexplored terrain-transcellular transport across the blood-brain barrier. Glia 64(7):1097\u20131123","journal-title":"Glia"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-018-1672-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-1672-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-018-1672-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T16:44:48Z","timestamp":1589561088000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-018-1672-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,21]]},"references-count":100,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["1672"],"URL":"https:\/\/doi.org\/10.1007\/s00109-018-1672-3","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,21]]},"assertion":[{"value":"2 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}