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Thus, the IgMi mouse offers a model system by which to dissect out antibody-dependent and antibody-independent B cell function. Here, we provide the first detailed characterisation of the IgMi mouse post-<jats:italic>Trichuris muris<\/jats:italic>(<jats:italic>T. muris<\/jats:italic>) infection, describing expulsion phenotype, cytokine production, gut pathology and changes in T regulatory cells, T follicular helper cells and germinal centre B cells, in addition to RNA sequencing (RNA seq) analyses of wild-type littermates (WT) and mutant B cells prior to and\u00a0post infection. IgMi mice were susceptible to a high-dose infection, with reduced Th2 cytokines and elevated B cell-derived IL-10 in mesenteric lymph nodes (MLN) compared to controls. A low-dose infection regime revealed IgMi mice to have significantly more apoptotic cells in the gut compared to WT mice, but no change in intestinal inflammation. IL-10 levels were again elevated. Collectively, this study showcases the potential of the IgMi mouse as a tool for understanding B cell biology and suggests that the B cell plays both antibody-dependent and antibody-independent roles post high- and low-dose<jats:italic>T. muris<\/jats:italic>infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key messages<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p>During a high-dose<jats:italic>T. muris<\/jats:italic>infection, B cells are important in maintaining the Th1\/Th2 balance in the MLN through an antibody-independent mechanism.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>High levels of IL-10 in the MLN early post-infection, and the presence of IL-10-producing B cells, correlates with susceptibility to<jats:italic>T. muris<\/jats:italic>infection.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>B cells maintain gut homeostasis during chronic<jats:italic>T. muris<\/jats:italic>infection via an antibody-dependent mechanism.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1007\/s00109-020-01954-3","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T22:02:44Z","timestamp":1597096964000},"page":"1301-1317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse"],"prefix":"10.1007","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-0417","authenticated-orcid":false,"given":"Rinal","family":"Sahputra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma A","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Forman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Mair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Z. 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