{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:50:53Z","timestamp":1781049053147,"version":"3.54.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772497"],"award-info":[{"award-number":["81772497"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370543"],"award-info":[{"award-number":["81370543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of beijing","doi-asserted-by":"crossref","award":["7162116"],"award-info":[{"award-number":["7162116"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Med"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s00109-019-01808-7","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T07:03:21Z","timestamp":1563433401000},"page":"1399-1412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver"],"prefix":"10.1007","volume":"97","author":[{"given":"Qi","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-8893","authenticated-orcid":false,"given":"Jinhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"issue":"4","key":"1808_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","volume":"12","author":"A Louvet","year":"2015","unstructured":"Louvet A, Mathurin P (2015) Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat Rev Gastroenterol Hepatol 12(4):231\u2013242","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"1808_CR2","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/j.jhep.2015.03.006","volume":"62","author":"P Mathurin","year":"2015","unstructured":"Mathurin P, Bataller R (2015) Trends in the management and burden of alcoholic liver disease. J Hepatol 62(1 Suppl):S38\u2013S46","journal-title":"J Hepatol"},{"issue":"2","key":"1808_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/cld.168","volume":"2","author":"AK Singal","year":"2013","unstructured":"Singal AK, Anand BS (2013) Recent trends in the epidemiology of alcoholic liver disease. Clin Liver Dis 2(2):53\u201356","journal-title":"Clin Liver Dis"},{"issue":"2","key":"1808_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","volume":"33","author":"V Purohit","year":"2009","unstructured":"Purohit V, Gao B, Song BJ (2009) Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 33(2):191\u2013205","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"1808_CR5","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1055\/s-0031-1276643","volume":"31","author":"QM Anstee","year":"2011","unstructured":"Anstee QM, Daly AK, Day CP (2011) Genetics of alcoholic and nonalcoholic fatty liver disease. Semin Liver Dis 31(2):128\u2013146","journal-title":"Semin Liver Dis"},{"issue":"1","key":"1808_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/hep.27036","volume":"60","author":"HJ Kwon","year":"2014","unstructured":"Kwon HJ, Won YS, Park O, Chang B, Duryee MJ, Thiele GE, Matsumoto A, Singh S, Abdelmegeed MA, Song BJ, Kawamoto T, Vasiliou V, Thiele GM, Gao B (2014) Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Hepatology 60(1):146\u2013157","journal-title":"Hepatology"},{"issue":"1","key":"1808_CR7","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/hep.23258","volume":"51","author":"RS O'Shea","year":"2010","unstructured":"O'Shea RS, Dasarathy S, McCullough AJ (2010) Alcoholic liver disease. Hepatology 51(1):307\u2013328","journal-title":"Hepatology"},{"issue":"1\u20132","key":"1808_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.mam.2007.09.004","volume":"29","author":"E Albano","year":"2008","unstructured":"Albano E (2008) Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Asp Med 29(1\u20132):9\u201316","journal-title":"Mol Asp Med"},{"issue":"5","key":"1808_CR9","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","volume":"141","author":"B Gao","year":"2011","unstructured":"Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141(5):1572\u20131585","journal-title":"Gastroenterology"},{"issue":"4","key":"1808_CR10","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","volume":"16","author":"AI Cederbaum","year":"2012","unstructured":"Cederbaum AI (2012) Alcohol metabolism. Clinics in liver disease 16(4):667\u2013685","journal-title":"Clinics in liver disease"},{"issue":"47","key":"1808_CR11","doi-asserted-by":"publisher","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","volume":"20","author":"E Ceni","year":"2014","unstructured":"Ceni E, Mello T, Galli A (2014) Pathogenesis of alcoholic liver disease: role of oxidative metabolism. World J Gastroenterol 20(47):17756\u201317772","journal-title":"World J Gastroenterol"},{"issue":"10","key":"1808_CR12","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/labinvest.2014.98","volume":"94","author":"YJ Choi","year":"2014","unstructured":"Choi YJ, Shin HS, Choi HS, Park JW, Jo I, Oh ES, Lee KY, Lee BH, Johnson RJ, Kang DH (2014) Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Lab Investig 94(10):1114\u20131125","journal-title":"Lab Investig"},{"issue":"1","key":"1808_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biochi.2004.11.008","volume":"87","author":"R Dentin","year":"2005","unstructured":"Dentin R, Girard J, Postic C (2005) Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver. Biochimie 87(1):81\u201386","journal-title":"Biochimie"},{"issue":"32","key":"1808_CR14","doi-asserted-by":"publisher","first-page":"29342","DOI":"10.1074\/jbc.M202411200","volume":"277","author":"M You","year":"2002","unstructured":"You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277(32):29342\u201329347","journal-title":"J Biol Chem"},{"issue":"2","key":"1808_CR15","doi-asserted-by":"publisher","first-page":"528","DOI":"10.2353\/ajpath.2010.090526","volume":"176","author":"K Boye","year":"2010","unstructured":"Boye K, Maelandsmo GM (2010) S100A4 and metastasis: a small actor playing many roles. Am J Pathol 176(2):528\u2013535","journal-title":"Am J Pathol"},{"issue":"2","key":"1808_CR16","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1083\/jcb.130.2.393","volume":"130","author":"F Strutz","year":"1995","unstructured":"Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG (1995) Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 130(2):393\u2013405","journal-title":"J Cell Biol"},{"issue":"1\u20132","key":"1808_CR17","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s10555-011-9338-4","volume":"31","author":"SK Mishra","year":"2012","unstructured":"Mishra SK, Siddique HR, Saleem M (2012) S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence. Cancer Metastasis Rev 31(1\u20132):163\u2013172","journal-title":"Cancer Metastasis Rev"},{"issue":"1","key":"1808_CR18","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1073\/pnas.1017547108","volume":"108","author":"CH \u00d6sterreicher","year":"2011","unstructured":"\u00d6sterreicher CH, Penz-\u00d6sterreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA (2011) Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci 108(1):308\u2013313","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"1808_CR19","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1158\/0008-5472.CAN-12-3022","volume":"73","author":"J Zhang","year":"2013","unstructured":"Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T, Qin Z (2013) Fibroblast-specific protein 1\/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res 73(9):2770\u20132781","journal-title":"Cancer Res"},{"issue":"1","key":"1808_CR20","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.ajpath.2010.11.017","volume":"178","author":"J Zhang","year":"2011","unstructured":"Zhang J, Chen L, Xiao M, Wang C, Qin Z (2011) FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation. Am J Pathol 178(1):382\u2013390","journal-title":"Am J Pathol"},{"issue":"1","key":"1808_CR21","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.canlet.2013.10.036","volume":"344","author":"IJ Bettum","year":"2014","unstructured":"Bettum IJ, Vasiliauskaite K, Nygaard V, Clancy T, Pettersen SJ, Tenstad E, Maelandsmo GM, Prasmickaite L (2014) Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties. Cancer Lett 344(1):28\u201339","journal-title":"Cancer Lett"},{"issue":"32","key":"1808_CR22","doi-asserted-by":"publisher","first-page":"5487","DOI":"10.1038\/sj.onc.1207720","volume":"23","author":"B Schmidt-Hansen","year":"2004","unstructured":"Schmidt-Hansen B, Ornas D, Grigorian M, Klingelhofer J, Tulchinsky E, Lukanidin E, Ambartsumian N (2004) Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 23(32):5487\u20135495","journal-title":"Oncogene"},{"issue":"42","key":"1808_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.18632\/oncotarget.18016","volume":"8","author":"F Fei","year":"2017","unstructured":"Fei F, Qu J, Zhang M, Li Y, Zhang S (2017) S100A4 in cancer progression and metastasis: a systematic review. Oncotarget 8(42):21\u201373239","journal-title":"Oncotarget"},{"issue":"1","key":"1808_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.2174\/156652413804486214","volume":"13","author":"R Donato","year":"2013","unstructured":"Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ, Geczy CL (2013) Functions of S100 proteins. Curr Mol Med 13(1):34\u201357","journal-title":"Curr Mol Med"},{"issue":"1","key":"1808_CR25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jhep.2014.07.035","volume":"62","author":"L Chen","year":"2015","unstructured":"Chen L, Zhang J, Dai C, Liu X, Wang J, Gao Z, Guo H, Wang R, Lu S, Wang F, Zhang H, Chen H, Fan X, Wang S, Qin Z (2015) S100A4 promotes liver fibrosis via activation of hepatic stellate cells. J Hepatol 62(1):156\u2013164","journal-title":"J Hepatol"},{"issue":"4","key":"1808_CR26","doi-asserted-by":"publisher","first-page":"e1296996","DOI":"10.1080\/2162402X.2017.1296996","volume":"7","author":"J Zhang","year":"2018","unstructured":"Zhang J, Song K, Wang J, Li Y, Liu S, Dai C, Chen L, Wang S, Qin Z (2018) S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. OncoImmunology 7(4):e1296996","journal-title":"OncoImmunology"},{"issue":"8","key":"1808_CR27","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/s41374-018-0067-y","volume":"98","author":"S Hou","year":"2018","unstructured":"Hou S, Jiao Y, Yuan Q, Zhai J, Tian T, Sun K, Chen Z, Wu Z, Zhang J (2018) S100A4 protects mice from high-fat diet-induced obesity and inflammation. Lab Investig 98(8):1025\u20131038","journal-title":"Lab Investig"},{"issue":"4","key":"1808_CR28","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1002\/hep.23837","volume":"52","author":"SH Ki","year":"2010","unstructured":"Ki SH, Park O, Zheng M, Morales-Ibanez O, Kolls JK, Bataller R, Gao B (2010) Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52(4):1291\u20131300","journal-title":"Hepatology"},{"issue":"6","key":"1808_CR29","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1172\/JCI109983","volume":"66","author":"RP McEver","year":"1980","unstructured":"McEver RP, Baenziger NL, Majerus PW (1980) Isolation and quantitation of the platelet membrane glycoprotein deficient in Thrombasthenia using a monoclonal Hybridoma antibody. J Clin Invest 66(6):1311\u20131318","journal-title":"J Clin Invest"},{"issue":"1","key":"1808_CR30","doi-asserted-by":"publisher","first-page":"12099","DOI":"10.1038\/s41598-017-12256-z","volume":"7","author":"J Zhang","year":"2017","unstructured":"Zhang J, Jiao Y, Hou S, Tian T, Yuan Q, Hao H, Wu Z, Bao X (2017) S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells. Sci Rep 7(1):12099","journal-title":"Sci Rep"},{"issue":"4","key":"1808_CR31","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"2","key":"1808_CR32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s004410050594","volume":"284","author":"N Kawada","year":"1996","unstructured":"Kawada N, Kuroki T, Kobayashi K, Inoue M, Nakatani K, Kaneda K, Nagata K (1996) Expression of heat-shock protein 47 in mouse liver. Cell Tissue Res 284(2):341\u2013346","journal-title":"Cell Tissue Res"},{"issue":"3","key":"1808_CR33","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41419-018-0319-1","volume":"9","author":"S Hou","year":"2018","unstructured":"Hou S, Tian T, Qi D, Sun K, Yuan Q, Wang Z, Qin Z, Wu Z, Chen Z, Zhang J (2018) S100A4 promotes lung tumor development through \u03b2-catenin pathway-mediated autophagy inhibition. Cell Death Dis 9(3):277","journal-title":"Cell Death Dis"},{"issue":"12","key":"1808_CR34","first-page":"3386","volume":"63","author":"CPD Xue","year":"2003","unstructured":"Xue CPD, Venkov C, Xu C, Neilson EG (2003) The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res 63(12):3386\u20133394","journal-title":"Cancer Res"},{"issue":"6","key":"1808_CR35","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jhep.2014.12.027","volume":"62","author":"K Cui","year":"2015","unstructured":"Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R, Tian Z (2015) Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1beta in mice. J Hepatol 62(6):1311\u20131318","journal-title":"J Hepatol"},{"issue":"3","key":"1808_CR36","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1053\/gast.2003.50087","volume":"124","author":"GE Arteel","year":"2003","unstructured":"Arteel GE (2003) Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124(3):778\u2013790","journal-title":"Gastroenterology"},{"issue":"2","key":"1808_CR37","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1172\/JCI29544","volume":"117","author":"CD Venkov","year":"2007","unstructured":"Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, Xu C, Dimitrova YN, Rauscher FJ, Neilson EG (2007) A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 117(2):482\u2013491","journal-title":"J Clin Invest"},{"issue":"5","key":"1808_CR38","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrc1877","volume":"6","author":"R Kalluri","year":"2006","unstructured":"Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6(5):392\u2013401","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"1808_CR39","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/onc.2013.568","volume":"34","author":"MT Hansen","year":"2015","unstructured":"Hansen MT, Forst B, Cremers N, Quagliata L, Ambartsumian N, Grum-Schwensen B, Klingelhofer J, Abdul-Al A, Herrmann P, Osterland M, Stein U, Nielsen GH, Scherer PE, Lukanidin E, Sleeman JP, Grigorian M (2015) A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Oncogene 34(4):424\u2013435","journal-title":"Oncogene"},{"issue":"3","key":"1808_CR40","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/art.24295","volume":"60","author":"RR Yammani","year":"2009","unstructured":"Yammani RR, Long D, Loeser RF (2009) Interleukin-7 stimulates secretion of S100A4 by activating the JAK\/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum 60(3):792\u2013800","journal-title":"Arthritis Rheum"},{"key":"1808_CR41","doi-asserted-by":"publisher","first-page":"495156","DOI":"10.1155\/2013\/495156","volume":"2013","author":"H Kawaratani","year":"2013","unstructured":"Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H (2013) The effect of inflammatory cytokines in alcoholic liver disease. Mediat Inflamm 2013:495156","journal-title":"Mediat Inflamm"},{"issue":"2","key":"1808_CR42","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jhep.2012.01.029","volume":"57","author":"B Gao","year":"2012","unstructured":"Gao B, Wang H, Lafdil F, Feng D (2012) STAT proteins \u2013 key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol 57(2):430\u2013441","journal-title":"J Hepatol"},{"issue":"4","key":"1808_CR43","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/j.1530-0277.2009.01141.x","volume":"34","author":"AM Miller","year":"2010","unstructured":"Miller AM, Wang H, Park O, Horiguchi N, Lafdil F, Mukhopadhyay P, Moh A, Fu XY, Kunos G, Pacher P, Gao B (2010) Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcohol Clin Exp Res 34(4):719\u2013725","journal-title":"Alcohol Clin Exp Res"},{"issue":"4","key":"1808_CR44","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1053\/j.gastro.2008.01.016","volume":"134","author":"NWL Horiguchi","year":"2008","unstructured":"Horiguchi NWL, Mukhopadhyay P, Park O, Jeong WI, Lafdil F, Osei-Hyiaman D, Moh A, Fu XY, Pacher P, Kunos G, Gao B (2008) Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134(4):1148\u20131158","journal-title":"Gastroenterology"},{"issue":"7","key":"1808_CR45","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1172\/JCI200317970","volume":"112","author":"S Haga","year":"2003","unstructured":"Haga S, Terui K, Zhang HQ, Enosawa S, Ogawa W, Inoue H, Okuyama T, Takeda K, Akira S, Ogino T, Irani K, Ozaki M (2003) Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Investig 112(7):989\u2013998","journal-title":"J Clin Investig"}],"container-title":["Journal of Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-019-01808-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00109-019-01808-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00109-019-01808-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T23:07:19Z","timestamp":1594940839000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00109-019-01808-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1808"],"URL":"https:\/\/doi.org\/10.1007\/s00109-019-01808-7","relation":{},"ISSN":["0946-2716","1432-1440"],"issn-type":[{"value":"0946-2716","type":"print"},{"value":"1432-1440","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"9 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}